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Search Results: 1 - 10 of 81023 matches for " Lizhi Liu "
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Engineering Antibody Fragment with the Quantum Dot in Cancer Cell Imaging and Diagnosis  [PDF]
Lizhi Liu, Weiming Xu
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.410B033
Abstract:
The conjugates of monoclonal antibodies and nanoparticles, including quantum-dot(QD), offer significant advantages over conventional fluorescent probes to image and study biological processes. The extend stability, intense fluorescence and low toxicity of QDs are well suited for biological applications. In the present study, we used QD-conjugated anti-glucose-regulated protein 78(GRP78) antibody to examine the gene expression in prostate cancer cells under the unfolded protein response (UPR). QDs have got unique, simple and fast properties over current diagnostic techniques such as peroxidase-based immunohistochemical staining procedures, therefore the nanocarrier-conjugated antibody fragment has potential to become a new therapeutic tool for cancer diagnosis and treatment.
Application of Dual-Energy CT Non-Linear Fusion Technology in Improving CTA Image Quality of Renal Cancer  [PDF]
Shuiqing Zhuo, Xiaoling Chen, Jingping Yu, Sihui Zeng, Lizhi Liu
Open Journal of Medical Imaging (OJMI) , 2018, DOI: 10.4236/ojmi.2018.83009
Abstract: Objective: To explore the significance of dual-energy CT non-linear fusion technique in improving the quality of CTA image of renal cancer. Methods: The CTA images of 100 patients who had been confirmed by pathology as renal cancer were collected and were randomly divided into experimental group and control group with 50 cases respectively. The two groups of patients were treated with iodine concentration of 300 mg/ml and 350 mg/ml non-ionic contrast agent, with a dosage of 1.5 ml/kg and an injection rate of 4 ml/s. The contrast agent intelligently tracking method was adopted bolus. The control group used the conventional CTA scanning, with a reference tube voltage/tube current of 100 kv/ref150 mas. The experimental group adopted the double energy scanning, with ball tube A and ball tube B. The reference tube voltage/tube current was 100 kv/ref250 mas and sn150 kv/ref125 mas respectively. The images of the experimental group were non-linear fused to obtain the Mono+ 55 kev single-energy images. The CT value, SNR contrast ratio of the abdominal aorta, renal artery and
Significance of an Advanced Image-Based Virtual Monoenergetic Reconstruction of Dual Source Dual-Energy CT Data at Low keV Increases Image Quality for Portal Vein System of Pancreatic Cancer Patients  [PDF]
Shuiqing Zhuo, Sihui Zeng, Jingping Yu, Lizhi Liu
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.910068
Abstract: Purpose: To explore the significance of dual-source computed tomography (DECT) virtual monoenergetic reconstructions technology in improving image quality for portal vein system of pancreatic cancer patients. Materials and methods: 47 patients with clinically suspected pancreatic cancer (all confirmed by pathology) were collected. Routine plain scan was performed with Siemens Force dual-source dual-energy CT followed by 3 scans respectively carried out in arterial phase, portal phase and delayed phase. Traditional virtual monoenergetic reconstructions (Mono_E) and new generation of virtual monoenergetic reconstructions (Mono+) were respectively performed on portal vein images to obtain virtual single energy images including Mono_ E70 keV, Mono_E 55 keV and Mono+ 70 keV and Mono+ 55 keV. The signal-to-noise ratio (SNR) and noise of portal vein, normal pancreatic tissues and pancreatic lesions of 100 kV, Mono_E and Mono+ images were compared. In addition, the contrast noise ratio of portal vein and lesions as well as pancreatic tissues and lesions (CNR PV, CNRtumor) were also compared. At the same time, two imaging physicians with rich clinical experiences read the films and scored the images of each group by using the 5-point scoring method. Results: Mono+ 55 keV images including SNRpv, SNRpanc, SNRtumor, Noise, CNRpv, CNRtumor were statistically different from 100 KV images and Mono_E images (P < 0.05). As for the
Application of Laws of PRC Concerning Air Transport Lawsuits: What Should We Do in the Future?  [PDF]
Lizhi Wang
Beijing Law Review (BLR) , 2015, DOI: 10.4236/blr.2015.62013
Abstract: It is found that some of the conflicts among Chinese domestic private laws relating to carriage of passengers by air may be settled according to the law application rules and while some may not. The author also observes the roles played by the legislative body of China on the conflicts among domestic private laws. This paper concludes that the issues on the application of laws will be a long-term puzzle for Chinese Lawyers. This paper proposes to revise the laws, especially the Civil Aviation Law forthwith.
c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway
Weiming Xu,Lizhi Liu,David Hornby
Molecules , 2012, DOI: 10.3390/molecules171012086
Abstract: Recent genetic studies have shown that PCSK9, one of the key genes in cholesterol metabolism, plays a critical role by controlling the level of low-density lipoprotein receptor. However, how PCSK9 mediates LDLR degradation is still unknown. By combining a shotgun proteomic method and differential analysis of natural occurring mutations of the PCSK9 gene, we found that an E3 ubiquitin ligase c-IAP1 binds and processes PCSK9 protein. One of the ‘gain-of-function’ mutations, S127R, is defective with respect to binding to c-IAP1, and thus has defective autocatalytic activity. Knockdown of c-IAP1 impairs PCSK9 processing and autocatalytic cleavage. In c-IAP1 null mouse embryonic fibroblasts (MEFs), there is a dramatic decrease in secreted mature PCSK9 protein accompanied by a significant increase in LDLR protein levels compared with matched wild-type MEF cells. c-IAP1 also acts as an E3 ligase for ubiquitination of PCSK9. Ubiquitin containing only lysine-27 mediated PCSK9 ubiquitination by c-IAP1. Given K27-linked polyubiquitination promotes lysosomal localization, the finding indicates the c-IAP1 acts on both secretion of PCSK9 and its lysosomal localization. The novel pathway described here will open new avenues for exploring novel disease treatments.
A CPN-based Software Testing Approach
Lizhi Cai,Juan Zhang,Zhenyu Liu
Journal of Software , 2011, DOI: 10.4304/jsw.6.3.468-474
Abstract: As a graphical and mathematical modeling tool, CPN (Colored Petri Net) is often used to describe the transition of states for an information system. The advantage of CPN model is that the model can be simulated dynamically. This paper presents an approach to generating test cases based on
Detection and Adaptation in Parasitic Angiosperm Host Selection  [PDF]
Lizhi Liang, Yue Liu, Jenil Jariwala, David G. Lynn, Andrew G. Palmer
American Journal of Plant Sciences (AJPS) , 2016, DOI: 10.4236/ajps.2016.78123
Abstract: Developmental transitions in some parasitic angiosperms are tied directly to host-derived chemical cues (xenognosins). The obligate hemi-parasite Striga asiatica, initiates the root apical meristem population (germination), development of the host attachment organ (the haustorium), and shoot apical meristem initiation (seed coat shedding) in response to specific xengonosins. These checkpoints synchronize spatial and temporal tissue development. We have now exploited the external control over these developmental transitions to trace functional expression in haustorial organogenesis. Genes associated with phytohormone regulation, metabolism, vascular tissue development, and reactive oxygen species (ROS) production identified in this study suggest an elaborate and global response closely tied to plant defense and redox chemistry that may also be components of a more general quorum sensing-type mechanism in plants.
3D Seismic Acquisition Technology and Effect in HX Volcanic Area in Liaohe Depression  [PDF]
Haibo Wang, Bing Liu, Qiwei Zou, Lizhi Sun, Wei Zhang, Jiantao Tian, Meibin Tang
International Journal of Geosciences (IJG) , 2016, DOI: 10.4236/ijg.2016.77071
Abstract: Multi-stages volcanic are available in HX area, shielding the seismic waves. Previous seismic acquisitions of large size bin, less fold coverage and narrow azimuth result in indistinct fault images, low S/N ratio and the difficulty of multi-stages volcanic characterization. In reference to the successful experience of domestic and overseas volcanic exploration, the low frequency excitation and receiving, and survey with wide range, high coverage, wide azimuth should be paid more attention, associated with two-dimensional and three-dimensional wave equation forward modeling and real data processing contrast analysis method. The image of underlying strata and fault are remarkably improved in the new method, according to the processing results of new seismic data. The new method will provide technical reference for the similar volcanic development area in the future seismic acquisition design.
Understanding the Factors That Control the Formation and Morphology of through Hydrothermal Route
Xu Liu,Chunrui Wang,Xiaoyun Liu,Lizhi Ouyang
Journal of Nanomaterials , 2013, DOI: 10.1155/2013/938370
Abstract:
Analysis of the Focusing Characteristics of Double Negative Binary Diffractive Lens  [PDF]
Zongxin Wang, Lizhi You
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.29072
Abstract: For a compact millimeter wave imaging system it is very important to design every component into small size, for the components in a millimeter wave system are usually much larger than those in an optical imaging system due to rela-tively long wave lengths. In this paper, we suggest a kind of binary diffractive lens (BDL) designed using double nega-tive materials (DNG) as the objective lens for a millimeter wave imaging system. The DNG-BDL has not only the ad-vantage of low profile but also small f number, which will be benefit for constructing a compact millimeter wave imaging system. Several DNG-BDL are designed and analyzed using the FDTD method. The numerical results of the focal plane field of the DNG-BDL are presented, which show that the DNG-BDL with small f number has relatively better focusing characteristic than that of a double positive BDL with same f number.
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