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Search Results: 1 - 10 of 3744 matches for " Louise Rose "
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Incidence and Prediction of Falls in Dementia: A Prospective Study in Older People
Louise M. Allan, Clive G. Ballard, Elise N. Rowan, Rose Anne Kenny
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005521
Abstract: Background Falls are a major cause of morbidity and mortality in dementia, but there have been no prospective studies of risk factors for falling specific to this patient population, and no successful falls intervention/prevention trials. This prospective study aimed to identify modifiable risk factors for falling in older people with mild to moderate dementia. Methods and Findings 179 participants aged over 65 years were recruited from outpatient clinics in the UK (38 Alzheimer's disease (AD), 32 Vascular dementia (VAD), 30 Dementia with Lewy bodies (DLB), 40 Parkinson's disease with dementia (PDD), 39 healthy controls). A multifactorial assessment of baseline risk factors was performed and fall diaries were completed prospectively for 12 months. Dementia participants experienced nearly 8 times more incident falls (9118/1000 person-years) than controls (1023/1000 person-years; incidence density ratio: 7.58, 3.11–18.5). In dementia, significant univariate predictors of sustaining at least one fall included diagnosis of Lewy body disorder (proportional hazard ratio (HR) adjusted for age and sex: 3.33, 2.11–5.26), and history of falls in the preceding 12 months (HR: 2.52, 1.52–4.17). In multivariate analyses, significant potentially modifiable predictors were symptomatic orthostatic hypotension (HR: 2.13, 1.19–3.80), autonomic symptom score (HR per point 0–36: 1.055, 1.012–1.099), and Cornell depression score (HR per point 0–40: 1.053, 1.01–1.099). Higher levels of physical activity were protective (HR per point 0–9: 0.827, 0.716–0.956). Conclusions The management of symptomatic orthostatic hypotension, autonomic symptoms and depression, and the encouragement of physical activity may provide the core elements for the most fruitful strategy to reduce falls in people with dementia. Randomised controlled trials to assess such a strategy are a priority.
Partial Ventilatory Support Modalities in Acute Lung Injury and Acute Respiratory Distress Syndrome—A Systematic Review
Sarah M. McMullen,Maureen Meade,Louise Rose,Karen Burns,Sangeeta Mehta,Robert Doyle,Dietrich Henzler
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040190
Abstract: The efficacy of partial ventilatory support modes that allow spontaneous breathing in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is unclear. The objective of this scoping review was to assess the effects of partial ventilatory support on mortality, duration of mechanical ventilation, and both hospital and intensive care unit (ICU) lengths of stay (LOS) for patients with ALI and ARDS; the secondary objective was to describe physiologic effects on hemodynamics, respiratory system and other organ function.
The Twin Bambili Maars (Bamenda Mountains, Cameroon Volcanic Line): Simulative Model of Formation  [PDF]
Wotchoko Pierre, Takojio Nguemo Rose Eugenie, Kouankap Nono Gus Djibril, Guedjeo Christian Suh, Nkouathio David Guimollaire, Bobga Stanley Babila, Chenyi Marie-Louise Vohnyui, Tchokona Seuwi dieudonne, Suh Emmanuel Cheo
Open Journal of Geology (OJG) , 2017, DOI: 10.4236/ojg.2017.74030
Abstract: The Bambili maars are twin contemporaneous maars embedded in trachytic rocks. The two maars are separated by a low lying inter-Maar dome whose inner walls dip towards the Southern Maar. The Bambili Northern Maar (BNM) contains water and its floor is found at an altitude lower than the Bambili Southern Maar (BSM) (50 m) which is swampy and drains into the BNM. Both maars have very steep vertical walls. Three different units are identified in the area. Unit 1 is 1 m thick sequence, characterize by the presence of matrix supported fine-grained fallouts (ash and lapilli size) with stratified diffused bedding planes. This unit is further subdivided into three different layers: L1, L2 and L3 from bottom to top with increasing sizes of particles respectively. This layer shows reverser grading and its grain sizes rarely exceed 2 cm and this unit shows no depositional structures. Unit 2 is an unstratified unit predominantly made up of tephra deposits. Within these deposits are found blocks of sizes ranging between 2 and 10 cm of different petrographic types. They include scoria, basalts, trachyte, and granite cognate. The last unit, Unit 3 is distinctly stratified characterized by well sorted, heterolithologic, graded bedding layers which are matrix supported. Base on the composition and grain sizes, this unit was subdivided into 7 horizons: h1 - h7. Within this unit, two sequences of deposits are distinguished: U1 and U2. Both sequences are characterized by alternation of lapilli and tuff beds. The clast comprises of juvenile materials, mudstone which are highly vesicular and altered rock fragments. Other products identified within the area are ferolithic volcanic bombs (5 - 20 cm), xenocrystals (2 - 4 cm) within finer deposits. They are elongated and show visible twinned planes. Explosion breccias are equally identified occurring as bolders. Along the inner walls of the maars are also found large basaltic and trachytic blocks which are remnants of pre-maar unit within maar deposits. The model proposed indicates the maars were emplaced simultaneously from adjacent vents followed by a succession of lava flows and pyroclastic ejections.
Endogenous Ranking in the Two-Sector Urn-Ball Matching Process  [PDF]
Giuseppe Rose
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.83024
Abstract: This paper contributes to the debate concerning micro-foundations of matching functions in frictional labor markets. The focus is on a particular matching regime, i.e., the so-called urn-ball process. It is shown that in a twosector economy, even in the presence of heterogeneous workers, the assumption of applicants-ranking may be misleading. Instead, the choice concerning the adoption of either ranking or no-ranking behavior is endogenous and it is affected by both the tightness of the two sectors and the composition of the labor force in terms of skills. Moreover it is proved that exogenous shocks may change the form of the matching function. This result casts additional doubts on the assumption of exogenous matching function often made in empirical works aimed at assessing the effectiveness of policy measures.
Social regulation of gene expression in human leukocytes
Steve W Cole, Louise C Hawkley, Jesusa M Arevalo, Caroline Y Sung, Robert M Rose, John T Cacioppo
Genome Biology , 2007, DOI: 10.1186/gb-2007-8-9-r189
Abstract: DNA microarray analysis identified 209 genes that were differentially expressed in circulating leukocytes from 14 high- versus low-lonely individuals, including up-regulation of genes involved in immune activation, transcription control, and cell proliferation, and down-regulation of genes supporting mature B lymphocyte function and type I interferon response. Promoter-based bioinformatic analyses showed under-expression of genes bearing anti-inflammatory glucocorticoid response elements (GREs; p = 0.032) and over-expression of genes bearing response elements for pro-inflammatory NF-κB/Rel transcription factors (p = 0.011). This reciprocal shift in pro- and anti-inflammatory signaling was not attributable to differences in circulating cortisol levels, or to other demographic, psychological, or medical characteristics. Additional transcription control pathways showing differential activity in bioinformatic analyses included the CREB/ATF, JAK/STAT, IRF1, C/EBP, Oct, and GATA pathways.These data provide the first indication that human genome-wide transcriptional activity is altered in association with a social epidemiological risk factor. Impaired transcription of glucocorticoid response genes and increased activity of pro-inflammatory transcription control pathways provide a functional genomic explanation for elevated risk of inflammatory disease in individuals who experience chronically high levels of subjective social isolation.A large body of epidemiological research has linked characteristics of the social environment to human physical health [1,2], but the genomic mechanisms of these effects remain largely unexplored. One of the most robust social risk factors involves the number and quality of an individual's close personal relationships. People who are socially isolated have increased risk of all-cause mortality [1,2], and several specific infectious, neoplastic, and cardiovascular diseases [3-6]. The biological basis for these epidemiological findings is poorl
Emergency department length of stay for patients requiring mechanical ventilation: a prospective observational study
Louise Rose, Sara Gray, Karen Burns, Clare Atzema, Alex Kiss, Andrew Worster, Damon C. Scales, Gordon Rubenfeld, Jacques Lee
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2012, DOI: 10.1186/1757-7241-20-30
Abstract: Prospective observational study of ED LOS for all patients receiving mechanical ventilation at four metropolitan EDs in Toronto, Canada over two six-month periods in 2009 and 2010.We identified 618 mechanically ventilated patients which represented 0.5% (95% CI 0.4%–0.5%) of all ED visits. Of these, 484 (78.3%) received invasive ventilation, 118 (19.1%) received NIV; 16 received both during the ED stay. Median Kaplan-Meier estimated duration of ED stay for all patients was 6.4?h (IQR 2.8–14.6). Patients with trauma diagnoses had a shorter median (IQR) LOS, 2.5?h (1.3–5.1), compared to ventilated patients with non-trauma diagnoses, 8.5?h (3.3–14.0) (p <0.001). Patients requiring NIV had a longer ED stay (16.6?h, 8.2–27.9) compared to those receiving invasive ventilation exclusively (4.6?h, 2.2–11.1) and patients receiving both (15.4?h, 6.4–32.6) (p <0.001). Longer ED LOS was associated with ED site and lower priority triage scores. Shorter ED LOS was associated with intubation at another ED prior to transfer.While patients requiring mechanical ventilation represent a small proportion of overall ED visits these critically ill patients frequently experienced prolonged ED stay especially those treated with NIV, assigned lower priority triage scores at ED presentation, and non-trauma patients.
Inner Ear Morphology Is Perturbed in Two Novel Mouse Models of Recessive Deafness
Kerry A. Miller, Louise H. Williams, Elizabeth Rose, Michael Kuiper, Hans-Henrik M. Dahl, Shehnaaz S. M. Manji
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051284
Abstract: Human MYO7A mutations can cause a variety of conditions involving the inner ear. These include dominant and recessive non-syndromic hearing loss and syndromic conditions such as Usher syndrome. Mouse models of deafness allow us to investigate functional pathways involved in normal and abnormal hearing processes. We present two novel mouse models with mutations in the Myo7a gene with distinct phenotypes. The mutation in Myo7aI487N/I487N ewaso is located within the head motor domain of Myo7a. Mice exhibit a profound hearing loss and manifest behaviour associated with a vestibular defect. A mutation located in the linker region between the coiled-coil and the first MyTH4 domains of the protein is responsible in Myo7aF947I/F947I dumbo. These mice show a less severe hearing loss than in Myo7aI487N/I487N ewaso; their hearing loss threshold is elevated at 4 weeks old, and progressively worsens with age. These mice show no obvious signs of vestibular dysfunction, although scanning electron microscopy reveals a mild phenotype in vestibular stereocilia bundles. The Myo7aF947I/F947I dumbo strain is therefore the first reported Myo7a mouse model without an overt vestibular phenotype; a possible model for human DFNB2 deafness. Understanding the molecular basis of these newly identified mutations will provide knowledge into the complex genetic pathways involved in the maintenance of hearing, and will provide insight into recessively inherited sensorineural hearing loss in humans.
Newspaper Reports on BSE around the Time of the Japan-US Trade Conflicts: Content Analysis of Japanese and US Dailies from 2002 to 2006  [PDF]
Hajime Sato, Rose G. Rose G. Campbell
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.21003
Abstract: Mass media can affect how people understand and react to particular health risks. Reporting of health risks during the international trade disputes, resulting from the difference in safety regulations, therefore can play a pivotal role in resolving them. This study compared the newspaper reports on BSE-related events in major national dailies between Japan and the US around the period when BSE-infected cattle were discovered in the US and the import of US beef products was banned (between December 2002 and November 2006). During the study period, the number of BSE-related newspaper articles increased in both the US and Japan, but the visibility of the issue was more prominent and persistent in Japan than in the US. Geographically, most of the articles had a domestic focus, but they also reported the news of each trade partner. After the discovery of BSE cattle in the US, articles of commerce and trade issues were dominant in Japan, while the incidence of BSE, agriculture, and trade dominated in the US. Overall, the US-based newspapers carried more advocacy articles than the Japanese ones. In Japan, calls for stronger domestic policy decreased, but those for stronger foreign policy increased slightly. Meanwhile, in the US, calls for a stronger domestic policy increased slightly whereas those for weaker foreign policy dropped-both only temporarily. The major rationale for policy advocacy was the economy and health in both Japan and the US. However, the balance of competing policy objectives and the rational acceptance of BSE risks were argued more in the US papers than in the Japanese ones. In conclusion, during the BSE-related dispute on health and trade, the visibility and faces of the issues in newspapers differed between Japan and the US. Acceptance of BSE-related risks was argued differently, and those differences reflected and affected the public's perception of BSE issues, the related safety policies by the governments, and the configuration of social interests in each country. The differences evident in the media could serve as a vehicle for reappraising the existing policies as well as the possible international harmonization of risk management policies.
Genetics of a sex-linked recessive red eye color mutant of the tarnished plant bug, Lygus lineolaris  [PDF]
Margaret Louise Allen
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.32A001
Abstract: An inbred colony of the tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Miridae: Hemiptera), was observed to contain specimens with abnormal traits including red eyes, deformed antennae, and deformed legs. These specimens were isolated and back crossed to create stable phenotypic strains. The only successful strain established was a red eyed strain named Cardinal. The trait was more prevalent and stable in males, suggesting that it could be sex linked. To test the hypothesis that the trait was based on a recessive sex linked allele, classical genetic crosses were performed. The hypothesis was confirmed, and the eye color phenotype was measured and characterized using color analysis software. The trait is similar to other red eyed phenotypes described in this species, but is clearly based on a different mutation since it is sex linked rather than autosomal. The results of crossing experiments also suggest that inbreeding in this species results in substantial fitness cost to laboratory insects.
Genetics of a sex-linked recessive red eye color mutant of the tarnished plant bug, Lygus lineolaris  [PDF]
Margaret Louise Allen
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.32A001
Abstract:

An inbred colony of the tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Miridae: Hemiptera), was observed to contain specimens with abnormal traits including red eyes, deformed antennae, and deformed legs. These specimens were isolated and back crossed to create stable phenotypic strains. The only successful strain established was a red eyed strain named Cardinal. The trait was more prevalent and stable in males, suggesting that it could be sex linked. To test the hypothesis that the trait was based on a recessive sex linked allele, classical genetic crosses were performed. The hypothesis was confirmed, and the eye color phenotype was measured and characterized using color analysis software. The trait is similar to other red eyed phenotypes described in this species, but is clearly based on a different mutation since it is sex linked rather than autosomal. The results of crossing experiments also suggest that inbreeding in this species results in substantial fitness cost to laboratory insects.

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