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Guadalajara city is the capital of the Mexican federal state of Jalisco. It is located close to the Pacific coast and is subjected to a large seismic risk. We present a seismic response study for some sites along the city. We calculated response spectra of shear-waves by using seismic records of actual earthquakes registered on rock and near the source as Green functions and propagated them trough a flat and horizontal layered media using a linear equivalent method to compare them with the response spectra calculated according to the Federal Commission of Electricity (CFE) seismic design buildings Manual (MOC-2008, 2008) which is widely used as reference on construction projects in Mexico. Our results show that MOC-2008 manual underestimates the spectral amplitudes and frequency band for the response spectra.