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Search Results: 1 - 10 of 104125 matches for " Linkun Zhang "
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Effects of Tension Force on Proliferation and Differentiation of Human Periodontal Ligament Cells Induced by Lipopolysaccharides  [PDF]
Yanqi Yang, Linkun Zhang, Chongshan Liao, Jiajing Lu, Chengfei Zhang
Journal of Biosciences and Medicines (JBM) , 2014, DOI: 10.4236/jbm.2014.23003
Abstract: Human periodontal ligament cells (hPDLCs), with the potential for multi-directional differentiation and reproduction, are the target cells of orthodontic tooth movement. The aim of this study was to examine the effect of mechanical tension force and lipopolysaccharides (LPS) on hPDLCs and whether they induce proliferative and differentiated characters in vitro. Tension force was applied to hPDLCs stimulated with and without LPS for 24 hrs. Real-time polymerase chain reaction (qPCR) was carried out to analyze the mRNA expression of Cyclin 2 (CCND2), WNT1 inducible signaling pathway protein 1 (WISP1), runt-related transcription factor 2 (RUNX2) and alkaline phosphatase (ALP). Analysis of variance (ANOVA) was used for statistical analysis. Significant differences were indicated by P < 0.05. The results showed that tension force promoted the mRNA expression of both the proliferation-related genes (CCND2 and WISP1) and differentiation-related genes (RUNX2 and ALP), and that both were enhanced by the simulation of LPS. In addition, the relative expression ratios CCND2/RUNX2 and CCND2/ALP both increased significantly after the application of tension, and this effect was further enhanced by LPS. All results indicated that with the assessed level of mechanical force loading, tension could promote both the proliferation and differentiation of hPDLCs, which could be enhanced by LPS, and that proliferation is promoted to a greater extent than differentiation. These findings may be valuable for understanding the importance of the application of suitable mechanical force in periodontal remodeling, especially in the process of orthodontic tooth movement with inflammation.
Blended learning in dentistry: 3-D resources for inquiry-based learning
Yanqi Yang,Linkun Zhang,Susan Bridges
Knowledge Management & E-Learning : an International Journal , 2012,
Abstract: Motivation is an important factor for inquiry-based learning, so creative design of learning resources and materials is critical to enhance students’ motivation and hence their cognition. Modern dentistry is moving towards “electronic patient records” for both clinical treatment and teaching. Study models have long been an essential part of dental records. Traditional plaster casts are, however, among the last type of clinical record in the dental field to be converted into digital media as virtual models. Advantages of virtual models include: simpler storage; reduced risk of damage, disappearance, or misplacement; simpler and effective measuring; and easy transferal to colleagues. In order to support student engagement with the rapidly changing world of digital dentistry, and in order to stimulate the students’ motivation and depth of inquiry, this project aims to introduce virtual models into a Bachelor and Dental Surgery (BDS) curriculum. Under a “blended” e-learning philosophy, students are first introduced to the new software then 3-D models are incorporated into inquiry-based problems as stimulus materials. Face-to-face tutorials blend virtual model access via interactive whiteboards (IWBs). Students’ perceptions of virtual models including motivation and cognition as well as the virtual models’ functionality were rated after a workshop introducing virtual models and plaster models in parallel. Initial student feedback indicates that the 3-D models have been generally well accepted, which confirmed the functionality of the programme and the positive perception of virtual models for enhancing students’ learning motivation. Further investigation will be carried out to assess the impact of virtual models on students’ learning outcomes.
Comparative Metaproteomic Analysis on Consecutively Rehmannia glutinosa-Monocultured Rhizosphere Soil
Linkun Wu, Haibin Wang, Zhixing Zhang, Rui Lin, Zhongyi Zhang, Wenxiong Lin
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0020611
Abstract: Background The consecutive monoculture for most of medicinal plants, such as Rehmannia glutinosa, results in a significant reduction in the yield and quality. There is an urgent need to study for the sustainable development of Chinese herbaceous medicine. Methodology/Principal Findings Comparative metaproteomics of rhizosphere soil was developed and used to analyze the underlying mechanism of the consecutive monoculture problems of R. glutinosa. The 2D-gel patterns of protein spots for the soil samples showed a strong matrix dependency. Among the spots, 103 spots with high resolution and repeatability were randomly selected and successfully identified by MALDI TOF-TOF MS for a rhizosphere soil metaproteomic profile analysis. These proteins originating from plants and microorganisms play important roles in nutrient cycles and energy flow in rhizospheric soil ecosystem. They function in protein, nucleotide and secondary metabolisms, signal transduction and resistance. Comparative metaproteomics analysis revealed 33 differentially expressed protein spots in rhizosphere soil in response to increasing years of monoculture. Among them, plant proteins related to carbon and nitrogen metabolism and stress response, were mostly up-regulated except a down-regulated protein (glutathione S-transferase) involving detoxification. The phenylalanine ammonia-lyase was believed to participate in the phenylpropanoid metabolism as shown with a considerable increase in total phenolic acid content with increasing years of monoculture. Microbial proteins related to protein metabolism and cell wall biosynthesis, were up-regulated except a down-regulated protein (geranylgeranyl pyrophosphate synthase) functioning in diterpenoid synthesis. The results suggest that the consecutive monoculture of R. glutinosa changes the soil microbial ecology due to the exudates accumulation, as a result, the nutrient cycles are affected, leading to the retardation of plant growth and development. Conclusions/Significance Our results demonstrated the interactions among plant, soil and microflora in the proteomic level are crucial for the productivity and quality of R. glutinosa in consecutive monoculture system.
The Rb-Sr age and geological implication of alkaline syenitic complex from Liangtun-Kuangdonggou at Gaixian, eastern Liaoning Province
Baoliang Xu,Guohan Yan,Baolei Mu,Linkun Tan,Zhongfu He,Guangsheng Qiao,Renhu Zhang
Chinese Science Bulletin , 1999, DOI: 10.1007/BF02909712
Abstract: Liangtun-Kuangdonggou complex, 30 km southeast of Gaixian Town, Liaoning Province, is composed of aegirine-augite hornblende syenite, aegirine-augite syenite, hornblende syenite, pyroxene syenite and syeno-aegirinolite. Rb-Sr isotopic data to the complex are reported and used for discussion of chronology and geological implication. They show that the complex occurred in early Proterozoic and is a tectonic sign of extension setting. Moreover, the date indicates that the Liaohe Group, which is metamorphic wall rock of the complex, formed over 1 900 Ma ago.
The Rb-Sr age and geological implication of alkaline syenitic complex from Liangtun-Kuangdonggou at Gaixian,eastern Liaoning Province

Baoliang Xu,Guohan Yan,Baolei Mu,Linkun Tan,Zhongfu He,Guangsheng Qiao,Renhu Zhang,

科学通报(英文版) , 1999,
Abstract: Liangtun-Kuangdonggou complex, 30 km southeast of Gaixian Town, Liaoning Province, is composed of aegirine-augite hornblende syenite, aegirine-augite syenite, hornblende syenite, pyroxene syenite and syeno-aegirinolite. Rb-Sr isotopic data to the complex are reported and used for discussion of chronology and geological implication. They show that the complex occurred in early Proterozoic and is a tectonic sign of extension setting. Moreover, the date indicates that the Liaohe Group, which is metamorphic wall rock of the complex, formed over 1 900 Ma ago.
An Efficient and Concise Algorithm for Convex Quadratic Programming and Its Application to Markowitz’s Portfolio Selection Model  [PDF]
Zhongzhen Zhang, Huayu Zhang
Technology and Investment (TI) , 2011, DOI: 10.4236/ti.2011.24024
Abstract: This paper presents a pivoting-based method for solving convex quadratic programming and then shows how to use it together with a parameter technique to solve mean-variance portfolio selection problems.
Investigation and Analysis of Sexual Harassment in Corporate Workplace of China  [PDF]
Xiaobing Zhang, Zewei Zhang
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.23038
Abstract: At present, sexual harassment in domestic workplace has a high probability of occurrence, which causes more and more attention. In this paper, the form of sexual harassment in workplace, and how to solve the sexual harassment were investigated and analyzed through questionnaires; and countermeasures and management suggestions were put forward from three aspects of corporate, employees and family.
Chaos Control in a Discrete Ecological System  [PDF]
Limin Zhang, Chaofeng Zhang
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2012, DOI: 10.4236/ijmnta.2012.13011
Abstract: In research [1], the authors investigate the dynamic behaviors of a discrete ecological system. The period-double bifurcations and chaos are found in the system. But no strategy is proposed to control the chaos. It is well known that chaos control is the first step of utilizing chaos. In this paper, a controller is designed to stabilize the chaotic orbits and enable them to be an ideal target one. After that, numerical simulations are presented to show the correctness of theoretical analysis.
Crystallization and Characterization of a New Fluorescent Molecule Based on Schiff Base  [PDF]
Dehua Zhang, Xiaoyan Zhang
Journal of Crystallization Process and Technology (JCPT) , 2013, DOI: 10.4236/jcpt.2013.31004
Abstract:


In this analysis, the single crystal of schiff base has been synthesized and the purity of material has been increased by repeated recrystallization process. Single crystal was grown by adopting the method growing in a slow evaporation solution using ethanol as solvent at room temperature. A new fluorescent molecule based on Schiff base has been synthesised and its binding properties investigated by fluorescence spectroscopy to show that it can selectively bind Cu2+ with fluorescence quenching.


Mathematical Reasoning of Economic Intervening Principle Based on “Yin Yang Wu Xing” Theory in Traditional Chinese Economics (I)  [PDF]
Ziqing Zhang, Yingshan Zhang
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.42016
Abstract:

By using mathematical reasoning, this paper demonstrates the economic intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” and “ Strong inhibition of the same time, support the weak” based on “Yin Yang Wu Xing” Theory in Traditional Chinese Economics (TCE). We defined generalized relations and generalized reasoning, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the intervening principle of TCE and treated the economic society as a steady multilateral system, it has been proved that the intervening principle above is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.

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