Abstract:
Acute Tubular Necrosis (ATN) causes severe damage to the kidney epithelial tubular cells and is often associated with severe renal dysfunction. Stem-cell based therapies may provide alternative approaches to treating of ATN. We have previously shown that clonal c-kitpos stem cells, derived from human amniotic fluid (hAFSC) can be induced to a renal fate in an ex-vivo system. Herein, we show for the first time the successful therapeutic application of hAFSC in a mouse model with glycerol-induced rhabdomyolysis and ATN. When injected into the damaged kidney, luciferase-labeled hAFSC can be tracked using bioluminescence. Moreover, we show that hAFSC provide a protective effect, ameliorating ATN in the acute injury phase as reflected by decreased creatinine and BUN blood levels and by a decrease in the number of damaged tubules and apoptosis therein, as well as by promoting proliferation of tubular epithelial cells. We show significant immunomodulatory effects of hAFSC, over the course of ATN. We therefore speculate that AFSC could represent a novel source of stem cells that may function to modulate the kidney immune milieu in renal failure caused by ATN.

Abstract:
Suppose customers need to choose when to arrive to a congested queue with some desired service at the end, provided by a single server that operates only during a certain time interval. We study a model where the customers incur not only congestion (waiting) costs but also penalties for their index of arrival. Arriving before other customers is desirable when the value of service decreases with every admitted customer. This may be the case for example when arriving at a concert or a bus with unmarked seats or going to lunch in a busy cafeteria. We provide game theoretic analysis of such queueing systems with a given number of customers, specifically we characterize the arrival process which constitutes a symmetric Nash equilibrium.

Abstract:
Let $S_\lambda$ denote the Specht module defined by Dipper and James for the Iwahori-Hecke algebra $\mathscr{H}_n$ of the symmetric group $\mathfrak{S}_n$. When $e=2$ we determine the decomposability of all Specht modules corresponding to hook partitions $(a,1^b)$. We do so by utilising the Brundan-Kleshchev isomorphism between $\mathscr{H}$ and a Khovanov-Lauda-Rouquier algebra and working with the relevant KLR algebra, using the set-up of Kleshchev-Mathas-Ram. When $n$ is even, we easily arrive at the conclusion that $S_\lambda$ is indecomposable. When $n$ is odd, we find an endomorphism of $S_\lambda$ and use it to obtain a generalised eigenspace decomposition of $S_\lambda$.

Abstract:
This study aims to assess the impact of technological specification and innovation dynamics in Schumpeterian perspective on the technological performance (innovation) of firms. Using an original data construction, our empirical analysis is carried out with patent and survey databases on French firms. We classify the various possible determinants of innovation into two groups of variables; firm-specific variables and sectorial-specific variables. We utilise patent data from European Patent Office (EPO) database (classified in 30 technological classes), survey of the R&D resources and, firm’s surveys in French (EAE) for French firms for the period 1993-2001. The results of our count data models show that entrepreneurial activity increases the innovation output and the sectorial-specific variables have an impact on patent application.

Abstract:
Due to the nonlinearities inherent in electromagnetic suspension systems, it is difficult to design a linear controller which gives satisfactory performance and stability over a wide range of operating points. Besides, uncertainties in modeling of the system make it difficult to control the system robustly. The parameter uncertainties such as mass and electric resistance variations of the system and external disturbances affect the performance of the system. In this study a sliding mode controller is designed which is robust to bounded mass and electric resistance changes and reject the external disturbances. Besides the robustness of the mentioned controller, its simplicity makes it interesting to apply to Electromagnetic Suspension System. The system and controller are simulated in Matlab/simulink environment. The results of the simulations confirm the satisfactory performance and robustness of the designed controller against uncertainties and disturbances.

Abstract:
In this paper, we study direct and indirect Galerkin method for solving linear Integral-Algebraic Equations of index 1. Convergence of indirect method is also analyzed.

Abstract:
The definition of index for differential algebraic equations (DAEs) or integral algebraic equations (IAEs) in the linear case (time variable) depends only on the coefficients of integrals or differential operators and the coefficients of the unknown functions. Is this possible for the nonlinear case? In this paper we answer this question. In this paper, we generalize the index notion for the nonlinear case. One of the difficulties for nonlinear case, is its dependence on the exact solution which motivates us to give an important warning to whom want to solve DAEs using numerical methods such as Runge-Kutta, multistep or collocation methods.

Abstract:
Consider an undirected weighted graph G=(V,E) with |V|=n and |E|=m, where each vertex v is assigned a label from a set L of \ell labels. We show how to construct a compact distance oracle that can answer queries of the form: "what is the distance from v to the closest lambda-labeled node" for a given node v in V and label lambda in L. This problem was introduced by Hermelin, Levy, Weimann and Yuster [ICALP 2011] where they present several results for this problem. In the first result, they show how to construct a vertex-label distance oracle of expected size O(kn^{1+1/k}) with stretch (4k - 5) and query time O(k). In a second result, they show how to reduce the size of the data structure to O(kn \ell^{1/k}) at the expense of a huge stretch, the stretch of this construction grows exponentially in k, (2^k-1). In the third result they present a dynamic vertex-label distance oracle that is capable of handling label changes in a sub-linear time. The stretch of this construction is also exponential in k, (2 3^{k-1}+1). We manage to significantly improve the stretch of their constructions, reducing the dependence on k from exponential to polynomial (4k-5), without requiring any tradeoff regarding any of the other variables. In addition, we introduce the notion of vertex-label spanners: subgraphs that preserve distances between every node v and label lambda. We present an efficient construction for vertex-label spanners with stretch-size tradeoff close to optimal.

Abstract:
An approximate distance oracle is a succinct data structure that provides fast answers to distance queries between any two nodes. In this paper we consider approximate distance oracles for general undirected graphs with non-negative edge weights with constant query time. We present a distance oracle of size O(k n^{1+1/k}), with 2k-1 stretch and O(1) query time. This improves the O(log{k}) query time of Wulff-Nilsen's distance oracle [SODA '13], which in turn improved the O(k) query time of Thorup and Zwick's distance oracle [J. ACM '05].

Human
functioning is influenced by the affective state. The literature contains
several references to the possibility that valence and arousal have separable
influences on attention. There are several methods of inducing affective state
but the most popular are by music and video clips. The latter are more vivid
and stimulate several sensory systems, leading to the hypothesis that a
stronger effect will result when using video clips for the induction of
affective state. Both methods have been used in many studies in the past but
their different contributions have never really been tested. Thus the aim of
the present study is to systematically establish or refute the assumption that
video clips are the stronger tool for affect induction. In order to test this
hypothesis a study was conducted in which 194 subjects participated in four
groups. Positive and negative affect conditions were induced by validated music
and video clips. The results established the validity of the hypothesis. The
results should be applied in cognitive research testing the relations between
induced affect and cognitive abilities in order to determine whether the effect
is replicated when the cognitive abilities are tested.