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Search Results: 1 - 10 of 5341 matches for " Luca Citi "
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A simple yet efficient algorithm for multiple kernel learning under elastic-net constraints
Luca Citi
Computer Science , 2015,
Abstract: This report presents an algorithm for the solution of multiple kernel learning (MKL) problems with elastic-net constraints on the kernel weights.
Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces
Silvestro Micera, Paolo M Rossini, Jacopo Rigosa, Luca Citi, Jacopo Carpaneto, Stanisa Raspopovic, Mario Tombini, Christian Cipriani, Giovanni Assenza, Maria C Carrozza, Klaus-Peter Hoffmann, Ken Yoshida, Xavier Navarro, Paolo Dario
Journal of NeuroEngineering and Rehabilitation , 2011, DOI: 10.1186/1743-0003-8-53
Abstract: Thin-film longitudinal intra-fascicular electrodes were implanted in the median and ulnar nerves of an amputee's stump during a four-week trial. The possibility of decoding motor commands suitable to control a dexterous hand prosthesis was investigated for the first time in this research field by implementing a spike sorting and classification algorithm.The results showed that motor information (e.g., grip types and single finger movements) could be extracted with classification accuracy around 85% (for three classes plus rest) and that the user could improve his ability to govern motor commands over time as shown by the improved discrimination ability of our classification algorithm.These results open up new and promising possibilities for the development of a neuro-controlled hand prosthesis.The human hand is a versatile organ that is used for grasping heavy or delicate objects and for performing highly complex manipulations on the basis of fine motor control and precise sensory feedback [1]. The restoration of these sensorimotor functions after upper limb amputation is particularly challenging. Two main components must be developed: (a) hand prostheses able to mimic the natural hand from both a biomechanical and sensory points of view [2]; (b) intimate interfaces for online bridging the user's nervous system and the external prosthesis. Several solutions are possible and are currently investigated by independent research groups using non-invasive [3-5], and invasive [6-8] approaches. For instance, intracortical signals can be used to simultaneously control reaching and one degree of freedom grasping of an artificial limb as recently shown in non-human primates [8].In case of amputation, it is also possible to use the residual part of amputee muscles and peripheral nerve fibers to control the artificial hand. This approach can be implemented by processing electromyographic (EMG) signals recorded using either non-invasive [9] or invasive [10,11] electrodes. The tra
The Junctional Proteins Cingulin and Paracingulin Modulate the Expression of Tight Junction Protein Genes through GATA-4
Laurent Guillemot, Domenica Spadaro, Sandra Citi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055873
Abstract: The cytoplamic junctional proteins cingulin and paracingulin have been implicated in the regulation of gene expression in different cultured cell models. In renal epithelial MDCK cells, depletion of either protein results in a Rho-dependent increase in the expression of claudin-2. Here we examined MDCK cell clones depleted of both cingulin and paracingulin (double-KD cells), and we found that unexpectedly the expression of claudin-2, and also the expression of ZO-3 and claudin-3, were decreased, while RhoA activity was still higher than in control cells. The decreased expression of claudin-2 and other TJ proteins in double–KD cells correlated with reduced levels of the transcription factor GATA-4, and was rescued by overexpression of GATA-4, but not by inhibiting RhoA activity. These results indicate that in MDCK cells GATA-4 is required for the expression of claudin-2 and other TJ proteins, and that maintenance of GATA-4 expression requires either cingulin or paracingulin. These results and previous studies suggest a model whereby cingulin and paracingulin redundantly control the expression of specific TJ proteins through distinct GATA-4- and RhoA-dependent mechanisms, and that in the absence of sufficient levels of GATA-4 the RhoA-mediated upregulation of claudin-2 is inhibited.
PLEKHA7 Is an Adherens Junction Protein with a Tissue Distribution and Subcellular Localization Distinct from ZO-1 and E-Cadherin
Pamela Pulimeno,Christoph Bauer,Jeffrey Stutz,Sandra Citi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012207
Abstract: The pleckstrin-homology-domain-containing protein PLEKHA7 was recently identified as a protein linking the E-cadherin-p120 ctn complex to the microtubule cytoskeleton. Here we characterize the expression, tissue distribution and subcellular localization of PLEKHA7 by immunoblotting, immunofluorescence microscopy, immunoelectron microscopy, and northern blotting in mammalian tissues. Anti-PLEKHA7 antibodies label the junctional regions of cultured kidney epithelial cells by immunofluorescence microscopy, and major polypeptides of Mr ~135 kDa and ~145 kDa by immunoblotting of lysates of cells and tissues. Two PLEKHA7 transcripts (~5.5 kb and ~6.5 kb) are detected in epithelial tissues. PLEKHA7 is detected at epithelial junctions in sections of kidney, liver, pancreas, intestine, retina, and cornea, and its tissue distribution and subcellular localization are distinct from ZO-1. For example, PLEKHA7 is not detected within kidney glomeruli. Similarly to E-cadherin, p120 ctn, β-catenin and α-catenin, PLEKHA7 is concentrated in the apical junctional belt, but unlike these adherens junction markers, and similarly to afadin, PLEKHA7 is not localized along the lateral region of polarized epithelial cells. Immunoelectron microscopy definitively establishes that PLEKHA7 is localized at the adherens junctions in colonic epithelial cells, at a mean distance of 28 nm from the plasma membrane. In summary, we show that PLEKHA7 is a cytoplasmic component of the epithelial adherens junction belt, with a subcellular localization and tissue distribution that is distinct from that of ZO-1 and most AJ proteins, and we provide the first description of its distribution and localization in several tissues.
Deregulated Electricity Market and Auctions: The Italian Case  [PDF]
Luca Grilli
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.23030
Abstract: The Electricity Market (in Europe) undergoes a period of transformations never seen before. The competitive model suggested by the European Commission is based on a gradual increase in the classes of consumers able to choice, freely, their providers. In general, liberalization, deregulation, competition result in a spur to development and low prices for consumers. The Electricity Market isn’t likely to follow such a rule. Electricity Markets are best described and analyzed as first-price multi-unit procurement iterated auctions. In this paper we present an analysis of the Italian case in order to show the effects of deregulation on final prices for users.
Positional release techniques as a diagnostic-therapeutic approach in physiotherapy  [PDF]
Luca Collebrusco
Open Journal of Therapy and Rehabilitation (OJTR) , 2014, DOI: 10.4236/ojtr.2014.21004
Abstract: Manual Therapy is a rehabilitative approach based on the use of therapeutic procedures that includes several techniques, but this paper focuses on what is known as Positional Release (PR), a therapeutic model that includes a series of manoeuvres that are mainly used for the treatment of soft tissue. A deeper understanding of this type of therapeutic approach, especially its well known and widespread variant, Strain-Counterstrain, could, through controlled trials and systematic reviews, confirm its effectiveness, definitively explain the neurophysiological mechanism, and therefore make Positional Release another indispensable option in the professional expertise of the physiotherapist.
An Integrated Rehabilitation Model: An Ideal Framework for Limiting Health Care Costs  [PDF]
Luca Collebrusco
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.31002
Abstract: The financial crisis has caused a severe limitation of resources for the public health service and rehabilitation. The proposal of integrated diagnosis and treatment in rehabilitation, involving the introduction of new therapeutic models alongside orthodox models, could lead to a reduction in health care costs through better patient compliance. In rehabilitative assistance in health care, the limiting of financial resources can be simplified, given its multifaceted nature and the need to integrate clinical experience with research. In addition, the phases of rehabilitative recovery do not focus on organ damage, but improved participation and the reduction of disability. For this reason, we have considered incorporating narrative based medicine (NBM) and Psycho-Neuro-Immuno-Endocrinology (PNEI) in the rehabilitation process through an empathetic approach, taking evidence based medicine (EBM) into account, thus creating a “framework” of reference. Managing patients through this “framework” would be a move towards an integrated model of care that could lead to a reduction in health care costs, given the aging population and the rise in patients with chronic pain. The decision to modify health care in rehabilitative assistance through a new “framework” will require time, organizational capacity and experimentation, but may represent the appropriate response for an improved quality of life for patients and a better allocation of resources.
New Risks and the Reframing of Local Welfare as Social Investment: The Case of the FORJAD Program in Switzerland  [PDF]
Luca Martignani
Open Journal of Political Science (OJPS) , 2016, DOI: 10.4236/ojps.2016.61002
Abstract: FORJAD (Formation Professionelle pour le Jeunes Adults en Difficulté) was a program of social policy implemented in Switzerland since 2006. Its specific aim is to sustain the professional training of young unemployed adults (18 - 25) in order to allow them to become autonomous from the social assistance and to (re)entry into the labour market. This paper deals with specific dimensions of this program, with particular reference to its complex and plural governance and to the cultural framework of the Social Investment Welfare State (SIWS). This paradigm tries to connect the logics of activation and training with the necessity to realize a better quality of welfare services and to invest in personal capabilities of welfare recipients. In this framework, FORJAD seems to represent a social innovation realized to contrast at a local level the young unemployment as an example of emergent new social risks.
A History of Italian Citizenship Laws during the Era of the Monarchy (1861-1946)  [PDF]
Luca Bussotti
Advances in Historical Studies (AHS) , 2016, DOI: 10.4236/ahs.2016.54014
Abstract: This article aims to present the evolution of Italian citizenship from political unification to the end of the Second World War, which in Italy corresponds with the end of the monarchy and the advent of the Republic. In this long period, the central definition of Italian citizenship was given by the Civil Code (1865), the basis of which was Ius sanguinis and the patrilineal system. The 1912 Law on Citizenship changed some aspects of the previous legislation, but did not alter the general legal scenario, despite great pressure from some organised movements such as those formed by Italian expatriates in the Americas. With the advent of fascism (1922), the discourse on the Italian nation became radicalised, but Mussolini’s regime did not pass any organic laws on citizenship. The innovations introduced under fascism were relatively modest; many were directed towards limiting the rights of particular categories of citizens, such as political opponents and Jewish people. Italy reached the beginning of the republican period with a legal apparatus on citizenship that was very similar to the one established for the first time in the Civil Code of 1865. This shows how Italian political classes have given more attention to the orthodoxy of the law than to the need to adapt it to the numerous transformations in Italian society.
Towards Green Remediation: Metal Phytoextraction and Growth Analysis of Sorghum bicolor under Different Agronomic Management  [PDF]
Guido Fellet, Luca Marchiol
Low Carbon Economy (LCE) , 2011, DOI: 10.4236/lce.2011.23018
Abstract: The role agronomy plays in the management of phytotechnologies is a significant example of the answers that the agrosciences can offer to the issues of society in the field of Green Remediation. This paper reports a study designed to test how the principles of classical plant growth analysis can be used in the field of phytoremediation. In the framework of a phytoremediation field trial set up in Torviscosa (Udine, Italy), Sorghum bicolor was grown receiving mineral fertilization, organic amendment, or neither as control. Crop growth was examined following classical functional growth analysis. Leaf area index (LAI), relative growth-rate (RGR) and shoot to weight ratio (SWR) showed how plants behaved in response to the treatments. Sorghum bicolor showed a poor potential for phytoremediation under our experimental conditions. However, some parameters of classical crop growth analysis resulted potentially useful also in the field of phytoremediation.
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