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Search Results: 1 - 10 of 26700 matches for " Lee Yee Choong "
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Proteome-Wide Profiling of the MCF10AT Breast Cancer Progression Model
Lee Yee Choong,Simin Lim,Poh Kuan Chong,Chow Yin Wong,Nilesh Shah,Yoon Pin Lim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011030
Abstract: Mapping the expression changes during breast cancer development should facilitate basic and translational research that will eventually improve our understanding and clinical management of cancer. However, most studies in this area are challenged by genetic and environmental heterogeneities associated with cancer.
Total Quality Management and Knowledge Sharing: Comparing Malaysia’s Manufacturing and Service Organizations
Weng-Choong Cheah,Keng-Boon Ooi,Pei-Lee Teh,Alain Yee-Loong Chong
Journal of Applied Sciences , 2009,
Abstract: The aim of this study was to examine the difference between Malaysian manufacturing and service organizations with regard to the multidimensionality of TQM practices and the relationship of these practices to knowledge sharing behavior from middle management employees’ perspective. The empirical data for this study were collected from 208 middle management employees from Malaysian manufacturing and service organizations with a response rate of 62.01% (129 respondents) from the manufacturing firms and 37.98% (79 respondents) from the service firms. The finding indicated there was no significance difference between Malaysian manufacturing and service organizations in the level of TQM practices and knowledge sharing. The multiple regression analysis also indicated a stronger relationship for manufacturing firms than for service firms between TQM practices and knowledge sharing, particularly in relation to teamwork. Results should be an interest to the TQM managers and practitioners in Malaysia. This finding increased our understanding on the applicability of TQM practices and the association of these practices to knowledge sharing in both Malaysian manufacturing and service organizations. This study has contributed towards advancing the TQM literature with a better understanding of the perception of middle management employees of TQM practices and its association with knowledge sharing in both Malaysian manufacturing and service organizations.
Knockdown of a-Synuclein Enhances Susceptibility to Staurosporine-Induced Apoptosis in Human Melanoma SK-MEL28 Cells
Chi-Jing Choong,Yee-How Say
Journal of Biological Sciences , 2011,
Abstract: a-Synuclein (a-Syn) is a central player in the pathophysiology of dopaminergic neurodegeneration that occurs in Parkinsons disease. Recently, it has been demonstrated that a-Syn is highly expressed in human melanoma cell line, SK-MEL28 but is undetectable in non-melanocytic cutaneous carcinoma and normal skin. Its wild-type form was also found to inhibit apoptosis in response to various pro-apoptotic stimuli, making it another attractive candidate in oncogenesis besides ?-Syn. Therefore, the objective of this study was to investigate the cyto-toxic/-protective roles of a-Syn in melanoma SK-MEL28 cells, by knockdown and subjecting cells to apoptotic stimulus, staurosporine. For knockdown, short hairpin RNAs (shRNAs) targeting a-Syn were constructed in the expression vector, pLKO.1 and then transfected into SK-MEL28 cells with pLKO.1-TRC control and pLKO.1-scramble shRNA as controls. Stably transfected cells were established by selection with puromycin and a-Syn protein expression was then confirmed by Western blotting. The effects of a-Syn knockdown on cell viability, morphology, expression of Bcl-2, Bcl-XL, Bax and cleaved caspase 9 and proliferative index after staurosporine treatment were studied. Cell viability MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide) assay showed that the survival of SK-MEL28 with a-Syn knockdown was significantly reduced as compared to controls. Depletion of endogenous a-Syn was found to enhance staurosporine-induced cytotoxicity in SK-MEL28 with greater Bax/Bcl-2 and Bax/Bcl-xL ratios and cleaved caspase 9 level. a-Syn knockdown also reduced the proliferative index of SK-MEL28. Overall, these results suggest that the endogenously high a-Syn confers resistance against apoptosis in SK-MEL28 cells.
A Survey on Classification of Components from Software Reuse Repository
Dr Leelavathi Rajamanickam, Kate Lam Woon Yee, Chen Woon Choong
International Journal of Scientific Engineering and Technology , 2017, DOI: 10.5958/2277-1581.2017.00016.X
Abstract: This paper proposes a new approach for locating software components from a large repository. The recent software reuse progress in the software component basedon engineering has offered many facilities in the field of software reuse. The software components are developed for a software product may be useful for them if they develop a similar product in the future. So the components that are identified as reusable are stored in the repository so that other teams can use them to serve in to get a quality product. But to get the reusable components from the repository, we need searches so that we can get our needed component. The user should be able to perform a search based on certain fixed categories by using different retrieval techniques. The work presented in this is a contribution to the first challenge which is to build a repository for supporting the use of software components in the development of retrieving software components. A tool for building such a repository has been implemented in software components with features to classify, store and retrieve components. This paper focuses on software tool with a new component classification scheme to make classification build of software components from software repository to make of retrieving software components and effective software reuse repositories.
Mathematics for Teaching or Mathematics for Teachers?
Lee Peng Yee
Mathematics Educator , 2006,
Interplay between local electron correlation and Janh-Teller electron-phonon interaction
Choong H. Kim,Hyun C. Lee
Physics , 2006, DOI: 10.1103/PhysRevB.73.113109
Abstract: The infinite-$U$ Anderson model coupled to a Jahn-Teller phonon is studied using the slave boson method on the basis of the large degeneracy expansion (1/N) scheme. The model Hamiltonian acts on the orbital degrees of freedom. The main focus is on the interplay between strong local electron correlation and weak Jahn-Teller electron-phonon interaction. The Kondo temperature is found to decrease by Jahn-Teller interaction. The influence of the Jahn-Teller interaction on dynamical correlation functions is very significant in sharp contrast with the case of the Holstein-type phonon which couples to charge degrees of freedom.
Study Protocol to Investigate the Efficacy of Participation in Qi-Gong by Breast Cancer Survivors  [PDF]
Shing Yee Lee, Siew Yim Loh, Liam Murray
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.25097
Abstract: Background: Physical activity improves quality of life and reduces the risks of breast cancer up to 30 - 40 percent. Qi-Gong is a form of exercise widely acknowledged by Asian survivors as health promoting, despite a lack of research evidence. This study aimed to investigate the efficacy of Qi-Gong on the Quality of Life (QOL) of survivors. Methods/ Design: A total of 114 women who had been treated for stage I or II breast cancer at least 12 months previously were randomly assigned to supervised aerobic exercise (n = 38), Qi-Gong exercise (n = 38), or usual care (n = 38). Supervised 1.5 hour exercise sessions took place three times per week for 8 weeks (face to face—once a week and home follow up twice a week). Outcomes included QoL (FACT-G), Functional Assessment of Cancer Therapy-Breast (FACT-B)], distress [Depression Anxiety Stress Scale (DASS)] assessed at baseline and at the 8-week follow-up. Secondary measures included exercise Self Efficacy Scale (ESS), Functional Assessment of Cancer Therapy-Fatigue (FACT-F) and exercise behavior (log) Two way (group × time) repeated measures ANOVA will examine differences between groups over time. Discussion: This research will provide insights on the efficacy of a 8 weeks structured Qi-Gong program designed for quality of life. The details of the Qi-Gong and the placebo (line dancing) over 8 weeks are delineated, with the study protocol for researcher’s replication. The result of the study can contribute towards understanding how Qi-Gong over other physical activity can be used for self managing physical health for people with breast cancer, an increasingly acknowledged chronic condition. Conclusion: Women with breast cancer need to start engaging in physically healthy-active living on a day-to-day basis for prevention of recurrence, mortality and wellbeing. However, many requires professional support with a structured intervention. This design of this study provides a protocol for 8 weeks Qi-Gong with implications on healthy survivorship, and a possible reduction on healthcare costs related to long-term effects and co morbidities that can be prevented via physical activity.
Acute Hip Pain—A Forgotten Cause  [PDF]
Tzay-Ping Fua, Yee Han Dave Lee
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.73018
Abstract: This is a case of acute left hip pain in a young male patient presenting to the Emergency Department (ED). The hip joint is painful with limited range of motion, and the patient is admitted to rule out septic arthritis of the hip. The subsequent inpatient serum uric acid level performed is elevated and the Magnetic Resonance Imaging (MRI) hip reveals a moderate hip effusion. A Computer Tomography (CT) guided hip joint aspiration confirms the diagnosis of gout with uric acid crystals seen in the hip synovial fluid analysis. The patient is treated as for gout with marked improvement in his symptoms.
A Robust Cad Tool for Integrated Design of UWB Antenna System
Zhan Zhang;Yee Hui Lee
PIER , 2011, DOI: 10.2528/PIER10110502
Abstract: This paper proposes a robust Computer-Aided Design (CAD) tool for an Ultra-Wideband (UWB) antenna system which successfully integrates the design of the transmitting antenna, the receiving antenna and the shaping of the transmitted pulse. The distinctive features of this tool include: the efficient characterization of transfer function in terms of an analytical model, the effective evaluation from system point of view and the simultaneous optimization of multiple objectives. Using this tool, an automatic and efficient design can be realized to deliver the UWB antenna system upon the optimal performance.
An Automatic Model Order Reduction of a UWB Antenna System
Zhan Zhang;Yee Hui Lee
PIER , 2010, DOI: 10.2528/PIER09103001
Abstract: This paper proposes an efficient and automatic means of achieving a reduced model of a transfer function for UWB antenna design. According to the formulation of a transfer function, we have derived two factors, which are critical in determining the radiation pattern and input impedance respectively. Their special formula allow us to establish a reduced model automatically using the Model Order Reduction (MOR) techniques of a second order system. The process is free of any human factors and suitable to any antenna systems, thus enabling a direct and efficient interface with the optimization process in the design of a UWB antenna system. In addition, the proposed way of establishing a transfer function of the whole antenna system has successfully cascaded the entire system into separate subsystems, thus offering deeper insights in analyzing a UWB antenna system.
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