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Search Results: 1 - 10 of 316531 matches for " Lombroso Paul J. "
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The current "next step" in neuropsychiatric disorders studies
Lombroso Paul J.,Mercadante Marcos T.
Revista Brasileira de Psiquiatria , 2002,
Abstract:
The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition
Christopher James Fitzpatrick,Paul J. Lombroso
Frontiers in Neuroanatomy , 2011, DOI: 10.3389/fnana.2011.00047
Abstract: Striatal-enriched protein tyrosine phosphatase (STEP) has recently been implicated in several neuropsychiatric disorders with significant cognitive impairments, including Alzheimer’s disease, schizophrenia, and fragile X syndrome. A model has emerged by which STEP normally opposes the development of synaptic strengthening and that disruption in STEP activity leads to aberrant synaptic function. We review the mechanisms by which STEP contributes to the etiology of these and other neuropsychiatric disorders. These findings suggest that disruptions in STEP activity may be a common mechanism for cognitive impairments in diverse illnesses.
Aprendizado e memória
Lombroso, Paul;
Revista Brasileira de Psiquiatria , 2004, DOI: 10.1590/S1516-44462004000300011
Abstract: memory is broadly divided into declarative and nondeclarative forms of memory. the hippocampus is required for the formation of declarative memories, while a number of other brain regions including the striatum, amygdala and nucleus accumbens are involved in the formation of nondeclarative memories. the formation of all memories require morphological changes of synapses: new ones must be formed or old ones strengthened. these changes are thought to reflect the underlying cellular basis for persistent memories. considerable advances have occurred over the last decade in our understanding of the molecular bases of how these memories are formed. a key regulator of synaptic plasticity is a signaling pathway that includes the mitogen activated protein (map) kinase. as this pathway is required for normal memory and learning, it is not surprising that mutations in members of this pathway lead to disruptions in learning. neurofibromatosis, coffin-lowry syndrome and rubinstein-taybi syndrome are three examples of developmental disorders that have mutations in key components of the map kinase signaling pathway.
Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Jian Xu,Manavi Chatterjee,Tyler D. Baguley,Jonathan Brouillette,Pradeep Kurup,Debolina Ghosh,Jean Kanyo,Yang Zhang,Kathleen Seyb,Chimezie Ononenyi,Ethan Foscue,George M. Anderson,Jodi Gresack,Gregory D. Cuny,Marcie A. Glicksman,Paul Greengard,TuKiet T. Lam,Lutz Tautz,Angus C. Nairn,Jonathan A. Ellman,Paul J. Lombroso
PLOS Biology , 2014, DOI: 10.1371/journal.pbio.1001923
Abstract: STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepr?opionicacid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in several neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease (AD). The increase in STEP activity likely disrupts synaptic function and contributes to the cognitive deficits in AD. AD mice lacking STEP have restored levels of glutamate receptors on synaptosomal membranes and improved cognitive function, results that suggest STEP as a novel therapeutic target for AD. Here we describe the first large-scale effort to identify and characterize small-molecule STEP inhibitors. We identified the benzopentathiepin 8-(trifluoromethyl)-1,2,3,4,5-benzopenta?thiepin-6-aminehydrochloride (known as TC-2153) as an inhibitor of STEP with an IC50 of 24.6 nM. TC-2153 represents a novel class of PTP inhibitors based upon a cyclic polysulfide pharmacophore that forms a reversible covalent bond with the catalytic cysteine in STEP. In cell-based secondary assays, TC-2153 increased tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibited no toxicity in cortical cultures. Validation and specificity experiments performed in wild-type (WT) and STEP knockout (KO) cortical cells and in vivo in WT and STEP KO mice suggest specificity of inhibitors towards STEP compared to highly homologous tyrosine phosphatases. Furthermore, TC-2153 improved cognitive function in several cognitive tasks in 6- and 12-mo-old triple transgenic AD (3xTg-AD) mice, with no change in beta amyloid and phospho-tau levels.
Adjustment of College Freshmen as Predicted by Both Perceived Parenting Style and the Five Factor Model of Personality—Personality and Adjustment  [PDF]
Jennifer Schnuck, Paul J. Handal
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24044
Abstract: The adjustment that freshmen make to college is important, and is related to student retention. The present study explored the relationships among freshmen students’ personality traits, their perceptions of the parenting styles employed by their mothers and fathers, their positive and negative adjustment, and their adaptation to college. Freshmen participants (74 men, 116 women) were from a Midwestern, religiously affiliated university. Results revealed that the relationships between parenting styles and adjustment to college, although statistically significant, were quite weak. In contrast, analyses revealed that strong relationships exist between personality traits and the adjustment that freshmen students make to college. These relationships were found to be different with regard to gender. The results have important implications for the adjustment that freshmen students make to college.
Continuous photometric observations at ENEA base in Lampedusa to estimate precipitable water
R. Santangelo,S. Pugnaghi,S. Corradini,L. Lombroso
Annals of Geophysics , 2003, DOI: 10.4401/ag-3413
Abstract: Water vapour is a variable component of the atmosphere both in space and time. It is one of the most important components because of its effects in many fi elds: Meteorology, Climatology, Remote Sensing, Energy-Budget, Hydrology, etc. This work compares radiometric (sun photometer) readings, Global Positioning System (GPS) data and a meteorological model forecasted data. The aim is to understand if GPS measurements may help Numerical Weather Prediction (NWP) models. It is well known that GPS measurements are affected by the so-called tropospheric delay. Part of it, the so-called wet delay is related mainly to the amount of water vapour along the path of the GPS signal through the troposphere. Precise knowledge of the abundance of water vapour, in space and time, is important for NWP model because water vapour is the predecessor of precipitation. Despite the high variability of water vapour compared to other meteorological fi elds, like pressure and wind, water vapour observations are scarce, so that additional measurements of water vapour are expected to benefi t meteorology. A new sun photometer, which is part of the AERONET (AErosol and RObotic NETwork) program, has been installed at the ENEA (Ente per le Nuove tecnologie, l'Energia e l'Ambiente) base of Lampedusa Island. The sun photometer is quite close (less then 4 km) to an ASI (Agenzia Spaziale Italiana) GPS permanent receiver. A long record (summer period of the year 2000) of sun photometric measurements is available for the station at Lampedusa. We found that the GPS and sun photometric data are better correlated (std. dev. about 10 mm for the wet delay) than are the GPS measurements with the NWP model predictions. This is an indication that GPS delay data may contain information useful for weather prediction.
GPS Zenith Total Delays and Precipitable Water in comparison with special meteorological observations in Verona (Italy)during MAP-SOP
M. Boccolari,S. Fazlagic,P. Frontero,L. Lombroso
Annals of Geophysics , 2002, DOI: 10.4401/ag-3534
Abstract: Continuous meteorological examination of the Pre-Alpine zones in Northern Italy (Po Valley)is important for determination of atmospheric water cycles connected with floods and rainfalls.During a special meteorological observing period (MAP-SOP),radiosounding and other measurements were made in the site of Verona (Italy). This paper deals with Zenith Total Delay (ZTD)and Precipitable Water (PW)comparisons obtained by GPS, radiosounding and other meteorological measurements.PW and ZTD from ground-based GPS data in comparisonwith classical techniques (e.g.,WVR,radiosounding)from recent literature present an accurate tool for use in meteorology applications (e.g.,assimilation in Numerical Weather Prediction (NWP)models on short-range precipitation forecasts).Comparison of such ZTD for MAP-SOP showed a standard deviation of 16.1 mm and PW comparison showed a standard deviation of 2.7 mm,confirming the accuracy of GPS measurements for meteorology applications.In addition,PW data and its time variation are also matched with time series of meteorological situations.Those results indicate that changes in PW values could be connected to changes in air masses,i.e.to passages of both cold and warm fronts.There is also a correlation between precipitation, forthcoming increase and the following decrease of PW.A good agreement between oscillation of PW and precipitation and strong cyclonic activities is found.
Practicing What We Preach: How Are Admissions Decisions Made for Clinical Psychology Graduate Programs, and What Do Students Need to Know?  [PDF]
Travis J. Pashak, Paul J. Handal, Megan Ubinger
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.31001
Abstract: As the application process to Clinical Psychology graduate programs becomes increasingly competitive, applicants and advisors have a need to know what to expect. The aim of this article is to provide a brief overview of the application process, an examination of characteristics of admission committees’ criteria and selection policies, and an analysis of differences among and between programs of different types. Programs offering doctoral degrees in clinical psychology (n = 59) were surveyed regarding their admissions procedures and criteria, and the results are discussed in light of what impacts applicants. Findings suggest that policies and procedures are mixed, that important differences exist between Ph.D. programs and Psy.D. programs, and that programs generally follow an assessment model in their selection decisions.
Early Onset Post-Radiation Cutaneous Angiosarcoma of the Breast with Features of Atypical-Vascular Lesion: A Diagnostic Pitfall and Its Biologic Significance  [PDF]
John B. Wojcik, Brian J. Czerniecki, Paul J. Zhang
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.46041
Abstract:
Vascular proliferations may arise in the breast following radiation treatment for a primary breast adenocarcinoma. A post-radiation vascular proliferation can usually be classified as angiosarcoma or as an atypical vascular lesion (AVL). Angiosarcomas with a “low-grade” morphology, behave aggressively but exhibit substantial histomorphologic overlap with AVLs, which have a generally benign clinical course. We present a case of a post-radiation angiosarcoma of the breast with histologic features that mimic an atypical vascular lesion and discuss this challenging differential diagnosis. In addition to histologic mimicry, the lesion exhibited only patchy amplification of the avian myelocytomatosis viral oncogene homolog (MYC) gene by present fluorescence in-situ hybridization (FISH), and patchy MYC overexpression by immunohistochemistry. These features further complicate the distinction between AVL and angiosarcoma, and would be particularly problematic on a small biopsy. We believe that the morphologic and immunohistochemical overlap between these entities is suggestive of a biologic spectrum, and thus that, at least in some instances, angiosarcoma may arise from a pre-existing AVL or AVL-like lesion.
System-on-Chip Test Data Compression Based on Split-Data Variable Length (SDV) Code  [PDF]
J. Robert Theivadas, V. Ranganathan, J. Raja Paul Perinbam
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.78105
Abstract: System-on-a-chips with intellectual property cores need a large volume of data for testing. The large volume of test data requires a large testing time and test data memory. Therefore new techniques are needed to optimize the test data volume, decrease the testing time, and conquer the ATE memory limitation for SOC designs. This paper presents a new compression method of testing for intellectual property core-based system-on-chip. The proposed method is based on new split- data variable length (SDV) codes that are designed using the split-options along with identification bits in a string of test data. This paper analyses the reduction of test data volume, testing time, run time, size of memory required in ATE and improvement of compression ratio. Experimental results for ISCAS 85 and ISCAS 89 Benchmark circuits show that SDV codes outperform other compression methods with the best compression ratio for test data compression. The decompression architecture for SDV codes is also presented for decoding the implementations of compressed bits. The proposed scheme shows that SDV codes are accessible to any of the variations in the input test data stream.
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