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Search Results: 1 - 10 of 5342 matches for " Luca Martignani "
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New Risks and the Reframing of Local Welfare as Social Investment: The Case of the FORJAD Program in Switzerland  [PDF]
Luca Martignani
Open Journal of Political Science (OJPS) , 2016, DOI: 10.4236/ojps.2016.61002
Abstract: FORJAD (Formation Professionelle pour le Jeunes Adults en Difficulté) was a program of social policy implemented in Switzerland since 2006. Its specific aim is to sustain the professional training of young unemployed adults (18 - 25) in order to allow them to become autonomous from the social assistance and to (re)entry into the labour market. This paper deals with specific dimensions of this program, with particular reference to its complex and plural governance and to the cultural framework of the Social Investment Welfare State (SIWS). This paradigm tries to connect the logics of activation and training with the necessity to realize a better quality of welfare services and to invest in personal capabilities of welfare recipients. In this framework, FORJAD seems to represent a social innovation realized to contrast at a local level the young unemployment as an example of emergent new social risks.
Deregulated Electricity Market and Auctions: The Italian Case  [PDF]
Luca Grilli
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.23030
Abstract: The Electricity Market (in Europe) undergoes a period of transformations never seen before. The competitive model suggested by the European Commission is based on a gradual increase in the classes of consumers able to choice, freely, their providers. In general, liberalization, deregulation, competition result in a spur to development and low prices for consumers. The Electricity Market isn’t likely to follow such a rule. Electricity Markets are best described and analyzed as first-price multi-unit procurement iterated auctions. In this paper we present an analysis of the Italian case in order to show the effects of deregulation on final prices for users.
Positional release techniques as a diagnostic-therapeutic approach in physiotherapy  [PDF]
Luca Collebrusco
Open Journal of Therapy and Rehabilitation (OJTR) , 2014, DOI: 10.4236/ojtr.2014.21004
Abstract: Manual Therapy is a rehabilitative approach based on the use of therapeutic procedures that includes several techniques, but this paper focuses on what is known as Positional Release (PR), a therapeutic model that includes a series of manoeuvres that are mainly used for the treatment of soft tissue. A deeper understanding of this type of therapeutic approach, especially its well known and widespread variant, Strain-Counterstrain, could, through controlled trials and systematic reviews, confirm its effectiveness, definitively explain the neurophysiological mechanism, and therefore make Positional Release another indispensable option in the professional expertise of the physiotherapist.
An Integrated Rehabilitation Model: An Ideal Framework for Limiting Health Care Costs  [PDF]
Luca Collebrusco
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.31002
Abstract: The financial crisis has caused a severe limitation of resources for the public health service and rehabilitation. The proposal of integrated diagnosis and treatment in rehabilitation, involving the introduction of new therapeutic models alongside orthodox models, could lead to a reduction in health care costs through better patient compliance. In rehabilitative assistance in health care, the limiting of financial resources can be simplified, given its multifaceted nature and the need to integrate clinical experience with research. In addition, the phases of rehabilitative recovery do not focus on organ damage, but improved participation and the reduction of disability. For this reason, we have considered incorporating narrative based medicine (NBM) and Psycho-Neuro-Immuno-Endocrinology (PNEI) in the rehabilitation process through an empathetic approach, taking evidence based medicine (EBM) into account, thus creating a “framework” of reference. Managing patients through this “framework” would be a move towards an integrated model of care that could lead to a reduction in health care costs, given the aging population and the rise in patients with chronic pain. The decision to modify health care in rehabilitative assistance through a new “framework” will require time, organizational capacity and experimentation, but may represent the appropriate response for an improved quality of life for patients and a better allocation of resources.
A History of Italian Citizenship Laws during the Era of the Monarchy (1861-1946)  [PDF]
Luca Bussotti
Advances in Historical Studies (AHS) , 2016, DOI: 10.4236/ahs.2016.54014
Abstract: This article aims to present the evolution of Italian citizenship from political unification to the end of the Second World War, which in Italy corresponds with the end of the monarchy and the advent of the Republic. In this long period, the central definition of Italian citizenship was given by the Civil Code (1865), the basis of which was Ius sanguinis and the patrilineal system. The 1912 Law on Citizenship changed some aspects of the previous legislation, but did not alter the general legal scenario, despite great pressure from some organised movements such as those formed by Italian expatriates in the Americas. With the advent of fascism (1922), the discourse on the Italian nation became radicalised, but Mussolini’s regime did not pass any organic laws on citizenship. The innovations introduced under fascism were relatively modest; many were directed towards limiting the rights of particular categories of citizens, such as political opponents and Jewish people. Italy reached the beginning of the republican period with a legal apparatus on citizenship that was very similar to the one established for the first time in the Civil Code of 1865. This shows how Italian political classes have given more attention to the orthodoxy of the law than to the need to adapt it to the numerous transformations in Italian society.
Met Receptor Acts Uniquely for Survival and Morphogenesis of EGFR-Dependent Normal Mammary Epithelial and Cancer Cells
Paolo Accornero, Silvia Miretti, Francesca Bersani, Elena Quaglino, Eugenio Martignani, Mario Baratta
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044982
Abstract: Mammary gland development and breast cancer growth require multiple factors both of endocrine and paracrine origin. We analyzed the roles of Epidermal Growth Factor Receptor (EGFR) and Hepatocyte Growth Factor Receptor (Met) in mammary epithelial cells and mammary tumor cells derived from a mutated-ErbB2 transgenic mice. By using highly specific tyrosine kinase inhibitors we found that MCF-10A and NMuMG mammary epithelial cell lines are totally dependent on EGFR activation for their growth and survival. Proliferation and 3D-morphogenesis assays showed that HGF had no role in maintaining mammary cell viability, but was the only cytokine able to rescue EGFR-inhibited mammary cells. Insulin-Like Growth Factor-I (IGF-I), basic-Fibroblast Growth Factor (b-FGF) and Neuregulin, which are well known mammary morphogenic factors, did not rescue proliferation or morphogenesis in these cell lines, following EGFR inhibition. Similarly, ErbB2-driven tumor cells are EGFR-dependent and also display HGF-mediated rescue. Western-blot analysis of the signaling pathways involved in rescue after EGFR inhibition indicated that concomitant ERK1/2 and AKT activation was exclusively driven by Met, but not by IGF-I or b-FGF. These results describe a unique role for EGFR and Met in mammary epithelial cells by showing that similar pathways can be used by tumorigenic cells to sustain growth and resist to EGFR-directed anti-tumorigenic drugs.
Human Milk Protein Production in Xenografts of Genetically Engineered Bovine Mammary Epithelial Stem Cells
Eugenio Martignani,Peter Eirew,Paolo Accornero,Connie J. Eaves,Mario Baratta
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013372
Abstract: In the bovine species milk production is well known to correlate with mammary tissue mass. However, most advances in optimizing milk production relied on improvements of breeding and husbandry practices. A better understanding of the cells that generate bovine mammary tissue could facilitate important advances in milk production and have global economic impact. With this possibility in mind, we show that a mammary stem cell population can be functionally identified and isolated from the bovine mammary gland. We also demonstrate that this stem cell population may be a promising target for manipulating the composition of cow's milk using gene transfer.
Towards Green Remediation: Metal Phytoextraction and Growth Analysis of Sorghum bicolor under Different Agronomic Management  [PDF]
Guido Fellet, Luca Marchiol
Low Carbon Economy (LCE) , 2011, DOI: 10.4236/lce.2011.23018
Abstract: The role agronomy plays in the management of phytotechnologies is a significant example of the answers that the agrosciences can offer to the issues of society in the field of Green Remediation. This paper reports a study designed to test how the principles of classical plant growth analysis can be used in the field of phytoremediation. In the framework of a phytoremediation field trial set up in Torviscosa (Udine, Italy), Sorghum bicolor was grown receiving mineral fertilization, organic amendment, or neither as control. Crop growth was examined following classical functional growth analysis. Leaf area index (LAI), relative growth-rate (RGR) and shoot to weight ratio (SWR) showed how plants behaved in response to the treatments. Sorghum bicolor showed a poor potential for phytoremediation under our experimental conditions. However, some parameters of classical crop growth analysis resulted potentially useful also in the field of phytoremediation.
Electromotive Force Generation with Hydrogen Release by Salt Water Flow under a Transverse Magnetic Field  [PDF]
Roberto De Luca
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.210138
Abstract: By considering an electrolyte solution in motion in a duct under a transverse magnetic field, we notice that a so called Faraday voltage arises because of the Lorentz force acting on anions and cations in the fluid. When salt water is considered, hydrogen production takes place at one of the electrodes if an electric current, generated by Faraday voltage, flows in an external circuit. The maximum amount of hydrogen production rate is calculated by basic electrochemical concepts.
Ordinal Logistic Regression for the Estimate of the Response Functions in the Conjoint Analysis  [PDF]
Amedeo De Luca
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.34051
Abstract: In the Conjoint Analysis (COA) model proposed here – a new approach to estimate more than one response function–an extension of the traditional COA, the polytomous response variable (i.e. evaluation of the overall desirability of alternative product profiles) is described by a sequence of binary variables. To link the categories of overall evaluation to the factor levels, we adopt – at the aggregate level – an ordinal logistic regression, based on a main effects experimental design.The model provides several overall desirability functions (aggregated part-worths sets), as many as the overall ordered categories are, unlike the traditional metric and non metric COA, which gives only one response function. We provide an application of the model and an interpretation of the main effects.
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