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Search Results: 1 - 10 of 25274 matches for " Lee Sejoon "
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Building the process-drug–side effect network to discover the relationship between biological Processes and side effects
Lee Sejoon,Lee Kwang H,Song Min,Lee Doheon
BMC Bioinformatics , 2011, DOI: 10.1186/1471-2105-12-s2-s2
Abstract: Background Side effects are unwanted responses to drug treatment and are important resources for human phenotype information. The recent development of a database on side effects, the side effect resource (SIDER), is a first step in documenting the relationship between drugs and their side effects. It is, however, insufficient to simply find the association of drugs with biological processes; that relationship is crucial because drugs that influence biological processes can have an impact on phenotype. Therefore, knowing which processes respond to drugs that influence the phenotype will enable more effective and systematic study of the effect of drugs on phenotype. To the best of our knowledge, the relationship between biological processes and side effects of drugs has not yet been systematically researched. Methods We propose 3 steps for systematically searching relationships between drugs and biological processes: enrichment scores (ES) calculations, t-score calculation, and threshold-based filtering. Subsequently, the side effect-related biological processes are found by merging the drug-biological process network and the drug-side effect network. Evaluation is conducted in 2 ways: first, by discerning the number of biological processes discovered by our method that co-occur with Gene Ontology (GO) terms in relation to effects extracted from PubMed records using a text-mining technique and second, determining whether there is improvement in performance by limiting response processes by drugs sharing the same side effect to frequent ones alone. Results The multi-level network (the process-drug-side effect network) was built by merging the drug-biological process network and the drug-side effect network. We generated a network of 74 drugs-168 side effects-2209 biological process relation resources. The preliminary results showed that the process-drug-side effect network was able to find meaningful relationships between biological processes and side effects in an efficient manner. Conclusions We propose a novel process-drug-side effect network for discovering the relationship between biological processes and side effects. By exploring the relationship between drugs and phenotypes through a multi-level network, the mechanisms underlying the effect of specific drugs on the human body may be understood.
Specific heat study of Ga1-xMnxAs
Sh. U. Yuldashev,Kh. T. Igamberdiev,Sejoon Lee,Y. H. Kwon,T. W. Kang,Yongmin Kim,Hyunsik Im,A. G. Shashkov
Physics , 2010, DOI: 10.1143/APEX.3.073005
Abstract: Specific heat measurements were used to study the magnetic phase transition in Ga1-xMnxAs. Two different types of Ga1-xMnxAs samples have been investigated. The sample with a Mn concentration of 1.6% shows insulating behavior, and the sample with a Mn concentration of 2.6% is metallic. The temperature dependence of the specific heat for both samples reveals a pronounced lambda-shaped peak near the Curie temperature, which indicates a second-order phase transition in these samples. The critical behavior of the specific heat for Ga1-xMnxAs samples is consistent with the mean-field behavior with Gaussian fluctuations of the magnetization in the close vicinity of TC.
Matching rules from Al-Co potentials in an almost realistic model
Sejoon Lim,M. Mihalkovic,C. L. Henley
Physics , 2008,
Abstract: We consider a model decagonal quasicrystal of composition Al$_{80.1}$Co$_{19.9}$ -- closely related to actual structures, and using realistic pair potentials -- on a quasilattice of candidate sites. Its ground state, according to simulations, is a Hexagon-Boat-Star tiling satisfying Penrose's matching rules. In this note, we rationalize these results in terms of the potentials; the Al-Co second-neighbor potential well is crucial.
Penrose Matching Rules from Realistic Potentials in a Model System
Sejoon Lim,M. Mihalkovic,C. L. Henley
Physics , 2008, DOI: 10.1080/14786430802302026
Abstract: We exhibit a toy model of a binary decagonal Al-Co quasicrystal -- closely related to actual structures -- in which realistic pair potentials yield a ground state which appears to perfectly implement Penrose's matching rules, for Hexagon-Boat-Star (HBS) tiles of edge 2.45 A. The second minimum of the potentials is crucial for this result.
The Relationship between Visual Satisfaction and Water Clarity and Quality Management in Tourism Fishing Ports  [PDF]
Lee-Hsueh Lee
Journal of Water Resource and Protection (JWARP) , 2016, DOI: 10.4236/jwarp.2016.88064
Abstract: Visual satisfaction of the tourists with a water body is strongly influenced by water clarity, which is in turn influenced by a number of water quality parameters. Visual satisfaction thus stands to benefit from having a water quality management tool that results in better water clarity. A Clarity Suitability Index of Water Quality (CSIWQ), derived from clarity suitability curves of selected water quality parameters, can allow estimation of optimal values for these parameters, while ensuring high visual satisfaction among tourists. The present study used sampling and survey methodologies to investigate water clarity and quality at five tourism fishing ports; simultaneously, tourists’ visual satisfaction with a water body was assessed through a questionnaire based on their perceptions. The relationship between tourists’ visual satisfaction and water clarity was found to be positive and strong, with water clarity having predictive power of 74.2%. The study showed that DO, BOD, TP, and SS were the most critical parameters for water clarity. A continued product approach of CSIWQ was found to be most appropriate for describing the relationship between water clarity and these four parameters. This enabled a CSIWQ Index value to be calculated. With a CSIWQ value of 0.6, water clarity would be more than 2.08 m, and tourists would experience very high satisfaction. CSI curves showed that DO would preferably be 9.0 mg/L, and BOD, TP, and SS less than 0.5 mg/L, 0.12 mg/L, and 45.0 mg/L, respectively. The model thus produced valuable insights for assessing and improving water quality and ensuring high levels of visual satisfaction among tourists in tourism fishing ports. This model identified only four parameters but could be improved by ensuring that other water quality parameters were included, to encourage an increase in the number of tourists and to include monitoring of more pollutant sources.
Appearance’s Aesthetic Appreciation to Inform Water Quality Management of Waterscapes  [PDF]
Lee-Hsueh Lee
Journal of Water Resource and Protection (JWARP) , 2017, DOI: 10.4236/jwarp.2017.913103
Abstract:
The appearance of the water is just one aspect of a waterscape that can be appreciated aesthetically. Water appearance is affected by water clarity and water colour. Here, an aesthetic assessment model of waterscape was suggested. In the model, water clarity and colour have direct effects, whereas water quality and phytoplankton biomass have indirect effects, on tourists’ aesthetic assessment of water bodies. The preferred water colour is aquamarine to blue, regardless of depth of clarity. Water colour ranges from pastel yellow to yellow-green are not favoured by tourists. Four water-quality parameters were correlated with water clarity and phytoplankton biomass. The coefficient of indirect effect of river pollution index on tourists’ aesthetic valuation of aquamarine to blue water colour was -0.457, and for pastel yellow to yellowgreen, it was -0.209. The research results showed observation of water colour could not only reflect waterscape aesthetic value, but also serve as a guide of judging water quality, and the status of phytoplankton benefited to simplify the process of water-quality management for waterscape.
Abdominal Fat Reduction through Cryolipolysis  [PDF]
Doyeop Lee, Kyurae Lee
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.69005
Abstract: Although several studies showed the efficacy and safety from this procedure, the comparative assessment of adipose tissue by cryolipolysis has not been studied until now. Therefore we investigated the quantitative change of cross sectional areas of abdominal SAT (subcutaneous adipose tissue) and VAT (visceral adipose tissue) following cryolipolysis. A prospective study for twelve subjects with a single session of cryolipolysis on abdomen was performed. We assessed for their height, weight, and waist circumferences, body contours by photographs, and the cross sectional areas of visceral and subcutaneous adipose tissues were measured at umbilicus level by computerized tomography for 2 months. The cross sectional areas in SAT reduced from 243.3 ± 24.7 to 238.5 ± 40.7 cm2 at 2 months post-treatment. Those of VAT reduced from 141.3 ± 46.4 to 125.1 ± 42.8 cm2 at 2 months post-treatment. Cross sectional areas of VAT, and waist circumferences were significantly reduced by 16.2 cm2, 4.1 cm respectively. Additionally visual improvement without unexpected adverse events was noted. In conclusion a single session cryolipolysis demonstrated to reduce visceral adipose tissue as well as waist circumferences tissue for 2 months. Further controlled study would be needed to evaluate for reduction of visceral adipose tissue by cryolipolysis.
Exponential Ergodicity and β-Mixing Property for Generalized Ornstein-Uhlenbeck Processes  [PDF]
Oesook Lee
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.21004
Abstract: The generalized Ornstein-Uhlenbeck process is derived from a bivariate Lévy process and is suggested as a continuous time version of a stochastic recurrence equation [1]. In this paper we consider the generalized Ornstein-Uhlenbeck process and provide sufficient conditions under which the process is exponentially ergodic and hence holds the expo-nentially β-mixing property. Our results can cover a wide variety of areas by selecting suitable Lévy processes and be used as fundamental tools for statistical analysis concerning the processes. Well known stochastic volatility models in finance such as Lévy-driven Ornstein-Uhlenbeck process is examined as a special case.
Coastal Planning Strategies for Adaptation to Sea Level Rise: A Case Study of Mokpo, Korea  [PDF]
Yumi Lee
Journal of Building Construction and Planning Research (JBCPR) , 2014, DOI: 10.4236/jbcpr.2014.21007
Abstract: Climate change and sea level rise necessitate adaptation strategies for coastal areas. This paper showcases five strategies for sea level rise adaptation: hard protection, soft protection, accommodation, retreat, and attack. This study proposes adaptation measures and a phased development strategy for coastal areas of Mokpo, an old port city on the southwestern tip of the Korean Peninsula that has been expanded by land reclamation. Mokpo presently experiences frequent flooding during high-water and storm events; due to their low elevation and land subsidence, most of the reclaimed areas are susceptible to future inundation via sea level rise. The fundamental adaptation strategies for the impact areas are: hard protection of important infrastructures via multi-tiered terraces; the retreat of coastal developments accompanied by green buffer zones such as wetlands and parks to accommodate temporary inundation; and up-leveling the ground for new development and phased relocation of existing development. Through the case study of Mokpo, the paper emphasizes the importance of resilient planning strategies for urban development, and highlights both the challenges and opportunities for sea level rise adaptation.
Study on the Classification of Speech Anxiety Using Q-Methodology Analysis  [PDF]
SeoYoung Lee
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.23008
Abstract: Public speaking is one of the cornerstones of mass communication, the influence of which has only been enhanced with the advent of the modern era. Yet despite its importance, up to 40% of the world’s population feels anxious when faced with the prospect of presenting in front of an audience (Wilbur, 1981). However, public speaking anxiety is human condition that can be understood and with effort, overcome by sufferers. Based on theoretical research, this study presents an empirical investigation of speech anxiety. The research uses Q-methodology to generate categories of speakers and then draws on the PQ-method program to suggest ways for speakers to improve their speaking confidence based on these categories. This research is of a value to those who are interested in speech anxiety for therapeutic or pedagogical practice.
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