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Search Results: 1 - 10 of 80844 matches for " Liu Degui "
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Intravesical Treatment with Vorinostat Can Prevent Tumor Progression in MNU Induced Bladder Cancer  [PDF]
Degui Wang, Siwei Ouyang, Yingxia Tian, Yan Yang, Bo Li, Xiangwen Liu, Yanfeng Song
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.46A3001

Background: Histone deacetylase inhibitors (HDACI) are promising class of drugs acting as antiproliferative agents by promoting differentiation as well as inducing apoptosis. Vorinostat (suberoylanilide hydroxamic acid, SAHA) is the first among this new class of anticancer drugs to be approved by FDA for the treatment of cancer but only for cutaneous T cell lymphoma (CTCL). The objective of this study is to investigate the inhibitory effect of SAHA on the viability of human bladder cancer cells and its synergetic effect with chemotherapy agents in vitro and in vivo. Methods: The cell viability of human bladder cancer cell lines after treated with SAHA or SAHA combining mitomycin c (MMC), Cisplatin (DDP) and Adriamycin (ADM) were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Hoechst staining was used to observe cell morphology for apoptotic cells. The survivin protein and acetylated histone H3 levels in bladder cancer were quantified by Western blot analysis. In vivo tumor growth inhibition of intravesical inject SAHA was determined in rats with N-methyl-N-nitrosourea (MNU) induced bladder cancer. Results: SAHA significantly inhibited growth of bladder cancer cell lines with concentration and time dependent manner. Furthermore, better results of tumor inhibition would be achieved when it was combined with chemotherapeutic agents in vitro and in vivo. Survivin expression decreased and acetylated histone H3 expression increased in bladder cancer cells lines after SAHA treatment. Intravesically injections of SAHA can inhibit tumor progress when combined with DDP. Conclusions: SAHA can act as HDACI which has direct anti-cancer effect and can enhance the action of several chemotherapy agents markedly. SAHA may sensitize bladder cancer to anti cancer drugs by down regulating survivin

Hierarchical Generalized Linear Models for Multiple Groups of Rare and Common Variants: Jointly Estimating Group and Individual-Variant Effects
Nengjun Yi ,Nianjun Liu,Degui Zhi,Jun Li
PLOS Genetics , 2011, DOI: 10.1371/journal.pgen.1002382
Abstract: Complex diseases and traits are likely influenced by many common and rare genetic variants and environmental factors. Detecting disease susceptibility variants is a challenging task, especially when their frequencies are low and/or their effects are small or moderate. We propose here a comprehensive hierarchical generalized linear model framework for simultaneously analyzing multiple groups of rare and common variants and relevant covariates. The proposed hierarchical generalized linear models introduce a group effect and a genetic score (i.e., a linear combination of main-effect predictors for genetic variants) for each group of variants, and jointly they estimate the group effects and the weights of the genetic scores. This framework includes various previous methods as special cases, and it can effectively deal with both risk and protective variants in a group and can simultaneously estimate the cumulative contribution of multiple variants and their relative importance. Our computational strategy is based on extending the standard procedure for fitting generalized linear models in the statistical software R to the proposed hierarchical models, leading to the development of stable and flexible tools. The methods are illustrated with sequence data in gene ANGPTL4 from the Dallas Heart Study. The performance of the proposed procedures is further assessed via simulation studies. The methods are implemented in a freely available R package BhGLM (http://www.ssg.uab.edu/bhglm/).


金属学报 , 1994,
Abstract: TEM is used to study the interface structure and the thickening kinetics of bainitic ferrite during isothermal transformation of an Fe-30wt-%Ni alloy with the hot stage. It is demonstrated that ferrite possesses ledge morphology with 111]b dislocations at the ferrite/austenite ledge interface. The experimentally measured ferrite thickening rate is shown to be of the same order with those calculated according to Zener-Hillert equation developed for the growth kinetics of ferrite controlled by the volume diffussion of carbon in austenite. All of the results are considered to be support for the ledge growth mechanism for the bainitic ferrite.

Chen Lirong Liu Degui,

计算数学 , 2000,
Abstract: This paper deals with a class of combined RK- Rosenbrock (CRKR) methods for a partitioned system of stiff differential equations based on the parallelism across the system. Nonstiff subsystem is integrated by a explicit RK method while a Rosenbrock method is used for the stiff subsystem. The paper discusses numerical stability, and the numerical tests are conducted on a multiprocessor system.
Colon Cancer-Specific Antigen-2 May Be Used as a Detecting and Prognostic Marker in Colorectal Cancer: A Preliminary Observation
Gang Xue, Xiaojuan Wang, Yong Yang, Degui Liu, Ying Cheng, Jun Zhou, Yongkuan Cao
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094252
Abstract: Background A specific and sensitive serum marker for colorectal cancer (CRC) detection and surveillance is central to effective treatment. It was preliminarily reported that some nuclear matrix proteins may be served as a specific blood based marker for colon cancer. The objective of this study is to evaluate the value of serum CCSA-2 detection in diagnosis, prognostic estimation and surveillance for CRC. Method Serum CCSA-2 protein was measured in 181 various patient populations and 20 healthy donors before surgery. For 106 CRC patients, it was also measured on day 7 after surgery. Among them, 49 CRC patients' CCSA-2 protein were measured during the follow-up period according to NCCN Guideline. Results The serum CCSA-2 concentration in CRC patients was significantly higher than which in other patients and healthy individuals. Serum CCSA-2, at the cut-off point of 64.10 ng/mL, had a sensitivity of 98.10% and a specificity of 97.90% in separating CRC populations from all other individuals. The CCSA-2 assay was significantly more sensitive than CEA and CA19-9 assay in CRC detection. After surgery, the serum CCSA-2 level of CRC patients declined significantly, but it rebounded to a high level when recurrences occurred. The pre-operative serum CCSA-2 level in patients who had a relapse within the follow-up period was significantly higher than which in patients without relapse. Conclusions Serum CCSA-2 not only may be a potential biomarker using in screening and surveillance of CRC, but also may be an independent prognostic marker for CRC patients. Further clinical trials need to be performed in a larger population of patients to ulteriorly confirm these results.
Cold-state Experimental Study on Flow Characteristics of Multi-nozzle in Natural Gas Reburning Burner  [PDF]
Baoming Chen, Zhongxiao Zhang, Degui Bi
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B064
Abstract: Based on the prototypes of a 130 t/h boiler, constant proportional cold-state test bench is established, flow characteristics of multi-nozzle in natural gas reburning burner and its influence on the covering effect for the upflow in the furnace are researched. Numerical simulations of this process are also made with standard  turbulence model. The results show that air flow fullness in furnace is better in the case of the reburning zone with 8 nozzles compared to 4 nozzles and also coverage effect of the reburning flow for the updraft gas in the furnace is better. In the condition each nozzle airflow velocity is constant, the effect of reburning flow on coverage of up-secondary air is best when the incident angle for four corners is 14.17?, while Center of the furnace wall is 84.57. And while the best incident angle is invariable, the effect of reburning flow on coverage of up-secondary air is best when the speed of reburning gas in the corners of furnace is 51 m/s, the same to the center of the furnace wall’s.

LIU Shikai,YANG Liu,ZHANG Jun,ZHU Degui,

金属学报 , 1992,
Abstract: 分析了六种Fe-C-Si、Fe-C-Mn及Fe-C-Si-Mn合金的贝氏体(α_b)形态和微观亚结构,结果表明α_b的形态与Si,Mn类拖曳作用有密切关系,由计算得出的相变体积自由能差△G_v可粗略地估算出贝氏体相变的理论孕育时间τ,与TTT曲线上实测孕育时间比较,表明Fe-C-Mn及FE—C—Si—Mn的τ值基本上不取决于△G_v。的大小,用SIMS+EDS与二次离子谱仪(SIMS)测出F-C-Si-Mn中Mn在原奥氏体晶界上偏聚,从而抑制了β_b在该处形核,本文还讨论了Si,Mn共存时对相变动力学的复合作用。
Investigation of Antimicrobial Resistance in Escherichia coli and Enterococci Isolated from Tibetan Pigs
Peng Li, Dongfang Wu, Kunyao Liu, Sizhu Suolang, Tao He, Xuan Liu, Congming Wu, Yang Wang, Degui Lin
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095623
Abstract: Objectives This study investigated the antimicrobial resistance of Escherichia coli and enterococci isolated from free-ranging Tibetan pigs in Tibet, China, and analyzed the influence of free-ranging husbandry on antimicrobial resistance. Methods A total of 232 fecal samples were collected from Tibetan pigs, and the disk diffusion method was used to examine their antimicrobial resistance. Broth microdilution and agar dilution methods were used to determine minimum inhibitory concentrations for antimicrobial agents for which disks were not commercially available. Results A total of 129 E. coli isolates and 84 Enterococcus isolates were recovered from the fecal samples. All E. coli isolates were susceptible to amoxicillin/clavulanic acid, and 40.4% were resistant to tetracycline. A small number of isolates were resistant to florfenicol (27.9%), ampicillin (27.9%), sulfamethoxazole/trimethoprim (19.4%), nalidixic acid (19.4%), streptomycin (16.2%) and ceftiofur (10.9%), and very low resistance rates to ciprofloxacin (7.8%), gentamicin (6.9%), and spectinomycin (2.3%) were observed in E. coli. All Enterococcus isolates, including E. faecium, E. faecalis, E. hirae, and E. mundtii, were susceptible to amoxicillin/clavulanic acid and vancomycin, but showed high frequencies of resistance to oxacillin (92.8%), clindamycin (82.1%), tetracycline (64.3%), and erythromycin (48.8%). Resistance rates to florfenicol (17.9%), penicillin (6.0%), ciprofloxacin (3.6%), levofloxacin (1.2%), and ampicillin (1.2%) were low. Only one high-level streptomycin resistant E. faecium isolate and one high-level gentamicin resistant E. faecium isolate were observed. Approximately 20% and 70% of E. coli and Enterococcus isolates, respectively, were defined as multidrug-resistant. Conclusions In this study, E. coli and Enterococcus isolated from free-ranging Tibetan pigs showed relatively lower resistance rates than those in other areas of China, where more intensive farming practices are used. These results also revealed that free-range husbandry and absence of antibiotic use could decrease the occurrence of antimicrobial resistance to some extent.
Genome-Wide Association Study Identifies Candidate Genes That Affect Plant Height in Chinese Elite Maize (Zea mays L.) Inbred Lines
Jianfeng Weng, Chuanxiao Xie, Zhuanfang Hao, Jianjun Wang, Changlin Liu, Mingshun Li, Degui Zhang, Li Bai, Shihuang Zhang, Xinhai Li
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0029229
Abstract: Background The harvest index for many crops can be improved through introduction of dwarf stature to increase lodging resistance, combined with early maturity. The inbred line Shen5003 has been widely used in maize breeding in China as a key donor line for the dwarf trait. Also, one major quantitative trait locus (QTL) controlling plant height has been identified in bin 5.05–5.06, across several maize bi-parental populations. With the progress of publicly available maize genome sequence, the objective of this work was to identify the candidate genes that affect plant height among Chinese maize inbred lines with genome wide association studies (GWAS). Methods and Findings A total of 284 maize inbred lines were genotyped using over 55,000 evenly spaced SNPs, from which a set of 41,101 SNPs were filtered with stringent quality control for further data analysis. With the population structure controlled in a mixed linear model (MLM) implemented with the software TASSEL, we carried out a genome-wide association study (GWAS) for plant height. A total of 204 SNPs (P≤0.0001) and 105 genomic loci harboring coding regions were identified. Four loci containing genes associated with gibberellin (GA), auxin, and epigenetic pathways may be involved in natural variation that led to a dwarf phenotype in elite maize inbred lines. Among them, a favorable allele for dwarfing on chromosome 5 (SNP PZE-105115518) was also identified in six Shen5003 derivatives. Conclusions The fact that a large number of previously identified dwarf genes are missing from our study highlights the discovery of the consistently significant association of the gene harboring the SNP PZE-105115518 with plant height (P = 8.91e-10) and its confirmation in the Shen5003 introgression lines. Results from this study suggest that, in the maize breeding schema in China, specific alleles were selected, that have played important roles in maize production.

Leng Xin,Liu Degui,Song Xiaoqiu,Chen Lirong,

计算数学 , 2006,
Abstract: In this paper, a class of two-step continuity Runge-Kutta(TSCRK) methods for solving delay differential equations where delay lies in the span of the current step is presented. Under certain conditions, we prove the convergence property of the method. Some examples show the efficiency of the method.
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