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Search Results: 1 - 10 of 11070 matches for " Lim Young-Hyo "
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A case report of type VI dual left anterior descending coronary artery anomaly presenting with non-ST-segment elevation myocardial infarction
Lee Yonggu,Lim Young-Hyo,Shin Jinho,Kim Kyung-Soo
BMC Cardiovascular Disorders , 2012, DOI: 10.1186/1471-2261-12-101
Abstract: Background Type VI dual left anterior descending artery (LAD) is a rare coronary anomaly, the first case of which has recently been described. This is the first report of type VI dual LAD anomaly in which the patient presented with non-ST-segment elevation myocardial infarction and percutaneous coronary intervention was performed in the anomalously originating LAD. Case presentation A 52-year-old man with diabetes, hypertension and hyperlipidemia presented with chest pain without ST elevation on EKG, although the patient’s troponin I level was elevated. Coronary angiography revealed a short LAD originating from the left main coronary artery and a long LAD originating from the proximal portion of the right coronary artery (RCA). Three-dimensional reconstruction of computed tomography of images revealed that the long LAD originated from the proximal RCA and coursed between the right ventricular outflow tract (RVOT) and the aortic root before entering the mid anterior interventricular groove. The high take-off RCA originated underneath the RVOT, pointing downwards and forming an acute angle with the proximal portion of the long LAD. The anomalous long LAD displayed significant stenosis. We performed successful percutaneous coronary intervention (PCI) in the anomalous artery. Conclusion With accurate understanding of the coronary anatomy and appropriate hardware selection, successful PCI can be performed in the in the long LAD in patients with type VI dual LAD anomaly.
Sinocorophium hangangense sp. n. (Crustacea, Amphipoda, Corophiidae), a new species from Korea, with a key to the genus Sinocorophium
Young-Hyo Kim
ZooKeys , 2012, DOI: 10.3897/zookeys.181.3043
Abstract: A new species of the corophiid gammaridean amphipod belonging to the genus Sinocorophium Bousfield and Hoover was collected from the lower reaches of the Han River in Gyeonggi-do, Korea. A relatively large body size and morphology of the uropods 1 and 3 are the major characteristics which serve to distinguish the new species from its congeners. The new species is fully illustrated and extensively compared with related species. A key to the species of Sinocorophium is also provided.
The Relationship between Adiponectin and Left Ventricular Mass Index Varies with the Risk of Left Ventricular Hypertrophy
Yonggu Lee, Bae Keun Kim, Young-Hyo Lim, Mi Kyung Kim, Bo Youl Choi, Jinho Shin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070246
Abstract: Background Adiponectin directly protects against cardiac remodeling. Despite this beneficial effect, most epidemiological studies have reported a negative relationship between adiponectin level and left ventricular mass index (LVMI). However, a positive relationship has also been reported in subjects at high risk of left ventricular hypertrophy (LVH). Based on these conflicting results, we hypothesized that the relationship between serum adiponectin level and LVMI varies with the risk of LVH. Methods A community-based, cross-sectional study was performed on 1414 subjects. LVMI was measured by echocardiography. Log-transformed adiponectin levels (Log-ADPN) were used for the analysis. Results Serum adiponectin level had a biphasic distribution (an increase after a decrease) with increasing LVMI. Although Log-ADPN did not correlate with LVMI, Log-ADPN was modestly associated with LVMI in the multivariate analysis (β = 0.079, p = 0.001). The relationship between adiponectin level and LVMI was bidirectional according to the risk of LVH. In normotensive subjects younger than 50 years, Log-ADPN negatively correlated with LVMI (r = ?0.204, p = 0.005); however, Log-ADPN positively correlated with LVMI in ≥50-year-old obese subjects with high arterial stiffness (r = 0.189, p = 0.030). The correlation coefficient between Log-ADPN and LVMI gradually changed from negative to positive with increasing risk factors for LVH. The risk of LVH significantly interacted with the relationship between Log-ADPN and LVMI. In the multivariate analysis, Log-ADPN was associated with LVMI in the subjects at risk of LVH; however, Log-ADPN was either not associated or negatively associated with LVMI in subjects at low risk of LVH. Conclusion Adiponectin level and LVMI are negatively associated in subjects at low risk of LVH and are positively associated in subjects at high risk of LVH. Therefore, the relationship between adiponectin and LVMI varies with the risk of LVH.
Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats
Young-Hyo Lim, Jun-Ho Joe, Ki-Seok Jang, Yi-Sun Song, Byung-Im So, Cheng-Hu Fang, Jinho Shin, Jung-Hyun Kim, Heon-Kil Lim, Kyung-Soo Kim
Cardiovascular Diabetology , 2011, DOI: 10.1186/1475-2840-10-92
Abstract: Twenty 7-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF: a rat model of diabetes) rats and 10 male Long-Evans Tokushima Otsuka (LETO: normal controls) rats were used. All of the LETO and 8 OLETF rats were fed on tap water while the rest were fed on sucrose-containing water. After 10 weeks, saline or recombinant human G-CSF (100 μg/kg/day) was injected intraperitoneally for 5 days. Blood levels of glucose, total cholesterol and triglyceride, and Doppler echocardiograms for diastolic dysfunction were obtained just before and 4 weeks after the saline or G-CSF treatment. Light microscopy, electron microscopy (EM) and immunohistochemistry for transforming growth factor-β were employed to examine myocardial histology 4 weeks after the saline or G-CSF treatment.Diastolic dysfunction developed at 17 weeks (before the saline or G-CSF treatment) in the OLETF rats whether or not they were fed sucrose water, but were more severe in those fed sucrose water. Four weeks after saline or G-CSF treatment, diastolic function had recovered in the G-CSF-treated group regardless of sucrose water feeding, and perivascular and/or interstitial fibrosis in the G-CSF-treated group had decreased significantly. TGF-β immunoreactivity in the interstitial and perivascular tissue was also reduced in the G-CSF-treated group, and EM studies revealed less severe disruption of myofilaments and mitochondrial cristae, and decreased collagen deposition.G-CSF can ameliorate cardiac diastolic dysfunction and morphological damage, especially fibrosis of the myocardium, in OLETF rats with diabetic CMP.Diabetic cardiomyopathy (CMP) is defined as cardiac failure when possible etiologies such as alcohol, hypertension, and coronary and structural heart disease have been excluded in diabetic patients [1]. In a previous study using type II diabetes mellitus (DM) rats model, diabetic CMP was characterized functionally by the presence of left ventricular diastolic dysfunction, and histologically by interstit
Population Changes of Moths (Insecta: Lepidoptera) from Mt. Wolchul National Park, Jeollanam-do, Korea
Choi, Sei-Woong,Marana Park,Young-Hyo Chang
Journal of Ecology and Field Biology , 2007,
Abstract: We investigated the moth fauna and monthly changes in moth populations at three sites -Dogapsa, Gyungpodae and Muwisa - in Mt. Wolchul National Park, Jeollanam-do, South Korea. From Februaryto October, 2006, we collected a total of 1677 individuals comprising 348 species in 14 families. Monthly changesin the abundance of species and individuals showed an M-shaped pattern, with the highest peak in June anda second high peak in August. The diversity of the three dominant families (Noctuidae, Geometridae and Pyralidae)at the three sites varied, possibly due to differences in vegetation and other environmental factors. Diversityat Dogapsa was relatively higher than Gyungpodae and Muwisa, but, the fauna at Dogapsa more closelyresembled Muwisa than Gyungpodae. 28 species occurred at the same time in all three sites, included thefamilies Geometridae (14 species), Noctuidae (9 species), Pyralidae (2 species), Arctiidae (1 species), Nolidae(1 species), and Limacodidae (1 species). The present study provided baseline information about biodiversity andphenological patterns of moth abundance and permitted evaluation of moth biodiversity as a monitoring tool forvegetation structure and environmental change.
Luminal and mucosal-associated intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome
Ian M Carroll, Young-Hyo Chang, Jiwon Park, R Balfour Sartor, Yehuda Ringel
Gut Pathogens , 2010, DOI: 10.1186/1757-4749-2-19
Abstract: Fecal and colonic mucosal biopsy samples were obtained from 10 D-IBS patients and 10 healthy controls. Colonic tissue was collected during a un-sedated un-prepped flexible sigmoidoscopy. Fecal and tissue samples were processed immediately upon collection for culture under aerobic and anaerobic conditions or frozen for further molecular analysis. DNA was extracted from all frozen samples and used to enumerate specific bacterial groups using quantitative real-time PCR (qPCR).Culture analysis of intestinal samples demonstrated a significant reduction in the concentration of aerobic bacteria in fecal samples from D-IBS patients when compared to healthy controls (1.4 × 107 vs. 8.4 × 108 CFUs/g feces, P = 0.002). qPCR analysis demonstrated a significant 3.6 fold increase (P = 0.02) in concentrations of fecal Lactobacillus species between D-IBS patients and healthy controls.Our culture and molecular data indicate that quantitative differences exist in specific bacterial groups in the microbiota between D-IBS and healthy subjects.Functional gastrointestinal disorders (FGID) are highly prevalent in Western countries with Irritable Bowel Syndrome (IBS) being the most common (affecting 10-20% of adults and adolescents)[1] and best studied condition. IBS is a heterogeneous disorder that can present as diarrhea-predominant IBS (D-IBS), constipation-predominant IBS (C-IBS), or mixed bowel habit IBS (M-IBS) subsets. Traditionally IBS has been considered a disorder that arises from an altered brain-gut axis that can be associated with gastrointestinal (GI) hypersensitivity and GI motor dysfunction[2,3]. Despite intensive research, the pathophysiology of this disorder is still unclear and no single etiological factor with a defined pathogenic mechanism has been identified. However, studies have implicated new theories that associate specific etiological factors in the pathogenesis of this disorder. These factors include alterations in the normal intestinal microbiota, genetic pre-de
Effects of Background Fluid on the Efficiency of Inactivating Yeast with Non-Thermal Atmospheric Pressure Plasma
Young-Hyo Ryu, Yong-Hee Kim, Jin-Young Lee, Gun-Bo Shim, Han-Sup Uhm, Gyungsoon Park, Eun Ha Choi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066231
Abstract: Non-thermal plasma at atmospheric pressure has been actively applied to sterilization. However, its efficiency for inactivating microorganisms often varies depending on microbial species and environments surrounding the microorganisms. We investigated the influence of environmental factors (surrounding media) on the efficiency of microbial inactivation by plasma using an eukaryotic model microbe, Saccharomyces cerevisiae, to elucidate the mechanisms for differential efficiency of sterilization by plasma. Yeast cells treated with plasma in water showed the most severe damage in viability and cell morphology as well as damage to membrane lipids, and genomic DNA. Cells in saline were less damaged compared to those in water, and those in YPD (Yeast extract, Peptone, Dextrose) were least impaired. HOG1 mitogen activated protein kinase was activated in cells exposed to plasma in water and saline. Inactivation of yeast cells in water and saline was due to the acidification of the solutions by plasma, but higher survival of yeast cells treated in saline may have resulted from the additional effect related to salt strength. Levels of hydroxyl radical (OH.) produced by plasma were the highest in water and the lowest in YPD. This may have resulted in differential inactivation of yeast cells in water, saline, and YPD by plasma. Taken together, our data suggest that the surrounding media (environment) can crucially affect the outcomes of yeast cell plasma treatment because plasma modulates vital properties of media, and the toxic nature of plasma can also be altered by the surrounding media.
Mathematical Modeling of Triphasic Viral Dynamics in Patients with HBeAg-Positive Chronic Hepatitis B Showing Response to 24-Week Clevudine Therapy
Hwi Young Kim, Hee-Dae Kwon, Tae Soo Jang, Jisun Lim, Hyo-Suk Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050377
Abstract: Background Modeling of short-term viral dynamics of hepatitis B with traditional biphasic model might be insufficient to explain long-term viral dynamics. The aim was to develop a novel method of mathematical modeling to shed light on the dissociation between early and long-term dynamics in previous studies. Methods We investigated the viral decay pattern in 50 patients from the phase III clinical trial of 24-week clevudine therapy, who showed virological response and HBsAg decline. Immune effectors were added as a new compartment in the model equations. We determined some parameter values in the model using the non-linear least square minimization method. Results Median baseline viral load was 8.526 Log10copies/mL, and on-treatment viral load decline was 5.683 Log10copies/mL. The median half-life of free virus was 24.89 hours. The median half-life of infected hepatocytes was 7.39 days. The viral decay patterns were visualized as triphasic curves with decreasing slopes over time: fastest decay in the first phase; slowest in the third phase; the second phase in between. Conclusions In the present study, mathematical modeling of hepatitis B in patients with virological response and HBsAg decline during 24-week antiviral therapy showed triphasic viral dynamics with direct introduction of immune effectors as a new compartment, which was thought to reflect the reduction of clearance rate of infected cells over time. This modeling method seems more appropriate to describe long-term viral dynamics compared to the biphasic model, and needs further validation.
Further clarifications of "Necessary and sufficient stability condition of fractional-order interval linear systems"
Hyo-Sung Ahn,Young-Hun Lim,Kwang-Kyo Oh,YangQuan Chen
Mathematics , 2014,
Abstract: This technical report replies to the comments of [2] in detail, and corrects a possible mis-interpretation of [1] in terms of the conventional robust stability concept. After defining the robust stability and quadratic stability concepts, it will be more clearly described that the condition established in [1] can be considered an exact condition for the quadratic stability of fractional-order interval systems.
Progressive Processing of Continuous Range Queries in Hierarchical Wireless Sensor Networks
Jeong-Hoon Lee,Kyu-Young Whang,Hyo-Sang Lim,Byung-Suk Lee,Jun-Seok Heo
Computer Science , 2009, DOI: 10.1587/transinf.E93.D.1832
Abstract: In this paper, we study the problem of processing continuous range queries in a hierarchical wireless sensor network. Contrasted with the traditional approach of building networks in a "flat" structure using sensor devices of the same capability, the hierarchical approach deploys devices of higher capability in a higher tier, i.e., a tier closer to the server. While query processing in flat sensor networks has been widely studied, the study on query processing in hierarchical sensor networks has been inadequate. In wireless sensor networks, the main costs that should be considered are the energy for sending data and the storage for storing queries. There is a trade-off between these two costs. Based on this, we first propose a progressive processing method that effectively processes a large number of continuous range queries in hierarchical sensor networks. The proposed method uses the query merging technique proposed by Xiang et al. as the basis and additionally considers the trade-off between the two costs. More specifically, it works toward reducing the storage cost at lower-tier nodes by merging more queries, and toward reducing the energy cost at higher-tier nodes by merging fewer queries (thereby reducing "false alarms"). We then present how to build a hierarchical sensor network that is optimal with respect to the weighted sum of the two costs. It allows for a cost-based systematic control of the trade-off based on the relative importance between the storage and energy in a given network environment and application. Experimental results show that the proposed method achieves a near-optimal control between the storage and energy and reduces the cost by 0.989~84.995 times compared with the cost achieved using the flat (i.e., non-hierarchical) setup as in the work by Xiang et al.
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