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Search Results: 1 - 10 of 61041 matches for " Lidan Yu "
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The Impact of Policy Intervention on Regional Economic Growth in China  [PDF]
Lidan Yu, Shiyu Shang
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.912137
Abstract: As a grand policy of realizing the rapid development of the western region and narrowing the income gap between the western region and the eastern and central regions after China’s reform and opening up, it is of great practical significance to objectively study its policy effects. This paper uses the data of municipal districts in Chinese cities from 1997 to 2014 in China City Statistical Yearbook to evaluate the policy effect of the western development strategy by using the method of difference-in-difference propensity score matching (PSM-DID). The research results show that the western development policy has not improved the economic growth of the western region, but has negatively affected the economic growth of the western region. In addition, economic growth in the western region may be due to factors such as fixed asset investment, foreign direct investment, and higher education levels, etc. Therefore, the strategic direction of the development of the western region should focus on human capital investment, improve the market economy system, and strengthen exchanges and cooperation between regions in the future.
The Problems and Solutions to the Building of the New-type Rural Cooperative Medical Workforce
Lidan Wang,Yu Zhang,Yahui Zhang,Yayun Yu
Asian Social Science , 2011, DOI: 10.5539/ass.v7n9p78
Abstract: In order to improve the rural medical conditions, China has started to try a new policy ---- New-type Rural Cooperative Medical Insurance from July, 2003, which has greatly improved rural medical facilities and alleviated the burden of the rural medical treatment. Rural health care reform has made great achievements. However, research shows that there are still some aspects which are worthy of attention and improvement. Focusing on the collection, collation and research of the survey data, we have found some relatively urgent issues, particularly on the medical team-building, such as an aging medical staff term; what’s more, the quality of the medical staff issues should be improved. From the perspective of the doctors, we are analyzing and proposing solutions to these issues. It is significant for the sustainable development of the New-type Rural Cooperative Medical Insurance.
Toll-Like Receptor 7 Agonists: Chemical Feature Based Pharmacophore Identification and Molecular Docking Studies
Hui Yu, Hongwei Jin, Lidan Sun, Liangren Zhang, Gang Sun, Zhanli Wang, Yongchun Yu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056514
Abstract: Chemical feature based pharmacophore models were generated for Toll-like receptors 7 (TLR7) agonists using HypoGen algorithm, which is implemented in the Discovery Studio software. Several methods tools used in validation of pharmacophore model were presented. The first hypothesis Hypo1 was considered to be the best pharmacophore model, which consists of four features: one hydrogen bond acceptor, one hydrogen bond donor, and two hydrophobic features. In addition, homology modeling and molecular docking studies were employed to probe the intermolecular interactions between TLR7 and its agonists. The results further confirmed the reliability of the pharmacophore model. The obtained pharmacophore model (Hypo1) was then employed as a query to screen the Traditional Chinese Medicine Database (TCMD) for other potential lead compounds. One hit was identified as a potent TLR7 agonist, which has antiviral activity against hepatitis virus in vitro. Therefore, our current work provides confidence for the utility of the selected chemical feature based pharmacophore model to design novel TLR7 agonists with desired biological activity.
Study of Construction Vehicles Automatic Transmission Wear Degree Based on Spectroscopic Technology
Lidan Chen
TELKOMNIKA : Indonesian Journal of Electrical Engineering , 2012, DOI: 10.11591/telkomnika.v10i4.853
Abstract: Flame atomic absorption spectrometry (FAAS) was adopted to detect the construction vehicles automatic transmission through simultaneous determination of typical metal elements contents (Copper, Chromium and Iron) in automatic transmission fluid (ATF). Standard curves of Copper, Chromium and Iron were portrayed. Six parallel tests were implemented and the relative standard deviations (RSD) were 2.59%, 2.89% and 2.71% for Copper, Chromium and Iron separately. Additionally, under the same test conditions and analysis methods, contents of Copper, Chromium and Iron in different mileages of construction vehicles automatic transmission were tested. Analysis showed that, with the increase of mileage, the wear degree of construction vehicles automatic transmission increased and the contents of Copper, Chromium and Iron in ATF were also increased follow specific functions for each element under certain driving condition, and the correlation coefficients R were 0.9994, 0.9993 and 0.9997 correspondingly. Finally, results illustrated that FAAS could serve as the rapid and non-destructive method to determine the contents of Copper, Chromium and Iron, and further to achieve the goal of examining the conditions of the major components of automatic transmission.
Binding Mode Prediction of Evodiamine within Vanilloid Receptor TRPV1
Zhanli Wang,Lidan Sun,Hui Yu,Yanhui Zhang,Wuzhuang Gong,Hongwei Jin,Liangren Zhang,Huaping Liang
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13078958
Abstract: Accurate assessment of the potential binding mode of drugs is crucial to computer-aided drug design paradigms. It has been reported that evodiamine acts as an agonist of the vanilloid receptor Transient receptor potential vanilloid-1 (TRPV1). However, the precise interaction between evodiamine and TRPV1 was still not fully understood. In this perspective, the homology models of TRPV1 were generated using the crystal structure of the voltage-dependent shaker family K + channel as a template. We then performed docking and molecular dynamics simulation to gain a better understanding of the probable binding modes of evodiamine within the TRPV1 binding pocket. There are no significant interspecies differences in evodiamine binding in rat, human and rabbit TRPV1 models. Pharmacophore modeling further provided confidence for the validity of the docking studies. This study is the first to shed light on the structural determinants required for the interaction between TRPV1 and evodiamine, and gives new suggestions for the rational design of novel TRPV1 ligands.
A Reputation-Based Multi-Agent Model for Network Resource Selection  [PDF]
Junfeng TIAN, Juan LI, Lidan YANG
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2009, DOI: 10.4236/ijcns.2009.28089
Abstract: Because of the anonymity and openness of online transactions and the richness of network resources, the problems of the credibility of the online trading and the exact selection of network resources have become acute. For this reason, a reputation-based multi-agent model for network resource selection (RMNRS) is presented. The model divides the network into numbers of trust domains. Each domain has one domain-agent and several entity-agents. The model prevents the inconsistency of information that is maintained by differ-ent agents through the periodically communication between the agents. The model enables the consumers to receive responses from agents significantly quicker than that of traditional models, because the global reputation values of service providers and consumers are evaluated and updated dynamically after each transaction. And the model allocates two global reputation values to each entity and takes the recognition value that how much the service provider knows the service into account. In order to make users choose the best matching services and give users with trusted services, the model also takes the similarity between services into account and uses the similarity degree to amend the integration reputation value with harmonic-mean. Finally, the effectiveness and feasibility of this model is illustrated by the experiment.
Orthogonal Stability of Mixed Additive-Quadratic Jensen Type Functional Equation in Multi-Banach Spaces  [PDF]
Xiuzhong Yang, Lidan Chang, Guofen Liu
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.56031

In this paper, we prove the Hyers-Ulam stability of the following mixed additive-quadratic Jensen type functional equation:?\"\"

A Novel Benzothiazole Derivative YLT322 Induces Apoptosis via the Mitochondrial Apoptosis Pathway In Vitro with Anti-Tumor Activity in Solid Malignancies
Song Xuejiao, Xia Yong, Wang Ningyu, Zhang Lidan, Shi Xuanhong, Xu Youzhi, Ye Tinghong, Shi Yaojie, Zhu Yongxia, Yu Luoting
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063900
Abstract: Benzothiazole derivatives are known for various biological activities, and their potency in cancer therapy has received considerable attention in recent years. YLT322, a novel synthesized benzothiazole derivative, exhibits potent anti-tumor activity via inducing apoptosis both in vitro and in vivo. In this study, we found that YLT322 showed growth inhibition against a broad spectrum of human cancer cells and induced apoptosis of HepG2 cells in a dose- and time-dependent manner. The occurrence of its apoptosis was associated with activation of caspases-3 and -9, but not caspase-8. YLT322 increased the expression of Bax, decreased the expression of Bcl-2, and induced the release of cytochrome c which activates the mitochondrial apoptotic pathway. The down-regulation of phosphorylated p42/44 MAPK and phosphorylated Akt was also observed. Moreover, YLT322 suppressed the growth of established tumors in xenograft models in mice without obvious side effects. Histological and immunohistochemical analyses revealed an increase in TUNEL and caspase-3-positive cells and a decrease in Ki67-positive cells upon YLT322. These results suggest that YLT322 may be a potential candidate for cancer therapy.
A Chaotic Attractor in Delayed Memristive System
Lidan Wang,Shukai Duan
Abstract and Applied Analysis , 2012, DOI: 10.1155/2012/726927
Abstract: Over the last three decades, theoretical design and circuitry implementation of various chaotic generators by simple electronic circuits have been a key subject of nonlinear science. In 2008, the successful development of memristor brings new activity for this research. Memristor is a new nanometre-scale passive circuit element, which possesses memory and nonlinear characteristics. This makes it have a unique charm to attract many researchers’ interests. In this paper, memristor, for the first time, is introduced in a delayed system to design a signal generator to produce chaotic behaviour. By replacing the nonlinear function with memristors in parallel, the memristor oscillator exhibits a chaotic attractor. The simulated results demonstrate that the performance is well predicted by the mathematical analysis and supports the viability of the design.
Research on Credit Risk Assessment of Small and Medium-Sized Enterprises in Commercial Banks  [PDF]
Yacui Gao, Lidan Zhang
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1105022
By using the data of 2014 and 2015 about the 90 small and medium-sized en-terprises credit default and normal samples from a joint-stock commercial bank, this paper builds the credit risk assessment evaluation index system to the small and medium-sized enterprise of commercial bank. Based on the logit model, we make a test for the 30 enterprises of the testing samples. Finally, the evaluation model draws that the predicted probability of default of the model is as high as 90%, the reliability of credit risk assessment model is verified.
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