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Search Results: 1 - 10 of 603 matches for " Lothar Fritsch "
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The Clean Privacy Ecosystem of the Future Internet
Lothar Fritsch
Future Internet , 2013, DOI: 10.3390/fi5010034
Abstract: This article speculates on the future of privacy and electronic identities on the Internet. Based on a short review of security models and the development of privacy-enhancing technology, privacy and electronic identities will be discussed as parts of a larger context—an ecosystem of personal information and electronic identities. The article argues for an ecosystem view of personal information and electronic identities, as both personal information and identity information are basic required input for many applications. Therefore, for both application owners and users, a functioning ecosystem of personal information and electronic identification is important. For the future of the Internet, high-quality information and controlled circulation of such information is therefore argued as decisive for the value of future Internet applications.
Editorial "Musik spielen - Computerspiele und Musik"
Melanie Fritsch
Act : Zeitschrift für Musik & Performance , 2011,
Abstract: Since video games go back some fifty years now, several generations have been raised entirely on video games, their aesthetics and their sound and music. Scholarly research is responding to this influence by becoming more and more interested and involved in game studies, particularly, in the field of video game music, which has begun to arouse growing enthusiasm. With this issue of Act, we would like to contribute to this discussion.
Untersuchung zur Identifizierung von Kommunikationsmerkmalen textbasierter Beratung bei Essst rungen“ - eine qualitative Inhaltsanalyse der Antworttexte der Online-Berater des ab-server
Susanne Fritsch
E-Beratungsjournal , 2010,
Abstract: Da es bisher kaum Untersuchungen über Merkmale und Mechanismen der Online‐Beratung bei Essst rungen gibt, ist Ziel der nachfolgenden Diplomarbeit, anhand einer qualitativen Inhaltsanalyse der Antworttexte der Online‐Berater, zentrale Kommunikationsmerkmale und ‐strukturen in den Beraterantworten zu identifizieren und zu Kategorien zusammen zufassen. Dabei werden die Antworttexte der Online‐Beratung durch eine pr zise Textanalyse methodisch‐inhaltlich strukturiert und klassifiziert, um sie anschlie end einer Prüfung im Hinblick auf die Einhaltung der in den Richtlinien der DFE e.V. verankerten Qualit tskriterien für die Online‐Beratung zu unterziehen. Die, aus der Verknüpfung der Richtlinien und der Analyse der Antworttexte der Online‐Berater abgeleiteten Beratungsziele: Vermittlung von Information, Entwicklung Problembewusstsein hinsichtlich Erkrankung und Aktivierung ins professionelle Hilfesystem, sowie der Beratungsstruktur: Begrü ung, Spiegelung, Intervention und Abschluss, sollten sich in den aufgestellten Kategorien des Kategoriensystems wiederfinden. Die vorliegende Arbeit soll einen Beitrag zur besseren theoretischen Fundierung der Online‐Beratung im allgemeinen und zur Qualit tssicherung bzw. ‐verbesserung des Online‐Beratungsangebotes des ab‐server im Sinne der Zielgruppe im besonderen leisten.
FCJ-137 Affective Experience in Interactive Environments
Jonas Fritsch
Fibreculture Journal , 2011,
Abstract: Ubiquitous computing is rapidly reconfiguring the physical, social and digital spaces we inhabit, thus altering our affective experience of the world we live in. This development calls for a renewed understanding of what happens when living with interactive technologies becomes an integral part of the way we experience the world. This understanding feeds into the theoretical and practical work of experience-oriented interaction design. In this article, the concept of affect as it has been developed in the philosophy of Brian Massumi is used to analyse these new fields of experience, making it possible to imagine future interaction designs experimenting with our affective experience of interactive environments. The theoretical vocabulary is used to analyse the experiential field of the interactive installation City Voices in affective terms. City Voices actively engages people in the exploration of, and interaction with, the installation, altering the affective tonality of the cityscape. The interactive technologies deployed create conditions of emergence for a range of relational events. Building on this analysis the article proposes the Massumian vocabulary as a rich field of questioning for the future analysis and design of interactive environments.
Hypertonie und Bewegung
Fritsch G
Journal für Hypertonie , 2009,
Abstract: Die zeitgem e Behandlung der Hypertonie wird sowohl mit Guideline-konformer Pharmakotherapie als auch mit der Optimierung von Lebensstilfaktoren durchgeführt. Dazu geh ren die Reduktion des K rpergewichts und eine Verbesserung von Bewegungs- und Ern hrungsverhalten. Die Ver nderung von Lebensstilfaktoren folgt, so wie alle Ver nderungsprozesse, definiertem stadiengerechtem Vorgehen bei der nderung eingefahrener Verhaltensmuster. Neben den üblichen diagnostischen Verfahren untersuchen wir eine Reihe von lebensstilabh ngigen Parametern wie die k rperliche Leistungsf higkeit, den Body-Mass-Index, den K rperfettgehalt sowie Kraftniveau und Gleichgewichtsf higkeit. Daraus ergeben sich individuelle Trainings- und Ern hrungsempfehlungen. In der praktischen Umsetzung begleiten wir unsere Patienten mittels Trainingstagebuch per Internet.
Connecting Territorial Knowledge Arenas – the Interrelationship between CEMAT and EU Activities in Spatial Development Policy
Matti Fritsch
European Journal of Spatial Development , 2012,
Abstract: Against the background of the increasing importance of evidence, knowledge and learning in both domestic and transnational policy development processes, this paper analyses how non-EU and intra-European Union knowledge arenas in spatial development policy and planning are connected by focussing specifically on the interrelationship between CEMAT and European Union activities and arenas of co-operation. The Council of Europe Conference of Ministers Responsible for Spatial/Regional Planning (CEMAT) has long served as a platform for pan-European (including both EU members and non-members) co-operation in spatial development, but has recently been sidelined by EU initiatives in this field of activity and even faced the possibility of discontinuation. Analysing potential areas of competition and complementarities/synergies and reviewing the recent Russian CEMAT Presidency, the paper argues that CEMAT retains an important role in connecting EU debates, practices and research with actors outside the European Union. However, institutionalised collaborative mechanisms and the systematic exchange of information between CEMAT and the EU in this field should be strengthened, particularly in a direction from EU to CEMAT and in the domain of research and evidence. Continuing with a sub-optimal level of co-operation between CEMAT and the EU in this field or even discontinuation of CEMAT would undoubtedly hamper the involvement and integration of non-EU members in the debate on European spatial development policy and would probably rather quickly lead to the significant disruption of the territorial knowledge channel linking the EU and Russia as well as that with the EU neighbourhood more broadly, while also significantly inhibiting the processes of learning on a pan-European level and stalling the development of a trajectory towards the emergence of something that would resemble a pan-European ‘epistemic community’ in spatial development policy and planning.
From signal to signification in interactive environments
Jonas Fritsch
Journal of Aesthetics & Culture , 2012, DOI: 10.3402/jac.v4i0.18155
Abstract: There is no doubt that the shift to real-time interactive and electronic media can benefit from a renewed focus on the signal and a signaletic paradigm in addition to the sign. However, in this article I argue that we must be careful not to simply fall into the idea of one paradigm to simply replace the other. Rather, we should investigate what the fusion between paradigms allows us to say about digital and interactive technologies. This article attempts to do this through a thinking-together of signal and signification as well as affect and emotion based on the work of French philosopher of technology Gilbert Simondon. Through an analysis of the minimal media installation Touched Echo, I argue that it is necessary to account for the dynamics of a larger experiential continuum to uncover the affective–emotive relations that occur through the transindividual workings of the signal and signification in interactive environments.
Mouse models for breast cancer
Lothar Hennighausen
Breast Cancer Research , 1999, DOI: 10.1186/bcr20
Abstract: Experiments conducted by Philip Leder and coworkers 15 years ago represent a milestone in breast cancer research [2]. They fused the long terminal repeat (LTR) of the mouse mammary tumor virus (MMTV) to the human c-myc proto-oncogene and incorporated this hybrid gene into mice. These transgenic mice expressed the human myc protein in their mammary glands, which resulted in the development of breast tumors [2]. This landmark paper helped to establish an entirely new research arena poised to identify genetic pathways that control breast cancer. After decades of research on tissue culture cells, both federal and private funding agencies saw the opportunity to extend investigations into settings that more closely resembled the human condition. Fifteen years after the study by Leder and coworkers, research by Deng (a former student of Leder) and coworkers set another milestone towards this goal. These investigators succeeded in inactivating the breast cancer gene Brca1 specifically in mammary epithelial cells of mice, and they demonstrated that mammary tumors coincided with genome instability [3]. The distinct lesson learned from these studies was that the wrongful expression of an oncogene and the inactivation of a tumor suppressor gene in mice can cause cancer, just like in humans. However, the myc and Brca1 mice differ in two fundamental aspects from the human situation. In the myc mice oncogene activity occurs as early as puberty, whereas in humans genetic changes leading to cancer may occur later in life. The appearance of tumors in Brca1 conditional mice depends on the loss of both alleles, whereas in humans only one BRCA1 allele is altered (for discussion, see [4]).Understanding genetic pathways was considered to be, and still remains the prerequisite for the development of molecular and pharmacological agents to treat and prevent cancer. Over the past 15 years almost 100 mouse models have been generated that permit the investigation of defined aspects of tumorige
Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation
Lothar Bohm
Radiation Oncology , 2006, DOI: 10.1186/1748-717x-1-12
Abstract: The methylxanthine drug Pentoxifylline (TRENTAL, Sanofi-Aventis) is clinically well established for the treatment of cerebral ischemia and a variety of other vasoocclusive disorders such as intermittent claudication. [14,50]. Systemically the drug operates by enhancing the flexibility of blood cell membranes and reducing blood viscosity. The positive influence of Pentoxifylline on the microcirculation and peripheral oxygenation has led to applications in experimental radiotherapy showing small but consistent improvements of the radiotoxicity. Injection of PFX followed by irradiation 45 minutes later produces a 1.1–1.5 fold enhancement of tumour growth delay and this is associated with a marked reduction of tumour anoxia.[10,23,25-27,41,42,47,52].Apart from the systemic effects there is now a long list of published data indicating that Pentoxifylline (and the related drug caffeine) influences the radiobiological responses of tumour cells in an oxygen independent manner. Given to tumour cell cultures before irradiation at the subtoxic dose of 2 mM, Pentoxifylline effectively enhances radiotoxicity measured by clonogenic cell survival by factors of 1.2–2.0 [3,4,9,45-47].In the following I summarize our own [54] and other new in vitro data which explore the effects of this interesting drug on the damage responses of tumour cells. It is shown that Pentoxifylline emerges as an effective repair inhibitor and that this new mechanistic understanding shows great promise for application in tumour therapy.The determination of the drug toxicity enhancement factors for Melphalan, Daunorubicin and Cisplatin are based on chemosensitivity measurements using the crystal violet assay. G2/M block abrogation and measurment of cell survival under conditions of G2 block abrogation and drug addition involved control experiments measuring cell survival for irradiation alone, Pentoxifylline alone, Pentoxifylline plus irradiation, Pentoxifylline plus drug at 5 % toxicity and cytostatic drug a
E-Books – den Wandel professionell gestalten / E-books – managing the change professionally
Nunnenmacher, Lothar
GMS Medizin-Bibliothek-Information , 2010,
Abstract: Even acknowledging the considerable reservations of some users – we have to recognize the overall trend towards the use of e-books. The situation resembles the transition from print to electronic journals about ten years ago. Two trends are converging here: On the one hand, there is a strongly growing offer of scientific monographic literature in electronic format, and on the other hand, there has been significant progress in the technological possibilities for the reception of e-books, in particular regarding display technologies. The transition from print to electronic books provides a multiplicity of new challenges to the libraries, not least because of the overwhelming quantity of current and potential titles. For example, the ETH-Bibliothek has doubled the number of e-books in the catalogue in each year in the past few years. In 2008, for the first time more electronic than print monographs were purchased and catalogued. For the selection of e-books, the ETH-Bibliothek has defined extensive criteria. To include the individual titles of larger e-book packages into the catalogue, metadata were imported in a complex semi-automated procedure. There is only one catalogue record for printed and digital forms of the same title, so that users can immediately see, whether they can borrow the book in print form or access it directly online. A key feature for optimal benefits within the cataloguing network is the linking via a link resolver. For a stable compilation of the usage of electronic resources, the calculation of yearly usage on the basis of the median is described. Of course, many developments concerning the relatively new media type e-book are under way, and many questions are therefore still open. They range from acquisition models and the selection and processing of titles to possible restrictions on the use and the integration of freely available sources to the use of e-books in interlibrary loan and archiving.
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