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Search Results: 1 - 10 of 88342 matches for " Liu Fei-Fei "
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Micro-RNAs as diagnostic or prognostic markers in human epithelial malignancies
Angela Hui, Christine How, Emma Ito, Fei-Fei Liu
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-500
Abstract: Micro-RNAs (miRs) are important regulators of mRNA and protein expression which play important yet complex roles in human cancers [1]. Their biogenesis and biological networks are complex (Figure 1); they are first synthesized as large RNA precursors, processed in the nucleus into approximately 70 nt pre-miRs, folded into imperfect stem-loop structures, transported to the cytoplasm, whereupon they are incorporated into RISC (RNA-induced silencing complex) (reviewed in [2]). Cleavage by Argonaute-2, then Dicer, results in an approximately 22-nt mature miR duplex; the "guide" strand is retained within the RISC; the "passenger" strand is degraded. Through the seed region (nt 2 to 8), the miR can then bind to the 3'UTR of target mRNA sequences, preventing protein translation, leading to mRNA degradation. More recently, miRs have also been described to target 5'UTR, and even coding regions of transcripts [3]. The current miRDatabase (http://www.mirbase.org webcite) has catalogued more than 1,300 human sequences. Given their ability to target mRNA with imperfect complementarity, and predicted to regulate the expression of approximately one-third of all human transcripts [4], miRs are considered to be among the largest class of gene regulators [5,6].Multiple mechanisms can mediate miR dysregulations in human cancers, including chromosomal gains or losses [7], mutations of miR located loci [8], or epigenetic aberrations [8]. Any misstep in miR biogenesis (Figure 1) can also affect miR expression [9,10], exemplified by the down-regulation of Drosha and Dicer being associated with worse survival in ovarian, lung, and breast cancers [11]. MiRs can be either over- or under-expressed, functioning as tumour suppressors or oncogenes, depending on their downstream target genes [12]. MiR-15a and miR-16-1 are two of the first described down-regulated miRs in chronic lymphocytic leukemia [13], both target Bcl-2 [14]; thus their absence inhibits apoptosis. Alternatively, miR-21, one of
Characterization of complexation of poly (N-isopropylacrylamide-co-2-(dimethylamino) ethyl methacrylate) thermoresponsive cationic nanogels with salmon sperm DNA
Jim Moselhy, Tasnim Vira, Fei-Fei Liu, et al
International Journal of Nanomedicine , 2009, DOI: http://dx.doi.org/10.2147/IJN.S6585
Abstract: racterization of complexation of poly (N-isopropylacrylamide-co-2-(dimethylamino) ethyl methacrylate) thermoresponsive cationic nanogels with salmon sperm DNA Original Research (4941) Total Article Views Authors: Jim Moselhy, Tasnim Vira, Fei-Fei Liu, et al Published Date August 2009 Volume 2009:4 Pages 153 - 164 DOI: http://dx.doi.org/10.2147/IJN.S6585 Jim Moselhy1, Tasnim Vira1, Fei-Fei Liu2, Xiao Yu Wu1 1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; 2Ontario Cancer Institute, Toronto, ON, Canada Abstract: Thermoresponsive cationic nanogel (TCNG) networks based on N-isopropylacrylamide (NIPAM), 2-(dimethylamino)ethyl methacrylate (DMAEMA), and quaternary alkyl ammonium halide salts of DMAEMA (DMAEMAQ) were synthesized by dispersion polymerization technique. The thermoresponsive properties of TCNGs and TCNG-salmon sperm DNA (sasDNA) polyplexes were characterized in aqueous media of various pH and ionic strength. P[NIPAM] and P[NIPAM/DMAEMA] TCNGs exhibited sharp volume phase transition (VPT) in water at critical temperatures (Tc) of 32 °C and 36 °C, respectively. Quaternized P[NIPAM/DMAEMAQ] TCNGs did not undergo sharp VPT up to 50 °C. The VPT of uncomplexed TCNGs were sensitive to the ionic composition and ionic strength of salts in solution, but were insensitive to pH in the range 5.0 to 7.4. The VPT of P[NIPAM/DMAEMAQ]/sasDNA diminished in magnitude with increasing Wp/Wd suggesting greater compaction of the polyplexes. The distinct phase-transition properties of P[NIPAM/DMAEMA]/sasDNA and P[NIPAM/DMAEMAQ]/sasDNA polyplexes were attributed to the condensing capability of polycations and to differences in the spatial distribution of structural charges in quaternized and nonquaternized networks. The findings demonstrate that stable TCNGs can be prepared with controllable responsive properties determined by the nature of the cationic charge incorporated and may have potential as vehicles for DNA delivery.
Characterization of complexation of poly (N-isopropylacrylamide-co-2-(dimethylamino) ethyl methacrylate) thermoresponsive cationic nanogels with salmon sperm DNA
Jim Moselhy,Tasnim Vira,Fei-Fei Liu,et al
International Journal of Nanomedicine , 2009,
Abstract: Jim Moselhy1, Tasnim Vira1, Fei-Fei Liu2, Xiao Yu Wu11Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; 2Ontario Cancer Institute, Toronto, ON, CanadaAbstract: Thermoresponsive cationic nanogel (TCNG) networks based on N-isopropylacrylamide (NIPAM), 2-(dimethylamino)ethyl methacrylate (DMAEMA), and quaternary alkyl ammonium halide salts of DMAEMA (DMAEMAQ) were synthesized by dispersion polymerization technique. The thermoresponsive properties of TCNGs and TCNG-salmon sperm DNA (sasDNA) polyplexes were characterized in aqueous media of various pH and ionic strength. P[NIPAM] and P[NIPAM/DMAEMA] TCNGs exhibited sharp volume phase transition (VPT) in water at critical temperatures (Tc) of 32 °C and 36 °C, respectively. Quaternized P[NIPAM/DMAEMAQ] TCNGs did not undergo sharp VPT up to 50 °C. The VPT of uncomplexed TCNGs were sensitive to the ionic composition and ionic strength of salts in solution, but were insensitive to pH in the range 5.0 to 7.4. The VPT of P[NIPAM/DMAEMAQ]/sasDNA diminished in magnitude with increasing Wp/Wd suggesting greater compaction of the polyplexes. The distinct phase-transition properties of P[NIPAM/DMAEMA]/sasDNA and P[NIPAM/DMAEMAQ]/sasDNA polyplexes were attributed to the condensing capability of polycations and to differences in the spatial distribution of structural charges in quaternized and nonquaternized networks. The findings demonstrate that stable TCNGs can be prepared with controllable responsive properties determined by the nature of the cationic charge incorporated and may have potential as vehicles for DNA delivery.Keywords: poly(N-isopropyl acryamide), poly(2-dimethylamino)ethyl methacrylate, polyplex, thermoresponsive cationic nanogels
Enhanced vesicular stomatitis virus (VSVΔ51) targeting of head and neck cancer in combination with radiation therapy or ZD6126 vascular disrupting agent
Nehad M Alajez, Joseph D Mocanu, Tiffany Krushel, John C Bell, Fei-Fei Liu
Cancer Cell International , 2012, DOI: 10.1186/1475-2867-12-27
Abstract: Our data demonstrated high toxicity of the virus against FaDu cells in vitro, which was associated with induction of apoptosis. In vivo, systemic injection of 1?×?109 pfu had minimal effect on tumour growth; however, when combined with two doses of ionizing radiation (IR; 5?Gy each) or a single injection of the vascular disrupting agent (ZD6126), the virus exhibited profound suppression of tumour growth, which translated to a prolonged survival in the treated mice. Concordantly, VSVΔ51 combined with ZD6126 led to a significant increase in viral replication in these tumours.Our data suggest that the combinations of VSVΔ51 with either IR or ZD6126 are potentially novel therapeutic opportunities for HNSCC.Head and neck squamous cell carcinoma (HNSCC) is the most common cancer type in the head and neck region, accounting for the 5th most common cancer worldwide [1]. Locally advanced diseases are treated with either radiation or chemo-radiotherapy, but are still associated with >50% mortality rate [1,2], underscoring the need to develop novel therapeutic strategies. Oncolytic viruses have recently garnered increasing interest as anti-cancer agents due to their preferential killing of transformed cells (reviewed in [3,4]). Among these, the mutant variant of vesicular stomatitis virus (VSV) has been evaluated in different tumour models, demonstrating promising results as either single agent or in combination with other treatment modalities [5-7]. We had previously demonstrated the exquisite sensitivity of EBV-positive nasopharyngeal carcinoma (NPC) to a mutant VSV (VSVΔ51), which has a single amino acid deletion in the VSV M protein, rendering lethality to cancer cells, whilst sparing normal cells [8]. Building upon this observation, herein we evaluated the efficacy of VSVΔ51 against the human FaDu hypopharyngeal squamous cell carcinoma model either as a single agent, or combined with radiation therapy (RT) or the vascular disrupting agent ZD6126. ZD6126 is a colchicine pr
Solitary adrenal metastasis from invasive ductal breast cancer: an uncommon finding
Xiao-Jiao Liu, Peng Shen, Xin-Feng Wang, Ke Sun, Fei-Fei Sun
World Journal of Surgical Oncology , 2010, DOI: 10.1186/1477-7819-8-7
Abstract: A 64-year-old woman was found a left adrenal mass on a follow- up visit two years after taking a right modified radical mastectomy for the breast cancer. She was subsequently given a left adrenalectomy. Postoperative histopathology findings were compatible with invasive ductal carcinoma (IDC) of the breast. Due to the patient's refusal, no further treatments were offered after the adrenalectomy. The patient now is still alive and has no sign of relapse. Survival time after taking the right modified radical mastectomy and the left adrenalectomy is more than five years and three years, respectively.This is the first case of a patient with solitary, metachronous adrenal metastasis from IDC of the breast to be reported. For patients in this condition, complete removal of metastasized organ may translate into survival benefit.Invasive ductal carcinoma (IDC) is the most common type of the breast cancer, which has been reported to constitute approximately 70-85% of all invasive breast carcinomas[1]. Usually, IDC can metastasize to the lungs, liver, bones and brain, but rarely to the adrenal glands[2,3]. In a study of metastatic patterns of breast cancer, Borst MJ[2] reported that in a group of the 2246 patients with IDC, none of them had shown adrenal metastasis. In fact, adrenal metastasis of breast cancer is generally associated with infiltrating lobular carcinomas (ILC) and often accompanied by synchronous multiorgan metastases[3]. A metachronous, isolated adrenal metastasis from ILC is rare, which is even rarer when it derives from IDC of the breast. So far there has been only one case of isolated adrenal metastasis arising from ILC of the breast documented [4], but the IDC with solitary adrenal metastasis has never been reported in the literature.Due to the rarity of solitary adrenal metastasis from breast cancer, the optimal treatment is still unclear. Generally, distant visceral metastasis is an upset aspect for cancer patient, palliative chemotherapy would be recom
Characteristics of soil respiration in artificial restoration process of subalpine coniferous forest in eastern Qinghai-Tibet plateau
青藏高原东缘亚高山针叶林人工恢复过程中的土壤呼吸特征

ZHOU Fei-fei,LIN Bo,LIU Qing,
周非飞
,林波,刘庆

应用生态学报 , 2009,
Abstract: 采用动态密闭气室红外CO2分析法,对青藏高原东缘云杉人工林的土壤呼吸进行连续定位测定,并用挖壕沟法区分土壤自养呼吸和异养呼吸.结果表明:4种云杉林的土壤呼吸速率与土壤5 cm层温度有显著的正指数关系,与土壤含水量的相关性不显著.4种云杉林土壤呼吸年通量在792.08~1070.20 g C·m-2·a-1,大小依次为:天然云杉林>22年生云杉人工林>65年生云杉人工林>35年生云杉人工林,随着人工林的恢复呈先降低后升高的趋势.在森林恢复过程中,人工云杉土壤自养和异养呼吸年通量均先减少后增加, 在253.36~357.05 g C·m-2·a-1和538.69~703.82 g C·m-2·a-1范围变化.22年生、35年生、65年生云杉人工林和天然云杉林非生长季 (2007-11—2008-03)和生长季(2008-04—2008-10)的Q10值分别为:4.59、6.54、4.77、3.18和4.17、4.66、3.11、2.74.除22年生云杉人工林,Q10值随云杉林的恢复更新而逐渐降低, 且非生长季节Q10值均明显高于生长季节.
Methyl 4-(3-chloropropoxy)benzoate
Ya-Bin Shi,Ke-Ke Liu,Song Xia,Fei-Fei He
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811011093
Abstract: In the crystal structure of the title compound, C11H13ClO3, intermolecular C—H...O hydrogen bonds link the molecules into zigzag chains along the c axis.
Spinal cord stimulators and radiotherapy: First case report and practice guidelines
Lorraine Walsh, Daipayan Guha, Thomas G Purdie, Philippe Bedard, Alexandra Easson, Fei-Fei Liu, Mojgan Hodaie
Radiation Oncology , 2011, DOI: 10.1186/1748-717x-6-143
Abstract: Radiotherapy (RT) is a major cancer treatment modality, applied to approximately 60% of patients at some point in their natural history for curative and palliative intent [1]. However, RT can interfere with and potentially damage implanted electronic devices such as cardiac pacemakers or implanted cardioverter-defibrillators (ICD) [2]. Given the increasing use of these devices for a broad range of medical applications, recommendations have been developed regarding the safe delivery of RT with such devices in-situ [3,4]. Safety guidelines do not yet exist however, for implanted electronic spinal cord stimulators (SCS).Spinal cord neuromodulation using implantable electrodes placed over the dorsal columns in the epidural space can be an effective strategy for the control of severe, longstanding, neuropathic pain [5,6]. The SCS system consists of 3 components: an electrode array which is implanted in the epidural space overlying the dorsal columns of the spinal cord; an implantable pulse generator (IPG) which consists of an electrical generator, battery, transmitter/receiver and a minicomputer, which is placed beneath the skin and controlled transcutaneously by the patient; and insulating wiring connecting the electrodes to the IPG. These devices are an important treatment modality for chronic neuropathic pain conditions refractory to conservative management, including complex regional pain syndrome, radiculopathies, failed back syndrome, phantom limb pain, and post-herpetic neuralgia. They are increasingly applied to other conditions including intractable angina and ischemic pain secondary to peripheral vascular disease, though long-term efficacy remains undetermined [7].Surgical techniques for SCS implantation are largely similar regardless of indication and are typically performed in two stages. One to four leads are placed in the epidural space in the cervical, thoracic or lumbar regions as appropriate, either percutaneously or via a small laminotomy. The SCS can a
Research on 3D Modeling Based on HOOPS Interface Technology
基于HOOPS接口技术的3D造型的研究

YAO Kun,LIU Xi-yu,LI Fei-fei,
姚坤
,刘希玉,李菲菲

计算机应用研究 , 2006,
Abstract: Abstract:ACIS is a famous global platform of 3D modeling application development. In this paper, HOOPS which is a new interface technology of ACIS with its components,functionality,features and applications are introduced.An application development example is displayed in this paper.
A Review of Approaches for Software Testability Analysis
软件的易测试性分析方法述评

LIU Fei-Fei,SHAN Jin-Hui,JIANG Ying,
刘菲菲
,单锦辉,姜瑛

计算机科学 , 2005,
Abstract: Software testing is an important part in the domain of software engineering. With the enlargement of soft- ware scale, software testing becomes more complex. The improvement of software testability is an efficient method to reduce the testing complexity. The precise measurement of software testability is the first step to achieve the above goal. Besides as a quantified guideline, the measurement result should be direction for the improvement of software testability and be helpful to testing design. In this paper, the existing analysis methods of software testability are classified roughly as analysis based on software complexity, analysis based on information theory, analysis based on PIE technology and analysis based on UML class graph. This paper briefly introduces some representative methods of each class, compares the merits and demerits of these methods. Finally, future research directions are discussed.
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