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Search Results: 1 - 10 of 50495 matches for " Luis Alberto; Velásquez "
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Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections
Vilos,Cristian; Constandil,Luis; Herrera,Natalia; Solar,Paula; Escobar-Fica,Jorge; Velásquez,Luis Alberto;
Electronic Journal of Biotechnology , 2012,
Abstract: background: the infectious diseases in the livestock breeding industry represent a significant drawback that generates substantial economic loss and have led to the indiscriminate use of antibiotics. the formulation of polymeric microparticles loaded with antibiotics for veterinary use can: reduce the number of required doses; protect the drug from inactivation; and maintain a sustained-release of the antibiotic drug at effective levels. accomplishing all of these goals would have a significant economic and animal health impact on the livestock breeding industry. results: in this work, we formulated ceftiofur-loaded phbv microparticles (phbv-cef) with a spherical shape, a smooth surface and diameter sizes between 1.65 and 2.37 μm. the encapsulation efficiency was 39.5 ± 1.1% w/w, and we obtained a sustained release of ceftiofur in pbs-buffer (ph 7.4) over 7 days. the antibacterial activity of ceftiofur was preserved after the encapsulation procedure, and toxicity of phbv-cef microparticles evaluated by mts was represented by an ic50 > 10 mg/ml. conclusions: our results suggest that phbv-cef particles have a potential application for improving the treatment of infectious diseases in the livestock breeding industry.
BIOMARCADORES DE ESTRéS COMO INDICADORES DE BIENESTAR ANIMAL EN GANADO DE CARNE: STRESS BIOMARKERS AS INDICATORS OF ANIMAL WELFARE IN CATTLE BEEF FARMING
Romero Pe?uela,Marlyn Hellen; Uribe-Velásquez,Luis Fernando; Sánchez Valencia,Jorge Alberto;
Biosalud , 2011,
Abstract: the present review presents the physiological changes that occur in cattle during acute stress, as well as blood biomarkers used to measure their impact on animal welfare. during the pre-slaughter process, cattle are often exposed to different factors that cause physical exhaustion and physiological stress which can have adverse effects on health, animal welfare, and meat quality. the most common stressors are: fast and forced movements of the truck, centrifuged force, breakdown of the social structure due to mixing of the animals, strange environment, rough treatment of cattle during loading and unloading, weather conditions, deprivation of feed and water among others. stress has been identified as an indicator of animal welfare. stress alters the internal animal homeostasis inducing changes in the hypothalamic-pituitary-adrenocortical (hpa) axis and the sympatho-adreno-medullary system. the endocrine activation promotes the release of several hormones: catecholamines, mainly adrenaline and noradrenaline; corticotrophin-releasing hormone (crh); adrenocorticotrophin (acth) and corticosteroids, mainly cortisol. different authors have used several blood constituents to determine stress. cortisol, despite its variability and short life, is still one the most used indicators of stress. these authors have also used the packed cell volume (pcv), glucose concentration, creatine phosphokinase (ck) activity, b-hidroxybutyrate and lactate concentration as stress indicators. the determination of these biomarkers is a practical method to monitor animal welfare in cattle beef.
EL TRANSPORTE TERRESTRE DE BOVINOS Y SUS IMPLICACIONES EN EL BIENESTAR ANIMAL: REVISIóN
Romero Pe?uela,Marlyn Hellen; Uribe Velásquez,Luis Fernando; Sánchez Valencia,Jorge Alberto;
Biosalud , 2010,
Abstract: introduction: bovine transportation from the farms to the meat processing plant is usually carried out using ground transportation. the transportation process produces stress and affects the animal welfare which has a negative bearing on the quality and harmlessness of the meat. besides, it produces economic losses because of confiscations, different contusions, mortality, loss in live weight, reduction in carcass weight and alteration of the meat organoleptic variables among others. colombia counts with an updated sanitary legislation for cattle and buffalo transportation which is an implementation requirement for the meat industry. objectives: to display the implications of transportation on animal welfare, and describe the guidelines to carry out adequate transportation according to the colombian sanitary legislation and international recommendations of the world organization for animal health (oie).
Sarcoidosis cardíaca con compromiso pulmonar estadio IV
Velásquez Franco,Carlos Jaime; Ramírez Gómez,Luis Alberto;
Revista Colombiana de Reumatología , 2006,
Abstract: the following case presents a 26 year-old man with heart failure, persistent respiratory symptoms, atrial fibrillation and sudden death due to non-sustained ventricular tachycardia with echocardiografic evidence of severe mitral insufficiency and histologic and imagenologic pulmonary evidence of sarcoidosis.
Sarcoidosis cardíaca con compromiso pulmonar estadio IV Cardiac sarcoidosis with stage IV pulmonary involvement
Carlos Jaime Velásquez Franco,Luis Alberto Ramírez Gómez
Revista Colombiana de Reumatología , 2006,
Abstract: Se presenta el caso de un paciente de 26 a os, con síndrome de falla cardíaca, síntomas respiratorios persistentes, fibrilación auricular y muerte súbita por taquicardia ventricular no sostenida; con evidencia ecocardiográfica de insuficiencia mitral severa y confirmación histológica e imaginológica pulmonar de sarcoidosis. The following case presents a 26 year-old man with heart failure, persistent respiratory symptoms, atrial fibrillation and sudden death due to non-sustained ventricular tachycardia with echocardiografic evidence of severe mitral insufficiency and histologic and imagenologic pulmonary evidence of sarcoidosis.
Asociación de actividad lúpica y el riesgo de infección nosocomial en pacientes de un Hospital universitario en Medellín: estudio prospectivo 2001-2004 Risk Factors for Nosocomial Infections in Patients with Systemic Lupus Erythematosus at a Teaching Hospital in Medellin, Colombia. Prospective Study: 2001-2004
Luis Alberto Ramírez Gómez,Juan Fernando Velásquez,Paula Granda,Carlos Alfonzo Builes
Revista Colombiana de Reumatología , 2007,
Abstract: Factores de riesgo para infección nosocomial en pacientes con lupus eritematoso sistémico en un Hospital universitario en Medellín, Colombia. Estudio prospectivo: 2001-2004 Introducción: los pacientes con lupus eritematoso sistémico (LES) tienen mayor morbilidad y mortalidad que la población general y ello está determinado por la actividad inflamatoria y la frecuencia de infecciones, las cuales participan en la presentación bimodal de la mortalidad de los pacientes con LES. Las infecciones se han asociado con la actividad de la enfermedad y con el uso de inmunosupresores. Objetivo: determinar los factores asociados con infección nosocomial en pacientes con LES que requirieron tratamiento intrahospitalario. Específicamente buscamos establecer asociación con actividad al ingreso y posterior desarrollo de la infección. Métodos: es un estudio de cohorte prospectivo y descriptivo cuya población está constituida por pacientes con LES de acuerdo a los criterios del ACR y que se hospitalizaron entre enero de 2001 y diciembre de 2004. Se excluyeron pacientes con infección adquirida en la comunidad o que la manifestaran dentro de las 48 horas siguientes al ingreso, pacientes con neoplasias y HIV. La actividad se cuantificó con la aplicación del SLEDAI y la infección fue definida con base en el aislamiento del germen y según los criterios del CDC de Atlanta, para los casos sin confirmación microbiológica. Se consideraron variables como edad, género, tiempo de diagnóstico, tiempo de estancia, uso de corticoides, ciclofosfamida (CFM), otros inmunosupresores, tipo de infección, agente y causa de mortalidad. Resultados: ingresaron al estudio 123 pacientes que tuvieron 155 hospitalizaciones, de ellos 106 (82,2%) mujeres, con un promedio de edad de 27,7+-12,6 a os (7-73) con tiempo de diagnóstico de 27,8+-49,4 meses (0-300), 56 pacientes (45,5%) con diagnóstico de novo, 25 pacientes estaban en insuficiencia renal crónica (IRC) con 10 de ellos en terapia dialítica. Con respecto al tratamiento 58 (47,1%) no habían recibido corticoides, 36 (29,3%) recibían una dosis menor de 20 mg/d de prednisona y 29 (23,6%) una dosis mayor, 31 (25,2%) habían recibido bolos de CFM y 13 (10,6%) otros inmunosupresores. El promedio y mediana de SLEDAI fueron de 14,7+-9,9 y 14 (IQR 7-20) respectivamente. Presentaron infección nosocomial 38 (30,9%) pacientes, 31 pacientes una infección y 13 pacientes más de una para un total de 69 eventos. En el análisis univariado se asociaron significativamente con infección intrahospitalaria: diagnóstico de novo, mayor tiempo de internación, uso durante la h
Reticulohistiocitosis multicéntrica
Vargas,Francisco; Restrepo,Juan Pablo; Velásquez,Carlos Jaime; Velásquez,Mónica Patricia; Eraso,Ruth; González,Luis Alonso; Vásquez,Gloria; Uribe,Oscar; Ramírez,Luis Alberto; Correa,Luis Alfonso;
Revista Colombiana de Reumatología , 2007,
Abstract: multicentric reticulohistiocytosis (mrh) is a disease of unknown etiology that affects primarily women in the fourth decade of life. articular involvement is characterized by the presence of symmetric synovitis of the upper extremities, particularly of the hands, and compromise of the skin with lesions of different morphology, more commonly nodules and papules localized mainly on the face and upper extremities. there can also be involvement of internal organs such as lung, heart, gastrointestinal tract and salivary glands. this disease has been linked to malignant neoplasms of different organs like breast, ovary, uterine cervix and lymphomas, leading some authors to consider this disease a manifestation of a paraneoplastic syndrome. laboratory testing in these patients show abnormalities of the complete blood count, liver function tests as well as markers of autoimmunity. histological studies confirm the diagnosis by demonstrating giant multinucleated histiocytic cells (mononuclear histiocytes-diammeter of 50 to 100 μm) with an eosinophilic cytoplasm and fine granules that give the cells a ground glass appearance. multiple medications have been used to treat this disease including cyclophosphamide, azathioprine, methotrexate, chlorambucil and combined regimens. we document the case of a 51 year old caucasian female patient that was evaluated because of a 4 month history of subjective fever, weakness, fatigue, weight loss, inflammatory bilateral polyarthritis of the wrists, elbows and knees as well as the appearance of painful violaceous papules on the surface of the face, elbows, hands and flanks.
Asociación de actividad lúpica y el riesgo de infección nosocomial en pacientes de un Hospital universitario en Medellín: estudio prospectivo 2001-2004
Ramírez Gómez,Luis Alberto; Velásquez,Juan Fernando; Granda,Paula; Builes,Carlos Alfonzo; Jaimes,Fabián;
Revista Colombiana de Reumatología , 2007,
Abstract: background: systemic lupus erythematosus (sle) patients have higher rates of morbility and mortality than general population because of inflammatory activity and high infections frequencies. the infections have been associated with activity index of the disease and the use of immunosuppressant drugs. objective: to determine the factors associated with nosocomial infections in sle patients who required in hospital treatment. methods: we performed a prospective study of sle patients who met the acr criteria and who were hospitalized between january 2001 and december 2004. exclusion criteria were community acquired infections, onset of infections in the first 48 hours of hospitalization, hiv and patients with neoplasm. the sle activity was quantified with the sledai index and infection was defined according to microorganism isolated or cdc criteria for those without an isolated microorganism. we studied this variables: age, sex, time from onset of sle, hospital stay, use of immunosuppressant drugs, type of infection, and cause of death. results: one hundred and twenty three patients were included who had 155 hospital admissions, 106 were women (82.2%). mean age was 27.7 +/- 12.6 years (7-73) with a mean time from diagnostic of 27.8 +/- 49.4 months (0-300), 56 patients (45.5%) had novo diagnosis, 25 patients had chronic renal insufficiency including 10 in hemodialysis. respect of previous treatment, 58 (47.1%) patients did not have received steroids, 36 (29.3%) have been receiving 20 mg of prednisone or less, and 29 (23.6%) more than 20 mg of prednisone, 31 (25.2%) patients pulses of ciclophosphamide and 13 others immunosuppressant drugs. the sledai median and mean were 14 (iqr 7-20) and 14.7 +/- 9.9 respectively. nosocomial infection was reported in 38 (30.9%), 31 patients just one episode of infection and 13 more than one, with a total of 69 events. in univariate analysis was noted that these factors were associated with nosocomial infections: de novo diagnosis, longe
Prevalencia de falla ovárica y factores de riesgo en pacientes con Lupus Eritematoso Sistémico tratadas con ciclofosfamida intravenosa
Velásquez Méndez,Mónica Patricia; Ramírez Ruiz,Francisco Alejandro; Vásquez Duque,Gloria María; Ramírez Gómez,Luis Alberto;
Revista Colombiana de Reumatología , 2006,
Abstract: background: premature ovarian failure is a cyclophosphamide (cyc) treatment adverse effect. the report of prevalence is among 11% and 59%, the variability depend on the route and dosage of cyc. there are few studies about gonadal toxicity with nhi cyc treatment protocol. we decided to establish the prevalence and risk factors associated with premature ovarian failure in a group of latin-american lupus patients. methods: 56 sle patients under 40 years treated with intravenous cyc, with regular menstrual cycle at the beginning of the treatment, were compared with respect to the frequency of amenorrhea with 43 sle patients without treatment with cyc as a control group. after that, we studied in the cyc group the differences between those who made amenorrhea and those that continued with regular cycles. this is a cross sectional and descriptive study. the data were analyzed by chi-square, fisher’s exact test and mann-withney when it was necessary. p < 0.05 was considered significant. results: 16.1% of sle patients under intravenous cyc treatment get premature ovarian failure vs. 4.3% in the control group. with respect to cyc group, the mean age in the amenorrhea group was higher than the age in patients with regular menstrual cycles 35.2 vs. 26.7 years (p=0.03). we found than patients older than 28 years have a mayor risk for amenorrhea induced by intravenous cyc. the mean disease duration was higher in the amenorrhea group than in the regular menstrual cycle patients, p= 0.003 (10.2 vs. 4.4 years). no significant differences were observed in cumulative dosage, treatment duration or immunologic findings between groups. conclusion: the prevalence of ovarian failure in colombian women tends to appear at an early age and with a greater time of evolution of the disease in spite of inferior accumulated doses than those that are informed in the literature, suggesting a mayor susceptibility to toxic effect of cyc.
Prevalencia de falla ovárica y factores de riesgo en pacientes con Lupus Eritematoso Sistémico tratadas con ciclofosfamida intravenosa Prevalence of ovarian failure and risk factor in patients with systemic lupus erythematosus
Mónica Patricia Velásquez Méndez,Francisco Alejandro Ramírez Ruiz,Gloria María Vásquez Duque,Luis Alberto Ramírez Gómez
Revista Colombiana de Reumatología , 2006,
Abstract: Introducción: la falla ovárica prematura es una consecuencia del manejo a largo plazo con ciclofosfamida, su prevalencia en pacientes con LES ha sido informada entre el 11 y el 59%, dependiendo de la ruta y dosis de administración. Estudios sobre la toxicidad gonadal con el régimen propuesto por el NIH son escasos en la literatura, por lo cual se realizó este estudio para determinar la prevalencia y los factores de riesgo asociados al desarrollo de falla ovárica en una población latinoamericana. Métodos: se tomaron 56 pacientes con LES tratadas con bolos de CFM mensuales, menores de 40 a os y con menstruación normal al momento de iniciar la terapia y se compararon con respecto a la frecuencia de amenorrea con 43 pacientes con LES sin tratamiento con ciclofosfamida como grupo control. Posteriormente estudiamos en el grupo de CYC, las diferencias entre aquellas que hicieron amenorrea y las que continuaron con ciclos regulares. Este es un estudio descriptivo de corte transversal. Se aplicó chi-cuadrado, test exacto de Fisher y Mann-Withney según estuviese indicado. P menor de 0,05 se consideró significativo. Resultados: el 16,1% de los pacientes con CYC desarrollaron falla ovárica frente al 4,3% del grupo control. Con respecto al grupo que recibió CYC, se encontró un promedio de edad mayor en el grupo que desarrolló amenorrea que en aquellas con ciclos regulares, 35,2 frente a 26,7 a os (p= 0,003), determinándose como punto de corte de riesgo ser mayor de 28 a os al inicio de la CFM. La evolución de la enfermedad fue mayor en el grupo de amenorrea en comparación con las que continuaban con menstruación normal con una p= 0,003 (10,2 frente a 4,4 a os). No se encontró diferencia en la dosis acumulativa, duración de la terapia o perfil inmunológico de las pacientes. Conclusión: la prevalencia de falla ovárica en mujeres colombianas tiende a presentarse a una edad más temprana y con mayor tiempo de evolución de la enfermedad a pesar de dosis acumuladas inferiores a las informadas en la literatura planteando una mayor labilidad al efecto tóxico de la CFM. Background: premature ovarian failure is a cyclophosphamide (CYC) treatment adverse effect. The report of prevalence is among 11% and 59%, the variability depend on the route and dosage of CYC. There are few studies about gonadal toxicity with NHI CYC treatment protocol. We decided to establish the prevalence and risk factors associated with premature ovarian failure in a group of Latin-American lupus patients. Methods: 56 SLE patients under 40 years treated with intravenous CYC, with regular menstrual cycle at
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