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Search Results: 1 - 10 of 25642 matches for " Lee-Hsueh Lee "
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The Relationship between Visual Satisfaction and Water Clarity and Quality Management in Tourism Fishing Ports  [PDF]
Lee-Hsueh Lee
Journal of Water Resource and Protection (JWARP) , 2016, DOI: 10.4236/jwarp.2016.88064
Abstract: Visual satisfaction of the tourists with a water body is strongly influenced by water clarity, which is in turn influenced by a number of water quality parameters. Visual satisfaction thus stands to benefit from having a water quality management tool that results in better water clarity. A Clarity Suitability Index of Water Quality (CSIWQ), derived from clarity suitability curves of selected water quality parameters, can allow estimation of optimal values for these parameters, while ensuring high visual satisfaction among tourists. The present study used sampling and survey methodologies to investigate water clarity and quality at five tourism fishing ports; simultaneously, tourists’ visual satisfaction with a water body was assessed through a questionnaire based on their perceptions. The relationship between tourists’ visual satisfaction and water clarity was found to be positive and strong, with water clarity having predictive power of 74.2%. The study showed that DO, BOD, TP, and SS were the most critical parameters for water clarity. A continued product approach of CSIWQ was found to be most appropriate for describing the relationship between water clarity and these four parameters. This enabled a CSIWQ Index value to be calculated. With a CSIWQ value of 0.6, water clarity would be more than 2.08 m, and tourists would experience very high satisfaction. CSI curves showed that DO would preferably be 9.0 mg/L, and BOD, TP, and SS less than 0.5 mg/L, 0.12 mg/L, and 45.0 mg/L, respectively. The model thus produced valuable insights for assessing and improving water quality and ensuring high levels of visual satisfaction among tourists in tourism fishing ports. This model identified only four parameters but could be improved by ensuring that other water quality parameters were included, to encourage an increase in the number of tourists and to include monitoring of more pollutant sources.
Appearance’s Aesthetic Appreciation to Inform Water Quality Management of Waterscapes  [PDF]
Lee-Hsueh Lee
Journal of Water Resource and Protection (JWARP) , 2017, DOI: 10.4236/jwarp.2017.913103
Abstract:
The appearance of the water is just one aspect of a waterscape that can be appreciated aesthetically. Water appearance is affected by water clarity and water colour. Here, an aesthetic assessment model of waterscape was suggested. In the model, water clarity and colour have direct effects, whereas water quality and phytoplankton biomass have indirect effects, on tourists’ aesthetic assessment of water bodies. The preferred water colour is aquamarine to blue, regardless of depth of clarity. Water colour ranges from pastel yellow to yellow-green are not favoured by tourists. Four water-quality parameters were correlated with water clarity and phytoplankton biomass. The coefficient of indirect effect of river pollution index on tourists’ aesthetic valuation of aquamarine to blue water colour was -0.457, and for pastel yellow to yellowgreen, it was -0.209. The research results showed observation of water colour could not only reflect waterscape aesthetic value, but also serve as a guide of judging water quality, and the status of phytoplankton benefited to simplify the process of water-quality management for waterscape.
A Novel Intra-U1 snRNP Cross-Regulation Mechanism: Alternative Splicing Switch Links U1C and U1-70K Expression
Tanja Dorothe R?sel-Hillg?rtner,Lee-Hsueh Hung,Ekaterina Khrameeva,Patrick Le Querrec,Mikhail S. Gelfand,Albrecht Bindereif
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003856
Abstract: The U1 small nuclear ribonucleoprotein (snRNP)-specific U1C protein participates in 5′ splice site recognition and regulation of pre-mRNA splicing. Based on an RNA-Seq analysis in HeLa cells after U1C knockdown, we found a conserved, intra-U1 snRNP cross-regulation that links U1C and U1-70K expression through alternative splicing and U1 snRNP assembly. To investigate the underlying regulatory mechanism, we combined mutational minigene analysis, in vivo splice-site blocking by antisense morpholinos, and in vitro binding experiments. Alternative splicing of U1-70K pre-mRNA creates the normal (exons 7–8) and a non-productive mRNA isoform, whose balance is determined by U1C protein levels. The non-productive isoform is generated through a U1C-dependent alternative 3′ splice site, which requires an adjacent cluster of regulatory 5′ splice sites and binding of intact U1 snRNPs. As a result of nonsense-mediated decay (NMD) of the non-productive isoform, U1-70K mRNA and protein levels are down-regulated, and U1C incorporation into the U1 snRNP is impaired. U1-70K/U1C-deficient particles are assembled, shifting the alternative splicing balance back towards productive U1-70K splicing, and restoring assembly of intact U1 snRNPs. Taken together, we established a novel feedback regulation that controls U1-70K/U1C homeostasis and ensures correct U1 snRNP assembly and function.
Amino Terminal Domains of the NMDA Receptor Are Organized as Local Heterodimers
Chia-Hsueh Lee,Eric Gouaux
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019180
Abstract: The N-methyl-D-aspartate (NMDA) receptor, an obligate heterotetrameric assembly organized as a dimer of dimers, is typically composed of two glycine-binding GluN1 subunits and two glutamate-binding GluN2 subunits. Despite the crucial role that the NMDA receptor plays in the nervous system, the specific arrangement of subunits within the dimer-of-dimer assemblage is not conclusively known. Here we studied the organization of the amino terminal domain (ATD) of the rat GluN1/GluN2A and GluN1/GluN2B NMDA receptors by cysteine-directed, disulfide bond-mediated cross-linking. We found that GluN1 ATDs and GluN2 ATDs spontaneously formed disulfide bond-mediated dimers after introducing cysteines into the L1 interface of GluN2A or GluN2B ATD. The formation of dimer could be prevented by knocking out endogenous cysteines located near the L1 interface of GluN1. These results indicate that GluN1 and GluN2 ATDs form local heterodimers through the interactions in the L1-L1 interface and further demonstrate a dimer-of-heterodimer arrangement in GluN1/GluN2A and GluN1/GluN2B NMDA receptors.
A Method for Balancing a Single-Phase Loaded Three-Phase Induction Generator
Yaw-Juen Wang,Ming-Hsueh Lee
Energies , 2012, DOI: 10.3390/en5093534
Abstract: When a three-phase induction generator (IG) supplies unbalanced loads, its terminal voltages and line currents are also unbalanced, which may cause the IG to overheat and need to be derated. A single-phase loaded self-excited induction generator (SEIG) works under most unfavorable load unbalance conditions. This paper proposes a three-capacitor circuit scheme and a method to find the values of the self-excitation capacitors that allow the SEIG to be balanced. The SEIG is modeled by a two-port network equivalent circuit that resolves the SEIG into its positive- and negative-sequence circuits associated with the self-excitation capacitors and the load. The network can then be analyzed by common AC circuit analysis techniques. Successful results for balancing the SEIG supplying a single-phase load have been achieved by properly choosing the values of the excitation capacitors. The proposed method has also been validated by experiments on a 0.37 kW SEIG.
Forecasting Tourism Demand Using Time Series, Artificial Neural Networks and Multivariate Adaptive Regression Splines:Evidence from Taiwan
Chang Jui Lin,Hsueh Fang Chen,Tian Shyug Lee
International Journal of Business Administration , 2011, DOI: 10.5430/ijba.v2n2p14
Abstract: In the past few decades, international tourism has grown rapidly and has become a very interesting topic in tourism research. Taiwan, acting as a citizen in the global community, improved traveling facilities, and governments’ strong promotion has drawn more and more visitors to visit Taiwan. This study tries to build the forecasting model of visitors to Taiwan using three commonly adopted ARIMA, artificial neural networks (ANNs), and multivariate adaptive regression splines (MARS). In order to evaluate the appropriateness of the proposed modeling approaches, the dataset of monthly visitors to Taiwan was used as the illustrative example. Analytic results demonstrated that ARIMA outperformed ANNs and MARS approaches in terms of RMSE, MAD, and MAPE and provided effective alternatives for forecasting tourism demand.
Sleep-disordered Breathing in Children
Hsueh-Yu Li,Li-Ang Lee
Chang Gung Medical Journal , 2009,
Abstract: Children with sleep-disordered breathing (SDB) can manifesta continuum from simple snoring and upper airway resistancesyndrome to obstructive sleep apnea (OSA) with secondarygrowth impairment, neurocognitive deficits, and lessoften cardiovascular sequelae. Most children who present withSDB are four to eight years old with variable clinical symptomsat different ages. In general, infants often present withnoisy breathing and disturbed nocturnal sleep, toddlers andpreschool-aged children with snoring and mouth breathing,and school-aged children with behavioral and dental problems.The pathogenesis of SDB in children remains incompletelyunderstood. Adenotonsillar hypertrophy is the leading cause ofOSA. Other risk factors include allergic rhinitis, craniofacialanomalies, cleft palate following pharyngeal flap surgery, neuromusculardiseases, laryngomalacia, and obesity.Polysomnography (PSG) is the gold standard diagnostic tool. However, great variationexists in the interpretation of PSG and criteria for the definition of pediatric OSA, eventhough consensus statements have been used to standardize the scoring of summary indicesfor the disorders. Adenotonsillectomy is the cardinal treatment for pediatric SDB. Rapidmaxillary expansion is a useful approach in upper jaw contraction. Distraction osteogenesishas become an acceptable procedure in the treatment of severe maxillomandibular deficiency.Continuous positive airway pressure has been successful in treating intractable or severeOSA in children with other underlying medical disorders and has modified the indicationsfor tracheotomy in pediatric patients with craniofacial anomalies and OSA. Follow-up inchildren treated for OSA reveals that underlying structural or neuromuscular abnormalitiescan decrease the response to treatment and obesity may lead to recurrence of OSA later duringadolescence.
Dynamical Linear Response of TDDFT with LDA+U Functional: strongly hybridized Frenkel excitons in NiO
Chi-Cheng Lee,H. C. Hsueh,Wei Ku
Physics , 2010, DOI: 10.1103/PhysRevB.82.081106
Abstract: Within the framework of time-dependent density-functional theory (TDDFT), we derive the dynamical linear response of LDA+U functional and benchmark it on NiO, a prototypical Mott insulator. Formulated using real-space Wannier functions, our computationally inexpensive framework gives detailed insights into the formation of tightly bound Frenkel excitons with reasonable accuracy. Specifically, a strong hybridization of multiple excitons is found to significantly modify the exciton properties. Furthermore, our study exposes a significant generic limitation of adiabatic approximation in TDDFT with hybrid functionals and in existing Bethe-Salpeter-equation approaches, advocating the necessity of strongly energy-dependent kernels in future development.
Replacement Paths via Row Minima of Concise Matrices
Cheng-Wei Lee,Hsueh-I Lu
Computer Science , 2013, DOI: 10.1137/120897146
Abstract: Matrix $M$ is {\em $k$-concise} if the finite entries of each column of $M$ consist of $k$ or less intervals of identical numbers. We give an $O(n+m)$-time algorithm to compute the row minima of any $O(1)$-concise $n\times m$ matrix. Our algorithm yields the first $O(n+m)$-time reductions from the replacement-paths problem on an $n$-node $m$-edge undirected graph (respectively, directed acyclic graph) to the single-source shortest-paths problem on an $O(n)$-node $O(m)$-edge undirected graph (respectively, directed acyclic graph). That is, we prove that the replacement-paths problem is no harder than the single-source shortest-paths problem on undirected graphs and directed acyclic graphs. Moreover, our linear-time reductions lead to the first $O(n+m)$-time algorithms for the replacement-paths problem on the following classes of $n$-node $m$-edge graphs (1) undirected graphs in the word-RAM model of computation, (2) undirected planar graphs, (3) undirected minor-closed graphs, and (4) directed acyclic graphs.
Fatty Acid and Phospholipid Syntheses Are Prerequisites for the Cell Cycle of Symbiodinium and Their Endosymbiosis within Sea Anemones
Li-Hsueh Wang, Hsieh-He Lee, Lee-Shing Fang, Anderson B. Mayfield, Chii-Shiarng Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072486
Abstract: Lipids are a source of metabolic energy, as well as essential components of cellular membranes. Although they have been shown to be key players in the regulation of cell proliferation in various eukaryotes, including microalgae, their role in the cell cycle of cnidarian-dinoflagellate (genus Symbiodinium) endosymbioses remains to be elucidated. The present study examined the effects of a lipid synthesis inhibitor, cerulenin, on the cell cycle of both cultured Symbiodinium (clade B) and those engaged in an endosymbiotic association with the sea anemone Aiptasia pulchella. In the former, cerulenin exposure was found to inhibit free fatty acid (FFA) synthesis, as it does in other organisms. Additionally, while it also significantly inhibited the synthesis of phosphatidylethanolamine (PE), it did not affect the production of sterol ester (SE) or phosphatidylcholine (PC). Interestingly, cerulenin also significantly retarded cell division by arresting the cell cycles at the G0/G1 phase. Cerulenin-treated Symbiodinium were found to be taken up by anemone hosts at a significantly depressed quantity in comparison with control Symbiodinium. Furthermore, the uptake of cerulenin-treated Symbiodinium in host tentacles occurred much more slowly than in untreated controls. These results indicate that FFA and PE may play critical roles in the recognition, proliferation, and ultimately the success of endosymbiosis with anemones.
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