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Search Results: 1 - 10 of 1479 matches for " Lidia Bernadeta Brydak "
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Accuracy of rapid influenza diagnostic test and immunofluorescence assay compared to real time RT-PCR in children with influenza A(H1N1)pdm09 infection
Aneta Nitsch-Osuch,Agnieszka Wo?niak-Kosek,Lidia Bernadeta Brydak
Post?py Higieny i Medycyny Do?wiadczalnej , 2012,
Abstract: Introduction:The influenza burden among children is underestimated. The aim of our study was to estimate the accuracy of the rapid influenza detection test (RIDT) BD Directigen EZ Flu A B and direct immunofluorescence assay (DFA) used among children with influenza-like illness (ILI) consulted in the ambulatory care clinic.Material/Methods:A total of 150 patients were enrolled in the study. Inclusion criteria were: age less than 59 months, presentation of ILI according to the CDC (Centers for Disease Control and Prevention) definition (fever >37.8°C, cough and/or sore throat in the absence of another known cause of illness), duration of symptoms shorter than 96 hours. Two nasal swabs and one pharyngeal swab were obtained from patients and tested by RIDT, DFA and real time RT-PCR as the reference method.Results:For influenza A (H1N1)pdm09 virus sensitivity of RIDT was 62.2 0(95 0CI 46.5–76.2 specificity 97.1 0(95 0CI 91.8–99.4 PPV 90.3 0(95 0CI 74.3–98 NPV 85.7 0(95 0CI 78.1–91.5 for DFA sensitivity was 60 0(95 0CI 51.9–63.2 specificity 96 0(95 0CI 88.7–98.8 PPV 93.1 0(95 0CI 80.5–98 NPV 72.7 0(95 0CI 67.2–74.9 Analysis of logistic regression revealed that the chance of receiving a true positive result of RIDT was twice as high when the test was conducted during the first 48 hours of symptoms (OR 0.40 vs OR 0.22).Conclusions:The accuracy of RIDT is comparable with DFA and both methods are very specific but moderately sensitive in diagnosis of influenza in young children. Both methods may be recommended for screening for influenza among children.
Methods of detection of selected respiratory viruses
Ilona Stefańska,Magdalena Romanowska,Lidia B. Brydak
Post?py Higieny i Medycyny Do?wiadczalnej , 2012,
Abstract: Respiratory viruses contribute to significant morbidity and mortality in healthy and immunocompromised individuals and are considered as a significant economic burden in the healthcare system. The similar clinical symptoms in the course of different viral and bacterial respiratory infections make the proper diagnosis difficult. An accurate and prompt diagnostics is crucial for infection control and patient management decisions, especially regarding the use of antibacterial or antiviral therapy and hospitalization. Moreover, the identification of the causative agent eliminates inappropriate use of antibiotics and may reduce the cost of healthcare.A wide variety of diagnostic procedures is applied for the detection of viral agents responsible for respiratory tract infections. For many years, the viral antigen detection and standard isolation technique in cell culture was the main method used in routine diagnostics. However, in recent years the nucleic acid amplification techniques have become widely used and have significantly improved the sensitivity of viral detection in clinical specimens. Molecular diagnostic assays have contributed to revealing high rates of co-infection (multiplex reactions) and allow identification of agents that are difficult to culture.This paper discusses a number of technical aspects of the current most commonly used techniques, their general principles, main benefits and diagnostic value, but also some of their limitations.
Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma
Karina Jahnz-Ró yk,Lidia B. Brydak,Tomasz Targowski,Magdalena Macha a,Tadeusz P usa
Mediators of Inflammation , 2004, DOI: 10.1080/09511920410001713501
Abstract: BACKGROUND: One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on the migration of eosinophils. Its serum content significantly correlates with the intensity of allergic symptoms, so it might be interesting to know whether vaccination has any influence on serum expression of this chemokine.
Zinc homeostasis and neurodegenerative disorders
Bernadeta Szewczyk
Frontiers in Aging Neuroscience , 2013, DOI: 10.3389/fnagi.2013.00033
Abstract: Zinc is an essential trace element, whose importance to the function of the central nervous system (CNS) is increasingly being appreciated. Alterations in zinc dyshomeostasis has been suggested as a key factor in the development of several neuropsychiatric disorders. In the CNS, zinc occurs in two forms: the first being tightly bound to proteins and, secondly, the free, cytoplasmic, or extracellular form found in presynaptic vesicles. Under normal conditions, zinc released from the synaptic vesicles modulates both ionotropic and metabotropic post-synaptic receptors. While under clinical conditions such as traumatic brain injury, stroke or epilepsy, the excess influx of zinc into neurons has been found to result in neurotoxicity and damage to postsynaptic neurons. On the other hand, a growing body of evidence suggests that a deficiency, rather than an excess, of zinc leads to an increased risk for the development of neurological disorders. Indeed, zinc deficiency has been shown to affect neurogenesis and increase neuronal apoptosis, which can lead to learning and memory deficits. Altered zinc homeostasis is also suggested as a risk factor for depression, Alzheimer's disease (AD), aging, and other neurodegenerative disorders. Under normal CNS physiology, homeostatic controls are put in place to avoid the accumulation of excess zinc or its deficiency. This cellular zinc homeostasis results from the actions of a coordinated regulation effected by different proteins involved in the uptake, excretion and intracellular storage/trafficking of zinc. These proteins include membranous transporters (ZnT and Zip) and metallothioneins (MT) which control intracellular zinc levels. Interestingly, alterations in ZnT and MT have been recently reported in both aging and AD. This paper provides an overview of both clinical and experimental evidence that implicates a dysfunction in zinc homeostasis in the pathophysiology of depression, AD, and aging.
Approximation numbers of Sobolev embeddings of radial functions on isotropic manifolds
Leszek Skrzypczak,Bernadeta Tomasz
Journal of Function Spaces and Applications , 2007, DOI: 10.1155/2007/549247
Abstract: We regard the compact Sobolev embeddings between Besov and Sobolev spaces of radial functions on noncompact symmetric spaces of rank one. The asymptotic formula for the behaviour of approximation numbers of these embeddings is described.
Constitutional Basis for the Civil Rights of Illegitimate Children
Bernadeta Resti Nurhayati
Pattimura Law Journal , 2017, DOI: -
Abstract: The specification of children into "legitimate children" and "illegitimate children" is well-known legally and socially. Illegitimate children suffer discrimination because of their status. In law, they only have their mothers and mother's family. Although there has been a Constitutional Court Decision No. 046 / PUU-VIII / 2010, but it does not automatically raise the dignity of illegitimate children. On the other hand Law No. 24 of 2014 has made the children who were not born from a marriage by religion lose their rights to be recognized. This paper was aimed to find the constitutional basis for the civil rights of illegitimate children as the basis to provide the civil rights for illegitimate children so that their civil rights are protected.The method used in this paper was normative.Based on the review, there is a constitutional basis to provide the protection to the civil rights of illegitimate children.
Asymptotic properties of solutions of some iterative functional inequalities
Dobies?aw Brydak,Bogdan Choczewski,Marek Czerni
Opuscula Mathematica , 2008,
Abstract: Continuous solutions of iterative linear inequalities of the first and second order are considered, belonging to a class $F_T$ of functions behaving at the origin as a prescribed function $T$.
Oxidative/Nitrosative Stress and Protein Damages in Aqueous Humor of Hyperglycemic Rabbits: Effects of Two Oral Antidiabetics, Pioglitazone and Repaglinide
Anna Gumieniczek,Beata Owczarek,Bernadeta Pawlikowska
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/653678
Abstract: The present study was undertaken to determine oxidative/nitrosative stress in aqueous humor of alloxan-induced hyperglycemic rabbits and to investigate the effects of two oral antidiabetic drugs, pioglitazone from peroxisome proliferator-activated receptor gamma (PPARγ) agonists and repaglinide from nonsulfonylurea KATP channel blockers. Ascorbic acid (AA), glutathione (GSH), total antioxidant status (TAS), lipid peroxidation products (LPO), total nitrites (NO2), advanced oxidized protein products (AOPP), and protein carbonyl groups (PCG) were determined using respective colorimetric and ELISA methods. In our hyperglycemic animals, AA decreased by 77%, GSH by 45%, and TAS by 66% as compared to control animals. Simultaneously, LPO increased by 78%, PCG by 60%, AOPP by 84%, and NO2 by 70%. In pioglitazone-treated animals, AA and TAS increased above control values while GSH and PCG were normalized. In turn, LPO was reduced by 54%, AOPP by 84%, and NO2 by 24%, in relation to hyperglycemic rabbits. With repaglinide, AA and TAS were normalized, GSH increased by 20%, while LPO decreased by 45%. Our results show that pioglitazone and repaglinide differ significantly in their ability to ameliorate the parameters like NO2, PCG, and AOPP. In this area, the multimodal action of pioglitazone as PPARγ agonist is probably essential.
Socioeconomic Indicator of Water Availability in the Lower Guayalejo-Tamesí River Basin  [PDF]
Lidia Rangel-Blanco
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.56007
Abstract: Water is the main element for development since it defines and limits the opportunities for growth and economic development. The lack of water will increase constantly owing to the increase of the economic activities, social requests, environmental damage, and the climate changes. The research has as purpose to build an indicator of water availability, in the lower Basin of Guayalejo-Tamesi River in Tamaulipas, Mexico. Considering a quantitative methodology that provides the application of mathematic models through a hydrologic simulation software and scenarios of climate change (WEAP) (MA-GICC); and the qualitative that represents a major economic engineering challenge to convert complex variables such as the human development, the rise of the economic activity, and the increase of the social-demographic in water requirement. Bearing in mind that the valley is one of the most important hydrological systems of the State of Tamaulipas that provides to productive areas; the chemical industry, petrochemical, energetic, agricultural and livestock such as the domestic. Which makes relevant to apply and analyze the IDA, being a new experience at the regional level that needs to be abroad in a general way by the binding instances to the development of these areas which will allow a better social usage and economic of the hydrological system in a sustainable integral environment.
Spin traps in the detection of free radicals in the blood of patients with ischemia
Ryszard Krzyminiewski, Zdzislaw Kruczynski, Aleksander Stepien, Bernadeta Dobosz
Polish Journal of Medical Physics And Engineering , 2009, DOI: 10.2478/v10013-009-0005-9
Abstract: Electron Paramagnetic Resonance and a nitrosobenzene spin trap were used to investigate free radicals in the human blood after angioplasty treatment. The nitrosobenzene anion radical was determined using EPR measurements and quantum-mechanical calculations. Differences were observed in the concentration of free radicals before and after angioplasty treatment. These results were compared with myocardium damage parameters (CPK, MB and TnT).
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