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Search Results: 1 - 10 of 2357 matches for " Leila Sadat Asadiar "
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Assessment of genetic diversity in the Russian olive (Elaeagnus angustifolia) based on ISSR genetic markers
Asadiar, Leila Sadat;Rahmani, Fatemeh;Siami, Abbas;
Revista Ciência Agron?mica , 2013, DOI: 10.1590/S1806-66902013000200013
Abstract: elaeagnus is a eurasian tree with 77 species worldwide. in this study, issr markers were used to establish the level of genetic relationships and polymorphism across nine genotypes of elaeagnus angustifolia collected from 9 different regions of west azarbaijan province. the issr analysis with 11 anchored primers also generated 116 scorable loci, of which 92 were polymorphic (79.3%). the estimated jaccard similarity coefficient ranged from 0.44 to 0.76 for the issr markers. cluster analysis was carried out, based on the unweighted pair group method with arithmetic averages (upgma) and the dendrogram drawn with the help of the ntsyspc 2.02 software. the analysis revealed 5 main clusters for the issr data. according to our results, there is a relatively high genetic distance across e. angustifolia genotypes in the west azarbaijan province of iran. furthermore, it could be inferred that issr markers are suitable tools for the evaluation of genetic diversity and relationships within the elaeagnus genus.
Assessment of genetic diversity in the Russian olive (Elaeagnus angustifolia) based on ISSR genetic markers Avalia o da diversidade genética em Oliva Russa (Elaeagnus angustifolia) com base em marcadores genéticos ISSR
Leila Sadat Asadiar,Fatemeh Rahmani,Abbas Siami
Revista Ciência Agron?mica , 2013,
Abstract: Elaeagnus is a Eurasian tree with 77 species worldwide. In this study, ISSR markers were used to establish the level of genetic relationships and polymorphism across nine genotypes of Elaeagnus angustifolia collected from 9 different regions of West Azarbaijan province. The ISSR analysis with 11 anchored primers also generated 116 scorable loci, of which 92 were polymorphic (79.3%). The estimated Jaccard similarity coefficient ranged from 0.44 to 0.76 for the ISSR markers. Cluster analysis was carried out, based on the Unweighted Pair Group Method with Arithmetic Averages (UPGMA) and the dendrogram drawn with the help of the NTSYSpc 2.02 software. The analysis revealed 5 main clusters for the ISSR data. According to our results, there is a relatively high genetic distance across E. angustifolia genotypes in the West Azarbaijan province of Iran. Furthermore, it could be inferred that ISSR markers are suitable tools for the evaluation of genetic diversity and relationships within the Elaeagnus genus. A Elaeagnus é uma árvore da Eurásia com 77 espécies em todo o mundo. Neste estudo, marcadores ISSR foram usados para estabelecer o nível de rela es genéticas e polimorfismo entre nove genótipos de Elaeagnus angustifolia, coletados em 9 diferentes regi es da província do Azerbaij o Ocidental. A análise ISSR, com 11 primers ancorados, também gerou 116 loci contáveis, dos quais 92 polimórficos (79,3%). O coeficiente de similaridade de Jaccard estimado, variou de 0,44 a 0,76 para os marcadores ISSR. A análise de agrupamento foi realizada com base no Método n o-ponderado de pares n o-agrupados, com médias aritméticas (UPGMA), e a dendrograma elaborada com a ajuda do software NTSYSpc 2.02. A análise revelou cinco grupos principais para os dados ISSR. De acordo com nossos resultados, há uma distancia genética relativamente alta entre genótipos de E. angustifolia na província de Azarbaijan Ocidental no Iran. Além disso, pode-se inferir que os marcadores ISSR s o ferramentas adequadas para a avalia o da diversidade genética e as rela es dentro do gênero Elaeagnus.
Casimir Energy for a Coupled Fermion-Kink System and its stability
Siamak Sadat Gousheh,Azadeh Mohammadi,Leila Shahkarami
Physics , 2012, DOI: 10.1103/PhysRevD.87.045017
Abstract: We compute the Casimir energy for a system consisting of a fermion and a pseudoscalar field in the form of a prescribed kink. This model is not exactly solvable and we use the phase shift method to compute the Casimir energy. We use the relaxation method to find the bound states and the Runge-Kutta-Fehlberg method to obtain the scattering wavefunctions of the fermion in the whole interval of $x$. The resulting phase shifts are consistent with the weak and strong forms of the Levinson theorem. Then, we compute and plot the Casimir energy as a function of the parameters of the pseudoscalar field, i.e. the slope of $\phi(x)$ at x=0 ($\mu$) and the value of $\phi(x)$ at infinity ($\theta_0$). In the graph of the Casimir energy as a function of $\mu$ there is a sharp maximum occurring when the fermion bound state energy crosses the line of E=0. Furthermore, this graph shows that the Casimir energy goes to zero for $\mu\rightarrow 0$, and also for $\mu\rightarrow \infty$ when $\theta_0$ is an integer multiple of $\pi$. Moreover, the graph of the Casimir energy as a function of $\theta_0$ shows that this energy is on the average an increasing function of $\theta_0$ and has a cusp whenever there is a zero fermionic mode. We finally compute the total energy of a system consisting of a valence fermion in the ground state. Most importantly, we show that this energy (the sum of the Casimir energy and the energy of the fermion) is minimum when the background field has winding number one, independent of the details of the background profile. Throughout the paper we compare our results with those of a simple exactly solvable model, where a piece-wise linear profile approximates the kink. We find that the kink is an almost reflectionless barrier for the fermions, within the context of our model.
Synthesis and Biological Evaluation of 99mTc(CO)3-OH-PP-CS2 for Brain Receptor Imaging
Mostafa Erfani,Leila Hassanzadeh,Seyed Esmaeil Sadat Ebrahimi,Mohammad Shafiei
Iranian Journal of Nuclear Medicine , 2012,
Abstract: Introduction: 5-HT1A receptor is related with a variety of neuropsychiatric disorders. . In this study a phenolic analogue derived from DWAY [Desmethyl WAY-100635 (N-(2-(1-(4-(2-methoxyphenyl)piperazinyl)-ethyl))-N-(2-pyridinyl) cyclohexanecarboxamide)] is used to design the desired structure of 5-HT1A receptor imaging agents after labeling with [99mTc (CO) 3(H2O) 3] + core via dithiocarbamate moiety. Methods: 2-(piperazin-1-yl) phenol Dithiocarbamate was synthesized by the reaction of 2-(piperazin-1-yl) phenol with an equivalent amount of carbon disulfide in KOH solution then radiolabeled with [99mTc(CO)3(H2O)3]+ core. Radioligand chemical analysis involved high-performance liquid chromatography methods. Radioconjugate stability and lipophilicity were determined. Biodistribution of labeled compound was studied in rats.Results: The final complex was characterized by HPLC and its radiochemical purity was more than 90%. In vitro stability studies have shown the complex was stable at least 6-hrs after labeling at room temperature. The n-octanol/water partition coefficient experiment demonstrated Log P = 0.74 for 99mTc(CO)3-OH-PP-CS2. Biodistribution results showed that radio tracer had moderate brain uptake (0.32 ± 0.03 %ID/g at 30 min post injection), Conclusion: This complex may lead to a further development of a radiotracer with specific binding to 5-HT1A receptor.
Synthesis and 99mTc labeling of a new radiopharmaceutical for imaging of 5HT1A receptors in brain diseases
Leila Hassanzadeh,Mostafa Gandomkar,Reza Najafi,Seyed Esmaeil Sadat Ebrahimi
Iranian Journal of Nuclear Medicine , 2010,
Abstract: Introduction: The 5-HT1A receptor has been studied extensively due to its role in a number of neuropsychiatry disorders such as schizophrenia, depression, hallucinogenic behavior, eating disorders and anxiety. The aim of this work was to evaluate preparation and labeling of a new WAY 100635 analogous for diagnosis of brain diseases. Methods: A WAY 100635 analogues with 5-HT1A receptor preference was synthesized. The structure of synthesized derivative was confirmed by NMR, IR and Mass spectroscopy. For labeling technetium tricarbonyl precursor prepared from an IsoLink kit was added to 0.5 ml of a solution of the produced final substance (1 mg/ml) adjusted to pH 11 by addition of 0.5 ml of a 0.5M phosphate buffer pH 11 and the mixture was heated in a water bath at 100 C for 15 min. For labeled compound radiochemical yield was evaluated by ITLC and HPLC methods. Results: WAY derivative was synthesized in overall yield of %56 and its structure confirmed by H-NMR. Synthesized final substance was labeled in high yields with a Tc(CO)3 core to form cationic complexes. Labeling yield of >90% was obtained corresponding to a high specific activity. Labeled compound was stable for more than 6 h. Conclusion: These data show that our WAY derivative is a suitable candidate for further evaluation as a new brain imaging radiopharmaceutical.
PER, CTX-M, TEM and SHV Beta-lactamases in Clinical Isolates of Klebsiella pneumoniae Isolated from Tehran, Iran
Leila Nasehi,Fereshteh Shahcheraghi,Vajihe Sadat Nikbin,Shoeib Nematzadeh
Iranian Journal of Basic Medical Sciences , 2010,
Abstract: Objective(s)Different types of extended spectrum beta-lactamases (ESBLs) are encountered in the clinical settings worldwide. There are a few studies regarding the prevalence of ESBL genes among Klebsiella pneumoniae isolates at Tehran especially those of blaPER and blaCTX. The aim of this study was to determine the prevalence of blaSHV, blaTEM ,blaPER and blaCTX genes among clinical K. pneumoniae of different hospitals in Tehran.Materials and MethodsTwo hundred isolates of K. pneumoniae were received from different clinical specimens. The susceptibility of the isolates to 10 different antibiotics was examined by disk diffusion test. The MICs for ceftazidime were also determined using micro-broth dilution assay. Isolates showing MIC 4 μg/ml for ceftazidime were screened for ESBL production by phenotypic confirmatory test (PCT) and subjected to PCR for studied genes. Variation among four amplified genes was evaluated using PCR-RFLP.ResultsBy disk diffusion test, resistance to ceftazidime and cefotaxime were 34.7% and 33.5% respectively. However, all strains were susceptible to imipenem. Eighty isolates showed MICs≥ 4 μg/ml for ceftazidime of which 77 (96%) were positive for ESBL in PCT. The prevalence of blaSHV, blaCTX-M, blaTEM and blaPER among these isolates were 26%, 24.5%, 18% and 7.5%, respectively. No variation was detected in the genes by PCR-RFLP.ConclusionAs far as we know this is the first report of the blaPER-1 in K. pneumoniae in Iran. The blaCTX-M was the second most common gene detected among the ESBL positive isolates of K. pneumoniae. For rapid identification of ESBL producing isolates it was recommended that clinical laboratories adopt simple test based on CLSI recommendation for confirming ESBL production in enterobacterial species.
Expressional patterns of chaperones in ten human tumor cell lines
Jae-Kyung Myung, Leila Afjehi-Sadat, Maureen Felizardo-Cabatic, Irene Slavc, Gert Lubec
Proteome Science , 2004, DOI: 10.1186/1477-5956-2-8
Abstract: Human tumor cell lines of neuroblastoma, colorectal and adenocarcinoma of the ovary, osteosarcoma, rhabdomyosarcoma, malignant melanoma, lung, cervical and breast cancer, promyelocytic leukaemia were homogenised, proteins were separated on two-dimensional gel electrophoresis with in-gel digestion of proteins and MALDI-TOF/TOF analysis was carried out for the identification of CH.A series of CH was identified including the main CH groups as HSP90/HATPas_C, HSP70, Cpn60_TCP1, DnaJ, Thioredoxin, TPR, Pro_isomerase, HSP20, ERP29_C, KE2, Prefoldin, DUF704, BAG, GrpE and DcpS.The ten individual tumor cell lines showed different expression patterns, which are important for the design of CH studies in tumor cell lines. The results can serve as a reference map and form the basis of a concomitant determination of CH by a protein chemical rather than an immunochemical method, independent of antibody availability or specificity.Chaperones (CH) and heat shock proteins (HSPs) play important roles in tumor biology and still are holding centre stage. The heat shock response was discovered in 1962 by Ritossa [1], who reported that elevated temperature led to the appearance of a new 'puffing' pattern in the salivary gland polytene chromosomes of Drosophila busckii. Since then, efforts from a large number of investigators have shown that the heat shock response is ubiquitous and highly conserved. It is observed in all organisms from bacteria to plants and animals. CH form an essential defense mechanism for protection of cells from a variety of harmful conditions, including temperature elevation or heat shock, decrease in pH, hypersalinity, alcohols, heavy metals, oxidative stress, inhibitors of energy metabolism, fever or inflammation [2,3]. This broad spectrum of functions gave rise to the term 'molecular chaperone' an entity that acts to assist other proteins' folding and maturation in the cell. However, not all HSPs are CH and not all CH are HSPs [4].Genetic studies showed that mos
Conversion of ethanol to acetone & other produces using nano-sensor SnO2(110): Ab initio DFT  [PDF]
Leila Mahdavian
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.36065
Abstract: The material considered in this study, SnO2 (110), has a widespread use as gas sensor and oxygen vacancies are known to act as active catalytic sites for the adsorption of small mo-lecules. In the following calculations crystal line SnO2 nano-crystal have been considered. The grains lattice, which has the rutile structure of the bulk material, includes oxygen vacancies and depositing a gaseous molecule, either ethanol, above an atom on the grain surface, generates the adsorbed system. The conduc-tance has a functional relationship with the structure and the distance molecule of the na-no- crystal and its dependence on these quanti-ties parallels the one of the binding energy. The calculations have quantum mechanical detail and are based on a semi-empirical (MNDO me-thod), which is applied to the evaluation of both the electronic structure and of the conductance. We study the structural, total energy, thermo-dynamic and conductive properties of absorp-tion C2H5OH on nano-crystal, which convert to acetaldehyde and acetone.
The Relationship between Maternal Environmental Tobacco Smoke Exposure during Pregnancy with Anthropometric Parameters of the Newborn
Z Sadat
Qom University of Medical Sciences Journal , 2012,
Abstract: Background and Objectives Maternal environmental tobacco smoke exposure (ETS) or passive smoking would be a risk factor for maternal and new born morbidity. This study was conducted to determine this relationship with in pregnant woman referring to Shabihkhani Maternity Hospital of kashan, Iran, during 2006-2007 Methods The study was carried out on 150 Nonsmoking pregnant women who were exposed to ETS greater than or equal to 5 cigarettes per day smoked by others in the mother's presence in all of pregnancy period as exposed group and 150 Nonsmoking pregnant women who were not exposed to ETS as the non-exposed group. Birth weight, height and head circumference were compared in the two groups and analyzed by t- and X2 tests. Results The mean birth weights in the exposed group and non exposed group were and 3137.5±437.8 and 3270±499.5 grams respectively, the t- test showed this difference to be significant (p=0.015). The mean birth height and head circumference in the two groups were not significantly different. Conclusion Nonsmoking pregnant women who were exposed to ETS gave 133 g reduction in birth weight compared to unexposed women. Further studies are needed to determine if ETS decreases birth height and birth head circumference
A Compiler Driven Simulation Technique for the Analysis of Digital Logic Circuit
Anwar Sadat
Journal of Applied Sciences , 2005,
Abstract: An interface technique for design and analysis of digital circuit has been devised and described in this study. Basically logic circuits are of two types, one combinational circuit and other is sequential circuit. Logic simulation usually means finding the transient response to a set of time-varying inputs. Simulation follows functional or behavioral level design. Behavioural simulation describes logic function and timing. Functional simulation describes the logic function of a system only but ignores the timing. A simulation program for giving output of digital logic circuits is available now-a-days. But, an approach taken here describes an efficient way to analyze both combinational and sequential circuit. To do this an algorithm has been developed. Finally, a program is coded in Turbo C language and tested for test cases to analyze and give output to that logic circuit.
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