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Search Results: 1 - 10 of 145346 matches for " Li Miao-Hui "
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Investigation of lower hybrid current drive during H-mode in EAST tokamak

Li Miao-Hui,Ding Bo-Jiang,Kong Er-Hu,Zhang Lei,Zhang Xin-Jun,Qian Jin-Ping,Yan Ning,Han Xiao-Feng,Shan Jia-Fang,Liu Fu-Kun,Wang Mao,Xu Han-Dong,Wan Bao-Nian,

中国物理 B , 2011,
Determining Antibody-Binding Site of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Group A Streptococcus Infection
Nina Tsao, Miao-Hui Cheng, Hsiu-Chen Yang, Yu-Chieh Wang, Yi-Ling Liu, Chih-Feng Kuo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055028
Abstract: Streptococcal pyrogenic exotoxin B (SPE B), a cysteine protease, is an important virulence factor in group A streptococcal (GAS) infection. SPE B binds and cleaves antibody isotypes and further impairs the immune system by inhibiting complement activation. In this study, we examined the antibody-binding site of SPE B and used it to block SPE B actions during GAS infection. We constructed different segments of the spe B gene and induced them to express different recombinant fragments of SPE B. Using an enzyme-linked immunosorbent assay (ELISA), we found that residues 345–398 of the C-terminal domain of SPE B (rSPE B345–398), but not the N-terminal domain, was the major binding site for antibody isotypes. Using a competitive ELISA, we also found that rSPE B345–398 bound to the Fc portion of IgG. The in vitro functional assays indicate that rSPE B345–398 not only interfered with cleavage of antibody isotypes but also interfered with SPE B-induced inhibition of complement activation. Immunization of BALB/c mice using rSPE B345–398 was able to induce production of a high titer of anti-rSPE B345–398 antibodies and efficiently protected mice from GAS-induced death. These findings suggest that SPE B uses its C-terminal domain to bind the Fc portion of IgG and that immunization of mice with this binding domain (rSPE B345–398) could protect mice from GAS infection.
Magnolol Reduces Glutamate-Induced Neuronal Excitotoxicity and Protects against Permanent Focal Cerebral Ischemia Up to 4 Hours
Wei-Ting Lee, Miao-Hui Lin, E-Jian Lee, Yu-Chang Hung, Shih-Huang Tai, Hung-Yi Chen, Tsung-Ying Chen, Tian-Shung Wu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039952
Abstract: Neuroprotective efficacy of magnolol, 5,5′-dially-2,2′-dihydroxydiphenyl, was investigated in a model of stroke and cultured neurons exposed to glutamate-induced excitotoxicity. Rats were subjected to permanent middle cerebral artery occlusion (pMCAO). Magnolol or vehicle was administered intraperitoneally, at 1 hr pre-insult or 1–6 hrs post-insult. Brain infarction was measured upon sacrifice. Relative to controls, animals pre-treated with magnolol (50–200 mg/kg) had significant infarct volume reductions by 30.9–37.8% and improved neurobehavioral outcomes (P<0.05, respectively). Delayed treatment with magnolol (100 mg/kg) also protected against ischemic brain damage and improved neurobehavioral scores, even when administered up to 4 hrs post-insult (P<0.05, respectively). Additionally, magnolol (0.1 μM) effectively attenuated the rises of intracellular Ca2+ levels, [Ca2+](i), in cultured neurons exposed to glutamate. Consequently, magnolol (0.1–1 μM) significantly attenuated glutamate-induced cytotoxicity and cell swelling (P<0.05). Thus, magnolol offers neuroprotection against permanent focal cerebral ischemia with a therapeutic window of 4 hrs. This neuroprotection may be, partly, mediated by its ability to limit the glutamate-induced excitotoxicity.
Estimation of precipitation condensation latent heat in rainy season over Qinghai-Tibet Plateau

DongLiang Li,Hui Wang,Miao Liu,

寒旱区科学 , 2009,
A Probabilistic Framework for Representing Dialog Systems and Entropy-Based Dialog Management through Dynamic Stochastic State Evolution
Ji Wu,Miao Li,Chin-Hui Lee
Computer Science , 2015,
Abstract: In this paper, we present a probabilistic framework for goal-driven spoken dialog systems. A new dynamic stochastic state (DS-state) is then defined to characterize the goal set of a dialog state at different stages of the dialog process. Furthermore, an entropy minimization dialog management(EMDM) strategy is also proposed to combine with the DS-states to facilitate a robust and efficient solution in reaching a user's goals. A Song-On-Demand task, with a total of 38117 songs and 12 attributes corresponding to each song, is used to test the performance of the proposed approach. In an ideal simulation, assuming no errors, the EMDM strategy is the most efficient goal-seeking method among all tested approaches, returning the correct song within 3.3 dialog turns on average. Furthermore, in a practical scenario, with top five candidates to handle the unavoidable automatic speech recognition (ASR) and natural language understanding (NLU) errors, the results show that only 61.7\% of the dialog goals can be successfully obtained in 6.23 dialog turns on average when random questions are asked by the system, whereas if the proposed DS-states are updated with the top 5 candidates from the SLU output using the proposed EMDM strategy executed at every DS-state, then a 86.7\% dialog success rate can be accomplished effectively within 5.17 dialog turns on average. We also demonstrate that entropy-based DM strategies are more efficient than non-entropy based DM. Moreover, using the goal set distributions in EMDM, the results are better than those without them, such as in sate-of-the-art database summary DM.
A Super High Resolution Distance Measurement Method Based on Phase Comparison

LI Zhi-Qi,ZHOU Wei,MIAO Miao,ZHOU Hui,ZHENG Sheng-Feng,

中国物理快报 , 2008,
On Maximal Regularity and Semivariation of α-Times Resolvent Families*  [PDF]
Fubo Li, Miao Li
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.38091

Let \"\" and A be the generator of an \"\"-times resolvent family \"\" on a Banach space X. It is shown that the fractional Cauchy problem \"\" has maximal regularity on \"\" if and only if \"\" is of bounded semivariation on \"\".

H?lder Regularity for Abstract Fractional Cauchy Problems with Order in (0,1)  [PDF]
Chenyu Li, Miao Li
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.61030
In this paper, we study the regularity of mild solution for the following fractional abstract Cauchy problem Dt αu(t)=Au(t)+f(t), t ∈ (0,T] u(0)= x0 on a Banach space X with order α ∈ (0,1), where the fractional derivative is understood in the sense of Caputo fractional derivatives. We show that if A generates an analytic α-times resolvent family on X and f ∈ Lp ([0,T];X) for some p > 1/α, then the mild solution to the above equation is in Cα-1/p[ò,T] for every ò > 0. Moreover, if f is H?lder continuous, then so are the Dt αu(t) and Au(t).
Coverage of Femoral Head at Weight-Bearing Interface of the Hip Joint in Children: An MRI Analysis  [PDF]
Si-Hui Zeng, Hong-Sheng Liu, Hong-Wen Xu, Yuan-Kai Chen, Ding-Qiang Miao, Li-Yi Nie
Open Journal of Medical Imaging (OJMI) , 2013, DOI: 10.4236/ojmi.2013.32008

Objective: To analyze the features of coverage of femoral head at weight-bearing interface of the hip joints in children. Material and Methods: MRI scans of the hips were performed in 95 normal children aged from 1 to 8 years. Radial scans of the hip joints were performed using FFE sequence. Review the morphological features of weight-bearing interface of the acetabulum and the femoral head. Total covering angle (TCA), acetabular covering angle (ACA) and labral covering angle (LCA) were measured, inter-group comparison and correlation analysis were done. Result: The acetabulum and the femoral head had congruent articulating surface at each weight-bearing position. There was no statistical TCA difference at each position. Average ACA increased, while average LCA decreased from anterior to posterior. TCA correlated with LCA, ACA negatively correlated with LCA. Conclusion: TCA is a good index in indicating stability of the hip joint. Cartilage ossifies slower at posterior than anterior positions. Cartilage acetabulum and the labrum serve as complementary structures that contribute in total stabilizing of the hip joint in development.

Peng LI,Cai-Hong JIN,San JIANG,Miao-Miao LI,Zi-Lu WANG,Hui ZHU,Cui-Yun CHEN,Tian-Miao HUA
动物学研究 , 2014, DOI: 10.13918/j.issn.2095-8137.2014.5.411
Abstract: Theinfluenceofintracorticalinhibitionontheresponseadaptationofvisualcorticalneuronsremainsindebate.Toclarifythisissue,inthepresentstudytheinfluenceofsurroundsuppressionevokedthroughthelocalinhibitoryinterneuronsontheadaptationeffectsofneuronsintheprimaryvisualcortex(V1)wereobserved.Moreover,theadaptationsofV1neuronstoboththehigh-contrastvisualstimulipresentedintheclassicalreceptivefield(CRF)andtothecostimulationpresentedintheCRFandthesurroundingnonclassicalreceptivefield(nCRF)werecompared.Theintensitiesofsurroundsuppressionweremodulatedwithdifferentsizedgratingstimuli.TheresultsshowedthattheresponseadaptationofV1neuronsdecreasedsignificantlywiththeincreaseofsurroundsuppressionandthisadaptationdecreasewasduetothereductionoftheinitialresponseofV1neuronstovisualstimuli.However,theplateauresponseduringadaptationshowednosignificantchanges.ThesefindingsindicatethattheadaptationeffectsofV1neuronsmaynotbedirectlyaffectedbysurroundsuppression,butmaybedynamicallyregulatedbyanegativefeedbacknetworkandbefinelyadjustedbyitsinitialspikingresponsetostimulus.Thisadaptiveregulationisnotonlyenergyefficientforthecentralnervoussystem,butalsobeneficiallyactstomaintainthehomeostasisofneuronalresponsetolong-presentingvisualsignals.
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