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Search Results: 1 - 10 of 625481 matches for " Linda S. Lindstr?m "
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Is Genetic Background Important in Lung Cancer Survival?
Linda S. Lindstrm, Per Hall, Mikael Hartman, Fredrik Wiklund, Kamila Czene
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005588
Abstract: Background In lung cancer, a patient's survival is poor with a wide variation in survival within the stage of disease. The aim of this study was to investigate the familial concordance in lung cancer survival by means of analyses of pairs with different degrees of familial relationships. Methods Our population-based Swedish family database included three million families and over 58 100 lung cancer patients. We modelled the proband (parent, sibling, spouse) survival utilizing a multivariate proportional hazard (Cox) model adjusting for possible confounders of survival. Subsequently, the survival in proband's relative (child, sibling, spouse) was analysed with a Cox model. Findings By use of Cox modelling with 5 years follow-up, we noted a decreased hazard ratio for death in children with good parental survival (Hazard Ratio [HR] = 0.71, 95% CI = 0.51 to 0.99), compared to those with poor parental survival. Also for siblings, a very strong protective effect was seen (HR = 0.14, 95% CI = 0.030 to 0.65). Finally, in spouses no correlation in survival was found. Interpretation Our findings suggest that genetic factors are important in lung cancer survival. In a clinical setting, information on prognosis in a relative may be vital in foreseeing the survival in an individual newly diagnosed with lung cancer. Future molecular studies enhancing the understanding of the underlying mechanisms and pathways are needed.
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling
Mikael S. Lindstr m
Biochemistry Research International , 2011, DOI: 10.1155/2011/195209
Abstract: At a first glance, ribosome biogenesis and chromatin remodeling are quite different processes, but they share a common problem involving interactions between charged nucleic acids and small basic proteins that may result in unwanted intracellular aggregations. The multifunctional nuclear acidic chaperone NPM1 (B23/nucleophosmin) is active in several stages of ribosome biogenesis, chromatin remodeling, and mitosis as well as in DNA repair, replication and transcription. In addition, NPM1 plays an important role in the Myc-ARF-p53 pathway as well as in SUMO regulation. However, the relative importance of NPM1 in these processes remains unclear. Provided herein is an update on the expanding list of the diverse activities and interacting partners of NPM1. Mechanisms of NPM1 nuclear export functions of NPM1 in the nucleolus and at the mitotic spindle are discussed in relation to tumor development. It is argued that the suggested function of NPM1 as a histone chaperone could explain several, but not all, of the effects observed in cells following changes in NPM1 expression. A future challenge is to understand how NPM1 is activated, recruited, and controlled to carry out its functions.
Elucidation of Motifs in Ribosomal Protein S9 That Mediate Its Nucleolar Localization and Binding to NPM1/Nucleophosmin
Mikael S. Lindstrm
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052476
Abstract: Biogenesis of eukaryotic ribosomes occurs mainly in a specific subnuclear compartment, the nucleolus, and involves the coordinated assembly of ribosomal RNA and ribosomal proteins. Identification of amino acid sequences mediating nucleolar localization of ribosomal proteins may provide important clues to understand the early steps in ribosome biogenesis. Human ribosomal protein S9 (RPS9), known in prokaryotes as RPS4, plays a critical role in ribosome biogenesis and directly binds to ribosomal RNA. RPS9 is targeted to the nucleolus but the regions in the protein that determine its localization remains unknown. Cellular expression of RPS9 deletion mutants revealed that it has three regions capable of driving nuclear localization of a fused enhanced green fluorescent protein (EGFP). The first region was mapped to the RPS9 N-terminus while the second one was located in the proteins C-terminus. The central and third region in RPS9 also behaved as a strong nucleolar localization signal and was hence sufficient to cause accumulation of EGFP in the nucleolus. RPS9 was previously shown to interact with the abundant nucleolar chaperone NPM1 (nucleophosmin). Evaluating different RPS9 fragments for their ability to bind NPM1 indicated that there are two binding sites for NPM1 on RPS9. Enforced expression of NPM1 resulted in nucleolar accumulation of a predominantly nucleoplasmic RPS9 mutant. Moreover, it was found that expression of a subset of RPS9 deletion mutants resulted in altered nucleolar morphology as evidenced by changes in the localization patterns of NPM1, fibrillarin and the silver stained nucleolar organizer regions. In conclusion, RPS9 has three regions that each are competent for nuclear localization, but only the central region acted as a potent nucleolar localization signal. Interestingly, the RPS9 nucleolar localization signal is residing in a highly conserved domain corresponding to a ribosomal RNA binding site.
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling
Mikael S. Lindstrm
Biochemistry Research International , 2011, DOI: 10.1155/2011/195209
Abstract: At a first glance, ribosome biogenesis and chromatin remodeling are quite different processes, but they share a common problem involving interactions between charged nucleic acids and small basic proteins that may result in unwanted intracellular aggregations. The multifunctional nuclear acidic chaperone NPM1 (B23/nucleophosmin) is active in several stages of ribosome biogenesis, chromatin remodeling, and mitosis as well as in DNA repair, replication and transcription. In addition, NPM1 plays an important role in the Myc-ARF-p53 pathway as well as in SUMO regulation. However, the relative importance of NPM1 in these processes remains unclear. Provided herein is an update on the expanding list of the diverse activities and interacting partners of NPM1. Mechanisms of NPM1 nuclear export functions of NPM1 in the nucleolus and at the mitotic spindle are discussed in relation to tumor development. It is argued that the suggested function of NPM1 as a histone chaperone could explain several, but not all, of the effects observed in cells following changes in NPM1 expression. A future challenge is to understand how NPM1 is activated, recruited, and controlled to carry out its functions. 1. Introduction Ribosome biogenesis and chromatin remodeling are different processes but some parallels can be drawn. Similar to the deposition of histones onto DNA, ribosomal proteins have to bind ribosomal RNA (rRNA), and it has been assumed that both processes are prone to aggregation. With regard to size and charge, histones are reminiscent of ribosomal proteins, namely, small and basic. Histones can be divided into core histones and the H1 family of linker histones. Core histones H2A, H2B, H3, and H4 associate as H2A/H2B dimers and H3/H4 tetramers to form the histone octamer, that thus contains two H2A/H2B dimers and a H3/H4 tetramer, that the DNA is wrapped around forming a repetitive structure known as the nucleosome. Assembly of histone octamer complexes with the help of chaperones was proposed to be an ancestral feature of eukaryotes [1]. Histone chaperones are factors that bind histones and stimulate reactions involving histone transfer without being part of the final product [2]. They can be involved in histone transfer onto DNA (deposition), off DNA (eviction), from one chaperone to another, and finally histone chaperones could facilitate transfer to enzymes that use histones as substrates [2]. An emerging trend is the increasing appreciation for more active roles of histone chaperones in chromatin remodeling, for instance to increase transcription rates and
Language learning in a wiki: Student contributions in a web based learning environment
Linda Bradley,Berner Lindstrm,Hans Rystedt,Sylvi Vigmo
Themes in Science and Technology Education , 2010,
Abstract: Emerging social writing platforms offer possibilities for language learners to collaboratearound joint assignments. One such environment is the wiki, generally hosting two prominentmodes of usage, web pages and discussion forums. This study investigates softwareengineering students’ use of a wiki as an integrated tool within the frames of a languagecourse. The purpose of the case study was to investigate the student interaction in a studentdriven design setting and what the implications are for language learning in such anenvironment. The findings show that the two modes of interaction host primarily three typesof activity, contributing and writing together, evaluating and peer reviewing, and arguing anddiscussing. These three activities convey different ways of collaborating and sharing textonline. Once a group had chosen a mode for their collaboration, they tend to stay with itthroughout their work.
Silencing of Ribosomal Protein S9 Elicits a Multitude of Cellular Responses Inhibiting the Growth of Cancer Cells Subsequent to p53 Activation
Mikael S. Lindstrm,Monica Nistér
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009578
Abstract: Disruption of the nucleolus often leads to activation of the p53 tumor suppressor pathway through inhibition of MDM2 that is mediated by a limited set of ribosomal proteins including RPL11 and RPL5. The effects of ribosomal protein loss in cultured mammalian cells have not been thoroughly investigated. Here we characterize the cellular stress response caused by depletion of ribosomal protein S9 (RPS9).
The Importance of Dispersal for Bacterial Community Composition and Functioning
Eva S. Lindstrm, ?rjan ?stman
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025883
Abstract: We conducted a metacommunity experiment to investigate the role of dispersal for bacterial community composition (BCC) and function of freshwater bacteria. Bacteria were dispersed from a common source pool into three different lake communities in their natural lake water. The experiment was conducted in dialysis bags to enable a decoupling between a change in the local environment and dispersal. BCC was determined by terminal restriction fragment length polymorphism (tRFLP) of the 16S rRNA gene. We show that the greatest changes in BCC occurred between 10% and 43% of dispersal of standing stock per day. Functioning, measured as growth rate, was also affected by dispersal in all three communities but the qualitative pattern differed between communities, sometimes showing a hump-shaped relationship to dispersal and sometimes decreasing with increasing dispersal. In all waters, functioning was related to BCC. Our results show that dispersal does affect BCC and functioning but that high dispersal rates are needed. Further, the effect of dispersal on BCC and function seem to depend on the quality of the habitat to which bacteria disperse into.
A note on erythrocyte reduced glutathione levels and there relationship with weight gain in Finnsheep
F Atroshi, S ?sterberg, UB Lindstrm
Genetics Selection Evolution , 1980, DOI: 10.1186/1297-9686-12-4-420a
Abstract:
A note on erythrocyte reduced glutathione levels and there relationship with weight gain in Finnsheep
Atroshi F,?sterberg S,Lindstrm UB
Genetics Selection Evolution , 1980, DOI: 10.1186/1297-9686-12-4-420
Abstract:
On the Stability-complexity Relation for Unsaturated Semelpareous Discrete Food-chains
Torsten Lindstrm,Gunnar S?derbacka
Studies in Mathematical Sciences , 2010,
Abstract: In this paper we formally prove that invading carnivores in the discrete food-chain derived and preliminary analyzed in [2] always makes the system less stable and thus, limit the food-chain length in the corresponding system. Hence, invading unsaturated carnivores are not able to stabilize oscillatory dynamics. What we prove constitutes a significant difference between discrete and continuous food-chains. Actually, Freedman and Waltman [3] related the stabilizing properties of an invading carnivore in continuous food-chains to absence of saturation: An unsaturated carnivore keeps at least one interior equilibrium - if one exists - locally stable. One consequence is that the dynamics of unsaturated discrete food-chains display similarities with saturated continuous food-chains. Indeed, discrete dynamics seem to have a similar destabilizing impact on the dynamics as saturation has. Key Words: Stability-complexity relation; Discrete food-chains
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