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Search Results: 1 - 10 of 138923 matches for " Leeb K "
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Psychosomatik und assistierte Reproduktion
Kemeter P,Fiegl J,Leeb K,Scholl T
Journal für Fertilit?t und Reproduktion , 2001,
Abstract: Nach unserem psychosomatischen Konzept hat die Berücksichtigung der bio-psycho-somatischen Zusammenh nge den gleichen Rang wie die ART. Dies wurde von unseren PatientInnen insoferne gewürdigt, als die meisten mit einer Beratung das Auslangen fanden, obwohl ihnen auch die ART angeboten wurde. Natürlich richtet sich die Behandlungsstrategie zun chst nach den organischen Befunden, l t aber die psychosozialen Einflu faktoren nie au er acht. Dies hat z. B. gro e Bedeutung für die Wahl des Behandlungszeitpunktes, für die Behandlungsumst nde, Behandlungspausen, sowie für etwaige Interventionen im psychosozialen Umfeld. Diese mehr personen- als schwangerschaftsorientierte Strategie soll die Kinderwunschproblematik entsch rfen und entlastend wirken. Die Tatsache, da etwa ein Viertel der Betroffenen in der Folge schwanger wurde, kann (auch) als Folge dieser Entlastung angesehen werden. Wenn man die doch deutlich h here Rate an gest rten Schwangerschaften (Aborte, EU) und Mehrlingsschwangerschaften nach ART bedenkt, so haben die spontan schwanger gewordenen PatientInnen, die sich, gestützt auf die Autorit t eines Reproduktionsmedizinischen Zentrums mehr auf die eigenen Ressourcen zur Gesundung verlassen haben, eindeutig gewonnen.
A characterization of irreducible symmetric spaces and Euclidean buildings of higher rank by their asymptotic geometry
Bernhard Leeb
Mathematics , 2009,
Abstract: We study geodesically complete and locally compact Hadamard spaces X whose Tits boundary is a connected irreducible spherical building. We show that X is symmetric iff complete geodesics in X do not branch and a Euclidean building otherwise. Furthermore, every boundary equivalence (cone topology homeomorphism preserving the Tits metric) between two such spaces is induced by a homothety. As an application, we can extend the Mostow and Prasad rigidity theorems to compact singular (orbi)spaces of nonpositive curvature which are homotopy equivalent to a quotient of a symmetric space or Euclidean building by a cocompact group of isometries.
Evaluation and selection of models for out-of-sample prediction when the sample size is small relative to the complexity of the data-generating process
Hannes Leeb
Mathematics , 2008, DOI: 10.3150/08-BEJ127
Abstract: In regression with random design, we study the problem of selecting a model that performs well for out-of-sample prediction. We do not assume that any of the candidate models under consideration are correct. Our analysis is based on explicit finite-sample results. Our main findings differ from those of other analyses that are based on traditional large-sample limit approximations because we consider a situation where the sample size is small relative to the complexity of the data-generating process, in the sense that the number of parameters in a `good' model is of the same order as sample size. Also, we allow for the case where the number of candidate models is (much) larger than sample size.
The distribution of a linear predictor after model selection: Unconditional finite-sample distributions and asymptotic approximations
Hannes Leeb
Mathematics , 2006, DOI: 10.1214/074921706000000518
Abstract: We analyze the (unconditional) distribution of a linear predictor that is constructed after a data-driven model selection step in a linear regression model. First, we derive the exact finite-sample cumulative distribution function (cdf) of the linear predictor, and a simple approximation to this (complicated) cdf. We then analyze the large-sample limit behavior of these cdfs, in the fixed-parameter case and under local alternatives.
3-manifolds with(out) metrics of nonpositive curvature
Bernhard Leeb
Mathematics , 1994, DOI: 10.1007/BF01231445
Abstract: In the context of Thurstons geometrisation program we address the question which compact aspherical 3-manifolds admit Riemannian metrics of nonpositive curvature. We show that non-geometric Haken manifolds generically, but not always, admit such metrics. More precisely, we prove that a Haken manifold with, possibly empty, boundary of zero Euler characteristic admits metrics of nonpositive curvature if the boundary is non-empty or if at least one atoroidal component occurs in its canonical topological decomposition. Our arguments are based on Thurstons Hyperbolisation Theorem. We give examples of closed graph-manifolds with linear gluing graph and arbitrarily many Seifert components which do not admit metrics of nonpositive curvature.
Conditional predictive inference post model selection
Hannes Leeb
Statistics , 2009, DOI: 10.1214/08-AOS660
Abstract: We give a finite-sample analysis of predictive inference procedures after model selection in regression with random design. The analysis is focused on a statistically challenging scenario where the number of potentially important explanatory variables can be infinite, where no regularity conditions are imposed on unknown parameters, where the number of explanatory variables in a "good" model can be of the same order as sample size and where the number of candidate models can be of larger order than sample size. The performance of inference procedures is evaluated conditional on the training sample. Under weak conditions on only the number of candidate models and on their complexity, and uniformly over all data-generating processes under consideration, we show that a certain prediction interval is approximately valid and short with high probability in finite samples, in the sense that its actual coverage probability is close to the nominal one and in the sense that its length is close to the length of an infeasible interval that is constructed by actually knowing the "best" candidate model. Similar results are shown to hold for predictive inference procedures other than prediction intervals like, for example, tests of whether a future response will lie above or below a given threshold.
On the conditional distributions of low-dimensional projections from high-dimensional data
Hannes Leeb
Statistics , 2013, DOI: 10.1214/12-AOS1081
Abstract: We study the conditional distribution of low-dimensional projections from high-dimensional data, where the conditioning is on other low-dimensional projections. To fix ideas, consider a random d-vector Z that has a Lebesgue density and that is standardized so that $\mathbb{E}Z=0$ and $\mathbb{E}ZZ'=I_d$. Moreover, consider two projections defined by unit-vectors $\alpha$ and $\beta$, namely a response $y=\alpha'Z$ and an explanatory variable $x=\beta'Z$. It has long been known that the conditional mean of y given x is approximately linear in x$ under some regularity conditions; cf. Hall and Li [Ann. Statist. 21 (1993) 867-889]. However, a corresponding result for the conditional variance has not been available so far. We here show that the conditional variance of y given x is approximately constant in x (again, under some regularity conditions). These results hold uniformly in $\alpha$ and for most $\beta$'s, provided only that the dimension of Z is large. In that sense, we see that most linear submodels of a high-dimensional overall model are approximately correct. Our findings provide new insights in a variety of modeling scenarios. We discuss several examples, including sliced inverse regression, sliced average variance estimation, generalized linear models under potential link violation, and sparse linear modeling.
Papel de la biopsia dinámica del ganglio centinela en el cáncer de próstata organoconfinado
Janetschek,G.; Jeschke,S.; Leeb,K.; Prammer,P.; Ziegerhofer,J.; Sega,W.;
Actas Urológicas Espa?olas , 2007, DOI: 10.4321/S0210-48062007000600015
Abstract: proper assessment of lymph node status is of crucial importance in the management of newly diagnosed prostate cancer. early stage metastatic disease takes the form of microscopic tumor-cell deposits rather than grossly enlarged nodes. so far there is no imaging technique, however, which allows detecting small metastases in the range of a few millimetres. therefore pelvic lymph node dissection (plnd) is the only reliable method of staging for clinically localized prostate cancer. the cornerstone of radioguided prostate surgery is a radiopharmaceutical - a carrier molecule labeled by radionuclide. after injection to at the prostate, the radiopharmaceutical crosses the lymphatic pores and migrates into the lymph vessels and from there to the first echelon of lymph nodes. we were the first to show that sentinel plnd can be performed by means of laparoscopy preceding laparoscopic radical prostatectomy. our most recent publication presents data of 140 patients with clinically localized prostate cancer in which laparoscopic sentinel plnd was performed preceding radical prostatectomy from november 2001 to january 200514. on the preoperative scintigraphy slns were detected bilaterally, unilaterally, not on the pelvic-walls in 113 (80.7%), 20 (14.2%) and 6 (4.2%) patients and intraoperatively in 96 (68.6%), 36 (25.7%), 8 (5.7%) patients respectively. in 99 out of 140 patients (70.7%) intraoperatively sln was detected in the same position as on preoperative scan. at least one sln was detected in 133 patients (95.3%). whenever plnd is indicated it should not be limited to lymph node sampling as provided by standard limited plnd but has to be performed in the template of extended plnd. there is only limited experience with sentinel plnd, but all the data collected so far indicate that this method has the potential to become an alternative to extended plnd since it allows for reduction of the extent of plnd without compromising diagnostic accuracy.
Medikament se Therapie entzündlich rheumatischer Erkrankungen in der Schwangerschaft unter besonderer Berücksichtigung der rheumatoiden Arthritis
Rintelen B,Leeb BF
Speculum - Zeitschrift für Gyn?kologie und Geburtshilfe , 2006,
Abstract: Chronische Krankheiten wie die rheumatoide Arthritis (RA) (auch als chronische Polyarthritis bezeichnet) ben tigen eine Langzeittherapie. Ist nun eine Schwangerschaft unter einer laufenden Therapie geplant oder tritt eine Schwangerschaft unter einer laufenden Therapie ein, so stellt sich die Frage der Teratogenit t oder Embryotoxizit t der angewendeten Substanzen. Dieser Artikel soll einen Beitrag zur Anwendung derzeit g ngiger Medikamente in der Behandlung der RA in der Schwangerschaft liefern.
Editorial: 60 Jahre sterreichische Gesellschaft für Rheumatologie
Schirmer M,Leeb B
Journal für Mineralstoffwechsel , 2009,
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