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Search Results: 1 - 10 of 152834 matches for " Linda H. Passmore "
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MicroRNA-218 Is Deleted and Downregulated in Lung Squamous Cell Carcinoma
Morgan R. Davidson,Jill E. Larsen,Ian A. Yang,Nicholas K. Hayward,Belinda E. Clarke,Edwina E. Duhig,Linda H. Passmore,Rayleen V. Bowman,Kwun M. Fong
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012560
Abstract: MicroRNAs (miRNAs) are a family of small, non-coding RNA species functioning as negative regulators of multiple target genes including tumour suppressor genes and oncogenes. Many miRNA gene loci are located within cancer-associated genomic regions. To identify potential new amplified oncogenic and/or deleted tumour suppressing miRNAs in lung cancer, we inferred miRNA gene dosage from high dimensional arrayCGH data. From miRBase v9.0 (http://microrna.sanger.ac.uk), 474 human miRNA genes were physically mapped to regions of chromosomal loss or gain identified from a high-resolution genome-wide arrayCGH study of 132 primary non-small cell lung cancers (NSCLCs) (a training set of 60 squamous cell carcinomas and 72 adenocarcinomas). MiRNAs were selected as candidates if their immediately flanking probes or host gene were deleted or amplified in at least 25% of primary tumours using both Analysis of Copy Errors algorithm and fold change (≥±1.2) analyses. Using these criteria, 97 miRNAs mapped to regions of aberrant copy number. Analysis of three independent published lung cancer arrayCGH datasets confirmed that 22 of these miRNA loci showed directionally concordant copy number variation. MiR-218, encoded on 4p15.31 and 5q35.1 within two host genes (SLIT2 and SLIT3), in a region of copy number loss, was selected as a priority candidate for follow-up as it is reported as underexpressed in lung cancer. We confirmed decreased expression of mature miR-218 and its host genes by qRT-PCR in 39 NSCLCs relative to normal lung tissue. This downregulation of miR-218 was found to be associated with a history of cigarette smoking, but not human papilloma virus. Thus, we show for the first time that putative lung cancer-associated miRNAs can be identified from genome-wide arrayCGH datasets using a bioinformatics mapping approach, and report that miR-218 is a strong candidate tumour suppressing miRNA potentially involved in lung cancer.
Genetic influences on right ventricular systolic pressure (RVSP) in chronic obstructive pulmonary disease (COPD)
Janet G Shaw, Annette G Dent, Linda H Passmore, Darryl J Burstow, Rayleen V Bowman, Paul V Zimmerman, Kwun M Fong, Ian A Yang
BMC Pulmonary Medicine , 2012, DOI: 10.1186/1471-2466-12-25
Abstract: In patients with COPD, we genotyped 7 SNPs in 6 candidate PH genes (NOS3, ACE, EDN1, PTGIS, SLC6A4, VEGFA). We tested for association with right ventricular systolic pressure (RVSP), spirometry and gas transfer, and hypoxemia.580 COPD patients were recruited, 341 patients had a transthoracic echocardiogram, with RVSP measurable in 278 patients (mean age 69?years, mean FEV1 50% predicted, mean RVSP 44?mmHg, median history of 50 pack-years). Of the 7 tested SNPs, the NOS3-VNTR polymorphism was significantly associated with RVSP in a dose-dependent fashion for the risk allele: mean RVSP for a/a and a/b genotypes were 52.0 and 46.6?mmHg respectively, compared to 43.2?mmHg for b/b genotypes (P?=?0.032). No associations were found between RVSP and other polymorphisms. ACE II or ID genotypes were associated with a lower FEV1% predicted than the ACE DD genotype (P?=?0.028). The NOS3-298 TT genotype was associated with lower KCO % predicted than the NOS3-298 GG or GT genotype (P?=?0.031).The NOS3-VNTR polymorphism was associated with RVSP in patients with COPD, supporting its involvement in the pathogenesis of PH in COPD. ACE and NOS3 genotypes were associated with COPD disease severity, but not with the presence of PH. Further study of these genes could lead to the development of prognostic and screening tools for PH in COPD.Pulmonary hypertension (PH) is a serious complication of chronic obstructive pulmonary disease (COPD) and develops in 30% to 70% of patients with COPD, increasing their morbidity and mortality [1]. PH is progressive in COPD, with mean pulmonary arterial pressure increasing over time [2,3]. Understanding variations in susceptibility to PH in patients with COPD could significantly enhance diagnosis, risk stratification and therapy for these patients.Vascular remodelling is the main pathological feature in PH and is mediated via vasoactive molecules [4]. Genes encoding these mediators contain genetic polymorphisms that potentially affect their function and
A Higher Education Leadership Distance Ph.D. Program: An Assessment Using Blocher’s Ecological Learning Theory  [PDF]
Linda Kuk, James H. Banning
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.59082
Abstract:

This study utilized a case study approach to discuss the issues of distance education in the delivery of doctoral education. The case study provided abroad background to the issues of distance education graduate programs and an assessment of the case. Blocher’s (1974) Ecological Learning Theory is applied to the case to provide for analytical generalization. The results support the need for distance delivery of academic programs to consider both the content and the program’s delivery structure as important components in realizing student success.

Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis  [PDF]
D. Staines, S. Du Preez, H. Cabanas, C. Balinas, N. Eaton, R. Passmore, R. Maksoud, J. Redmayne, S. Marshall-Gradisnik
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.95038
Abstract: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disabling condition of unknown cause having multi-system manifestations. Our group has investigated the potential role of transient receptor potential (TRP) ion channels in the etiology and pathomechanism of this illness. Store-operated calcium entry (SOCE) signaling is the primary intracellular calcium signaling mechanism in non-excitable cells and is associated with TRP ion channels. While the sub-family (Canonical) TRPC has been traditionally associated with this important cellular mechanism, a member of the TRPM sub-family group (Melastatin), TRPM3, has also been recently identified as participating in SOCE in white matter of the central nervous system. We have identified single nucleotide polymorphisms (SNPs) in TRP genes in natural killer (NK) cells and peripheral blood mononuclear cells (PBMCs) in CFS/ME patients. We also describe biochemical pathway changes and calcium signaling perturbations in blood cells from patients. The ubiquitous distribution of TRP ion channels and specific locations of sub-family group members such as TRPM3 suggest a contribution to systemic pathology in CFS/ME.
Book Review - Sustaining Distance Education: Integrating learning technologies into the fabric of the enterprise. Edited by Zane L. Berge
David Passmore
International Review of Research in Open and Distance Learning , 2002,
Abstract: I am an eager reader of the published works of Zane L. Berge. As director of training systems for the Instructional Systems Development Program at the University of Maryland at Baltimore County, Berge brings a strong intellectual perspective to any discussion of distance education. He has a wide and practical vision of practices in distance education through his extensive consulting experience. Moreover, much of his research and writing does not focus on the desiccated, hair splitting academic disputations in which distance education “theorists” engage frequently. His research and writing in the field of computer-mediated communication gets “down and dirty” with the difficult and often unexamined processes by which technology users collaborate and build community. It is no surprise to me, then, that Berge’s work is often so well received by his peers. He is the co-editor (with Deborah Schreiber) of Distance training: How innovative organizations are using technology to maximize learning and meet business objectives, a 1998 Jossey-Bass volume that won The Charles A. Wedemeyer Award.
Crises in Education: Online Learning as a Solution  [PDF]
Hershey H Friedman, Linda Weiser Friedman
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.23022
Abstract: There are three serious problems facing education today. These include working with draconian budgets that mean reduced spending for education, making education interesting and relevant for students, and raising standards. Several issues that the legislators are especially concerned about are the low retention rates at the college level, the high dropout rates in the high schools, and the long time it takes undergraduate students to graduate college. The authors show how online learning may be an important tool for solving these problems.
The Use of an Agent-Based Programmable Modeling Tool in 8th Grade Students’ Model-Based Inquiry
Lin Xiang,Cynthia Passmore
Journal of the Research Center for Educational Technology , 2010,
Abstract: This is an interpretive case study seeking to develop detailed descriptions of how agent-based programming activities support a group of eighth-grade students in conducting model-based inquiry. Videotape of students’ programming processes and group discussion are used as the data sources to identify student activity and conversation patterns and gain insight into the changes in student understanding. Findings suggest that an agent-based programming task can 1) expose students’ personal model and understandings, 2) provoke and support a series of model-based inquiry activities, such as elaborating target phenomenon, abstracting patterns, and revising conceptual model, and 3) provoke and support tangible and productive conversations among students, as well as between an instructor and students.
Decidability of Univariate Real Algebra with Predicates for Rational and Integer Powers
Grant Olney Passmore
Computer Science , 2015,
Abstract: We prove decidability of univariate real algebra extended with predicates for rational and integer powers, i.e., $(x^n \in \mathbb{Q})$ and $(x^n \in \mathbb{Z})$. Our decision procedure combines computation over real algebraic cells with the rational root theorem and witness construction via algebraic number density arguments.
Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings
Gayle M. Passmore,Joanne M. Reilly,Matthew Thakur,Vanessa N. Keasberry,Stephen J. Marsh,Anthony H. Dickenson,David A. Brown
Frontiers in Molecular Neuroscience , 2012, DOI: 10.3389/fnmol.2012.00063
Abstract: M-channels carry slowly activating potassium currents that regulate excitability in a variety of central and peripheral neurons. Functional M-channels and their Kv7 channel correlates are expressed throughout the somatosensory nervous system where they may play an important role in controlling sensory nerve activity. Here we show that Kv7.2 immunoreactivity is expressed in the peripheral terminals of nociceptive primary afferents. Electrophysiological recordings from single afferents in vitro showed that block of M-channels by 3 μM XE991 sensitized Aδ- but not C-fibers to noxious heat stimulation and induced spontaneous, ongoing activity at 32°C in many Aδ-fibers. These observations were extended in vivo: intraplantar injection of XE991 selectively enhanced the response of deep dorsal horn (DH) neurons to peripheral mid-range mechanical and higher range thermal stimuli, consistent with a selective effect on Aδ-fiber peripheral terminals. These results demonstrate an important physiological role of M-channels in controlling nociceptive Aδ-fiber responses and provide a rationale for the nocifensive behaviors that arise following intraplantar injection of the M-channel blocker XE991.
Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, A?, and Alzheimer's Disease
Minerva M. Carrasquillo,Olivia Belbin,Fanggeng Zou,Mariet Allen,Nilufer Ertekin-Taner,Morad Ansari,Samantha L. Wilcox,Mariah R. Kashino,Li Ma,Linda H. Younkin,Samuel G. Younkin,Curtis S. Younkin,Toros A. Dincman,Melissa E. Howard,Chanley C. Howell,Chloe M. Stanton,Christopher M. Watson,Michael Crump,Veronique Vitart,Caroline Hayward,Nicholas D. Hastie,Igor Rudan,Harry Campbell,Ozren Polasek,Kristelle Brown,Peter Passmore,David Craig,Bernadette McGuinness,Stephen Todd,Patrick G. Kehoe,David M. Mann,A. David Smith,Helen Beaumont,Donald Warden,Clive Holmes,Reinhard Heun,Heike K?lsch,Noor Kalsheker,V. Shane Pankratz,Dennis W. Dickson,Neill R. Graff-Radford,Ronald C. Petersen,Alan F. Wright,Steven G. Younkin,Kevin Morgan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008764
Abstract: The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD).
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