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Search Results: 1 - 10 of 266872 matches for " Luis F. Monta?o "
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The $Λ_0$ Polarization and the Recombination Mechanism
G. Herrera,J. Magnin,Luis M. Montao,F. R. A. Sim?o
Physics , 1997, DOI: 10.1063/1.53223
Abstract: We use the recombination and the Thomas Precession Model to obtain a prediction for the $\Lambda _0$ polarization in the $p+p \to \Lambda_0+X$ reaction. We study the effect of the recombination function on the $\Lambda_0$ polarization.
Levels of TNF-α, IL-1β, TGF-β, and IL-6 in patients with chronic hepatitis C virus infection and hyperinsulinemia  [PDF]
Luis A. Salazar, Xóchitl García-Samper, Susana Alcázar-Leyva, Patricia Gorocica, Eduarda Cerón, María Cristina Negrete-García, Luis F. Montao, Noé Alvarado-Vásquez
Open Journal of Immunology (OJI) , 2013, DOI: 10.4236/oji.2013.31003
Abstract: Background: Previous evidences support to inflammatory process associated with the IR those important factors in the development of fibrosis and hepatic damage in patients with HCV infection. Objectives: Determine the presence of immunological or histological differentces between hyperinsulinemic and non-hyperinsulinemic chronic HCV-infected patients with at least 10 years of evolution. Material and Methods: The body mass index, Child-Puigh score, liver function tests, and biochemical profile were evaluated in 30 control, 40 chronic HCV-infected patients with hyperinsulinemia, and in 40 normoinsulinemic chronic HCV-infected patients with at least 10 years of evolution. In addition, HCV genotype and viral load were established with the Amplicor System. In addition, nitrites in plasma, and TNF-α, IL-1β, TGF-β, IL-6, and insulin levels were determined. Results: No differences were found in BMI, Child-Pugh “A” scores, ALT, viral load, or genotype between the hyperinsulinemic (>25 IU/ml) and normoinsulinemic (<25 IU/ml) patients. Hyperinsulinemia patients had a higher HOMA- IR value (13.6) than normoinsulinemia patients (3.4), and none had a glycemia > 126 mg/dl. Cy- tokines concentration did not show differences with respect to controls. Nitrites showed a slight increase only in patients with HCV infection. Conclusions: Absence of changes in the proinflammatory cytokines concentration or in some inflammation markers in chronic HCV patients with hyperinsulinemia suggests that long-term insulin levels, in presence of HCV, cannot explain by themselves the hepatic alterations observed in the patient with HCV infection, the presence of others elements (alcoholism, cirrhosis, etc.) is necessary to onset hepatic damage in these patients.
CXCR4+ and SDF-1+ Bone Marrow Cells Are Mobilized into the Blood Stream in Acute Myocardial Infarction and Acute Ischemia  [PDF]
José Luis Aceves, Rafael Vilchis, María Antonieta Medina, Monserrat Borja, Silvia Cortes, Guillermo Díaz, Armando Castro, Alexis Gómez, José J. Parra, Martha Alvarado, Manuel López Hernández, Virna Poveda, Felipe Masso, Luis F. Montao
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.47045
Abstract: Cell therapy has shown beneficial effects on ventricular function and tissue regeneration in patients with acute and chronic myocardial infarction, although with diverse grades of variability in the results, possibly by proportion, subtype and cell cycle status. Objective: Identify and phenotypically characterize, via CXCR4 and SDF-1 expression, the bone marrow cell subpopulations that are mobilized into the bloodstream in patients with Acute Myocardial Infarction (AMI) and Acute Ischemia (AI) such as acute angina and Chronic Ischemia (CI) such as chronic stable angina, and also determine the cell cycle status of these cells. Method: Patients with AMI and AI were recruited in the ICCU, and patients with CI in the departments of cardiology and cardiovascular surgery. The quantification of cellular subpopulations was made by cytofluorometry with a FACS caliburcyto fluorometry (Becton Dickinson) with specific FITC-labeled anti human monoclonal antibodies against CD34, CD133, CD117, CD48, CXCR4, SDF-1 and Ki67 (Becton Dickinson). Serum concentration of IL-6 and IL-8 were determined by a sequential solid phase chemiluminescent assay performed in a SIEMENS IMMULITE 1000 Analyzer. Statistical analysis was made with the SPSS version 20.0 for Windows. A p value < 0.05 was considered as statistical significant. Results: We analyzed 174 patients. 67 had Acute Myocardial Infarction, 55 Acute Ischemia and 52 Chronic Ischemia. Total cellularity of bone marrow and SDF-1+ cells was significantly higher in patients with AMI (14.6 ± 1.5 × 103/ml) than that in AI (9.2 ± 1.3 × 103/ml) and CI (6.6 ± 1.1 × 103/ml) patients (p < 0.001). There were no significant differences in the amount of CD34+, CD117+, CD133+ and CD48+ cells between AMI (49.9 ± 3.9, 45 ± 4.7, 43.2 ± 3.7, 35.4 ± 6.7 respectively) and AI (36.7 ± 2.5, 36 ± 3.2, 33.7 ± 5.1, 32 ± 5 respectively) patients (p = 0.22 to 0.39), but interestingly in AMI and AI patients, cells were CXCR4+ in almost half of these mobilized cells, although the proportion was significantly higher in AMI patients (46.8% ± 7.1% to 55.7% ± 6.3% vs 23% ± 1.6% to 28.4% ± 2.1%, p = 0.03 to 0.05). A similar behavior was observed with the Ki67 antibody (29.9% ± 2.1% to 36.1% ± 6.3% vs 10% ± 1.2% to 24% ± 1.1%, p = 0.001 to 0.05). Bivariate analysis of the results showed a significant correlation of the cell proportion in AMI but not in AI and CI patients (p = 0.001 to 0.05; 0.12 to
Dilemas y desafíos de la investigación en administración en México
Luis Montao Hirose
Contaduría y administración , 2001,
Neurocitoma central com apresenta??o incomum por hemorragia intraventricular: relato de caso
Hanel, Ricardo Alexandre;Montao, Juan Carlos;Gasparetto, Emerson;Ditzel,o F. da Silva;Torres, Luis Fernado Bleggi;Araujo, Jo?o Candido;
Arquivos de Neuro-Psiquiatria , 2001, DOI: 10.1590/S0004-282X2001000400030
Abstract: central neurocytoma was first described by hassoun et al. in 1982 as a well-differentiated tumor from neuronal origin. this tumor typically occurs in young adults, localized in the ventricular system. it usually presents as intracranial hypertension due to obstructive hydrocephalus. the differential diagnosis should be done with others intraventricular tumors as oligodendroglioma, subependymoma and choroidal plexus papilloma. there are few cases of central neurocytoma presented by intraventricular hemorrhage in the literature. we report a case of 35 year-old woman, who presented with obstructive hydrocephalus due to intraventricular hemorrhage within the tumor. mri revealed a tumor localized in the right lateral ventricle. histopathological and immunohystochemical analysis confirmed the diagnosis of central neurocytoma. we review options for the treatment of this entity as well reinforce the inclusion of central neurocytoma as a differential diagnosis for intraventricular hemorrhage.
Comunicación y Contabilidad: Implicaciones y Propuestas para la formación en Contabilidad
José Luis Arquero Montao
Revista de Contabilidad : Spanish Accounting Review , 2001,
Abstract: En la medida en que la información contable se elabora para ser comunicada, las capacidades de comunicación son esenciales para un contable. Este argumento se soporta en las definiciones de contabilidad que resaltan su carácter de proceso de comunicación, en las opiniones de numerosas asociaciones y organizaciones de gran relevancia en el ámbito contable, (p.e. IFAC, AAA, AICPA, AECC) y en los resultados de la investigación que explícitamente indican la importancia de estas capacidades para un contable. Esto, unido a la existencia de efectos sinérgicos entre el desarrollo de las capacidades de comunicación y el aprendizaje de conocimientos técnico-contables y de una comunidad discursiva contable nos lleva a considerar la necesidad de desarrollar de forma integrada, en las asignaturas de contabilidad, las habilidades comunicativas. El trabajo presenta una propuesta de integración del desarrollo de estas capacidades, suficientemente general para ser adaptada a las características particulares de las diferentes asignaturas y contextos. To the extent that accounting information is in tended to be communicated, communication skills are essential for a professional accountant. This claim is supported by: several definitions of accounting which stress its character as a process of communication; the opinion of numerous, highly relevant accounting associations and organisations (e.g. IFAC, AAA, AICPA, AECC); and the results of research that explicitly point to the importance of those skills for an accountant. When added to the existence of synergies between the development of communication skills, the learning of technical accounting knowledge and a discursive accounting community, it leads to a consideration of the need for an integrated development in the subjects of accounting and communication skills. This paper presents a proposal to develop these skills in an integrated fashion, one wide enough to be adapted to the particular subjects and contexts.
Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells
Luis A. Salazar,Xóchitl Garcia-Samper,Rafael Suarez-Carpio,María C. Jimenez-Martínez,Erika P. Rendón-Huerta,Felipe A. Masso,Teresa I. Fortoul,Luis F. Montao
Hepatitis Research and Treatment , 2010, DOI: 10.1155/2010/971095
Abstract: HCV-Ag-specific TH17 cells secrete IL17, a cytokine involved in autoimmune diseases and regulated by IL10 and TGF-b. 5–12% of patients with chronic HCV infection have hypothyroidism. We evaluated the role of these cytokines in this patients by determining serum concentration of TsH, T3, free T4, IL2, IL10, IL12, IL17, TGF-b, anti-TG, TPO, CCP, GBM, and cardiolipin antibodies in 87 chronically noninterferon treated HCV-infected patients. 20 patients (group A) had elevated TsH values (>5? UI/ml) whereas the remaining 67 (group B) had normal values. The percentage of anti-TPO, TG, GBM, and cardiolipin antibodies in group A patients (33%, 41%, 5% and 5%, resp.) as well as IL17, IL2 and TGF-b concentrations ( pg/ml, pg/ml, and pg/ml, resp.) were significantly higher than group B. Abnormal Th17 regulation mediated by IL-2 and low TGF-b concentrations is associated with hypothyroidism in chronically-infected HCV patients. 1. Introduction There is ample evidence showing that 7–11% of HCV-infected children and adult individuals have thyroid dysfunction, mainly subclinical hypothyroidism, prior to the initiation of treatment [1, 2]. The association between autoimmune thyroiditis in HCV-infected patients, in particular in subjects with HCV-related mixed cryoglobulinemia, has also been confirmed [3]. Once combined pegIFNalpha2b + ribavirin therapy is initiated, the percentage of patients with thyroid dysfunction goes up to 15–20% [4]. Immunological mechanisms at the origin of this thyroid dysfunction are presumed but the precise mechanism still is unknown. IL-17A, a proinflammatory cytokine, is secreted by the CD4+Th17 cells [5]. It is involved in some organ-specific autoimmune diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease, multiple sclerosis, and even organ allograft rejection [6–9], among many others. The main function of IL-17-secreting T cells is to mediate inflammation, by stimulating production of inflammatory cytokines, such as TNF-a, IL-1b, IL-6, and inflammatory chemokines that promote the recruitment of neutrophils and macrophages [10]. Initial evidence suggested that human Th17 cells were regulated by CD4+25+FoxP3+ regulatory T cells, but recent evidence suggests an alternative regulatory mechanism mediated by IL-10 and TGF-b [11, 12]. Ag-specific Th17 cells are induced in HCV-infected patients, but the HCV-NS4 protein also induces the secretion of IL-10 and TGF-b by monocytes [13]. Neutralization of both anti-inflammatory cytokines significantly enhances NS4-specific IL-17 and IFN-gamma production by T cells from HCV-infected
Posición oficial de la Sociedad Chilena de Climaterio para el manejo clínico de la mujer climatérica
Revista médica de Chile , 2010, DOI: 10.4067/S0034-98872010000500017
Abstract: the health of many women is affected in the climacteric period, either by symp-toms that deteriorate their life quality (ql) or by chronic diseases that affect their life expectancy. therefore, it is mandatory to evaluate these two aspects, having as core objectives for any eventual therapeutic intervention, the improvement of ql and the reduction of cardiovascular risk and fractures. to evaluate ql it is mandatory to follow structured interviews that weigh systematically climacteric symptoms such as the menopause rating scale (mrs). the paradigm of the metabolic syndrome constitutes a suitable frame to evaluate cardiovascular risk. age, a low body weight, a history of fractures and steroid use are risk factors for fractures. a proper evaluation will allow the detection of patients with a low ql or a high risk for chronic disease, therefore identifying those women who require therapy. the clinical management should include recommendations to improve lifestyles, increase physical activity, avoidance of smoking and to follow a low calorie diet rich in vegetables and fruits. hormonal therapy is the most effcient treatment to improve the ql and its risk is minimized when it is used in low doses or by the transdermal route. tibolone is an alternative, especially useful in patients with mood disorders and sexual dysfunction. vaginal estrogens are also a good option, when urogenital symptoms are the main complaint. some antidepressants can be an effective therapy in patients with vasomotor symptoms who are not willing or cannot use estrogens. the effectiveness of any alternative therapy for menopausal symptoms has not been demonstrated. dyslipidemia, hypertension, obesity and insulin resistance should be managed ac-cording to guidelines. calcium and vitamin d have positive effects on bone density and certain tendency to reduce vertebral fractures. bisphosphonates decrease the risk of vertebral fractures.
Revisión taxonómica de la familia Celastraceae para la flora de Colombia Revisión taxonómica de la familia Celastraceae para la flora de Colombia
Sanchez Montao Luis Roberto,Fernandez Alonso José Luis
Acta Biológica Colombiana , 2000,
Abstract: ABSTRACTTaxonomic processing of the Celastraceae was made based on morphological characters andpollen from exsiccates pertaining to the different herbaria from Colombia an some fromoutside: MO, NY y US, along with characters taken directly from plants in the field,concatenating with the distributions patterns. Besides the taxonomical study, a review of thisplant group nomenclature was made, in order to establish the valid names, those ones whichare synonymous, and species location. The characters established in the descriptions of thespecies were compared with the observed ones in the study material. The study of pollen tookinto account grain type, opening of the pores, presence of rims and ribs ambit, exine, sexine andnexine, reticulation and measurements including equatorial and polar axis and the ratio long-width of pores and colpes. Fourteen pollen samples were analyzed, belonging to 8 nativegenera, revealing that palinology makes valuable contributions in the boundary of taxons,providing valid characters, that they are complemented with the other morphologic characters.The taxonomic description of the family fits with the Colombian constituent taxons.Dichotomizing keys were made in order to identify genera and species, and descriptions of eachone of the species, as well as their distribution, citation studied material of each taxon and insome cases illustrations of the species, were drawn at least one for each genus. Eigth native and1 cultivated genera were found: Celastrus 4, andean and subandean woody scandent species.Crossopetalum: 2 species of islands of Tintipán and San Andrés and Providencia. Goupia: 1species from equatorial rain forest. Gymnosporia: 2 species, one of forest of the median valleyof Magdalena and the other of the andean and subandean forest. Maytenus considered aspreliminary synopsis, with 26 species coming of different habitats. Perrottetia with 10 species,4 of these new; 1 species from piedemonte, the rest live in andean and subandean mist belts.Schaefferia: 1 species from subxerofitic and warm places. Zinowiewia: 4 species from Andeanand subandean mist belts. Euonymus: 1 cultivated species in cold climate towns. Se adelantó el tratamiento taxonómico de las Celastraceae, con base en un estudio decaracteres morfológicos y de polen, a partir de exsicados pertenecientes a los distintosherbarios del país y a algunos del exterior como lo son MG, MO, NY y US, junto con caracterestomados directamente de plantas en campo, concatenado con los patrones de distribución.Además del estudio taxonómico también se hizo una revisión de la nome
Novel Antibody-Based Proteins for Cancer Immunotherapy
Jaheli Fuenmayor,Ramon F. Montao
Cancers , 2011, DOI: 10.3390/cancers3033370
Abstract: The relative success of monoclonal antibodies in cancer immunotherapy and the vast manipulation potential of recombinant antibody technology have encouraged the development of novel antibody-based antitumor proteins. Many insightful reagents have been produced, mainly guided by studies on the mechanisms of action associated with complete and durable remissions, results from experimental animal models, and our current knowledge of the human immune system. Strikingly, only a small percent of these new reagents has demonstrated clinical value. Tumor burden, immune evasion, physiological resemblance, and cell plasticity are among the challenges that cancer therapy faces, and a number of antibody-based proteins are already available to deal with many of them. Some of these novel reagents have been shown to specifically increase apoptosis/cell death of tumor cells, recruit and activate immune effectors, and reveal synergistic effects not previously envisioned. In this review, we look into different approaches that have been followed during the past few years to produce these biologics and analyze their relative success, mainly in terms of their clinical performance. The use of antibody-based antitumor proteins, in combination with standard or novel therapies, is showing significant improvements in objective responses, suggesting that these reagents will become important components of the antineoplastic protocols of the future.
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