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Search Results: 1 - 10 of 427690 matches for " Luis; M Ford "
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An Independent Assessment of the Monthly PRISM Gridded Precipitation Product in Central Oklahoma  [PDF]
Jeanne M. Schneider, Donald L. Ford
Atmospheric and Climate Sciences (ACS) , 2013, DOI: 10.4236/acs.2013.32026

Accurate, long-term records of precipitation are required for the development of climate-informed decision support tools for agriculture. But rain gauges are too sparsely located to meet this need, and radar-derived precipitation measurements are too recent in duration. Using all readily available station records, spatiotemporally continuous estimates of precipitation were created by the PRISM Climate Group to address this problem. As with all interpolated data, the validity of the gridded PRISM product requires validation, and given the extreme spatiotemporal variability of precipitation, such validation is essential. Previous work comparing the monthly precipitation product against contributing rain gauge data revealed inconsistencies that prompted the analysis reported herein. As a basis for checking the accuracy of the PRISM product, independent precipitation data gathered at a USDA research laboratory in central Oklahoma were quality controlled, including comparison to a co-located automated rain gauge operated by the Oklahoma Mesonet. Results indicate that the independent USDA gauge data are of sufficient quality to use in the evaluation of the PRISM product. The area average of the independent USDA data over a matching size area was then used to validate colocated gridded PRISM estimates. The validation results indicate that the monthly gridded PRISM precipitation estimates are close to the independent observed data in terms of means (smaller by 3% to 4.5%) and cumulative probability distributions (within ~4%), but with variances too small by 7% to 11%. From the point of view of agricultural decision support, these results indicate that PRISM estimates might be useful for probabilistic applications, such as downscaling climate forecasts or driving weather generators, assuming appropriate corrections to the higher-order statistics were applied. However, the number of months with potentially significant differences precludes the use of PRISM estimates for any retrospective month-by-month analyses of possible interactions between climate, crop management, and productivity.

Leucemia linfoma T del adulto en Chile.: Estudio clínico-patológico y molecular de 26 pacientes
Cabrera C,M Elena; Labra G,Silvia; Meneses C,Pedro; Matutes,Estella; Cartier R,Luis; M Ford,Anthony; F Greaves,Melvyn;
Revista médica de Chile , 1999, DOI: 10.4067/S0034-98871999000800007
Abstract: background: adult t cell leukemia lymphoma is a lymphoproliferative syndrome etiologically associated to human t cell lymphotropic virus type i. aim: to describe the clinical and laboratory features of 26 caucasian chilean patients, with htlv-i positive adult t-cell leukemia lymphoma (atll). material and methods: diagnostic criteria included clinical features, cell morphology, immunophenotype, htlv-i serology and/or dna analysis by southern blot or pcr. results: according to the clinical presentation, 12 cases had the acute atll form, 6 had a lymphoma, 4 the chronic form and 4 had smoldering atll. the median presentation age was 50 years, younger than the japanese patients, but significantly older than patients from other south american countries (eg brasil, jamaica, colombia). the main clinical features: lymphadenopathy, skin lesions and hepatosplenomegaly, were similar in frequency to those of patients from other countries, except for the high incidence of associated neurological disease. tropical spastic paraparesis (tsp) in our series of atll, was seen in one third of the patients (8/26). a t-cell immunophenotype was shown in all 26 cases and htlv-i serology was positive in 25/26 patients. molecular analysis on the seronegative patient showed clonal integration of proviral htlv-i dna into the lymphocytes dna, and thus he may have been a poor responder to the retroviral infection. proviral dna integration was also demonstrated in 15/16 patients being clonal in 10, polyclonal in 3 (all smoldering cases) and oligoclonal in one. conclusions: atll in chile has similar clinical and laboratory features than the disease in other parts of the world, except for a younger age than japanese patients but older than those from other latin american countries and a high incidence of patients with associated tsp. detailed morphological and immunophenotypic analysis of the abnormal circulating lymphocytes, together with the documentation of htlv-i by serology and/or dna analysis
Is breast cancer a part of Lynch syndrome?
James M Ford
Breast Cancer Research , 2012, DOI: 10.1186/bcr3241
Abstract: In a comprehensive analysis of all available breast cancers from among 200 Lynch syndrome (LS) families in a nationwide registry in Finland, Lotsari and colleagues [1] address the question of whether breast cancer is an integral part of LS. The results, published in the previous issue of Breast Cancer Research, are compelling and could inform the way we conduct genetic testing in the diagnosis of LS and set guidelines for breast cancer surveillance in LS mutation carriers.A central tenet in cancer biology is that most human tumors are associated with, and often are caused by, abnormally elevated levels of genomic instability due to inherited or sporadically acquired defects in DNA repair mechanisms [2]. Although the comprehensiveness of this hypothesis is vigorously argued in the literature, LS (also known as hereditary non-polyposis colorectal cancer) is considered a paradigm for the mutator phenotype [3,4]. An autosomal dominant Mendelian disorder caused by heterozygous germline mutations in one of four DNA mismatch repair (MMR) genes [5], tumors arising in LS mutation carriers usually undergo loss-of-heterozygosity in the corresponding normal MMR gene, typically resulting in loss of protein expression as assessed by immunohistochemistry (IHC), and exhibit an MMR functional deficiency as defined by the presence of microsatellite instability (MSI) [6]. Therefore, a set of readily available phenotypic assays (MSI and IHC for MMR proteins) can help identify underlying genomic instability and guide germline genetic testing to the appropriate causative allele, thereby greatly facilitating screening [7]. In addition to the two most common cancers that define LS (colorectal and endometrial cancer), a spectrum of malignancies - ovarian, stomach, small bowel, hepatobiliary, ureteral tract, pancreas, skin, brain, and others - has been associated with LS on the basis of their increased incidence in MMR gene mutation carriers and more recently on the basis of documented molec
Assessing the diagnostic accuracy of the identification of hyperkinetic disorders following the introduction of government guidelines in England
Foreman David M,Ford Tamsin
Child and Adolescent Psychiatry and Mental Health , 2008, DOI: 10.1186/1753-2000-2-32
Abstract: Background Previous studies have suggested that both underdiagnosis and overdiagnosis routinely occur in ADHD and hyperkinesis (hyperkinetic disorders). England has introduced governmental guidelines for these disorders' detection and treatment, but there has been no study on clinical diagnostic accuracy under such a regime. Methods All open cases in three Child and Adolescent Mental Health Services (CAMHS) in the South East of England were assessed for accuracy in the detection of hyperkinetic disorders, using a two-stage process employing the Strengths and Difficulties Questionnaire (SDQ) for screening, with the cut-off between "unlikely" and "possible" as the threshold for identification, and the Development And Well-Being Assessment (DAWBA) as a valid and reliable standard. Results 502 cases were collected. Their mean age 11 years (std dev 3 y); 59% were clinically diagnosed as having a hyperkinetic disorder including ADHD. Clinicians had missed two diagnoses of hyperkinesis and six of ADHD. The only 'false positive' case was one that had become asymptomatic on appropriate treatment. Conclusion The identification of children with hyperkinetic disorders by three ordinary English CAMHS teams appears now to be generally consistent with that of a validated, standardised assessment. It seems likely that this reflects the impact of Governmental guidelines, which could therefore be an appropriate tool to ensure consistent accurate diagnosis internationally.
Doubly Periodic Instantons and their Constituents
Chris Ford,Jan M. Pawlowski
Physics , 2003, DOI: 10.1103/PhysRevD.69.065006
Abstract: Using the Nahm transform we investigate doubly periodic charge one SU(2) instantons with radial symmetry. Two special points where the Nahm zero modes have softer singularities are identified as the locations of instanton core constituents. For a square torus this constituent picture is closely reflected in the action density. In rectangular tori with large aspect ratios the cores merge to form monopole-like objects. For particular values of the parameters the torus can be cut in half yielding two copies of a twisted charge 1/2 instanton. These findings are illustrated with plots of the action density within a two-dimensional slice containing the constituents.
Doubly Periodic Instanton Zero Modes
Chris Ford,Jan M. Pawlowski
Physics , 2005, DOI: 10.1016/j.physletb.2005.08.094
Abstract: Fermionic zero modes associated with doubly periodic SU(2) instantons of unit charge are considered. In cases where the action density exhibits two `instanton cores' the zero mode peaks on one of four line-segments joining the two constituents. Which of the four possibilities is realised depends on the fermionic boundary conditions; doubly periodic, doubly anti-periodic or mixed.
Constituents of Doubly Periodic Instantons
Chris Ford,Jan M. Pawlowski
Physics , 2002, DOI: 10.1016/S0370-2693(02)02130-5
Abstract: Using the Nahm transform we investigate doubly periodic charge one SU(2) instantons with radial symmetry. Two special points where the Nahm zero modes have softer singularities are identified as constituent locations. To support this picture, the action density is computed analytically and numerically within a two dimensional slice containing the two constituents. For particular values of the parameters the torus can be cut in half yielding two copies of a twisted charge 1/2 instanton. Such objects comprise a single constituent.
Cataloguing In Special Libraries In The 1990s
Elizabeth Makin,Nigel Ford,Alexander M. Robertson
Information Research: an international electronic journal , 1996,
Abstract: Cataloguing in special libraries has been virtually ignored in the literature since the turn of the century, although there are many books and papers on cataloguing in general. It is not clear why this should be so, since it can be argued that the needs of special libraries are different from those of public, academic and national libraries. Special libraries are primarily interested in the information content of documents in the sense that they have little or no interest in documents except as "packages" in which information may be encapsulated. It is therefore reasonable to assume, a priori, that special libraries would undertake detailed indexing and light cataloguing, perhaps reducing the catalogue to the status of a finding list. This paper reports the results of a survey of current cataloguing practice in special libraries.
Perceived Leader Effectiveness across Organizational Roles: Exploratory Evidence from Central Eurasia
David L. FORD,M. Ismail KIRAN
Eurasian Journal of Business and Economics , 2008,
Abstract: SYMLOG methodology was used by a sample of respondents from Central Eurasia to rate their perceptions of the values shown in the behavior of leaders occupying three kinds of organizational roles: (1) chief executive officers of business enterprises, NGO’s, or key governmental agencies; (2) immediate supervisors of the respondents in their respective organizations; and (3) country leaders or Heads of State (e.g., President, Prime Minister, etc.) of the respondents’ home country. Respondents were participants who took part in a two-week leadership development program in their region. Respondents also rated the leaders’ role performance and their satisfaction with the leaders. Respondents who categorized themselves as transformational leaders evaluated the supervisor role occupants as most effective while non-transformational leaders perceived the CEO role occupants to be most effective. The results are discussed in light of future needs for crosscultural leadership research.
Relationship between Dual-Energy X-Ray Absorptiometry-Derived Appendicular Lean Tissue Mass and Total Body Skeletal Muscle Mass Estimated by Ultrasound  [PDF]
Takashi Abe, Nicole C. Dabbs, Vinayak K. Nahar, M. Allison Ford, Martha A. Bass, Mark Loftin
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.46049

Dual-energy X-ray absorptiometry (DXA) is an attractive method for evaluating sarcopenia, age-related loss of skeletal muscle mass and function, using appendicular lean tissue (aLT) mass for criteria of diagnosis, although minimal radiation is exposed. Skeletal muscle (SM) mass can be estimated by using ultrasound-measured muscle thickness (MTH). However, the association between these two methods is unclear. To examine the relationship between DXA-derived aLT mass and total body SM mass estimated by ultrasound, thirty-six healthy adults (18 men and 18 women) aged 19 - 65 years participated in this study. Ultrasound-measured muscle thickness was used to estimate the total SM mass. DXA was used to estimate whole body and regional body composition, and aLT mass was considered equivalent to the sum of lean tissue in both the right and left arms and legs. Total SM mass (26.3 ± 4.4 kg for men and 15.7 ± 2.6 kg for women) estimated by ultrasound was similar to DXA-estimated aLT mass (24.5 ± 3.8 kg for men and 15.7 ± 2.7 kg for women). There was a strong correlation between DXA-measured aLT mass and total SM mass estimated by ultrasound in men (r = 0.927, n = 18) and women (r = 0.931, n = 18) as well as overall sample (r = 0.975, n = 36). The ratio of total SM mass to aLT mass was 1.07 for men and 1.00 for women. These results suggest that DXA-derived aLT mass can be accurately predicted from ultrasound estimated total SM mass, although the predicted value may

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