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Search Results: 1 - 10 of 370 matches for " Lotfipour Farzaneh "
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Evaluation of the effect of CaCl2 and alginate concentrations and hardening time on the characteristics of Lactobacillus acidophilus loaded alginate beads using response surface analysis
Farzaneh Lotfipour,Shahla Mirzaeei,Maryam Maghsoodi
Advanced Pharmaceutical Bulletin , 2012,
Abstract: Purpose: This article describes preparation and characterization of beads of alginate containing probiotic bacteria of Lactobacillus acidophilus DMSZ20079. Methods: Fourteen formulations using different alginate (ALG) and CaCl2 concentrations as well as hardening times were prepared using extrusion technique. The prepared beads were characterized in terms of size, morphology, encapsulation efficiency and bacterial viabilities in acid (pH 1.8, 2 hours) condition. Results: The results showed that spherical beads with narrow size distribution ranging from 1.32±0.04 to 1.70±0.07 mm were achieved with encapsulation efficiency higher than 98%. Surface response analysis revealed that alginate concentration was the important factor for the size, shape and encapsulation efficiency of prepared beads. Furthermore, survived bacteria after acid exposure in all prepared beads (63-83%) were significantly higher than those of untreated cells (39%) and enhanced by increasing alginate concentration. Surface response analysis revealed that the effect of all three factors of alginate and CaCl2 concentrations as well as hardening times were significant in acid viability, however alginate concentration played the most important role according to its regression coefficient. Conclusion: Among alginate and CaCl2 concentrations as well as hardening times, alginate concentration was the most variable in the characteristics of Alginate beads.
Effect of Taurine on the antimicrobial efficiency of Gentamicin
Islambulchilar Mina,Sattari Mohammad Reza,Sardashti Mohammad,Lotfipour Farzaneh
Advanced Pharmaceutical Bulletin , 2011,
Abstract: Context: Gentamicin is mainly used in severe infections caused by gram-negatives. However toxicity including nephrotoxicity and ototoxicity is one of the most important complications of its treatment. The production of free radicals seems to be involved in gentamicin toxicity mechanism. Taurine, a major intracellular free β-amino acid, is known to be an endogenous antioxidant. So potentially the co-therapy of taurine and gentamicin would reduce the adverse effects of the antibiotic. Objectives: In this study, we wished to know the effect of taurine on the antibiotic capacity of gentamicin. methods: strains of P. aeruginosa, E. coli, S. aureus and S. epidermidis were used as test organisms. Minimum inhibitory concentrations of gentamicin in the presence and absence of taurine at quantities from 40 to 2 mg/L were determined using macro-dilution method. Results: MICs were determined in the various concentrations of taurine for bacterial indicators. The MIC values of gentamicin for P. aeruginosa, S. aureus and E. coli remained unchanged in the values of 2.5, 5 and 20 μg/ml respectively in the absence and presences of different concentrations of taurine. The bactericidal activity of gentamicin against S. epidermidis was increased by addition of taurine in the concentrations higher than 6 mg/L. Conclusion: According to our study the antibacterial activity of gentamicin against the indicator microorganisms were not interfere with taurine at selected concentrations. Further in vivo studies are needed to establish if a combination of gentamicin and taurine would have the same effect.
Determination of comparative minimum inhibitory concentration (MIC) of bacteriocins produced by enterococci for selected isolates of multi-antibiotic resistant Enterococcus spp.
Maryam Hassan,Yousef Javadzadeh,Farzaneh Lotfipour,Rajabali Badomchi
Advanced Pharmaceutical Bulletin , 2011,
Abstract: Introduction: The occurrence of multi-antibiotic resistance among enterococci is a prevalent clinical problem worldwide and continues to get serious due to the lack of efficient therapeutic options by the time. In this regards, prokaryotic antimicrobial peptides with bactericidal or bacteriostatic activity which are directed against bacterial strains closely related to producer strains looks one of the promising alternative to conventional antibiotics. Methods: The antibiotic susceptibility pattern of 20 clinical isolates of enterococci was evaluated and subsequently the isolates were screened for antibacterial activity against three different indicator strains. The efficacy of potential bacteriocinogenic isolates were assayed against multi-antibiotic resistant Enterococcus spp. by comparative minimum inhibitory concentration (MIC). Results: Antibiotic resistant pattern of enterococcal isolates demonstrated that multi-antibiotic resistant to conventional antibiotics were significantly high and the prevalent pattern of resistance was combination of gentamicin, streptomycin, chloramphenicol and vancomycin. In addition, the data from comparative MIC showed the noticeable activity of selected potential bacteriocinogenic strains against pathogenic enterococci. Conclusion: The present survey may address the potential applicability of antimicrobial peptides in alleviating the problems of antibiotic resistance.
Anti-bacterial performance of azithromycin nanoparticles as colloidal drug delivery system against different gram-negative and gram-positive bacteria
Morteza Azhdarzadeh,Farzaneh Lotfipour,Parvin Zakeri-Milani,Ghobad Mohammadi
Advanced Pharmaceutical Bulletin , 2012,
Abstract: Purpose: Azithromycin (AZI) is a new macrolide antibiotic with a better activity against intracellular gram negative bacteria in comparison with Erythromycin. The purpose of this research was to prepare AZI nanoparticles (NPs) using PLGA polymer and to compare the effectiveness of prepared nanoparticles with untreated AZI solution. Methods: AZI NPs were prepared by Modified Quasi-Emulsion Solvent Diffusion method. The antibacterial activities of prepared NPs in comparison with AZI solution were assayed against indicator bacteria of Escherichia coli (PTCC 1330), Haemophilus influenzae (PTCC 1623) and Streptococcus pneumoniae (PTCC 1240) using agar well diffusion. Inhibition zone diameters (IZD) of nano-formulation were compared to the corresponding untreated AZI. Mean Inhibitory Concentration (MIC) values of AZI were also determined using serial dilution method in nutrient broth medium. Results: Mean IZD of nano-formulations for all indicator bacteria were significantly higher than that of untreated AZI (P<0.01). The enhanced antibacterial efficacy was more dominant in the gram positive species. The MIC values of NPs against the tested bacteria were reduced 8 times in comparison to those of untreated AZI. Conclusion: These results indicated an improved potency of AZI NPs which could be attributed to the modified surface characteristics as well as increased drug adsorption and uptake.
Antioxidant and Antimicrobial activity of Pedicularis sibthorpii Boiss. And Pedicularis wilhelmsiana Fisch ex.
Laleh khodaie,Abbas Delazar,Farzaneh Lotfipour,Hossein Nazemiyeh
Advanced Pharmaceutical Bulletin , 2012,
Abstract: Purpose: This research paper presents antioxidant and antimicrobial activities of Pedicularis sibthorpii and Pedicularis wilhelmsiana which grow in Azerbaijan/Iran with claimed a lot of therapeutic effects. Methods: DPPH assay and agar well diffusion method were carried out to determine antioxidant and antimicrobial activities respectively. Results: Methanolic extract showed better antioxidant activity compared to other crude extracts (n-hexane and dichloromethane). Methanolic extracts of both Pedicularis sibthorpii and Pedicularis wilhelmsiana were found to have antibacterial activity especially against gram positive strains of S. ureus, S.epidermidis. No antifungal activity was observed in the tested extracts. Conclusion: Existence of some phenolic compounds in methanolic extracts, such as phenylethanoids and flavonoids (found in other species of Pedicularis), which cause both antioxidant and antibacterial activities, is probable. Antimicrobial and antioxidant activity of the methanolic extracts supports further studies related to phytochemical investigation and bioassay of different fractions to isolate pure compounds of plants.
The California Budget Crisis and How It Is Affecting The Emergency Care Funds
Lotfipour, Shahram
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2002,
Abstract:
Legislative Update: Is There a "Perfect Storm" in the California Horizon?
Lotfipour, Shahram
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2003,
Abstract:
The Dilemma of Increasing Media Scrutiny on Older-Adult Driving Fitness
Grotsky, Thomas,Lotfipour, Shahram
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2006,
Abstract: As several highly publicized traffic collisions occurred in 2003 and 2004, the nation began to give more attention to the issue of older drivers. After several older-driver collisions, California, Minnesota, Wisconsin, and Massachusetts examined their license renewal and driver testing policies for both the young and old. We describe these major traffic incidents and discuss their impact on the political, medical, and social forums.
Advantages of a Three-Year Residency
Langdorf, Mark,Lotfipour, Shahram
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2004,
Abstract:
Facile Synthesis and Characterization of Nanoporous NiO with Folic Acid as Photodegredation Catalyst for Congo Red  [PDF]
Faezeh Farzaneh, Sara Haghshenas
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.310102
Abstract: In this study nanoporous NiO was prepared using Ni(CH3COO)2,4H2O, folic acid and water as starting material, template and solvent respectively, by sol gel method followed by calcination at 400℃. The solid product was characterized by X-ray diffraction (XRD), nitrogen adsorption-desorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM) Fourier transform infrared (FT-IR) and photoluminescence (PL) techniques. The particle size of the nanoparticles estimated by XRD was in good agreement with the particle size obtained by TEM analysis (4-5nm). It was also found that the prepared nanoporous NiO show very good activity for photodegredation of dye organic pollutants such as Congo red (91%) during 1.5 hours.
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