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Search Results: 1 - 10 of 39793 matches for " Luis Alfredo; Batista "
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Protección inducida por nanococleatos derivados de proteoliposomas de Leptospira interrogans serovar Canicola
Beatriz Tamargo,Luis Alfredo Rosario,Niurka Batista,Daniel Francisco Arencibia
Vaccimonitor , 2012,
Abstract: Desde los a os 20 del pasado siglo, hasta el presente, en el mundo se han desarrollado y empleado vacunas de células enteras contra la leptospirosis que confieren una corta inmunidad; la mayoría no adyuvadas y dirigidas,fundamentalmente, contra los diferentes serogrupos de la especie Leptospira interrogans, contenidos en laspreparaciones. Numerosos han sido los intentos realizados para lograr una formulación vacunal más pura, efectiva,de amplio espectro y duración de la protección que las bacterinas de células enteras inactivadas. Sin embargo,hasta el momento no se ha registrado ninguna vacuna con tales características. En el presente trabajo seobtuvieron antígenos de membrana externa a partir de una cepa cubana autóctona (Cepa 87, L. interrogans serovar Canicola), mediante una modificación de la tecnología para la producción de vesículas de membrana,patentada por investigadores del Instituto Finlay. Estos antígenos con estructura nanoproteoliposómica fueronformulados/adyuvados mediante diferentes estrategias, logrando cinco preparaciones con estructura coclear,que constituyen nanopartículas de aproximadamente 100 a 150 nm de largo y entre 15 a 30 nm de diámetro. Los inmunógenos se inocularon en el biomodelo Mesocrisetus aureatus, con dos dosis e intervalo de seis semanas.El reto fue realizado con 100.000 DL50. Los resultados demuestran que las nuevas formulaciones vacunales confieren protección frente al reto homólogo y fueron capaces de eliminar el estado de portador, lo que unido a la robustez del método de preparación, el mayor nivel de pureza, en comparación con las bacterinas, y la no necesidad del hidróxido de aluminio, las convierten en una alternativa de interés para continuar su desarrollo.
Caracterización de aislamientos clínicos de Leptospira por métodos fenotípicos y moleculares en la República de Nicaragua
Luis Alfredo Rosario,Daniel Francisco Arencibia,Niurka Batista,William Jirón
Vaccimonitor , 2012,
Abstract: En este trabajo se caracterizaron ocho cepas de Leptospira, aisladas de casos clínicos en Nicaragua mediante métodos fenotípicos y moleculares, las cuales no mostraron crecimiento a 13 °C ni en medio suplementado con 8-azaguanina (2,25 mg/mL). Se observó la conversión a formas esféricas a los 60 min de estar expuestas en un medio suplementado con NaCl 1M. Para la caracterización molecular de los aislamientos se realizó la reacción en cadena de la polimerasa (RCP) de genes conservados con cepas patógenas, cuyos productos génicos confieren virulencia al microorganismo (ompL1 y lipL32). Los resultados de este ensayo demostraron la presencia de bandas de amplificación de los genes ompL1 y lipL32 para los ocho aislamientos, lo que permite afirmar que los microorganismos analizados constituyen cepas de Leptospira patógenas, según los métodos fenotípicos y moleculares recomendados.
Immunity and hypersensibility
Daniel Francisco Arencibia Arrebola,Luis Alfredo Rosario Fernández,Niurka Batista Santiesteban,Lisset Ortiz Zamora
RETEL : Revista de Toxicología en Línea , 2009,
Abstract: he Inmunotoxicology was born with the objective of research the well founded suspicions of the existence of a relationship cause-effect among the exponential increase in the environmental chemical toxicity taken place in the last decades and the parallel increment in the allergic illnesses incidence and autoinmune base illnesses in our environment. The aim of this work is to give a bring up to date in a schematic way of the general immune answer to toxic, carrying out an analysis with depth on the hypersensibility types and its mechanisms, for this way to facilitate the summary and understanding of such an extensive content and with great variety of opinions, since it is necessary a knowledge basic but in turn wide envelope the topic.
Protección inducida por nanococleatos derivados de proteoliposomas de Leptospira interrogans serovar Canicola
Tamargo,Beatriz; Rosario,Luis Alfredo; Batista,Niurka; Arencibia,Daniel Francisco; Fernández,Kenia; Villegas,Aileen; Ayala,Juan Alfonso; Sierra,Victoriano Gustavo;
Vaccimonitor , 2012,
Abstract: whole cell leptospirosis vaccines have been developed and used from the 20`s of last century up today , most of them are not adjuvated and do not confer a long-lasting immunity. these vaccines are mainly against different serogroups of leptospira interrogans contained in the preparation. though several attempts to obtain a vaccinal formulation more effective, purer, with wider spectrum and longer protection than the bacterines of inactivated whole cells have been made no vaccine with these characteristics have been registered yet. this paper deals with the obtainment of outer membrane antigens from a cuban autochthonous strain (strain 87, l. interrogans serovar canicola), by a modification of the technology for the production of outer membrane vesicles, patented by researchers from finlay institute these antigens with nanoproteoliposomic structure were formulated/adjuvated by different strategies, obtaining five preparations with cochlear structures which are nanoparticles of approximately 100 to 150 nm of lenght and from 15 to 30 nm of diameter. two doses of the immunogens are inoculated in the biomodel mesocrisetus aureatus, with an interval of six weeks. the challenge was carried out with 100.000 dl 50 . results showed that the new vaccinal formulations confer protection against the homologous challenge and were able to eliminate the carrier status. this, together with the robutness of the preparation method, the higher level of purity, compared to the bacterines, and the no need of aluminium hydroxide make the formulations an alternative of interest for continuing their development
Efficacy of Leptospiral vaccine (vax-SPIRAL®) against challenge with strains isolated from leptospirosis epidemic in Nicaragua using the hamster as biomodel
Luis Alfredo Rosario Fernández,Niurka Batista Santiesteban,Daniel Francisco Arencibia Arrebola,Bárbara Yolanda Valdés Abreú
Veterinary World , 2012,
Abstract: A hamster model was used to determine the protector capacity of vax-SPIRAL against the lethal infection after challenge with 10,000 LD50 of four strains isolated of a leptospirosis outbreaks in Nicaragua. These strains were selected from a primary group of 16 belonging to the serogroups strains Ballum, Icterohemorragiae, Pomona, Serjoe and Pyrogenes. Most of these, except Pyrogenes serogroup, reproduced the infection in animal model and the most virulent representatives of each serogroup were selected for the challenge. The results of this study suggest that vax-SPIRAL conferred high percents of heterologous protection which aimed to consider it as a prophylactic measure useful in situations of floods and natural disasters in Nicaragua. [Vet. World 2012; 5(1.000): 5-12]
Luis Alfredo Anchordoqui
Advances in High Energy Physics , 2012, DOI: 10.1155/2012/129879
Abstract: We outline the basic setting of the (3)×(1)×(1)×(1) gauge theory and review the associated phenomenological aspects related to experimental searches for new physics at hadron colliders. In this construction, there are two massive Z′-gauge bosons, which can be naturally associated with baryon number and?( being lepton number). We discuss the potential signals which may be accessible at the Tevatron and at the Large Hadron Collider (LHC). In particular, we provide the relevant cross sections for the production of Z′-gauge bosons in the TeV region, leading to predictions that are within reach of the present or the next LHC run. After that we direct attention to embedding the gauge theory into the framework of string theory. We consider extensions of the standard model based on open strings ending on D-branes, with gauge bosons due to strings attached to stacks of D-branes and chiral matter due to strings stretching between intersecting D-branes. Assuming that the fundamental string mass scale is in the TeV range and the theory is weakly coupled, we explore the LHC discovery potential for Regge excitations.
Notas sobre la ética y la literatura
álvarez,Luis Alfredo;
Letras , 2010,
Abstract: literature prevails thanks to acknowledgement and to the reflective illusory possibility of its discourse. in this sense, literature can be stated as that space in the mirror where subjects reflect, and reflect upon, their individual and collective experience. the novel as a literary genre can be understood as the representation of modern ?ποχ? that allows the ethical projection of the subject and the staging of multiple mechanisms for vital decisions in different social contexts. the aesthetic activity of the novel could be called ethics as far as it becomes what adela cortina understands as "that form of reflection upon reflection and the language of morality". the aim of these notes is to show, on the basis of bajtin, how literature allows one to reflect upon the valuative experience of man.
ANATOMíA DE LOS PRAE
OBANDO GUERRERO,LUIS ALFREDO;
Luna Azul , 2011,
Abstract: school environmental projects allow the making of diagnoses of environmental conditions in a particular region depending on the population's intervention when interacting with natural environments and with the resources they provide. in colombia, decree 1743 from august 3, 1994 provides guidelines for the design of such projects and the way in which the ministry of education and the ministry of environment, housing and territorial development must intervene for such purpose. from the national level, the implementation of these projects through the development of five phases which make possible the creation of sound, feasible and sustainable projects over time that also transcend the classroom boundaries to project themselves into the educational communities trying to generate an environmental conscience and the preservation of natural resources for future generations, has been proposed, thus ensuring the survival of human species. accordingly, a relevant process related to the design of the school environmental projects, adjusted to the proposals of the central government for the fulfillment of these objectives, has ben developed in the municipality of pasto.
Seguridad y migración en el espacio fronterizo Tabasco-El Petén
Arriola Vega, Luis Alfredo;
Migración y desarrollo , 2009,
Abstract: this paper analyzes the relationship between the complex subjects of migration and security, which encompasses issues such as national sovereignty versus free human mobility; what is judicially legal versus what is socially legitimate, and the defense of particular notions of security when faced by both real and potential threats, such as a pandemic or a terrorist attack. a qualitative description of the flow of undocumented migrants across the region of tabasco (mexico) and el petén (guatemala), an activity labeled as illicit by the state, provides an initial look into the relationship between migration and security on a local level. however, the ultimately global presence of this process requires new ways of conceiving security, ways that can ensure a democratic management of the migration phenomenon.
Mujeres del agua: Desarrollo, participación y corresponsabilidad de la mujer como ejercicio cotidiano
Ramírez,Luis Alfredo;
Revista Venezolana de Estudios de la Mujer , 2007,
Abstract: this analysis arise from participation study in a communitarian context developed in a water technical desk from las brisas del paraíso, cota 905, urban people neighborhood, southwestern caracas, república bolivariana de venezuela. objectives of this study included to determine the meaning of participation in the context of the studied community through people assisting water technical desk which mainly it is conformed by women. the qualitative reseach is intend to make a comprehension an interpretation the current situation in the studies area and it is transformed through alive relationship, changing and constant in the community, in which it is essential the women action as propellers of development, participation and co-responsibility in quotidianity.
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