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Search Results: 1 - 10 of 67670 matches for " Linhares José Juvenal "
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Resultados perinatais em grávidas com mais de 35 anos: estudo controlado
Andrade, Priscilla Chamelete;Linhares, José Juvenal;Martinelli, Silvio;Antonini, Marcelo;Lippi, Umberto Gazi;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000900004
Abstract: purpose: to evaluate perinatal results in pregnant women over 35 years old and to check differences between two groups: 35 to 39-year-old women and women older than 40. methods: a retrospective survey was made during the period between january/2000 and july/2003, through the analysis of obstetric charts of 3,093 pregnant women who delivered in the "hospital do servidor público estadual - francisco morato de oliveira", excluding 933 patients. the patients were divided into 3 groups: 18 to 29 years old (control group), 35 to 39 years old, and over 40 years old. data collection was done with standardized forms, and the data were transferred to an electronic spreadsheet (excel - microsoft office 2000). statistical analysis was performed using the c2 test and the fisher test. the alpha risk was less or equal to 5% and the confidence interval 95%. results: cesarean section was the most used method not only in the 35 to 39-year-old group (438/792; 55.3%) but also in the group of women over 40 (153/236; 64.8%). the rates of prematurity (39/236; 16.5%), low weight (37/236; 15.7%), and restriction of fetal growth (38/236; 16.1%) were significantly higher in the group of women over 40, when compared to the other groups. concerning fetal death, a five times higher incidence was observed in the group over 40 years old, as compared to the other groups, a statistically significant difference. conclusion: the only difference between the 35 to 39-year-old group and the control group was the cesarean section rate. this allows us to suggest a differentiated prenatal attendance for pregnant women over 40.
Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer
Linhares José Juvenal,Azevedo Marcos,Siufi Adalberto Abra?o,de Carvalho Cristina Valleta
BMC Medical Genetics , 2012, DOI: 10.1186/1471-2350-13-119
Abstract: Background Emerging evidence has shown that miRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) located in pre-miRNAs may affect the processing and therefore, influence the expression of mature miRNAs. Previous studies generated conflicting results when reporting association between the hsa-miR-196a2 rs11614913 common polymorphism and breast cancer. Methods This study evaluated the hsa-miR-196a2 rs11614913 SNP in 388 breast cancer cases and 388 controls in Brazilian women. Polymorphism was determined by real-time PCR; control and experimental groups were compared through statistical analysis using the X2 or Fisher’s exact tests. Results The analysis of the SNPs frequencies showed a significant difference between the groups (BC and CT) in regards to genotype distribution (χ2: p = 0.024); the homozygous variant (CC) was more frequent in the CT than in the BC group (p = 0.009). The presence of the hsa-miR-196a2 rs11614913 C/T polymorphism was not associated with histological grades (p = 0.522), axillary lymph node positive status (p = 0.805), or clinical stage (p = 0.670) among the breast cancer patients. Conclusions The results of this study indicated that the CC polymorphic genotype is associated with a decreased risk of BC and the presence of the T allele was significantly associated with an increased risk of BC.
High risk pregnancy referrals adequacy in the Basic Health Services of Sobral, Ceará, Brazil
José Juvenal Linhares,Samille Frota Monte Coelho,érica Monteiro Vieira,Eugênio Araújo Costa
Einstein (S?o Paulo) , 2009,
Abstract: Objective: To describe the appropriateness of referrals of high-risk pregnancies in the basic healthcare network of Sobral, in Ceará, Brazil. Methods: A descriptive quantitative study. The medical files of 173 pregnant patients referred to the high-risk outpatient clinic of Centro de Especialidades Médicas of Sobral, during the period from July 2006 to April 2007, were analyzed. Variables analyzed were correctness of the referrals, professionals who made them, causes and origins of the referrals, and age bracket of the patients referred. The referrals were divided into “appropriate” and “inappropriate”, according to the classification of risk established by the technical manual of the Ministry of Health. Rresults: Of the 173 cases, 102 (59%) were considered appropriate/correct, and 71 (41%) referrals were considered inappropriate/incorrect. The referrals were divided according to the professional class of the referring individuals: physicians or nurses. Of the 173 referrals, 49 (28.3%) were made by physicians, and 124 (71.7%) by nurses. Of the 49 patients referred by physicians, 39 (79.6%) were considered correct. Of the 124 referrals made by nurses, 63 (50.8%) were considered incorrect, revealing a significant difference between the groups (p < 0.00001). The most common causes of referrals of pregnant patients were hypertensive syndromes (23.6%), physiological modifications of pregnancy (22.6%), prolonged pregnancy (15.1%), and diabetes (12.3%). Cconclusions: There was a low rate of appropriate/correct referrals. There is a need for training in the basic healthcare network for quality prenatal care, with special emphasis on referring nurses.
Comprimento cervical como preditor do período de latência e de infec??o na rotura prematura pré-termo de membranas
Sousa, Carla Roberta Macedo de;Linhares, José Juvenal;Arcanjo, Francisco Carlos Nogueira;Andrade, Renata Nogueira;Vieira, Márcio Fragoso;
Revista Brasileira de Ginecologia e Obstetrícia , 2012, DOI: 10.1590/S0100-72032012000400004
Abstract: purpose: to verify cervical length using transvaginal ultrasonography in pregnant women between 28 and 34 weeks of gestation, correlating it with the latent period and the risk of maternal and neonatal infections. methods: 39 pregnant women were evaluated and divided into groups based on their cervical length, using 15, 20 and 25 mm as cut-off points. the latency periods evaluated were three and seven days. included were pregnant women with live fetuses and gestational age between 28 and 34 weeks, with a confirmed diagnosis on admission of premature rupture of membranes. patients with chorioamnionitis, multiple gestation, fetal abnormalities, uterine malformations (bicornus septate and didelphic uterus), history of previous surgery on the cervix (conization and cerclage) and cervical dilation greater than 2 cm in nulliparous women and 3 cm in multiparae were excluded from the study. results: a <15 mm cervical length was found to be highly related to a latency period of up to 72 hours (p=0.008). a <20 mm cervical length was also associated with a less than 72 hour latency period (p=0.04). a <25 mm cervical length was not found to be statistically associated with a 72 hour latency period (p=0,12). there was also no significant correlation between cervical length and latency period and maternal and neonatal infection. conclusion: the presence of a short cervix (<15 mm) was found to be related to a latency period of less than 72 hours, but not to maternal or neonatal infections.
Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
JOSé JUVENAL LINHARES,ISMAEL DALE COTRIM GUERREIRO DA SILVA,NAIARA C NOGUEIRA DE SOUZA,EMMANUELLE COELHO NORONHA
Biological Research , 2005,
Abstract: Due to the conflicting results regarding the association between breast cancerand the GSTM1 null mutation, our aim was to research this associationin a Brazilian population and correlations withsmoking, reproductive history and several clinical pathologies. A case-control study was performed on 105 women with breast cancer and 278 controls. Extraction of DNA was accomplished according to the protocol of the GFX kit and polymorphism analysis by the PCR technique. The control and experimental groups were compared and statistical analysis assessed by X2 or Fisher's exact test. The deletion in the GSTM1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. In the control group, the null mutation was present in 104 (37.4%) women. Upon comparison of the two groups, no statistically significant difference of the GSTM1 gene was observed, with an odds ratio (OR) of 0.74, 95%, confidence interval (CI) 0.45 - 1.20, p = 0.277. The results conclusively show that singlegene GSTM1 polymorphisms do not confer a substantial risk of breastcancer to its carriers. Furthermore, in this study no correlation was found between GSTs andsmoking, reproductive history and several clinical pathologies with respect to cancer risk.
Epidemiology of vulvar lichen sclerosus and its correlation with other conditions
José Juvenal Linhares,Julieta Massabni Zalc,Renata de Loreto Ribeiro do Val,Eduardo Sérgio Borges da Fonseca
Einstein (S?o Paulo) , 2003,
Abstract: OBJECTIVES: To investigate some epidemiological data of lichensclerosus patients; to verify its association with other conditionsand compare these data with the literature. METHODS:Retrospective analysis of medical records of patients submitted to12,724 vaginal/cervical examinations and vulvoscopies, at Hospitaldo Servidor Público Estadual “Francisco Morato de Oliveira” – S oPaulo, from August 1998 to August 2001. RESULTS: The frequencyof lichen sclerosus confirmed by pathological examination was0.73% among these patients. Mean age was 63.6 years. Mostpatients presenting the condition were aged over 50 years (81/93), and the difference was statistically significant as comparedwith younger subjects (12/93). Caucasian women represented91.4% of the sample and black, 8.6%. Smokers accounted for 8.6%of the cases. Autoimmune diseases were detected in 31.2%,psychiatric disorders in 17.2%, and neoplasms in 11.8% of thosesuffering from lichen sclerosus. The colpocytology of one patientwas classified as Papanicolaou class V. CONCLUSION: These datashow the population studied presented findings similar to thosereported in the literature.
Coexistência de linfadenite axilar tuberculosa e metástase ganglionar de carcinoma lobular de mama: relato de um caso
Linhares, José Juvenal;Millen, Eduardo Camargo;Antonini, Marcelo;Fagundes, Pedro César;Falc?o, Pedro Gustavo;Araújo Neto, Joaquim Teodoro de;
Revista Brasileira de Ginecologia e Obstetrícia , 2005, DOI: 10.1590/S0100-72032005000700009
Abstract: report of a case of an 83-year-old woman presenting a nodule and skin retraction in the right breast for eight months. on physical examination, a solid nodule of 5 cm was observed, located in the upper-lateral quadrant of the right breast, associated with skin retraction and ipsilateral lymph nodes. mammographic findings showed irregularly limited nodules of 4 cm in the upper-lateral quadrant of the right breast (bi-rads v). clinical staging: t2n1m0 (iib). surgical treatment included a modified radical mastectomy with axillary dissection levels i, ii, and iii. histopathologic evaluation demonstrated the presence of an infiltrating lobular carcinoma measuring 2.5 cm (t2), presence of granulomatous lymphadenitis caused by tuberculosis in level i, ii, and iii lymph nodes, associated with lobular carcinoma metastasis in a single level i lymph node. pathologic staging: pt2pn1am0. the treatment for the axillary tuberculous lymphadenitis was done with rifampin, isoniazid and pyrazinamide for one year. hormone receptors were positive, and adjuvant therapy was initiated with tamoxifen. during the first year of follow-up the patient had no signal of local recurrence or distant metastases.
Tratamento de gesta??o cervical viável com aplica??o intra-amniótica de metotrexato: relato de um caso
Linhares, José Juvenal;Prado, Daniela Siqueira;Silva, Hudson Ferraz e;Garcia, Sidney Logrosa;David, Simone Denise;Ruas, Fabiana;Lippi, Umberto Gazzi;
Revista Brasileira de Ginecologia e Obstetrícia , 2006, DOI: 10.1590/S0100-72032006001000007
Abstract: cervical pregnancy is a rare condition in which the egg is implanted in the cervical canal causing it to distend as the egg grows. cervical pregnancy constitutes less than 1% of all ectopic pregnancies. painless hemorrhage is a habitual clinical characteristic and on physical examination a very vascularized hypertrophic cervix is observed with a tissue surpassing the external orifice. ultrasonography may be used as a complementary diagnostic tool to show directly the presence of a gestational sac. a successful management of a viable seven-week gestation cervical pregnancy is reported herein. feticide was performed with a single intraamniotic methotrexate injection (25 mg) guided by transvaginal ultrasonography. systemic methotrexate in a single dose intramuscular (50 mg/m2) was associated. the conservative management of cervical ectopic pregnancy with methotrexate was effective and safe.
Polimorfismo do gene do receptor de progesterona (PROGINS) em mulheres com cancer de mama: estudo caso-controle
Linhares, José Juvenal;Silva, Ismael Dale Cotrim Guerreiro da;Souza, Naiara Correa Nogueira de;Noronha, Emmanuelle Coelho;Ferraro, Odair;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2005, DOI: 10.1590/S0100-72032005000800007
Abstract: purpose: to analyze the correlation between progins polymorphism and breast cancer. methods: a case-control study was carried out from april to october 2004. the genotypes of 50 women with breast cancer and 49 healthy women were analyzed. the 306-base pair alu insertion polymorphism in the g intron of progesterone receptor gene was detected by polymerase chain reaction and analyzed on 2% agarose gel stained with ethidium bromide. the control and experimental groups were compared regarding genotypes using the statistical epi-info 6.0 program and for frequencies the exact fisher test or c2 test were used. p value smaller p than 5% was considered to be significant. results: in relation to progins we found in the studied population a prevalence of 62 (62.6%) wild homozygous, 35 (35.3%) heterozygous individuals and two (2.1%) cases with the presence of the mutation. regarding progins polymorphism, significance was not evidenced when cases and controls were compared, as related to homozygosis (62 vs 65.3%), heterozygosis (36 vs 34,6%) or the mutation (2.0 vs 2.1%), with p=0.920 (or=1.01), 0.891 (or=1.06), and 0.988 (or=1.10), respectively. conclusions: the results show that single-gene progins polymorphism does not confer a substantial risk of breast cancer to its carriers.
Prevalência de coloniza??o por Streptococcus agalactiae em gestantes atendidas em maternidade do Ceará, no Brasil, correlacionando com os resultados perinatais
Linhares, José Juvenal;Cavalcante Neto, Pedro Gomes;Vasconcelos, Janssen Loiola Melo;Saraiva, Thiago de Vasconcelos;Ribeiro, Amélia Mayara Frota;Siqueira, Tamises Melo;Rocha, Francisco Ruliglésio;
Revista Brasileira de Ginecologia e Obstetrícia , 2011, DOI: 10.1590/S0100-72032011001200004
Abstract: purpose: to assess the prevalence of streptococcus agalactiae, a group b streptococcus, in pregnant women, and their possible risk factors, as well as the impact of perinatal colonization and antimicrobial susceptibility. methods: we evaluated 213 pregnant women from 20 weeks of gestation, regardless of risk factors, attending a tertiary teaching hospital. the technique used was a single sterile swab to collect secretions from the vaginal and perianal regions. the newly obtained samples were stored in stuart transport medium and taken to the laboratory, where they were inoculated in todd-hewitt selective medium supplemented with gentamicin (8 ug/ml) and nalidixic acid (15 ug/ml), with subsequent cultivation on blood agar plates. the materials were tested with gram, catalase with hydrogen peroxide and camp (christie, atkins, munch-petersen), and results were serologically confirmed with the streptococcal grouping kit, oxoid?. the positive samples were tested for antimicrobial susceptibility. we also assessed socioeconomic, reproductive, clinical, and obstetric variables, and newborn care. statistical analysis was performed with epi-info 6.04. results: the prevalence of colonization obtained by field tests was 9.8% by camp test, but only 4.2% by serology. the only protective factor was white skin color (p=0.01, 0.45>or>0.94, 95%ci). there was no difference in prevalence of group b streptococcus regarding other reproductive and obstetric variables. infection occurred in only one of the newborns from colonized mothers; although it was revealed infection with pseudomonas spp. high resistance to ampicillin (4/9), cephalothin (4/9), penicillin (4/9), erythromycin (3/9), clindamycin (7/9), and cloramphenicol (1/9) was detected. conclusions: the infection rate was lower than that found in other studies, although a high rate of resistance to antibiotics commonly used for treatment was detected. since there are no studies on the prevalence of group b streptococcus in ceará, we
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