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Search Results: 1 - 10 of 4437 matches for " Lucas Goh "
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Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells
Stefan W. Metz,Joy Gardner,Corinne Geertsema,Thuy T. Le,Lucas Goh,Just M. Vlak,Andreas Suhrbier,Gorben P. Pijlman
PLOS Neglected Tropical Diseases , 2013, DOI: 10.1371/journal.pntd.0002124
Abstract: The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful production of CHIKV virus-like particles (VLPs) in insect cells using recombinant baculoviruses. This well-established expression system is rapidly scalable to volumes required for epidemic responses and proved well suited for processing of CHIKV glycoproteins and production of enveloped VLPs. Herein we show that a single immunization with 1 μg of non-adjuvanted CHIKV VLPs induced high titer neutralizing antibody responses and provided complete protection against viraemia and joint inflammation upon challenge with the Réunion Island CHIKV strain in an adult wild-type mouse model of CHIKV disease. CHIKV VLPs produced in insect cells using recombinant baculoviruses thus represents as a new, safe, non-replicating and effective vaccine candidate against CHIKV infections.
The need for evidence-based aesthetic dermatology practice
Goh C
Journal of Cutaneous and Aesthetic Surgery , 2009,
Mechanism in allergic contact dermatitis
Goh C
Indian Journal of Dermatology, Venereology and Leprology , 1991,
Placing Place: Speech in José María Arguedas’ The Foxes  [PDF]
Lucas Izquierdo
Advances in Literary Study (ALS) , 2013, DOI: 10.4236/als.2013.14011

Critical approximations carried out from the global south entail spatial and epistemological challenges to the hegemony of western modernity. This article argues that José María Arguedas’ The Fox from Up Above and the Fox from Down Below(1971) produces a language that embodies and transforms an Aris-totelian conception of speech. Written in an avant-garde vernacular, the novelcongeals a multiplicity of worldviews, utopias, and mercantile discourses that converge in Chimbote-Peru. Guided by Jacques Ran-ciere’s Disagreement(1998) and Dissensus(2010), the analysis is divided in two stages. The first stage examines the notion of speech and a constitutive wrong that establishes a community. The second stage addresses the symbiotic relationship of speech, its place of enunciation, and the conception of an alternate social order. The analysis places Arguedas incritical dialogue with Aristotelian speech, Ranciere’s notion of wrong, and the emergence or failure of claiming speech in canonical history.

Relationship between Video Game Violence and Long-Term Neuropsychological Outcomes  [PDF]
Yoshiyuki Tamamiya, Goh Matsuda, Kazuo Hiraki
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.513159
Abstract: The current study examined the long-term effects of video game violence on aggressiveness and facial expression recognition using multiple measures. In Experiment 1, participants unfamiliar with video games were randomly assigned to play a violent or nonviolent video game for four weeks. Before and after the game play interval, event-related potentials (ERP) evoked by facial expressions were recorded, and aggressiveness was measured with a questionnaire. Results showed that playing a violent video game delayed peak latency of a positive component of the ERP evoked by angry faces and increased aggressiveness among male participants. Experiment 2 included a 3-month follow-up assessment. Results showed preservation of delayed neural activity, while levels of aggressiveness diminished to some extent. These findings highlight differential aspects regarding the long-term effects of playing a violent video game: more enduring for facial expression recognition and short-lived for aggressiveness.
Supply Chain Orchestration Leveraging on MNC Networks and Local Resources: Approach Strategies  [PDF]
Zhengping Li, Robert De Souza, Mark Goh
Journal of Service Science and Management (JSSM) , 2016, DOI: 10.4236/jssm.2016.94036
Abstract: Competition is becoming more global and is between the networks of businesses rather than between the firms. Operating in such an increasing networked environment, companies have to innovate their business, either be orchestrators or be orchestrated. This exploratory paper proposes an overarching Supply Chain Orchestration (SCO) framework which leverages on the capabilities of the MNC’s networks and the local Logistics Service Providers (LSPs) at a strategic level. This framework comprises integrated components including orchestrated Supply Chain Network (SCN), the relationship model of the actors, a “Win-for-All” pro-orchestration model, and the collaboration platform for the LSPs. Specifically, the paper proposes a practical approach for upgrading the local industry through a virtuous model whereby the MNCs, LSPs, and government agencies collaborate to create a pro-orchestration environment for greater value adding. Using a semi-structured interview approach, key players across the logistics sector in Singapore were interviewed. The approach strategies for realizing this orchestration are investigated and the implications are discussed through a few application scenarios.
User Goals, Behaviours and Attitudes: Developing Web User Personas of Art and Design Students  [PDF]
Chu Hiang Goh, Nurul Hanim Romainoor
Art and Design Review (ADR) , 2019, DOI: 10.4236/adr.2019.71001
Abstract: User personas are one of the most understandable deliverables which used to improve user experience and enhance design communication in web design process. Myriad studies and design research were conducted in this area which was largely based on qualitative research methods. This posted a challenge empirically in the validation of the personas created. To set on this gap, a qualitative-quantitative validation method was adapted with the focus in the three main attributes of personas: user goals, behaviours, and attitudes in this research to create student web user personas in the School of The Arts, Universiti Sains Malaysia web site. As an outcome, a set of art and design student web user personas were presented.
On Mining Movement Pattern from Mobile Users
David Taniar,John Goh
International Journal of Distributed Sensor Networks , 2007, DOI: 10.1080/15501320601069499
Abstract: In the era in which activities performed by mobile users are tracked through various sensing mechanisms, the movement data collected through these sensors is submitted into a data mining algorithm in order to determine the movement pattern. The movement pattern refers to the pattern that mobile users generally take to move from one base location to another base location through multiple intermediate locations. This paper provides a proposal and case study on how the movement pattern can be extracted from mobile users through transforming the user movement database to the location movement database and subsequently transferred to an algorithm Apriori-like movement pattern (AMP) and movement tree (M-tree). The result is a list of sequences in which mobile users frequently go through that which satisfies min-support and min-confidence. The result of this movement pattern mining exercise opens up a new future for the prediction of the movement for the individual mobile user.
Plasmid selection in Escherichia coli using an endogenous essential gene marker
Shan Goh, Liam Good
BMC Biotechnology , 2008, DOI: 10.1186/1472-6750-8-61
Abstract: The new cloning vector, pFab, enabled selection by triclosan at 1 μM. Interestingly, pFab out-performed the parent pUC19-ampicillin system in cell growth, plasmid stability and plasmid yield. Also, pFab was toxic to host cells in a way that was reversed by triclosan. Therefore, pFab and triclosan are toxic when used alone but in combination they enhance growth and plasmid production through a gene-inhibitor interaction.The fabI-triclosan model system provides an alternative plasmid selection method based on essential gene over-expression, without the use of antibiotic-resistance genes and conventional antibiotics.Antibiotic resistance marker genes are commonly used to select and maintain recombinant bacteria in the presence of antibiotics. However, the use of antibiotics is undesirable for manufacturing gene therapy products [1,2]. Also, the introduction of antibiotic resistance genes into biohazardous strains is not recommended [3], and antibiotic selection fails in bacteria that are naturally resistant [3,4]. Finally, the use of antibiotics can be costly in industrial scale production, especially in the case of enzymatic depletion of antibiotic during culture. An alternative system should avoid antibiotic resistance markers and therapeutic antibiotics, be cost effective, but still be convenient, robust and flexible.A variety of strategies for antibiotic-free selection have been developed, but none are widely used in bacteria. The first reported non-antibiotic system involves an auxotrophic bacterial strain and complementation using a plasmid-encoded biosynthesis gene, such that only transformants grow on defined media lacking the nutrient [5]. Another system is termed repressor-titration, where the lac operator functions as the vector-borne selection marker, which de-represses a modified chromosomal essential gene [6]. A third general approach is to alter the expression of growth essential genes using synthetic [7] or expressed antisense sequences [8]. Unfortunate
Investigational new drugs in the treatment of inflammatory bowel disease: a review
Imogen Williams, Jason Goh
Journal of Experimental Pharmacology , 2011, DOI: http://dx.doi.org/10.2147/JEP.S7806
Abstract: vestigational new drugs in the treatment of inflammatory bowel disease: a review Review (3953) Total Article Views Authors: Imogen Williams, Jason Goh Published Date February 2011 Volume 2011:3 Pages 13 - 19 DOI: http://dx.doi.org/10.2147/JEP.S7806 Imogen Williams, Jason Goh GI Unit, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, England, UK Abstract: The unraveling of the immuno-pathobiology of inflammatory bowel disease (IBD) in the past three decades has ushered in a new era of translational medicine. The biotechnology revolution has resulted in a paradigm shift in how clinicians view and treat IBD. Anti-tumor necrosis factor (TNF)-α strategies using infliximab and adalimumab currently dominate the therapeutic arena. Better understanding of how these biologicals work is driving the quest for loftier therapeutic goals of achieving mucosal healing, sustaining deep remission, and even modifying the natural history of IBD. However, not all patients respond to anti-TNF drugs. Immune-mediated adverse reactions and loss of efficacy with time also limit their use. There are many investigational drugs undergoing active clinical trials. Many have not fulfilled their early promises but some are potentially making the transition from bench to trial and to the bedside in the near future. Clinicians and investigators need to underpin our excitement with caution for the unknown long-term consequences of modulating cytokines and selective adhesion molecules in human. Here we provide an overview of investigational new drugs and other therapeutic strategies currently undergoing clinical trials in IBD.
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