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Enfoque práctico de la pubarquia precoz
Revista Venezolana de Endocrinología y Metabolismo , 2006,
Abstract: precocious pubarche was believed to be a normal variant of pubertad developpement, without long-term consequences.recently premature pubarche has been associated to endocrine-metabolic disturbances in the pre-puberal age and especially after puberty. at present, premature pubarche represent a predictive factor of ovarian and/or adrenal disfunction and metabolic syndrome. this article result from a bilbliographic review about this entity, the objective is to dispose of tools to make the adequate diagnosis, approach, treatment and follow-up.
Enfoque práctico de la pubarquia precoz
Minerva Licha
Revista Venezolana de Endocrinología y Metabolismo , 2006,
Abstract: La pubarquia precoz, es considerada una variante normal del desarrollo, sin consecuencias a largo plazo. Recientemente se ha relacionado con alteraciones endocrino-metabólicas en la pre-pubertad y fundamentalmente en la post-pubertad. La pubarquia precoz, hoy por hoy, representa un factor predictivo de disfunción ovárica y/o adrenal y de síndrome metabólico. Este artículo es resultado de una revisión bibliográfica sobre esta entidad, realizado con el objetivo de disponer de las herramientas que nos permitan el diagnostico, la evaluación, el seguimiento y los tratamientos adecuados Precocious pubarche was believed to be a normal variant of pubertad developpement, without long-term consequences.Recently premature pubarche has been associated to endocrine-metabolic disturbances in the pre-puberal age and especially after puberty. At present, premature pubarche represent a predictive factor of ovarian and/or adrenal disfunction and Metabolic Syndrome. This article result from a bilbliographic review about this entity, the objective is to dispose of tools to make the adequate diagnosis, approach, treatment and follow-up.
Identification and characterization of repetitive extragenic palindromes (REP)-associated tyrosine transposases: implications for REP evolution and dynamics in bacterial genomes
Jaroslav Nunvar, Tereza Huckova, Irena Licha
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-44
Abstract: In this report, we describe a novel class of putative transposases related to IS200/IS605 transposase family and we demonstrate that they are obligately associated with bacterial REPs. Open reading frames coding for these REP-associated tyrosine transposases (RAYTs) are always flanked by two REPs in inverted orientation and thus constitute a unit reminiscent of typical transposable elements. Besides conserved residues involved in catalysis of DNA cleavage, RAYTs carry characteristic structural motifs that are absent in typical IS200/IS605 transposases. DNA sequences flanking rayt genes are in one third of examined cases arranged in modular BIMEs. RAYTs and their flanking REPs apparently coevolve with each other. The rayt genes themselves are subject to rapid evolution, substantially exceeding the substitution rate of neighboring genes. Strong correlation was found between the presence of a particular rayt in a genome and the abundance of its cognate REPs.In light of our findings, we propose that RAYTs are responsible for establishment of REPs and BIMEs in bacterial genomes, as well as for their exceptional dynamics and species-specifity. Conversely, we suggest that BIMEs are in fact a special type of nonautonomous transposable elements, mobilizable by RAYTs.Transposable elements (TEs), or transposons, are a large group of mobile genetic elements with ability to actively transfer themselves into new locations in their host′s DNA. This process, called transposition, is catalyzed by transposases, coded for by TEs themselves. Insertion sequences (ISs) present the simplest examples of TEs.The IS200/IS605 family of transposable elements was first described in genus Salmonella [1] and further in many other bacterial and archaeal genomes [2]. Contrary to the majority of TEs that transpose using transposases whose active site is composed of a triad of acidic residues (DDE transposases), known members of the IS200/IS605 family lack terminal inverted repeats and do not generat
Gesualdo Bufalino,Minerva Licha,Orlando Arcia,Ayarí Aponte
Revista de Obstetricia y Ginecología de Venezuela , 2006,
Um modelo evolucionário setorial
Possas, Mario L.;Koblitz, Arthur;Licha, Antonio;Oreiro, José Luís;Dweck, Esther;
Revista Brasileira de Economia , 2001, DOI: 10.1590/S0034-71402001000300002
Abstract: this paper presents a sectoral evolutionary simulation model combining neo-schumpeterian and post-keynesian microfoundations, and exhibits some preliminary results. as to different market environment conditions, the simulations suggest: a positive effect of productivity growth of the technological frontier on market concentration; an ambiguous result of "learning by doing", from which innovation leaders may be found "locked in" new technologies that eventually become obsolete; a "counter-selective" effect of very high interest rates which may increase innovators indebtedness to the extent of impairing their investment efforts and competitive success as compared to some imitators. as to different price strategies, major findings are: greater selectivity of strategies in which innovators put more emphasis on their own desired mark-up than on average market price, thus enhancing market concentration, an effect that can be restrained by higher market demand growth and "learning by doing"; the importance, for the survival of less innovative firms, of a feedback from competitive performance to desired and effective mark-ups (price strategies), which increases their adaptability to market selection conditions.
Dendritic Polyglycerolsulfate Near Infrared Fluorescent (NIRF) Dye Conjugate for Non-Invasively Monitoring of Inflammation in an Allergic Asthma Mouse Model
Stefania Biffi, Simeone Dal Monego, Christian Dullin, Chiara Garrovo, Berislav Bosnjak, Kai Licha, Pia Welker, Michelle M. Epstein, Frauke Alves
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057150
Abstract: Background Non-invasive in vivo imaging strategies are of high demand for longitudinal monitoring of inflammation during disease progression. In this study we present an imaging approach using near infrared fluorescence (NIRF) imaging in combination with a polyanionic macromolecular conjugate as a dedicated probe, known to target L- and P-selectin and C3/C5 complement factors. Methodology/Principal Findings We investigated the suitability of dendritic polyglycerol sulfates (dPGS), conjugated with a hydrophilic version of the indocyanine green label with 6 sulfonate groups (6S-ICG) to monitor sites of inflammation using an experimental mouse model of allergic asthma. Accumulation of the NIRF-conjugated dPGS (dPGS-NIRF) in the inflamed lungs was analyzed in and ex vivo in comparison with the free NIRF dye using optical imaging. Commercially available smart probes activated by matrix metalloproteinase's (MMP) and cathepsins were used as a comparative control. The fluorescence intensity ratio between lung areas of asthmatic and healthy mice was four times higher for the dPGS in comparison to the free dye in vivo at four hrs post intravenous administration. No significant difference in fluorescence intensity between healthy and asthmatic mice was observed 24 hrs post injection for dPGS-NIRF. At this time point ex-vivo scans of asthmatic mice confirmed that the fluorescence within the lungs was reduced to approximately 30% of the intensity observed at 4 hrs post injection. Conclusions/Significance Compared with smart-probes resulting in a high fluorescence level at 24 hrs post injection optical imaging with dPGS-NIRF conjugates is characterized by fast uptake of the probe at inflammatory sites and represents a novel approach to monitor lung inflammation as demonstrated in mice with allergic asthma.
Differentiation of angiogenic burden in human cancer xenografts using a perfusion-type optical contrast agent (SIDAG)
Alexander Wall, Thorsten Persigehl, Peter Hauff, Kai Licha, Michael Schirner, Silke Müller, Angelika von Wallbrunn, Lars Matuszewski, Walter Heindel, Christoph Bremer
Breast Cancer Research , 2008, DOI: 10.1186/bcr1875
Abstract: Mice were xenografted with moderately (MCF7, DU4475) or highly vascularized (HT1080, MDA-MB435) tumours and scanned up to 24 hours after intravenous SIDAG injection using fluorescence reflectance imaging. Contrast-to-noise ratio was calculated for all tumours, and fluorochrome accumulation was quantified using fluorescence-mediated tomography. The vascular volume fraction of the xenografts, serving as a surrogate marker for angiogenesis, was measured using magnetic resonance imaging, and blood vessel profile (BVP) density and vascular endothelial growth factor expression were determined.SIDAG accumulation correlated well with angiogenic burden, with maximum contrast to noise ratio for MDA-MB435 (P < 0.0001), followed by HT1080, MCF7 and DU4475 tumours. Fluorescence-mediated tomography revealed 4.6-fold higher fluorochrome concentrations in MDA-MB435 than in DU4475 tumours (229 ± 90 nmol/l versus 49 ± 22 nmol/l; P < 0.05). The vascular volume fraction was 4.5-fold (3.58 ± 0.9% versus 0.8 ± 0.53%; P < 0.01), blood vessel profile density 5-fold (399 ± 36 BVPs/mm2 versus 78 ± 16 BVPs/mm2) and vascular endothelial growth factor expression 4-fold higher for MDA-MB435 than for DU4475 tumours.Our data suggest that perfusion-type cyanine dyes allow assessment of angiogenesis in vivo using planar or tomographic imaging technology. They may thus facilitate characterization of solid tumours.Contrast-enhanced optical imaging is an emerging modality that may be used to detect and characterize solid tumours such as breast cancer [1,2]. Optical techniques based on intrinsic optical contrast (such as diffuse optical tomography) can provide spectroscopic information about physiological and functional tissue parameters (for instance, tissue oxygenation) [3,4]. However, there have been several unsuccessful attempts to demonstrate that nonenhanced optical mammography has diagnostic utility [5]. More recently, substantial effort has been invested in the development of fluorescent probes,
Microbial and Chemical Characterization of Underwater Fresh Water Springs in the Dead Sea
Danny Ionescu, Christian Siebert, Lubos Polerecky, Yaniv Y. Munwes, Christian Lott, Stefan H?usler, Mina Bi?i?-Ionescu, Christian Quast, J?rg Peplies, Frank Oliver Gl?ckner, Alban Ramette, Tino R?diger, Thorsten Dittmar, Aharon Oren, Stefan Geyer, Hans-Joachim St?rk, Martin Sauter, Tobias Licha, Jonathan B. Laronne, Dirk de Beer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038319
Abstract: Due to its extreme salinity and high Mg concentration the Dead Sea is characterized by a very low density of cells most of which are Archaea. We discovered several underwater fresh to brackish water springs in the Dead Sea harboring dense microbial communities. We provide the first characterization of these communities, discuss their possible origin, hydrochemical environment, energetic resources and the putative biogeochemical pathways they are mediating. Pyrosequencing of the 16S rRNA gene and community fingerprinting methods showed that the spring community originates from the Dead Sea sediments and not from the aquifer. Furthermore, it suggested that there is a dense Archaeal community in the shoreline pore water of the lake. Sequences of bacterial sulfate reducers, nitrifiers iron oxidizers and iron reducers were identified as well. Analysis of white and green biofilms suggested that sulfide oxidation through chemolitotrophy and phototrophy is highly significant. Hyperspectral analysis showed a tight association between abundant green sulfur bacteria and cyanobacteria in the green biofilms. Together, our findings show that the Dead Sea floor harbors diverse microbial communities, part of which is not known from other hypersaline environments. Analysis of the water’s chemistry shows evidence of microbial activity along the path and suggests that the springs supply nitrogen, phosphorus and organic matter to the microbial communities in the Dead Sea. The underwater springs are a newly recognized water source for the Dead Sea. Their input of microorganisms and nutrients needs to be considered in the assessment of possible impact of dilution events of the lake surface waters, such as those that will occur in the future due to the intended establishment of the Red Sea?Dead Sea water conduit.
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