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Search Results: 1 - 10 of 514 matches for " Lothar Bohm "
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Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation
Lothar Bohm
Radiation Oncology , 2006, DOI: 10.1186/1748-717x-1-12
Abstract: The methylxanthine drug Pentoxifylline (TRENTAL, Sanofi-Aventis) is clinically well established for the treatment of cerebral ischemia and a variety of other vasoocclusive disorders such as intermittent claudication. [14,50]. Systemically the drug operates by enhancing the flexibility of blood cell membranes and reducing blood viscosity. The positive influence of Pentoxifylline on the microcirculation and peripheral oxygenation has led to applications in experimental radiotherapy showing small but consistent improvements of the radiotoxicity. Injection of PFX followed by irradiation 45 minutes later produces a 1.1–1.5 fold enhancement of tumour growth delay and this is associated with a marked reduction of tumour anoxia.[10,23,25-27,41,42,47,52].Apart from the systemic effects there is now a long list of published data indicating that Pentoxifylline (and the related drug caffeine) influences the radiobiological responses of tumour cells in an oxygen independent manner. Given to tumour cell cultures before irradiation at the subtoxic dose of 2 mM, Pentoxifylline effectively enhances radiotoxicity measured by clonogenic cell survival by factors of 1.2–2.0 [3,4,9,45-47].In the following I summarize our own [54] and other new in vitro data which explore the effects of this interesting drug on the damage responses of tumour cells. It is shown that Pentoxifylline emerges as an effective repair inhibitor and that this new mechanistic understanding shows great promise for application in tumour therapy.The determination of the drug toxicity enhancement factors for Melphalan, Daunorubicin and Cisplatin are based on chemosensitivity measurements using the crystal violet assay. G2/M block abrogation and measurment of cell survival under conditions of G2 block abrogation and drug addition involved control experiments measuring cell survival for irradiation alone, Pentoxifylline alone, Pentoxifylline plus irradiation, Pentoxifylline plus drug at 5 % toxicity and cytostatic drug a
Claus von Holt (1925–2009)
Lothar Bohm
South African Journal of Science , 2010, DOI: 10.4102/sajs.v105i5/6.80
Abstract:
International astronomer Phil Charles meets the ire of the National Research Foundation
Lothar Bohm
South African Journal of Science , 2010, DOI: 10.4102/sajs.v106i3/4.168
Abstract:
Two-factor theory – at the intersection of health care management and patient satisfaction
Bohm J
ClinicoEconomics and Outcomes Research , 2012, DOI: http://dx.doi.org/10.2147/CEOR.S29347
Abstract: -factor theory – at the intersection of health care management and patient satisfaction Original Research (1339) Total Article Views Authors: Bohm J Published Date October 2012 Volume 2012:4 Pages 277 - 285 DOI: http://dx.doi.org/10.2147/CEOR.S29347 Received: 20 December 2011 Accepted: 28 February 2012 Published: 04 October 2012 Josef Bohm Health Services Administration, New York City College of Technology, City University of New York, Brooklyn, NY, USA Abstract: Using data obtained from the 2004 Joint Canadian/United States Survey of Health, an analytic model using principles derived from Herzberg’s motivational hygiene theory was developed for evaluating patient satisfaction with health care. The analysis sought to determine whether survey variables associated with consumer satisfaction act as Hertzberg factors and contribute to survey participants' self-reported levels of health care satisfaction. To validate the technique, data from the survey were analyzed using logistic regression methods and then compared with results obtained from the two-factor model. The findings indicate a high degree of correlation between the two methods. The two-factor analytical methodology offers advantages due to its ability to identify whether a factor assumes a motivational or hygienic role and assesses the influence of a factor within select populations. Its ease of use makes this methodology well suited for assessment of multidimensional variables.
Two-factor theory – at the intersection of health care management and patient satisfaction
Bohm J
ClinicoEconomics and Outcomes Research , 2012,
Abstract: Josef BohmHealth Services Administration, New York City College of Technology, City University of New York, Brooklyn, NY, USAAbstract: Using data obtained from the 2004 Joint Canadian/United States Survey of Health, an analytic model using principles derived from Herzberg’s motivational hygiene theory was developed for evaluating patient satisfaction with health care. The analysis sought to determine whether survey variables associated with consumer satisfaction act as Hertzberg factors and contribute to survey participants' self-reported levels of health care satisfaction. To validate the technique, data from the survey were analyzed using logistic regression methods and then compared with results obtained from the two-factor model. The findings indicate a high degree of correlation between the two methods. The two-factor analytical methodology offers advantages due to its ability to identify whether a factor assumes a motivational or hygienic role and assesses the influence of a factor within select populations. Its ease of use makes this methodology well suited for assessment of multidimensional variables.Keywords: two-factor theory, behavioral theory, sociology of health care, patient satisfaction
Irreversible Quantum Mechanics in the Neutral K-System
Arno Bohm
Physics , 1997, DOI: 10.1007/BF02768924
Abstract: The neutral Kaon system is used to test the quantum theory of resonance scattering and decay phenomena. The two dimensional Lee-Oehme-Yang theory with complex Hamiltonian is obtained by truncating the complex basis vector expansion of the exact theory in Rigged Hilbert space. This can be done for K_1 and K_2 as well as for K_S and K_L, depending upon whether one chooses the (self-adjoint, semi-bounded) Hamiltonian as commuting or non-commuting with CP. As an unexpected curiosity one can show that the exact theory (without truncation) predicts long-time 2 pion decays of the neutral Kaon system even if the Hamiltonian conserves CP.
Time Asymmetric Quantum Physics
A. Bohm
Physics , 1999, DOI: 10.1103/PhysRevA.60.861
Abstract: Mathematical and phenomenological arguments in favor of asymmetric time evolution of micro-physical states are presented.
Mouse models for breast cancer
Lothar Hennighausen
Breast Cancer Research , 1999, DOI: 10.1186/bcr20
Abstract: Experiments conducted by Philip Leder and coworkers 15 years ago represent a milestone in breast cancer research [2]. They fused the long terminal repeat (LTR) of the mouse mammary tumor virus (MMTV) to the human c-myc proto-oncogene and incorporated this hybrid gene into mice. These transgenic mice expressed the human myc protein in their mammary glands, which resulted in the development of breast tumors [2]. This landmark paper helped to establish an entirely new research arena poised to identify genetic pathways that control breast cancer. After decades of research on tissue culture cells, both federal and private funding agencies saw the opportunity to extend investigations into settings that more closely resembled the human condition. Fifteen years after the study by Leder and coworkers, research by Deng (a former student of Leder) and coworkers set another milestone towards this goal. These investigators succeeded in inactivating the breast cancer gene Brca1 specifically in mammary epithelial cells of mice, and they demonstrated that mammary tumors coincided with genome instability [3]. The distinct lesson learned from these studies was that the wrongful expression of an oncogene and the inactivation of a tumor suppressor gene in mice can cause cancer, just like in humans. However, the myc and Brca1 mice differ in two fundamental aspects from the human situation. In the myc mice oncogene activity occurs as early as puberty, whereas in humans genetic changes leading to cancer may occur later in life. The appearance of tumors in Brca1 conditional mice depends on the loss of both alleles, whereas in humans only one BRCA1 allele is altered (for discussion, see [4]).Understanding genetic pathways was considered to be, and still remains the prerequisite for the development of molecular and pharmacological agents to treat and prevent cancer. Over the past 15 years almost 100 mouse models have been generated that permit the investigation of defined aspects of tumorige
E-Books – den Wandel professionell gestalten / E-books – managing the change professionally
Nunnenmacher, Lothar
GMS Medizin-Bibliothek-Information , 2010,
Abstract: Even acknowledging the considerable reservations of some users – we have to recognize the overall trend towards the use of e-books. The situation resembles the transition from print to electronic journals about ten years ago. Two trends are converging here: On the one hand, there is a strongly growing offer of scientific monographic literature in electronic format, and on the other hand, there has been significant progress in the technological possibilities for the reception of e-books, in particular regarding display technologies. The transition from print to electronic books provides a multiplicity of new challenges to the libraries, not least because of the overwhelming quantity of current and potential titles. For example, the ETH-Bibliothek has doubled the number of e-books in the catalogue in each year in the past few years. In 2008, for the first time more electronic than print monographs were purchased and catalogued. For the selection of e-books, the ETH-Bibliothek has defined extensive criteria. To include the individual titles of larger e-book packages into the catalogue, metadata were imported in a complex semi-automated procedure. There is only one catalogue record for printed and digital forms of the same title, so that users can immediately see, whether they can borrow the book in print form or access it directly online. A key feature for optimal benefits within the cataloguing network is the linking via a link resolver. For a stable compilation of the usage of electronic resources, the calculation of yearly usage on the basis of the median is described. Of course, many developments concerning the relatively new media type e-book are under way, and many questions are therefore still open. They range from acquisition models and the selection and processing of titles to possible restrictions on the use and the integration of freely available sources to the use of e-books in interlibrary loan and archiving.
Von der Bibliothek zum Lernzentrum - Ver nderungen in der Medizinischen Bibliothek der Charité
Nunnenmacher, Lothar
GMS Medizin-Bibliothek-Information , 2005,
Abstract: Nowadays it has become quite natural for the doctors and scientists of the Charité to use the services of the Medical Library at their desktops. Therefore the library as a physical location can be adopted to better suit the needs of the students. This means, first of all, more space for the textbook and reference collections as well as more seats for reading and learning. However, learning media will also develop towards digital forms in the coming years. Beyond the supply of media the challenge for the library will therefore increasingly consist in offering environments and services for the different forms of learning.
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