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Search Results: 1 - 10 of 4484 matches for " Lucia Pettinari "
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Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sj?gren's Syndrome
Maria Giovanna Danieli,Lucia Pettinari,Ramona Morariu,Fernando Monteforte,Francesco Logullo
Case Reports in Immunology , 2012, DOI: 10.1155/2012/186320
Abstract: Sensory neuronopathy is described in association with the Sjögren's syndrome (SS). We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. In a few months, she developed ataxia with increased hypoanaesthesia. Electrodiagnostic tests revealed undetectable distal and proximal sensory nerve action potential in upper and lower limbs. Cervical spine magnetic resonance showed a signal hyperintensity of posterior columns. Previous treatment with high-dose glucocorticoids and azathioprine was ineffective. A combined treatment with intravenous immunoglobulin and mycophenolate mofetil was followed by a progressive and persistent improvement. This case documented the efficacy and the safety of the coadministration of intravenous immunoglobulin and mycophenolate mofetil in sensory neuronopathy associated with SS refractory to conventional immunosuppressive therapy.
Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sj?gren's Syndrome
Maria Giovanna Danieli,Lucia Pettinari,Ramona Morariu,Fernando Monteforte,Francesco Logullo
Case Reports in Immunology , 2012, DOI: 10.1155/2012/186320
Abstract: Sensory neuronopathy is described in association with the Sj?gren's syndrome (SS). We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. In a few months, she developed ataxia with increased hypoanaesthesia. Electrodiagnostic tests revealed undetectable distal and proximal sensory nerve action potential in upper and lower limbs. Cervical spine magnetic resonance showed a signal hyperintensity of posterior columns. Previous treatment with high-dose glucocorticoids and azathioprine was ineffective. A combined treatment with intravenous immunoglobulin and mycophenolate mofetil was followed by a progressive and persistent improvement. This case documented the efficacy and the safety of the coadministration of intravenous immunoglobulin and mycophenolate mofetil in sensory neuronopathy associated with SS refractory to conventional immunosuppressive therapy. 1. Introduction Central nervous system involvement in Sj?gren’s syndrome (SS) is rarely reported and may be severe and varied [1]. Sensory neuronopathy (or sensory ganglionopathy, SN) is a distinctive neuropathy of SS, accounting for 15–20% of all neuropathies seen in this condition [2]. A sensory neuropathy is often the presenting feature of SS, and, therefore, a high index of suspicion is required, particularly in female patients with non-length-dependent, painful, or ataxic sensory neuropathy or those with trigeminal sensory and autonomic involvement [3]. At the onset of SN, numbness, tingling, burning, and pain sensations are reported in all limbs, usually with asymmetric distribution. With the disease progression, the sensory disturbances can involve the trunk, the face or they develop into a symmetric way. On examination, degeneration of large sensory neurons leads to gait ataxia, proprioceptive sensory loss, and widespread deep tendon areflexia [3]. When smaller sensory neurons are affected, deficits are those of hypoesthesia to pain and thermal stimuli with hyperacute pain. Autonomic nervous system involvement may cause fixed tachycardia, orthostatic hypotension, and gastrointestinal pseudo-obstruction. The response to treatment is usually poor, even with glucocorticoids, immunosuppressants, and plasmapheresis [3]. Here we report the case of a woman with primary SS who presented with SN that was successfully managed with intravenous immunoglobulin and mycophenolate mofetil coadministration. 2. Case Report In 2001, a 55-year-old woman presented with progressive asymmetric numbness distal tingling and
Mucho ruido y muchas nueces: Se completó el proyecto genoma humano.
Julia Pettinari
Química Viva , 2003,
Abstract:
El camino hacia la clonación
Julia Pettinari
Química Viva , 2004,
Abstract:
Spanglish
María Julia Pettinari
Química Viva , 2010,
Abstract:
Entrevista a Carolina Vera, Vicedecana:"Me sentiría satisfecha si Exactas fortaleciera su proyecto institucional y que todos los investigadores se sintieran parte"
Susana Gallardo,Julia Pettinari
Química Viva , 2006,
Abstract:
"Más que dar respuesta, hay que estimular las preguntas"
Susana Gallardo,Julia Pettinari
Química Viva , 2005,
Abstract:
Las bacterias y nosotros, tan diferentes... y tan parecidos. Mitos y verdades de las diferencias entre eucariotas y procariotas
María Julia Pettinari
Química Viva , 2010,
Abstract: Desde que Stanier y Van Niel propusieron la utilización de los términos procariota y eucariota para diferenciar a las células con núcleo rodeado de membrana nuclear de aquellas que no poseen esta estructura, el conocimiento que tenemos de los diferentes tipos de células presentes en los organismos vivos ha aumentado enormemente. En particular, el estudio de la información genética y los análisis filogenéticos basados en estos estudios permiten observar grandes diferencias entre organismos pertenecientes al grupo de los procariotas, que han llevado a definir dos dominios dentro de este grupo (Bacteria y Archaea), y otro conteniendo a los eucariotas (Eukarya). En este trabajo se analizan las diferencias y similitudes entre los organismos de los diferentes dominios, teniendo en cuenta diferentes aspectos o criterios, y los cambios que éstos sufrieron a lo largo del tiempo.
"Contar la ciencia, sin perder rigor ni agregar solemnidad, es de lo más entretenido"
Susana Gallardo,Julia Pettinari
Química Viva , 2005,
Abstract:
Entrevista a Eduardo Cánepa: "Es necesario estimular la comunicación y la integración entre los distintos grupos de investigación"
Susana Gallardo,Julia Pettinari
Química Viva , 2006,
Abstract:
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