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Search Results: 1 - 10 of 197460 matches for " Lori D Wilson "
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Higher IL-6 and IL6:IGF Ratio in Patients with Barth Syndrome
Lori D Wilson, Sadeeka Al-Majid, Cyril Rakovsky, Christina D Schwindt
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-25
Abstract: Plasma from 36 subjects, 22 patients with Barth Syndrome (0.5 - 24?yrs) and 14 healthy control males (8 - 21?yrs) was analyzed for two growth factors: IGF-1 (bound and free) and Growth Hormone (GH); and two inflammatory cytokines IL-6 and TNF-α using high-sensitivity enzyme-linked immunosorbent assays.The average IL-6 and IL6:IGF ratio levels were significantly higher in the BTHS (p?=?0.046 and 0.02 respectively). As for GH, there was a significant group by age interaction (p?=?0.01), such that GH was lower for BTHS patients under the age of 14.4?years and higher than controls after age 14.4?years. TNF-α levels were not significantly different, however, the TNF-α:GH was lower in BTHS patients than controls (p?=?0.01).Comparison of two anabolic growth mediators, IGF and GH, and two catabolic cytokines, IL-6 and TNF-α, in BTHS patients and healthy age-matched controls demonstrated a potential imbalance in inflammatory cytokines and anabolic growth factors. Higher rates of IL-6 (all ages) and lower GH levels were observed in BTHS patients (under age 14.5) compared to controls. These findings may implicate inflammatory processes in the catabolic nature of Barth Syndrome pathology as well as provide a link to mitochondrial function. Furthermore, interactions between growth factors, testosterone and inflammatory mediators may explain some of the variability in cardiac and skeletal myopathies seen in Barth Syndrome.
Probing the Cell Cycle with Flow Cytometry  [PDF]
George D. Wilson
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.79069
Abstract: Flow cytometry is a versatile technique to study different aspects of the cell cycle from subpopulations of cells to detailed cell kinetic information. In this paper a basic review of cell kinetic parameters is presented followed by detailed descriptions of the different flow cytometric methodologies that can be used to extract pertinent information for a particular study. The methodologies range from simple DNA profile analysis, the use of bromodeoxyuridine to cell cycle-associated proteins such as the cyclins.
Cationic Amino Acid Transporter 2 Enhances Innate Immunity during Helicobacter pylori Infection
Daniel P. Barry, Mohammad Asim, Brooks P. Scull, M. Blanca Piazuelo, Thibaut de Sablet, Nuruddeen D. Lewis, Lori A. Coburn, Kshipra Singh, Lesley G. Ellies, Alain P. Gobert, Rupesh Chaturvedi, Keith T. Wilson
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0029046
Abstract: Once acquired, Helicobacter pylori infection is lifelong due to an inadequate innate and adaptive immune response. Our previous studies indicate that interactions among the various pathways of arginine metabolism in the host are critical determinants of outcomes following infection. Cationic amino acid transporter 2 (CAT2) is essential for transport of l-arginine (L-Arg) into monocytic immune cells during H. pylori infection. Once within the cell, this amino acid is utilized by opposing pathways that lead to elaboration of either bactericidal nitric oxide (NO) produced from inducible NO synthase (iNOS), or hydrogen peroxide, which causes macrophage apoptosis, via arginase and the polyamine pathway. Because of its central role in controlling L-Arg availability in macrophages, we investigated the importance of CAT2 in vivo during H. pylori infection. CAT2?/? mice infected for 4 months exhibited decreased gastritis and increased levels of colonization compared to wild type mice. We observed suppression of gastric macrophage levels, macrophage expression of iNOS, dendritic cell activation, and expression of granulocyte-colony stimulating factor in CAT2?/? mice suggesting that CAT2 is involved in enhancing the innate immune response. In addition, cytokine expression in CAT2?/? mice was altered from an antimicrobial Th1 response to a Th2 response, indicating that the transporter has downstream effects on adaptive immunity as well. These findings demonstrate that CAT2 is an important regulator of the immune response during H. pylori infection.
Symptom Distress Associated with Biopsy in Women with Suspect Breast Lesions
Jayesh Kamath,Dean G. Cruess,Kevin Claffey,Lori Wilson
ISRN Oncology , 2012, DOI: 10.5402/2012/898327
Structural Study of Cellulose-Iron Oxide Composite Materials  [PDF]
Dexu Kong, Lee D. Wilson
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.64009
There are limited structural studies of iron oxide coated cellulose materials despite their use as adsorbents for the removal of waterborne arsenic species. This study reports on the structural characterization of cellulose-iron oxide composites at variable iron oxide content using spectroscopy methods (Raman, solids 13C NMR, powder X-ray diffraction (pXRD)) and thermal gravi-metric analysis (TGA). Iron oxide was supported onto cellulose (ca. 25 wt.%) without significant loss in the Fe coating efficiency, where the accessibility of the biopolymer -OH groups affect the coating efficiency and yield of the iron oxide-cellulose composite. Isotherm adsorption studies for cellulose, iron oxide species and the cellulose composite materials with roxarsone (3-nitro- 4-hydroxyphenylarsonic acid) were studied to characterize the surface chemical properties of these potential adsorbent materials.
Diagnosing HIV-associated tuberculosis
D Wilson
Southern African Journal of HIV Medicine , 2005,
Abstract: The world has made defeating AIDS a top priority. This is a blessing. But TB remains ignored. Today we are calling on the world to recognise that we can't fight AIDS unless we do much more to fight TB as well.' Nelson Mandela: Media briefing on ‘Confronting the Joint HIV-TB Epidemics', co-convened by the Bill & Melinda Gates Foundation, Thursday 15 July 2004. Southern African Journal of HIV Medicine Vol. 6 (2) 2005: pp. 23-26
Plant Community Development in a Dryland CREP in Northeastern Oregon  [PDF]
John D. Williams, Heidi M. Hartman, Lori M. Spencer, James O. Loiland
American Journal of Plant Sciences (AJPS) , 2011, DOI: 10.4236/ajps.2011.26089
Abstract: Riparian areas in dryland crop regions of the Intermountain Pacific Northwest have largely been converted to cropland or pasture during the last 140 years. Some formerly cultivated floodplains have become difficult to farm; enrollment of these lands into conservation programs provides the opportunity to use them as wildlife habitat and as buffer areas near streams. Our objective was to evaluate plant community development on an USDA Conservation Reserve Enhan- cement Program site in northeastern Oregon from when the plant was planted in 1999 through 2008. The research was designed as a descriptive study. We established permanent line-transects to quantify vegetation establishment and changes in species composition through time. We collected data in 2000-2001 and 2007-2008. Vegetation cover in 2000-2001 was 100%, dominated by tall wheatgrass. Living plant material cover decreased from 98% in 2000-2001 to 33% in 2007 and 68% in 2008; dead plant residue significantly increased and tall wheatgrass cover decreased. Native species were present in similar percentages from 2000 to 2008, although there was a shift from target to nontarget species. The 1999 seeding can be judged a success because of the ground cover provided and the establishment of one target species, tall wheatgrass. However, the increased ratio of dead to living plant material and shift to non-target annual weed species suggests that more active management (i.e., fire, grazing, or mowing) of the tall wheatgrass stand is needed to maintain its productivity and/or a healthy mix of multiple species.
Association between change in HDL-C and vascular events in patients treated with statins: Report from the UK general practice research database  [PDF]
Lori D. Bash, Tun-Ying Hsu, Vasilisa Sazonov, Baishali Ambegaonkar
World Journal of Cardiovascular Diseases (WJCD) , 2012, DOI: 10.4236/wjcd.2012.22011
Abstract: Dyslipidemia, including low levels of high-density lipoprotein cholesterol (HDL-C), is a relatively well-established risk factor for cardiovascular disease. However, the independent association between changes in HDL-C and the subsequent risk of cardiovascular events has not been well studied. The retrospective cohort analysis was conducted to evaluate the association between changes in HDL-C and cardiovascular (CV) and/or cerebrovascular (CB) events among statin-treated patients. Patient demo-graphics, clinical characteristics, laboratory data, and CV/CB events, were collected from the UK General Practice Research Database. The association between the risk of an incident event and changes in patients’ HDL-C was estimated using multivariate Cox pro-portional hazards models. Among 17,923 statin-treated patients with an average follow-up of 1.9 years, there were 815 CV events and 220 CB events. The average change in HDL-C experienced was 0.4 mg/dL, ranging from 11 mg/dL average decrease in the lowest change quartile to 12 mg/dL average increase in the highest change quartile. CV events occurred at an average overall rate of 21 per 1000 person-years and 17 per 1000 person-years among individuals in the highest quartile of change in HDL-C levels. Fully adjusted Cox regression estimated a 6% decrease in hazards (HR, 0.94; 95% CI, 0.90, 0.98) of a subsequent CV event associated with each 5 mg/dL increase in HDL-C. Similar results (HR: 0.95, 95% CI, 0.92, 0.98) were observed when assessing the association with changes in HDL-C and the composite outcome of CV/CB event. Among statin-treated patients from UK clinical practices, increases in HDL-C were associated with a significantly decreased relative risk of experiencing CV/CB events with a more pronounced effect on CV events. Therefore, a more aggressive treatment to increase HDL-C could benefit patients by reducing the risk of CV/CB events.
A Framework for Content Area Writing: Mediators and Moderators
Perry D. Klein,Lori C. Kirkpatrick
Journal of Writing Research , 2010,
Abstract: Writing can be a tool for communicating and learning in content area subjects. This pretest-posttest quasi-experiment examined the effects of instruction in a content area writing framework on students’ text quality and ability to use writing to learn. It also examined the effects of possible moderator variables (gender, previous writing achievement) and mediator variables (genre knowledge, approach to writing). A multilevel analysis was conducted with students nested within classes. Instruction significantly increased argument genre knowledge and explanation text quality, but not argument text quality, explanation genre knowledge, or learning during writing. Gender predicted previous writing achievement and posttest argument text quality, but did not interact significantly with instruction. Previous writing achievement strongly affected several posttest measures, but did not interact significantly with instruction. A path analysis supported the theory that instruction affects genre knowledge, which affects text quality, which predicts learning during writing.
Increasing Employees’ Fruit Consumption through Access and Peer Support at Work  [PDF]
Amanda D. Hutchinson, Georgina Howlett, Carlene Wilson
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.410A013

Objective: To assess the effect of providing free fruit and peer support in the workplace, on employees’ consumption of fruits and high fat snacks at work and home. Methods: Three worksites, including 75 employees, were randomly assigned to a free fruit condition (Group A), a free fruit and peer education and modelling condition (Group B), and a control group (Group C). Groups A and B had free fruit delivered to their workplace each morning for four weeks. Consumption of fruit and high fat snacks was measured pre- and post-intervention, and after a two week maintenance period. Results: Despite a small sample, the intervention increased employees’ fruit intake at work, decreased high fat snacks and was more successful in those who were not currently meeting the recommendations of two pieces of fruit per day. Peer support led to increased fruit consumption at work and sustained decreases in unhealthy snacks post-intervention. Conclusions: The provision of fruit in the workplace with peer support is a simple and effective method for improving fruit consumption at work in the short-term, particularly in those not meeting current recommendations. In addition, those participating in the intervention reduced their consumption of high fat snacks. Further research is necessary to determine whether a longer larger scale intervention can sustain dietary changes and thereby reduce risk for chronic disease in the Australian population.

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