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Search Results: 1 - 10 of 7266 matches for " Lisa Ayers Lawrence "
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The Bridge Web Site: Growing and Sustaining Partnerships Between Ocean Science and Education
Vicki Price Clark,Lisa Ayers Lawrence,Christopher Petrone,Lee Larkin
Oceanography , 2009,
Abstract: When physicist Tim Berners-Lee and a team of fellow scientists at the European Center for High Energy Physics (CERN) launched the first-ever Web site in 1989, their goal was to make it easier for scientists to access research documents and scientific data (CERN, 2008). In 1998, Virginia Sea Grant educators at the Virginia Institute of Marine Science (VIMS) had a similar goal: to make ocean science educational resources and current research data more accessible to classroom teachers. The Virginia Sea Grant education team took the first step toward accomplishing this goal by launching a Web site of its own, called "Bridge." The name was inspired by the idea of a ship's bridge with a teacher at the helm, navigating "an ocean of marine education data." It also represents a bridge spanning the divide between the education and the ocean research communities, which is the essence of the Bridge project's mission.
Relationships between Cadmium in Tissues of Cacao Trees and Soils in Plantations of Trinidad and Tobago  [PDF]
Gideon Ramtahal, Ivan Chang Yen, Isaac Bekele, Frances Bekele, Lawrence Wilson, Kamaldeo Maharaj, Lisa Harrynanan
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.71005
Abstract: The primary source of cadmium in cocoa beans has been linked to its direct uptake by the cacao plant from cadmium contaminated soils. This research was conducted to evaluate and interpret significant relationships between cadmium levels in tissues of the cacao plant and soils from cocoa-growing areas in Trinidad and Tobago. Total (HNO3-extractable) concentrations of cadmium in both tissues and soils were determined. The levels of cadmium measured varied in the order: leaves > pods > shells > nibs > soil. Cadmium levels in all the cacao tissues analyzed were significantly (p < 0.05), positively and strongly correlated with each other. Additionally, significant (p < 0.05) positive relationships were also identified between Cd in cacao tissues and corresponding total HNO3-extractable Cd levels in soils. These findings suggest that they can possibly be used as predictive tools for assessing Cd levels in cacao.
Mapping Regional Distribution of a Single Tree Species: Whitebark Pine in the Greater Yellowstone Ecosystem
Lisa Landenburger,Rick L. Lawrence,Shannon Podruzny,Charles C. Schwartz
Sensors , 2008, DOI: 10.3390/s8084983
Abstract: Moderate resolution satellite imagery traditionally has been thought to be inadequate for mapping vegetation at the species level. This has made comprehensive mapping of regional distributions of sensitive species, such as whitebark pine, either impractical or extremely time consuming. We sought to determine whether using a combination of moderate resolution satellite imagery (Landsat Enhanced Thematic Mapper Plus), extensive stand data collected by land management agencies for other purposes, and modern statistical classification techniques (boosted classification trees) could result in successful mapping of whitebark pine. Overall classification accuracies exceeded 90%, with similar individual class accuracies. Accuracies on a localized basis varied based on elevation. Accuracies also varied among administrative units, although we were not able to determine whether these differences related to inherent spatial variations or differences in the quality of available reference data.
Mapping Regional Distribution of a Single Tree Species: Whitebark Pine in the Greater Yellowstone Ecosystem
Lisa Landenburger,Rick L. Lawrence,Shannon Podruzny,Charles C. Schwartz
Sensors , 2008,
Abstract: Moderate resolution satellite imagery traditionally has been thought to be inadequate for mapping vegetation at the species level. This has made comprehensive mapping of regional distributions of sensitive species, such as whitebark pine, either impractical or extremely time consuming. We sought to determine whether using a combination of moderate resolution satellite imagery (Landsat Enhanced Thematic Mapper Plus), extensive stand data collected by land management agencies for other purposes, and modern statistical classification techniques (boosted classification trees) could result in successful mapping of whitebark pine. Overall classification accuracies exceeded 90%, with similar individual class accuracies. Accuracies on a localized basis varied based on elevation. Accuracies also varied among administrative units, although we were not able to determine whether these differences related to inherent spatial variations or differences in the quality of available reference data.
Utilisation of Nanoparticle Technology in Cancer Chemoresistance
Duncan Ayers,Alessandro Nasti
Journal of Drug Delivery , 2012, DOI: 10.1155/2012/265691
Abstract: The implementation of cytotoxic chemotherapeutic drugs in the fight against cancer has played an invariably essential role for minimizing the extent of tumour progression and/or metastases in the patient and thus allowing for longer event free survival periods following chemotherapy. However, such therapeutics are nonspecific and bring with them dose-dependent cumulative adverse effects which can severely exacerbate patient suffering. In addition, the emergence of innate and/or acquired chemoresistance to the exposed cytotoxic agents undoubtedly serves to thwart effective clinical efficacy of chemotherapy in the cancer patient. The advent of nanotechnology has led to the development of a myriad of nanoparticle-based strategies with the specific goal to overcome such therapeutic hurdles in multiple cancer conditions. This paper aims to provide a brief overview and recollection of all the latest advances in the last few years concerning the application of nanoparticle technology to enhance the safe and effective delivery of chemotherapeutic agents to the tumour site, together with providing possible solutions to circumvent cancer chemoresistance in the clinical setting.
A Bayesian Method Reexamined
Derek D. Ayers
Computer Science , 2013,
Abstract: This paper examines the "K2" network scoring metric of Cooper and Herskovits. It shows counterintuitive results from applying this metric to simple networks. One family of noninformative priors is suggested for assigning equal scores to equivalent networks.
Effects of Acute Exposure to Moderate Altitude on Vascular Function, Metabolism and Systemic Inflammation
Anne-Christin St?whas, Tsogyal D. Latshang, Christian M. Lo Cascio, Sina Lautwein, Katrin Stadelmann, Noemi Tesler, Lisa Ayers, Kaspar Berneis, Philipp A. Gerber, Reto Huber, Peter Achermann, Konrad E. Bloch, Malcolm Kohler
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070081
Abstract: Background Travel to mountain areas is popular. However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown. Objectives To investigate the effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. Methods In 51 healthy male subjects with a mean (SD) age of 26.9 (9.3) years, oxygen saturation, blood pressure, heart rate, arterial stiffness, lipid profiles, low density lipoprotein (LDL) particle size, insulin resistance (HOMA-index), highly-sensitive C-reactive protein and pro-inflammatory cytokines were measured at 490 m (Zurich) and during two days at 2590 m, (Davos Jakobshorn, Switzerland) in randomized order. The largest differences in outcomes between the two altitudes are reported. Results Mean (SD) oxygen saturation was significantly lower at 2590 m, 91.0 (2.0)%, compared to 490 m, 96.0 (1.0)%, p<0.001. Mean blood pressure (mean difference +4.8 mmHg, p<0.001) and heart rate (mean difference +3.3 bpm, p<0.001) were significantly higher at 2590 m, compared to 490 m, but this was not associated with increased arterial stiffness. At 2590 m, lipid profiles improved (median difference triglycerides ?0.14 mmol/l, p = 0.012, HDL +0.08 mmol/l, p<0.001, total cholesterol/HDL-ratio ?0.25, p = 0.001), LDL particle size increased (median difference +0.45 nm, p = 0.048) and hsCRP decreased (median difference ?0.18 mg/l, p = 0.024) compared to 490 m. No significant change in pro-inflammatory cytokines or insulin resistance was observed upon ascent to 2590 m. Conclusions Short-term stay at moderate altitude is associated with increased blood pressure and heart rate likely due to augmented sympathetic activity. Exposure to moderate altitude improves the lipid profile and systemic inflammation, but seems to have no significant effect on glucose metabolism. Trial Registration ClinicalTrials.gov NCT01130948
Fixed Monthly versus Less Frequent Ranibizumab Dosing and Predictors of Visual Response in Exudative Age-Related Macular Degeneration
Seenu M. Hariprasad,Lawrence S. Morse,Howard Shapiro,Pamela Wong,Lisa Tuomi
Journal of Ophthalmology , 2012, DOI: 10.1155/2012/690641
Abstract: Purpose. To examine temporal patterns of visual acuity (VA) response to pooled 0.3 mg/0.5 mg ranibizumab treatment in patients with age-related macular degeneration and identify potential baseline predictors of response. Design. Retrospective analysis. Methods. Results from 1824 ranibizumab-treated patients receiving fixed monthly, quarterly, or as-needed dosing after three monthly loading doses in four phase III/IIIb trials (ANCHOR, MARINA, PIER, and SAILOR) were analyzed. Results. At month 3, 14.9% to 29.4% of patients had gained ≥15 letters. Not all patients achieved peak gains at month 3; many continued to have VA increases throughout treatment. After three monthly loading doses, continued monthly dosing resulted in further gains, as there were more delayed 15-letter responders at month 12 (14.7–16.1%) than with less frequent dosing (5.0–6.0%). Monthly dosing also resulted in more patients maintaining VA gains at later time points. Early 15-letter responders had lower baseline mean VA than delayed 15-letter responders in ANCHOR and MARINA; no other differences in baseline characteristics were noted. Conclusions. Although some patients have rapid improvements in VA, others do not experience peak VA until later during treatment. Continued monthly dosing resulted in a greater percentage of patients gaining ≥15 letters than with switching to less frequent dosing regimens.
Lung Cancer Presenting as Acrometastasis to the Finger: A Case Report
Lawrence Stephen Long,Leslea Brickner,Lisa Helfend,Tony Wong,Derek Kubota
Case Reports in Medicine , 2010, DOI: 10.1155/2010/234289
Abstract: Lung cancer is the commonest cause of acrometastatic disease to the fingers. Here we describe a case of occult lung cancer presenting as unrelenting finger pain and swelling from a metastatic phalangeal fracture. The patient's management was largely palliative and he died soon after discovery of the primary tumor. Digital acrometastatic disease rarely becomes symptomatic before the primary lung cancer is diagnosed and, as observed in this case, carries a very poor prognosis. Clinicians should be cognizant of the strong association between digital acrometastases and bronchogenic carcinoma and vigilant in screening high-risk patients with importunate finger symptoms.
Fixed Monthly versus Less Frequent Ranibizumab Dosing and Predictors of Visual Response in Exudative Age-Related Macular Degeneration
Seenu M. Hariprasad,Lawrence S. Morse,Howard Shapiro,Pamela Wong,Lisa Tuomi
Journal of Ophthalmology , 2012, DOI: 10.1155/2012/690641
Abstract: Purpose. To examine temporal patterns of visual acuity (VA) response to pooled 0.3?mg/0.5?mg ranibizumab treatment in patients with age-related macular degeneration and identify potential baseline predictors of response. Design. Retrospective analysis. Methods. Results from 1824 ranibizumab-treated patients receiving fixed monthly, quarterly, or as-needed dosing after three monthly loading doses in four phase III/IIIb trials (ANCHOR, MARINA, PIER, and SAILOR) were analyzed. Results. At month 3, 14.9% to 29.4% of patients had gained ≥15 letters. Not all patients achieved peak gains at month 3; many continued to have VA increases throughout treatment. After three monthly loading doses, continued monthly dosing resulted in further gains, as there were more delayed 15-letter responders at month 12 (14.7–16.1%) than with less frequent dosing (5.0–6.0%). Monthly dosing also resulted in more patients maintaining VA gains at later time points. Early 15-letter responders had lower baseline mean VA than delayed 15-letter responders in ANCHOR and MARINA; no other differences in baseline characteristics were noted. Conclusions. Although some patients have rapid improvements in VA, others do not experience peak VA until later during treatment. Continued monthly dosing resulted in a greater percentage of patients gaining ≥15 letters than with switching to less frequent dosing regimens. 1. Introduction During the pivotal phase III clinical trials of ranibizumab for the treatment of age-related macular degeneration (AMD), MARINA (Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab In the Treatment of Neovascular Age-Related Macular Degeneration) and ANCHOR (ANti-VEGF Antibody for the Treatment of Predominantly Classic CHORoidal Neovascularization in Age-Related Macular Degeneration), patients were treated with ranibizumab using a fixed monthly dosing regimen that resulted in 35.7% and 40.3% of patients in ANCHOR and 24.8% and 33.8% of patients in MARINA experiencing ≥15 letter visual acuity (VA) gains at month 12 (ranibizumab 0.3?mg and 0.5?mg, resp.) [1, 2]. At month 12, mean VA improvements were 8.5 and 11.3 letters from baseline in ANCHOR and 6.5 and 7.2 letters in MARINA (in patients treated with ranibizumab 0.3?mg and 0.5?mg, resp.) [1, 2]. Lack of clinically significant differences between the lower and higher doses of ranibizumab and rapid mean VA increases in the initial 3 months that were sustained in later months suggested that monthly dosing may have reached a “ceiling effect” with no additional improvement in VA possible at those doses. As
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