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Search Results: 1 - 10 of 4330 matches for " Louis Dubeau "
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On a generalization of u-means
Francois Dubeau
International Journal of Mathematics and Mathematical Sciences , 1991, DOI: 10.1155/s0161171291001072
Abstract: In this paper we present an extension of Bauer's work about u-means. We consider a kind of composition of an admissible function u(x) (described by Bauer) and of a compatible function (x). This construction allows us to define (u, )-means. When (x)=x, the (u, )-means are the u-means introduced by Bauer. The arithmetic, geometric and harmonic means are special cases.
Fast Computation of Pareto Set for Bicriteria Linear Programs with Application to a Diet Formulation Problem  [PDF]
F. Dubeau, M. E. Ntigura Habingabwa
American Journal of Operations Research (AJOR) , 2018, DOI: 10.4236/ajor.2018.85019
Abstract: In case of mathematical programming problems with conflicting criteria, the Pareto set is a useful tool for a decision maker. Based on the geometric properties of the Pareto set for a bicriteria linear programming problem, we present a simple and fast method to compute this set in the criterion space using only an elementary linear program solver. We illustrate the method by solving the pig diet formulation problem which takes into account not only the cost of the diet but also nitrogen or phosphorus excretions.
Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism
Beth M. Palian equal contributor,Aarti D. Rohira equal contributor,Sandra A. S. Johnson equal contributor,Lina He,Ni Zheng,Louis Dubeau,Bangyan L. Stiles,Deborah L. Johnson
PLOS Genetics , 2014, DOI: doi/10.1371/journal.pgen.1004789
Abstract: Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes, yet little is known about its other potential target genes or its biological function. Here, we show that Maf1 is a key downstream target of PTEN that drives both its tumor suppressor and metabolic functions. Maf1 expression is diminished with loss of PTEN in both mouse models and human cancers. Consistent with its role as a tumor suppressor, Maf1 reduces anchorage-independent growth and tumor formation in mice. PTEN-mediated changes in Maf1 expression are mediated by PTEN acting on PI3K/AKT/FoxO1 signaling, revealing a new pathway that regulates RNA pol III-dependent genes. This regulatory event is biologically relevant as diet-induced PI3K activation reduces Maf1 expression in mouse liver. We further identify lipogenic enzymes as a new class of Maf1-regulated genes whereby Maf1 occupancy at the FASN promoter opposes SREBP1c-mediated transcription activation. Consistent with these findings, Maf1 inhibits intracellular lipid accumulation and increasing Maf1 expression in mouse liver abrogates diet-mediated induction of lipogenic enzymes and triglycerides. Together, these results establish a new biological role for Maf1 as a downstream effector of PTEN/PI3K signaling and reveal that Maf1 is a key element by which this pathway co-regulates lipid metabolism and oncogenesis.
La sexopérinatalité : où en sommes-nous?
Viola Polomeno,Diane Dubeau
L'Infirmière Clinicienne , 2009,
Abstract: La sexopérinatalité est un nouveau domaine en soins périnataux qui porte sur l’intimité du couple en période postnatale. Le haut taux de séparation et de divorce après la naissance d’un enfant interpelle les professionnels de la santé à s’intéresser au vécu du couple au plan de la sexualité, de l’intimité. Les participants à un atelier réflexif sur ce thème s’entendent pour dire que les rencontres prénatales sont un moment clé pour aborder ces questions. Tous les intervenants, qu’ils soient médecins, sages-femmes ou infirmières devraient détenir une expertise pour parler de sexualité avec le couple. La formation et une approche interdisciplinaire pourraient soutenir le développement de ce domaine d’expertise.
Widespread EEG Changes Precede Focal Seizures
Piero Perucca, Fran?ois Dubeau, Jean Gotman
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080972
Abstract: The process by which the brain transitions into an epileptic seizure is unknown. In this study, we investigated whether the transition to seizure is associated with changes in brain dynamics detectable in the wideband EEG, and whether differences exist across underlying pathologies. Depth electrode ictal EEG recordings from 40 consecutive patients with pharmacoresistant lesional focal epilepsy were low-pass filtered at 500 Hz and sampled at 2,000 Hz. Predefined EEG sections were selected immediately before (immediate preictal), and 30 seconds before the earliest EEG sign suggestive of seizure activity (baseline). Spectral analysis, visual inspection and discrete wavelet transform were used to detect standard (delta, theta, alpha, beta and gamma) and high-frequency bands (ripples and fast ripples). At the group level, each EEG frequency band activity increased significantly from baseline to the immediate preictal section, mostly in a progressive manner and independently of any modification in the state of vigilance. Preictal increases in each frequency band activity were widespread, being observed in the seizure-onset zone and lesional tissue, as well as in remote regions. These changes occurred in all the investigated pathologies (mesial temporal atrophy/sclerosis, local/regional cortical atrophy, and malformations of cortical development), but were more pronounced in mesial temporal atrophy/sclerosis. Our findings indicate that a brain state change with distinctive features, in the form of unidirectional changes across the entire EEG bandwidth, occurs immediately prior to seizure onset. We postulate that these changes might reflect a facilitating state of the brain which enables a susceptible region to generate seizures.
Genome-Scale Screen for DNA Methylation-Based Detection Markers for Ovarian Cancer
Mihaela Campan, Melissa Moffitt, Sahar Houshdaran, Hui Shen, Martin Widschwendter, Günter Daxenbichler, Tiffany Long, Christian Marth, Ite A. Laird-Offringa, Michael F. Press, Louis Dubeau, Kimberly D. Siegmund, Anna H. Wu, Susan Groshen, Uma Chandavarkar, Lynda D. Roman, Andrew Berchuck, Celeste L. Pearce, Peter W. Laird
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028141
Abstract: Background The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical relevance for early detection and/or monitoring of disease recurrence. We developed a systematic multi-step biomarker discovery and verification strategy to identify candidate DNA methylation markers for the blood-based detection of ovarian cancer. Methodology/Principal Findings We used the Illumina Infinium platform to analyze the DNA methylation status of 27,578 CpG sites in 41 ovarian tumors. We employed a marker selection strategy that emphasized sensitivity by requiring consistency of methylation across tumors, while achieving specificity by excluding markers with methylation in control leukocyte or serum DNA. Our verification strategy involved testing the ability of identified markers to monitor disease burden in serially collected serum samples from ovarian cancer patients who had undergone surgical tumor resection compared to CA-125 levels. We identified one marker, IFFO1 promoter methylation (IFFO1-M), that is frequently methylated in ovarian tumors and that is rarely detected in the blood of normal controls. When tested in 127 serially collected sera from ovarian cancer patients, IFFO1-M showed post-resection kinetics significantly correlated with serum CA-125 measurements in six out of 16 patients. Conclusions/Significance We implemented an effective marker screening and verification strategy, leading to the identification of IFFO1-M as a blood-based candidate marker for sensitive detection of ovarian cancer. Serum levels of IFFO1-M displayed post-resection kinetics consistent with a reflection of disease burden. We anticipate that IFFO1-M and other candidate markers emerging from this marker development pipeline may provide disease detection capabilities that complement existing biomarkers.
Justifying Tolerance in Liberal Societies: The Need for Public Morality  [PDF]
Louis Tietje
Open Journal of Philosophy (OJPP) , 2012, DOI: 10.4236/ojpp.2012.21002
Abstract: One of the most important assumptions in liberal societies is that citizens should be tolerant of a diversity of values. We are challenged by this assumption to justify restraint when we confront what we oppose, disapprove of, or perceive to be immoral, even if we have the power to suppress perceived immoralities. Based on the work of Elliot Turiel, Jonathan Haidt, and Gerald Gaus, the argument developed in this article is that the best way to address the challenge is to distinguish between public morality and other normative categories such as convention and private morality. Public morality circumscribes what should not be publicly tolerated. Conventional and private immoralities that are not prohibited by public morality should be tolerated.
Logical Difficulty from Combining Counterfactuals in the GHZ-Bell Theorems  [PDF]
Louis Sica
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.410A3012
Abstract:

In eliminating the fair sampling assumption, the Greenberger, Horne, Zeilinger (GHZ) theorem is believed to confirm Bell’s historic conclusion that local hidden variables are inconsistent with the results of quantum mechanics. The GHZ theorem depends on predicting the results of sets of measurements of which only one may be performed. In the present paper, the noncommutative aspects of these unperformed measurements are critically examined. Classical examples and the logic of the GHZ construction are analyzed to demonstrate that combined counterfactual results of noncommuting operations are in general logically inconsistent with performed measurement sequences whose results depend on noncommutation. The Bell theorem is also revisited in the light of this result. It is concluded that negative conclusions regarding local hidden variables do not follow from the GHZ and Bell theorems as historically reasoned.

Bell Correlations without Entanglement: A Local Wave Model Using Gaussian-Poisson Statistics and Single Count-Pair Selection  [PDF]
Louis Sica
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.518276
Abstract: Based on the violation of Bell inequalities, it has been believed that the derivation of Bell correlations requires a quantum description that depends on entanglement. However, the present paper computes Bell correlations among polarization analyzer output intensities from two spatially separated sets of superposed random wave pairs. To obtain proper Bell correlations, the general statistics must be modified to represent single event pair selection. The correlations between analyzer output components are then in one-to-one correspondence with those computed from the entanglement formalism.
The Bell Inequality Is Satisfied by Quantum Correlations Computed Consistently with Quantum Non-Commutation  [PDF]
Louis Sica
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.74041
Abstract: In constructing his theorem, Bell assumed that correlation functions among non-commuting variables are the same as those among commuting variables. However, in quantum mechanics, multiple data values exist simultaneously for commuting operations while for non-commuting operations data are conditional on prior outcomes, or may be predicted as alternative outcomes of the non-commuting operations. Given these qualitative differences, there is no reason why correlation functions among non-commuting variables should be the same as those among commuting variables, as assumed by Bell. When data for commuting and noncommuting operations are predicted from quantum mechanics, their correlations are different, and they now satisfy the Bell inequality.
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