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Search Results: 1 - 10 of 24102 matches for " Liqin Jiang "
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Thiolated chitosan-modified PLA-PCL-TPGS nanoparticles for oral chemotherapy of lung cancer
Liqin Jiang, Xuemin Li, Lingrong Liu and Qiqing Zhang
Nanoscale Research Letters , 2013, DOI: 10.1186/1556-276X-8-66
Abstract: Oral chemotherapy is a key step towards ‘chemotherapy at home’, a dream of cancer patients, which will radically change the clinical practice of chemotherapy and greatly improve the quality of life of the patients. In this research, three types of nanoparticle formulation from commercial PCL and self-synthesized d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-PCL-TPGS) random copolymer were prepared in this research for oral delivery of antitumor agents, including thiolated chitosan-modified PCL nanoparticles, unmodified PLA-PCL-TPGS nanoparticles, and thiolated chitosan-modified PLA-PCL-TPGS nanoparticles. Firstly, the PLA-PCL-TPGS random copolymer was synthesized and characterized. Thiolated chitosan greatly increases its mucoadhesiveness and permeation properties, thus increasing the chances of nanoparticle uptake by the gastrointestinal mucosa and improving drug absorption. The PLA-PCL-TPGS nanoparticles were found by FESEM that they are of spherical shape and around 200 nm in diameter. The surface charge of PLA-PCL-TPGS nanoparticles was reversed from anionic to cationic after thiolated chitosan modification. The thiolated chitosan-modified PLA-PCL-TPGS nanoparticles have significantly higher level of the cell uptake than that of thiolated chitosan-modified PLGA nanoparticles and unmodified PLA-PCL-TPGS nanoparticles. In vitro cell viability studies showed advantages of the thiolated chitosan-modified PLA-PCL-TPGS nanoparticles over Taxol in terms of cytotoxicity against A549 cells. It seems that the mucoadhesive nanoparticles can increase paclitaxel transport by opening tight junctions and bypassing the efflux pump of P-glycoprotein. In conclusion, PLA-PCL-TPGS nanoparticles modified by thiolated chitosan could enhance the cellular uptake and cytotoxicity, which revealed a potential application for oral chemotherapy of lung cancer.
Synthesis of the Key Precursor of Hirsutellide A
Yanjie Xu,Xuemin Duan,Meiling Li,Liqin Jiang,Guangle Zhao,Yi Meng,Ligong Chen
Molecules , 2005, DOI: 10.3390/10010259
Abstract: Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
The Association between Leptin Level and Breast Cancer: A Meta-Analysis
Jingping Niu, Le Jiang, Weiheng Guo, Liang Shao, Yi Liu, Liqin Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0067349
Abstract: Background Contradictory results have been reported regarding the association between leptin level and breast cancer. Therefore, a meta-analysis was performed to investigate this issue. Methods Published literature from PubMed and the Chinese National Knowledge Infrastructure (CNKI) Database was retrieved. This study was performed based on different cases and control groups. The combined effect () with 95% confidence interval (CI) was calculated using fixed-effects or random-effects model analysis. Results Overall, the mean serum leptin level of case groups was significantly higher than that of control groups. A) For 9 studies comparing breast cancer cases and healthy controls the combined effect was 0.58 with 95% CI (0.48, 0.68). B) For 4 studies comparing premenopausal breast cancer cases and healthy controls the was 0.32 (0.12, 0.52). C) For 5 studies comparing postmenopausal cases and healthy controls the was 0.65 (0.46, 0.84). D) For 4 studies comparing breast cancer cases and breast benign controls the was 0.38 (0.17, 0.59). E) For 2 studies comparing premenopausal breast cancer cases and breast benign controls the was 0.33 (-0.25, 0.91). F) For 6 studies comparing postmenopausal breast cancer cases and breast benign controls the was 0.39 (0.19, 0.60). G) For 4 studies comparing lymph node metastasis positive cases and negative controls the was 0.72 (0.45, 1.00). H) For 3 studies comparing breast benign cases and healthy controls the was 0.71 (0.41, 1.01). Conclusion This meta-analysis suggests that leptin level plays a role in breast cancer and has potential for development as a diagnostic tool.
The Authority and Construction of the Confucian Classics Hermeneuticst
Liqin LI
Cross-Cultural Communication , 2012, DOI: 10.3968/2302
Abstract: Confucian Classics, The Thirteen Ching, have been regarded as Canon in the traditional Chinese hermeneutics. Confucian scholars’ultimate telos is to understand the significance of Confucian Classics. The Confucian Classics hermeneutics, which is related to Confucian scholars’ultimate concern, has not been served entirely as the theory of the art of interpretation but the ontological hermeneutics from the beginning.However, it is the interpretation that has given and established its authority. And, it requires a hermeneutical reflection of some sophistication to discover how it is possible to acquire and regain its scholarly legitimacy in Chinese history. The Confucian Classics had been understood and interpreted in a different way by Confucian scholars, in fact, it is a kind of transmission and sharing of a unified belief in Confucian Tao and Sheng. It is necessary to interpret the continuity of meaning or the break in some given stages in the course of construction of the Chinese Classics hermeneutics, in which the interpretation systematicity has been established as well. Key words: Classics; Authority; Confucian Classics Hermeneutics; Interpretation; Understanding Résumé: Les confucéens classiques, le Yi King Treize, ont été considérés comme Canon dans l’herméneutique traditionnelle chinoise confucéenne scholars’ultimate telos est de comprendre la signification de Classiques confucéens Le herméneutique confucéenne Classics, qui est liée à confucéenne préoccupation scholars’ultimate, a pas été entièrement desservi que la théorie de l’art de l’interprétation, mais l’herméneutique ontologique de la beginning.However, c’est l’interprétation qui a donné et a établi son autorité. et, il nécessite une réflexion herméneutique de certaine sophistication de découvrir comment il est possible d’acquérir et de retrouver sa légitimité scientifique dans l’histoire chinoise. Les Classiques confucéens ont été comprises et interprétées d’une manière différente par les lettrés confucéens, en fait, il est une sorte de transmission et le partage d’une croyance unifiée dans confucéenne Tao et Sheng. il est nécessaire d’interpréter la continuité de signification ou de la rupture dans certains stades donnés dans le cadre de la construction de la Chine herméneutique Classics, dans lequel la systématicité interprétation a été créé ainsi. Mots clés: Classiques, l’Autorité, Les Confucéens classques, Herméneutique; Interprétation, La Compréhension
Enlightenment on the Crisis of Confucian Hermeneutics in Song Dynasty and the Establishment of the Ultimate Concern in Confucianism
Liqin LI
Canadian Social Science , 2012, DOI: 10.3968/j.css.1923669720120802.788
Abstract: “Scholars are determined to follow Dao.” Confucianists conform to “Dao”, which transcends their realm of cognition. “Dao” is inevitably represented through the medium of the “studies” on Confucianism. Therefore, the Confucian Hermeneutics as the ultimate concern for the Confucianists is designed to be Existential Hermeneutics from the very beginning, part of which is the Technical Hermeneutics. When Zhu Xi set a self-evident Absolute Presupposition for the benevolent Dao with his hermeneutics about “heart-nature-reason”, the ultimate concern in Confucianism which the Confucianists had been seeking was fully established on an ontological sense. The piety and veneration contained in it might enlighten the contemporary academics and thoughts on beliefs. Key words: Confucian Hermeneutics; Crisis; Ultimate concern; Zhu Xi Résumé “Shi zhi yu dao,” le “dao” et le confucianisme et au-delà même, la présentation du “dao” sera inévitablement la capacité de compter sur ”par les médias. Par conséquent, concernant quant à la préoccupation ultime des classiques l’herméneutique confucéenne, depuis le début de la série, c’est qu’il ya des théories herméneutique, c’est plut t que de simplement sur les compétences herméneutique. Lorsque l’interprétation de la raison des conceptions de Zhu Xi “pour le chemin de la vertu et de défi nir la base absolue pour un ensemble de soi du confucianisme, des lettres confucéens a cherché à construire dans le sens ontologique d’y terminer par la préoccupation ultime. L’implication de ces crainte pieuse, ou peut être une révélation de penser académique d’aujourd’hui et de la foi. Mots clés: Interprêtations du classique; Dangers; Attachement fi nale; Zhu Xi
Restoring Culture Back to Its True Nature: The Perception of “Culture” in Traditional Chinese Hermeneutics
Liqin LI
Canadian Social Science , 2012, DOI: 10.3968/2328
Abstract: In the ancient The Book of Change of China, “script” means the manifestation of all things into certain phenomena or appearances. The “human scripts” refers to the human culture that “saints are using to organize things”. In this sense, “culture” refers to “achieving universal peace and order” with the “scripts” as the means of education so as to realize the harmony and prosperity of the world. In this case, the cultural activities show the meaning of things in nature or the artificial products, which presents the unique lifestyles and values of the Chinese people. The concept of “culture” in traditional Chinese Hermeneutics has become a “meaningful pattern” because of the people living with it. Key words: Chinese culture; Traditional Chinese Hermeneutics; The Book of Change; Achieving universal peace and order with scripts Résumé Dans le livre ancien de Chine qui s’intitule ‘‘Mutations’’,le sens du texte se réfère aux cieux et la terre est affichée dans tous les phénomènes de l’extérieur (la manifestation) ou physionomie, les sciences humaines se réfèrent aux saints utilisées pour soigner la question de la culture humaine. En ce sens, la culture est le texte dans sont définies par l’illumination de la culture , de manière à parvenir à la paix et l’ordre d’efficacité. à ce stade, le point culminant des activités culturelles, est la caractérisation de la signification des objets naturels ou artificiels pièce, qui ont été présentés dans des ensembles de style de vie unique et des valeurs. Concept traditionnel chinois herméneutique de la culture dans l’arrière-plan, en raison des activités de personnes au cours de la spéciale forme significative . Mots clés : La culture chinoise; L’Interprêtation du chinois traditionnel; Livre des Mutations; Le texte traduit en
The Effect of Plant Growth Regulator and Active Charcoal on the Development of Microtubers of Potatoes  [PDF]
Maolin Peng, Xiyao Wang, Liqin Li
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.311185
Abstract: With the detoxicated seedling of a potato cultivation breed named “Mire” as the material, the effect of auxins CCC, 6-BA, and active carbon to microtubers of potato (Solanum tubersum L.) was investigated under the in-vitro circumstances. The result indicated the exogenous auxins improved the production and quality of microtubers of potatoes. The effect of induction can be described as CCC > CCC + 6-BA > 6-BA > CK, the number of microtubers in per flask is 8.17 > 7.67 > 7.29 > 5.46, and the number of large potatoes in per flask is 6.33 > 5.17 > 3.17 > 1. In addition, by adding 0.5‰ of active charcoal, the growth period was shortened from 25.0 days to 9.33 days on average, and the amount of larger potatoes increased 8.54%. These results benefited the growth of microtubers of potato.
Select estrogens within the complex formulation of conjugated equine estrogens (Premarin?) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease
Liqin Zhao, Roberta Brinton
BMC Neuroscience , 2006, DOI: 10.1186/1471-2202-7-24
Abstract: Cultured basal forebrain neurons were exposed to either β-amyloid25–35 or excitotoxic glutamate with or without pretreatment with estrogens followed by neuroprotection analyses. Three indicators of neuroprotection that rely on different aspects of neuronal damage and viability, LDH release, intracellular ATP level and MTT formazan formation, were used to assess neuroprotective efficacy. Results of these analyses indicate that the estrogens, 17α-estradiol, 17β-estradiol, equilin, 17α-dihydroequilin, equilinen, 17α-dihydroequilenin, 17β-dihydroequilenin, and Δ8,9-dehydroestrone were each significantly neuroprotective in reducing neuronal plasma membrane damage induced by glutamate excitotoxicity. Of these estrogens, 17β-estradiol and Δ8,9-dehydroestrone were effective in protecting neurons against β-amyloid25–35-induced intracellular ATP decline. Coadministration of two out of three neuroprotective estrogens, 17β-estradiol, equilin and Δ8,9-dehydroestrone, exerted greater neuroprotective efficacy than individual estrogens. Computer-aided analyses to determine structure/function relationships between the estrogenic structures and their neuroprotective activity revealed that the predicted intermolecular interactions of estrogen analogues with ER correlate to their overall neuroprotective efficacy.The present study provides the first documentation of the neuroprotective profile of individual estrogens contained within the complex formulation of CEE at concentrations commensurate with their plasma levels achieved after an oral administration of 0.625 mg CEE in women. Our analyses demonstrate that select estrogens within the complex formulation of CEE contribute to its neuroprotective efficacy. Moreover, our data predict that the magnitude of neuroprotection induced by individual estrogens at relatively low concentrations may be clinically undetectable and ineffective, whereas, a combination of select neuroprotective estrogens could provide an increased and clinically mean
Coh-Metrix: A Computational Tool to Discriminate Writing Qualities
Wang Hongwei,Yan Liqin
International Education Studies , 2012, DOI: 10.5539/ies.v5n2p204
Abstract: The editorial board announced that this article has been retracted on November 27, 2012. If you have any further question, please contact us at: ies@ccsenet.org
Gaming of Strategy--Strategic Realignment of Chinese Dairy Industry
Liqin Shan,Jinzhao An
International Business Research , 2010, DOI: 10.5539/ibr.v3n3p222
Abstract: Over the past ten-odd years, the dizzying prosperity and rapid development achieved in Chinese Dairy Industrial t actually covered up a fundamental defect concerning the strategy, which eventually led to the "Melamine Event”. Today, the troubled waters have been poured oil on, but it still needs time to be recovered. China's Dairy Industry, which suffered heavy losses and casualties, is about to seek for a transformation and will have to help himself out of the crisis. This paper will apply the game theory of "Prisoner's Dilemma" case to reflect the strategic defects appeared in the early dairy industrial development, with the combination of the new changes in the dairy industrial development environment after "Melamine Event”, it also points out that the key to revitalize the domestic dairy enterprises is to put the emphasis on the nature of the dairy industry itself, to return to consumers standard, to try to establish the undifferentiated marketing strategy and differentiated marketing strategy system.
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