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Search Results: 1 - 10 of 80891 matches for " Liu MengRen "
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Neuroprotective Effects of Ginsenoside Rb1 on High Glucose-Induced Neurotoxicity in Primary Cultured Rat Hippocampal Neurons
Di Liu, Hong Zhang, Wenjuan Gu, Yuqin Liu, Mengren Zhang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079399
Abstract: Ginsenoside Rb1 is one of the main active principles in traditional herb ginseng and has been reported to have a wide variety of neuroprotective effects. Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, so the present study aimed to observe the effects of ginsenoside Rb1 on ER stress signaling pathways in high glucose-treated hippocampal neurons. The results from MTT, TUNEL labeling and Annexin V-FITC/PI/Hoechst assays showed that incubating neurons with 50 mM high glucose for 72h decreased cell viability and increased the number of apoptotic cells whereas treating neurons with 1 μM Rb1 for 72h protected the neurons against high glucose-induced cell damage. Further molecular mechanism study demonstrated that Rb1 suppressed the activation of ER stress-associated proteins including protein kinase RNA (PKR)-like ER kinase (PERK) and C/EBP homology protein (CHOP) and downregulation of Bcl-2 induced by high glucose. Moreover, Rb1 inhibited both the elevation of intracellular reactive oxygen species (ROS) and the disruption of mitochondrial membrane potential induced by high glucose. In addition, the high glucose-induced cell apoptosis, activation of ER stress, ROS accumulation and mitochondrial dysfunction can also be attenuated by the inhibitor of ER stress 4-phenylbutyric acid (4-PBA) and anti-oxidant N-acetylcysteine(NAC). In conclusion, these results suggest that Rb1 may protect neurons against high glucose-induced cell injury through inhibiting CHOP signaling pathway as well as oxidative stress and mitochondrial dysfunction.
The research of component- based software testing technique
基于构件的软件测试技术研究

Ma LiangLi,Lu YanSheng,Liu MengRen,
马良荔
,卢炎生,刘孟仁

计算机系统应用 , 2005,
Abstract: 1 引言 过去的几十年,软件开发模式发生了很大的改 变。随着软件开发机构对开发成本、周期要求的提 高,产生了软件构件化。 软件构件技术的提出解决了面向对象技术无法 使大量结构相似的应用程序结构得到重用的矛盾。 因此构件技术对软件重用和集成具有非常重大的意 义,已成为当前软件领域主流技术和研究热点。
The Model of Mobile Knowledge Services System in the Management of Complex Cluster Project  [PDF]
Yong Liu, Bingxin Liu
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.31006
Abstract: Cluster projects are projects of large-scale or with huge investment, such as Beijing 2008 Olympic Games and Shanghai 2010 Expo. A lot of on-site management works are involved in the process of cluster project management, especially the treatment of sudden accidents which would produce plenty of knowledge and experience. As cluster project on-site management spots change frequently, knowledge produced by mobile workers in the process of on-site management is hard to be saved into the knowledge repository on time. It may cause a knowledge distortion or even missing. On the other hand, in the process of cluster project management, a lot of knowledge is required by on-site workers to deal with on-site activities. However, due to lack of effective mechanisms for knowledge communion, they often face the risk of making wrong decisions. To solve the problems of knowledge management and acquisition in the process of cluster project on-site management, this paper presents a system model for mobile knowledge service.
The Collusion Deterrence with Prisoner’s Dilemma  [PDF]
Aidong Liu, Jinfang Liu
Journal of Service Science and Management (JSSM) , 2010, DOI: 10.4236/jssm.2010.34053
Abstract: I tried to present a new method to prevent collusion through employing two auditors at the same time and inspiring them provide true report by exploiting their prisoner’s dilemma. But I found this method cannot be put into practice because of the high cost. So I analyzed whether sending the second auditor in a probability, a low cost method, can deter the audit collusion. I find sending the second auditor in a probability, enforcing the rigidly lawful punishment and perfecting the reward mechanism can prevent audit collusion. I also find the auditor’s ethical constraint do good to prevent collusion and the charger of state assets management can play the same role as the real owner of the state-owned enterprise in deterring collusion. This finding provides theory support for the government to implement the publicly audit bidding and random double auditing system on state-owned enterprise. The supervision of PCAOB on auditors is also the operation of this theory.
Using Insulation in China’s Buildings: Potential for Significant Energy Savings and Carbon Emission Reductions  [PDF]
Guoliang Liu, Hans Liu
Low Carbon Economy (LCE) , 2011, DOI: 10.4236/lce.2011.24027
Abstract: Most old residential and commercial buildings in China are not insulated or not to new standards. This is true even in regions with very cold winters or regions with very hot summers. The insulation in new buildings is very poor relative to North American standards. However, insulating the exterior walls, attic roofs, and foundation walls to new standards of buildings in China would reduce the need for heating and air conditioning, and thus would save roughly 200 million tons of coal each year. This in turn would lead to a reduction in CO2 emissions of about 510 million tons per year, which is equal to about 8.4% of China’s total carbon emissions in 2006. The use of insulation in buildings will help homeowners save money, help China save energy and help the environment all at the same time. Insulation will provide a continued payback to the homeowner, not only in dollars and cents, but also by providing a more enjoyable and comfortable living environment for many years.
An Elementary Introduction to Training the Postgraduates for Professional Degrees in Oil and Gas Engineering  [PDF]
Qingyou Liu, Zhibin Liu
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326126
Abstract: The demand of the talents in petroleum engineering of petroleum enterprises is analyzed in this paper according the current situation of the engineering education. The four levels of the professional talents needed by the petroleum enterprises are specified, which makes it clear that what the purpose and orientation of the higher education in petroleum engineering should be. The qualities of the petroleum engineers are discussed specifically and it is pointed out that the training of the postgraduate for professional degree in oil and gas engineering should be the cradle of the petroleum engineers. A training schedule is listed in this paper based on the discussion, including curriculum provision, practice link, thesis and training mode, which will be a pathfinder of the education of the professional degree graduate student in oil and gas engineering. Moreover, the practice can provide useful experience for the training and education of different type of graduates.
Overall Framework and Module of Distribution Network Coordinated Planning Considering Distributed Generation  [PDF]
Qianjin LIU, Huanghuang LIU
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.51B006
Abstract: Combining with the characteristics of China's energy and the strategy of sustainable development, analyzing the pros and cons which caused by the appearance of DG and their operation connecting to grid, this paper points out that the two sides can achieve win-win under a reasonable combination between DG and distribution system, so as to optimize the allocation of resources, improve the utilization ratio of resource, and obtain maximum social benefit, harmoniously promote the development of power industry, economy and environment. As a word, this paper puts forward a new model of distribution network planning including DG and brings in penalty factorto guide the investment and construction of DG. Last of all, this paper presents the adoption of the coordination development coefficients which is to evaluate the power planning.
Let Professional Degrees Graduate Education for Oil and Gas Engineering Become the Cradle for the Birth and Growth of Petroleum Engineers  [PDF]
Zhibin Liu, Qingyou Liu
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B026
Abstract:

The demand of the talents in petroleum engineering of petroleum enterprises is analyzed in this paper according the current situation of the engineering education. The four levels of the professional talents needed by the petroleum enterprises are specified, which makes it clear that what the purpose and orientation of the higher education in petroleum engineering should be. The qualities of the petroleum engineers are discussed specifically and it is pointed out that the training of the postgraduate for professional degree in oil and gas engineering should be the cradle of the petroleum engineers. A training schedule is listed in this paper based on the discussion, including curriculum provision, practice link, thesis and training mode, which will be a pathfinder of the education of the professional degree graduate student in oil and gas engineering.

A Review of Models in Experimental Studies of Implicit Language Learning  [PDF]
Si Liu, Huangmei Liu
Open Journal of Modern Linguistics (OJML) , 2014, DOI: 10.4236/ojml.2014.41006
Abstract:

The present review analyzes experimental research on implicit learning using linguistic stimuli, and proposes five key procedures of a framework for empirical studies of implicit learning. Our review begins with a brief overview of the current state of research on implicit learning, and then presents the procedures in detail: 1) choosing theoretical assumptions from psychology; 2) designing stimuli; 3) exposing subjects to information; 4) testing implicit learning; and 5) measuring subjects’ state of awareness. This framework is intended to assist researchers in designing experiments on implicit learning both more comprehensively and with fewer flaws.

Investment Value Evaluation of Hi-Tech Industry: Based on Multi-Factor Dynamic Model  [PDF]
Chen Liu, Yang Liu
Open Journal of Business and Management (OJBM) , 2014, DOI: 10.4236/ojbm.2014.23027
Abstract: By constructing a multi-factor dynamic model based on the theory of the lifecycle with China’s A-share data from 2007 to 2013, we analysis the factors affect the investment value and risk of hi-tech industry and their mechanism of action. After the regression, we can draw conclusions: Firstly, hi-tech industries in China are mostly in the growth stage and maturity stage. Investment value of the industries in the growth stage are mostly influenced by market premium factor, market factor, P/E ratio factor and R & D density factor, while hi-tech industries in maturity stage are mainly affected by the market premium factor, market factor, P/E ratio factor. Secondly, dynamic multi-factor model can measure the investment value of hi-tech industries adequately. The conclusions give a reference for investors on how to make investment plan on the stocks of hi-tech enterprises, and provide some policy recommendations on the way promoting hi-tech enterprises to enhance their core technology as well.
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