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Search Results: 1 - 10 of 281256 matches for " Luis I de Lasa "
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REPRESENTACIONES DEL ESPACIO PATAGóNICO: UNA INTERPRETACIóN DE LA CARTOGRAFíA JESUíTICA DE LOS SIGLOS XVII Y XVIII
de Lasa,Luis I; Luiz,María Teresa;
Cuadernos de historia (Santiago) , 2011, DOI: 10.4067/S0719-12432011000200001
Abstract: jesuit cartography serves as an exceptional sourcefor gaining access to the ways of production and use of the geographical and cartographic knowledge related to the southern borders of the spanish empire. taking into account that the maps produced by the missionaries from the society ofjesus were the first to explicitly incorporate the spatial knowledge of the local inhabitants, we examined the conditions for collecting information, the strategiesfor appropriation and organization ofindigenous lore and the reconciliation ofdifferent spatial conceptions and representations upon producing the map. considering the use made of the jesuit production, we have identified the main beneficiaries from this intimate knowledge. at the present study we examine the general maps ofpatagonia produced by alonso de ovalle (1646), josé cardiel (1746-1747, 1749y 1751) and thomas falkner (1772).
REPRESENTACIONES DEL ESPACIO PATAGóNICO: UNA INTERPRETACIóN DE LA CARTOGRAFíA JESUíTICA DE LOS SIGLOS XVII Y XVIII REPRESENTATIONS OF THE PATAGONIAN SPACE: AN INTERPRETATION OF 17TH- AND 18TH-CENTURY JESUIT CARTOGRAPHY
Luis I de Lasa,María Teresa Luiz
Cuadernos de historia , 2011,
Abstract: La cartografía jesuítica constituye una fuente privilegiada para acceder a las formas de producción y uso del conocimiento geográfico y cartográfico referido a las fronteras australes del imperio espa ol. Considerando que los mapas elaborados por los misioneros de la Compa ía de Jesús son los primeros en integrar explícitamente el conocimiento espacial de los habitantes del territorio, indagamos sobre las condiciones de obtención de la información, las estrategias de apropiación y organización de los saberes indígenas y la compatibilización de distintas concepciones y representaciones del espacio en la elaboración del mapa. Atendiendo al uso de la producción de los jesuitas, identificamos los principales beneficiarios de este saber calificado. En este estudio examinamos los mapas generales de Patagonia de Alonso de Ovalle (1646), José Cardiel (1746-1747, 1749 y 1751) y Thomas Falkner (1772). Jesuit cartography serves as an exceptional sourcefor gaining access to the ways of production and use of the geographical and cartographic knowledge related to the southern borders of the Spanish empire. Taking into account that the maps produced by the missionaries from the Society ofJesus were the first to explicitly incorporate the spatial knowledge of the local inhabitants, we examined the conditions for collecting information, the strategiesfor appropriation and organization ofindigenous lore and the reconciliation ofdifferent spatial conceptions and representations upon producing the map. Considering the use made of the Jesuit production, we have identified the main beneficiaries from this intimate knowledge. At the present study we examine the general maps ofPatagonia produced by Alonso de Ovalle (1646), José Cardiel (1746-1747, 1749y 1751) and Thomas Falkner (1772).
Towards the identification of the common features of bacterial biofilm development
Lasa,I?igo;
International Microbiology , 2006,
Abstract: microorganisms can live and proliferate as individual cells swimming freely in the environment, or they can grow as highly organized, multicellular communities encased in a self-produced polymeric matrix in close association with surfaces and interfaces. this microbial lifestyle is referred to as biofilms. the intense search over the last few years for factors involved in biofilm development has revealed that distantly related bacterial species recurrently make use of the same elements to produce biofilms. these common elements include a group of proteins containing ggdef/eal domains, surface proteins homologous to bap of staphylococcus aureus, and some types of exopolysaccharides, such as cellulose and the poly-b-1,6-n-acetylglucosamine. this review summarizes current knowledge about these three common elements and their role in biofilm development.
Base Pairing Interaction between 5′- and 3′-UTRs Controls icaR mRNA Translation in Staphylococcus aureus
Igor Ruiz de los Mozos,Marta Vergara-Irigaray,Victor Segura,Maite Villanueva,Nerea Bitarte,Margarida Saramago,Susana Domingues,Cecilia M. Arraiano,Pierre Fechter,Pascale Romby,Jaione Valle,Cristina Solano,I?igo Lasa ,Alejandro Toledo-Arana
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1004001
Abstract: The presence of regulatory sequences in the 3′ untranslated region (3′-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 3′-UTRs in bacterial mRNA functionality has been disregarded. Here, we report evidences showing that around one-third of the mapped mRNAs of the major human pathogen Staphylococcus aureus carry 3′-UTRs longer than 100-nt and thus, potential regulatory functions. We selected the long 3′-UTR of icaR, which codes for the repressor of the main exopolysaccharidic compound of the S. aureus biofilm matrix, to evaluate the role that 3′-UTRs may play in controlling mRNA expression. We showed that base pairing between the 3′-UTR and the Shine-Dalgarno (SD) region of icaR mRNA interferes with the translation initiation complex and generates a double-stranded substrate for RNase III. Deletion or substitution of the motif (UCCCCUG) within icaR 3′-UTR was sufficient to abolish this interaction and resulted in the accumulation of IcaR repressor and inhibition of biofilm development. Our findings provide a singular example of a new potential post-transcriptional regulatory mechanism to modulate bacterial gene expression through the interaction of a 3′-UTR with the 5′-UTR of the same mRNA.
The Application of K Phosphites to Seed Tubers Enhanced Emergence, Early Growth and Mycorrhizal Colonization in Potato (Solanum tuberosum)  [PDF]
Cecilia Tambascio, Fernanda Covacevich, María Candela Lobato, Carolina de Lasa, Daniel Caldiz, Guillermo Dosio, Adriana Andreu
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.51017
Abstract:

Rapid emergence and a vigorous growth prevent the seed tubers from infections by soil microbes and allow a rapid interception of solar radiation. In this work, the effect of the potassium phosphites (KPhi) applied to seed tubers of two potato cultivars on crop emergence and early growth was studied. Two experiments were performed under greenhouse and field conditions. Emergence of plants, leaf area, dry matter and the number of primary stems were measured in both experiments. Furthermore, mycorrhizal colonization was also measured on roots under field conditions. The application of KPhi reduced the period between planting and emergence, and increased leaf area and dry matter. The ratio between dry matter of aerials and underground organs was not affected by KPhi. Indigenous mycorrhizal colonization increased after KPhi application to seed tubers. These results confirm the benefit of the application of KPhi to seed tubers on early plant growth and suggest that their application in crop production would be advantageous.

Test epicutáneos con inhalantes en el estudio de la dermatitis atópica Epicutaneous test with inhalers in the study of atopic dermatitis
S. Echechipía,B. Gómez,E. Lasa,I. Larrea
Anales del Sistema Sanitario de Navarra , 2003,
Abstract: En un 80% de pacientes con dermatitis atópica se demuestra la presencia de IgE específica frente a alergenos alimentarios o ambientales. También se ha demostrado la exacerbación de las lesiones de la dermatitis tras ingestión o inhalación de alergenos y su mejoría al reducir la exposición alergénica en un subgrupo de pacientes con dermatitis atópica. Aunque el prick y la determinación de IgE específica en suero son técnicas muy sensibles, las pruebas epicutáneas aplicando el alergeno directamente en la piel podrían ser el método diagnóstico ideal ya que reproducen la respuesta inflamatoria característica de la enfermedad en el propio órgano de choque que es la piel. Sin embargo, existe gran variabilidad en los resultados obtenidos mediante pruebas epicutáneas con aeroalergenos, debido fundamentalmente a diferencias metodológicas, que se revisan en este trabajo. Por último, presentamos los resultados de realizar pruebas epicutáneas con alergenos inhalantes a nuestros pacientes con dermatitis atópica y controles, obteniendo un 27% de parches positivos, fundamentalmente con ácaros y en aquellos pacientes con dermatitis más grave sin que exista una completa concordancia con la técnica del prick. Por ello, las pruebas epicutáneas parecen un método de diagnóstico alergológico que puede ser útil y complementario a las técnicas de rutina como el prick o la determinación de IgE específica en suero, pero queda pendiente su adecuada estandarización. In some 80% of patients with atopic dermatitis, the presence of specific IgE is found when facing food or environmental allergens. It has also been demonstrated in a sub-group of patients with atopic dermatitis that the dermatitis lesions are exacerbated following the ingestion or inhalation of allergens, and that they improve with reduction of exposure to allergens. Although the prick method and the determination of specific IgE in serum are highly sensitive techniques, epicutaneous tests, applying the allergen directly to the skin, might be the ideal diagnostic method since they reproduce the characteristic inflammatory response of the disease on the affected organ itself, the skin. However, there is great variability in the results obtained through epicutaneous tests with aeroallergens, basically due to methodological differences, which are reviewed in this paper. Finally, we present the results of carrying out epicutaneous tests with inhalant allergens on our patients with atopic dermatitis and controls, where some 27% of positive patches were obtained, basically with acari, and in those patients with more severe d
The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes La combinación de resveratrol y CLA no incrementa el efecto hipolipemiante de cada molécula en adipocitos 3T3-L1
A. Lasa,J. Miranda,I. Churruca,E. Simón
Nutrición Hospitalaria , 2011,
Abstract: Introduction: Trans-10, cis-12 conjugated linoleic acid (CLA) and resveratrol have been shown to reduce TG content in cultured 3T3-L1 adipocyte acting on different pathways. In recent years, the method of simultaneously targeting several signal transduction pathways with multiple natural products in order to achieve additive or synergistic effects has been tested. However, the combined effect of both molecules on lipid metabolism has not been described before. Objective: The aim of the present work was to analyze the effect of the combination of trans-10, cis-12 CLA and resveratrol on TG accumulation as well as on FAS, HSL and ATGL expression in 3T3-L1 mature adipocytes, in order to assess a potential interaction between both molecules. Methods: For this purpose, 3T3-L1 mature adipocytes were treated with the two molecules, both separately and combined, in 10 and 100 μM for 20 hours. TG content and FAS, ATGL and HSL expression were measured by spectrophotometry and Real Time RT-PCR respectively. Results: Both doses of CLA and 100 M resveratrol decreased TG content in mature adipocytes. The combination of both molecules reduced TG accumulation to the same extent as each one separately. No change in FAS and HSL mRNA levels after CLA and resveratrol treatment was observed. ATGL was not modified by CLA but it was increased by resveratrol and by the combination. This combination did not increase the effect caused by resveratrol on its own. Conclusion: Lipolysis increase via ATGL is involved in the TG reduction induced by resveratrol and the combination of both molecules. The combination of these two molecules does not increase the efficacy of each molecule separately in mature adipocytes and thus it does not represent an advantage for obesity treatment or prevention. Introducción: Se ha demostrado que el ácido linoleico trans-10, cis-12 conjugado (ALC) y el resveratrol reducen el contenido de TG en el adipocito 3T3-L1 cultivado actuando sobre distintas vías. En los últimos a os, se ha probado el método de llegar a diferentes vías de transducción de se al simultáneamente con múltiples productos naturales con el fin de alcanzar efectos aditivos o sinérgicos. Sin embargo, el efecto combinado de ambas moléculas sobre el metabolismo de los lípidos no se ha descrito previamente. Objetivo: El objetivo de este estudio fue analizar el efecto de la combinación del ALC trans-10, cis-12 y el resveratrol sobre la acumulación de TG así como sobre la expresión de FAS, HSL y ATGL en los adipocitos maduros 3T3-L1 con el propósito de evaluar la interacción potencial entre amba
Management of Grass and Broadleaf Weeds in Processing Potatoes (Solanum tuberosum L.) with Clomazone, in the Argentinian Pampas  [PDF]
Daniel Osmar Caldiz, Carolina de Lasa, Pablo Eugenio Bisio
American Journal of Plant Sciences (AJPS) , 2016, DOI: 10.4236/ajps.2016.716205
Abstract: Weed competition in the potato crop could cause up to a 95% yield reduction depending on the variety, the weed species and the competition period. In this work the effect of Clomazone (Command 36 CS®), when applied alone or in combination with Metribuzin (Sencorex® 48) upon grass and broad-leaved weeds was assessed. The work was carried out under the environmental conditions of the Argentinian Pampas, where close to 50% of the potatoes produced in the country are grown. The field trial was performed during the spring-summer crop, season 2008/09, with cv. Innovator, in a completely randomized design of the following treatments: (a) control, without weed control; (b) Clomazone 1.6 l·ha-1; (c) Clomazone 2.0 l·ha-1; (d) Clomazone 1 l·ha-1 + Metribuzin 0.75 l·ha-1; (e) Clomazone 1.6 l·ha-1 + Metribuzin 0.5 l·ha-1; and (f) Metribuzin 1.35 l·ha-1. Treatment effectiveness (TE), crop competition level (CCL) and weed suppression index (WSI) were assessed at 38, 53 and 72 days after planting (DAP), while yield and quality were also evaluated, following industry protocols. In those treatments were Clomazone was used alone, at 2 l·ha-1, or combined (Clomazone 1 l·ha-1 + Metribuzin 0.75 l·ha-1), a higher yield was observed. Besides, a high correlation between TE, WSI and tuber yield was also achieved. Clomazone improved TE, CCL and WSI, which was not only reflected in higher tuber yields, but also on better tuber quality.
Calor: Una Propuesta Didáctica Constructivista con Enfoque de Ciencia Integrada
Castillo, Alberto de L.;Granados, Dora I.;Marino, Luis A.;
Revista Brasileira de Ensino de Física , 2002, DOI: 10.1590/S1806-11172002000300010
Abstract: we made a comparative study between two constructivists didactic design, for teaching the theme heat in students of natural sciences careers. one with a integrated science focus and another with a non integrator focus. in the first design the student could build his own understanding, by solving problematical situations related to the biology and the natural environment, that allows him to analyze how are related the involucrated concepts, while in the second he build his understanding by solving physics but non biological problematic situations. we concluded that the first design allows to build in the students an cognitive structure of integrated type, wath makes it easier for them to internalize and transfer the physical concepts to problems of his specialty.
Situación actual de la nutrición clínica en la red de hospitales públicos de Castilla y León Current status of clinical nutrition at the network of public hospitals from Castilla y León
D. de Luis,Ma Ballesteros,I. Cano,M. Fernández
Nutrición Hospitalaria , 2006,
Abstract: Introducción: La nutrición clínica se ha ido implantando paulatinamente en los diferentes Centros de Atención Sanitaria a nivel nacional siguiendo la experiencia de otros países como Francia, Canadá, Gran Breta a, y Estados Unidos. Por tanto nos planteamos en nuestro trabajo determinar la situación funcional y recursos de las Unidades de Nutrición de los Hospitales de la red pública(SACYL) de la Comunidad de Castilla y León. Material y métodos: Se realizó una encuesta (fig. 1), remitida a todos los Hospitales de la red pública de la Comunidad de Castilla y León (SACYL). La encuesta fue remitida a los Hospitales de nuestra Comunidad; Hospital Universitario Río Hortega, Hospital Clinico Universitario, Hospital Comarcal de Medina del Campo, Hospital General Yagüe-Divino Vallés (Burgos), Complejo Hospitalario de León, Hospital General de Segovia, Hospital Virgen de Sonsoles de ávila, Hospital Virgen de la Concha de Zamora, Hospital Comarcal de Aranda de Duero, Hospital Comarcal de Miranda, Hospital General de Soria, Hospital Clínico Universitario de Salamanca. Resultados: Del total de 12 Hospitales encuestados contestaron nueve, realizándose el estudio con estos Centros y considerando representativa la muestra al suponer un 75% de los encuestados. Un total de 5 Hospitales reconocía disponer de una Unidad de Nutrición clínica estructurada(55,6%). Los resultados muestran una media de 0,37± 0,55 especialista por cada 400 camas, 0,87 ± 0,63 enfermera por cada 400 camas y 1,91 ± 2,3 auxiliar por cada 400 camas, con una media de 0,21 ± 0,41 especialista por 100.000 habitantes, 0,49 ± 0,36 enfermera por 100.000 habitantes y 1,09 ± 1,2 auxiliares por 100.000 habitantes La actividad asistencial de estas Unidades se ve reflejada a modo de interconsulta desde otras Unidades o Servicios, recibiendo una media de 3,2 ± 3,4 interconsultas/día. La principal patología que motiva la realización de una interconsulta a una Unidad de Nutrición es en el 33,3% de los Centros patología tumoral, en el 55,6% cirugía programada y en el 11,1% patología neurológica. Siendo la principal intervención la utilización de un suplemento. Solo 3 centros (33,3%) tienen estructurada una consulta monográfica de nutrición. Estos 3 centros presentan un programa de seguimiento de nutrición artificial domiciliaria, siendo la patología que con más frecuencia motiva la inclusión de un paciente en el programa de nutrición artificial domiciliaria es la patología postquirúrgica(33,3%) y patología tumoral (33,3%), en segundo lugar la patología neurológica (22%) y por último patología inflamatoria digestiva
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