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Search Results: 1 - 10 of 25343 matches for " Lee Caplan "
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Delay in Breast Cancer: Implications for Stage at Diagnosis and Survival
Lee Caplan
Frontiers in Public Health , 2014, DOI: 10.3389/fpubh.2014.00087
Abstract: Breast cancer continues to be a disease with tremendous public health significance. Primary prevention of breast cancer is still not available, so efforts to promote early detection continue to be the major focus in fighting breast cancer. Since early detection is associated with decreased mortality, one would think that it is important to minimize delays in detection and diagnosis. There are two major types of delay. Patient delay is delay in seeking medical attention after self-discovering a potential breast cancer symptom. System delay is delay within the health care system in getting appointments, scheduling diagnostic tests, receiving a definitive diagnosis, and initiating therapy. Earlier studies of the consequences of delay on prognosis tended to show that increased delay is associated with more advanced stage cancers at diagnosis, thus resulting in poorer chances for survival. More recent studies have had mixed results, with some studies showing increased survival with longer delays. One hypothesis is that diagnostic difficulties could perhaps account for this survival paradox. A rapidly growing lump may suggest cancer to both doctors and patients, while a slow growing lump or other symptoms could be less obvious to them. If this is the case, then the shorter delays would be seen with the more aggressive tumors for which the prognosis is worse leading to reduced survival. It seems logical that a tumor that is more advanced at diagnosis would lead to shorter survival but the several counter-intuitive studies in this review show that it is dangerous to make assumptions.
Bioethics Grows Up
Arthur Caplan
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060095
Paul Caplan
PLATFORM : Journal of Media and Communication , 2010,
Abstract: he Olympic Games in London in 2012 is being built online as well as off through official and unofficial photographs which serve to position ‘2012’ within a discourse of legacy and participation. This paper looks at how network protocols can be addressed as what Bruno Latour would call ‘actants’, non-human actors that generate and discipline that visualisation within a particular network scopic regime (Jay, 1988). Following Galloway (2004), protocols such as JPEG/EXIF and XML can be seen as generating new scopic texts/practices around archive and openness which underpin 2012 ideologies of legacy and participation. The paper goes on to explore the potential of critical intervention in that regime using Benjamin’s model of writing history developed in The Arcades Project (1999).
Bioethics Grows Up
Arthur Caplan
PLOS Biology , 2008, DOI: 10.1371/journal.pbio.0060095
GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation
Steve Caplan
Frontiers in Cell and Developmental Biology , 2014, DOI: 10.3389/fcell.2014.00022
Abstract: The biogenesis of tubular recycling endosomes (TREs) and their subsequent vesiculation after cargo-sorting has occurred, is essential for receptor and lipid recycling to the plasma membrane. Although recent studies have implicated the C-terminal Eps15 Homology Domain (EHD) protein, EHD1, as a key regulator of TRE vesiculation, additional proteins involved in this process have been largely uncharacterized. In the present study, we identify the GTPase Regulator Associated with Focal adhesion kinase-1 (GRAF1) protein in a complex with EHD1 and the TRE hub protein, Molecules Interacting with CasL-Like1 (MICAL-L1). Over-expression of GRAF1 caused vesiculation of MICAL-L1-containing TRE, whereas GRAF1-depletion led to impaired TRE vesiculation and delayed receptor recycling. Moreover, co-addition of purified EHD1 and GRAF1 in a semi-permeabilized cell vesiculation assay produced synergistic TRE vesiculation. Overall, based on our data, we suggest that in addition to its roles in clathrin-independent endocytosis, GRAF1 synergizes with EHD1 to support TRE vesiculation.
Psychopathology in Pediatric Epilepsy: Role of Antiepileptic Drugs
Rochelle Caplan
Frontiers in Neurology , 2012, DOI: 10.3389/fneur.2012.00163
Abstract: Children with epilepsy are usually treated with antiepileptic drugs (AEDS). Some AEDs adversely affect behavior in susceptible children. Since psychiatric comorbidity is prevalent in pediatric epilepsy, this paper attempts to disentangle these AED side effects from the psychopathology associated with this illness. It first outlines the clinical and methodological problems involved in determining if AEDs contribute to the behavior and emotional problems of children with epilepsy. It then presents research evidence for and against the role AEDs play in the psychopathology of children with epilepsy, and outlines how future studies might investigate this problem. A brief description of how to clinically separate out AED effects from the complex illness-related and psychosocial factors that contribute to the behavior difficulties of children with epilepsy concludes the paper.
Is It Ethical to Use Enhancement Technologies to Make Us Better than Well?
Arthur Caplan,Carl Elliott
PLOS Medicine , 2004, DOI: 10.1371/journal.pmed.0010052
Abstract: Background to the Debate A variety of biomedical technologies are being developed that can be used for purposes other than treating disease. Such “enhancement technologies” can be used to improve our appearance and regulate our emotions, with the goal of feeling “better than well.” While these technologies can help people adapt to their rapidly changing lifestyles, their use raises important ethical issues.
Cardioembolic stroke: An update on etiology, diagnosis and management
Leary Megan,Caplan Louis
Annals of Indian Academy of Neurology , 2008,
Abstract: Stroke and ischemic heart diseases are among the most common causes of death and disability throughout the world. Even more worrisome is the suggestion that stroke rates may further increase in certain developing nations. The purpose of this article is to review the particular subtype of stroke known as cardioembolic stroke. A cardioembolic stroke occurs when the heart pumps unwanted materials into the brain circulation, resulting in the occlusion of a brain blood vessel and damage to the brain tissue. The etiology, clinical manifestations, diagnosis and management of cardioembolic stroke are reviewed.
The Actress, the Court, and What Needs to Be Done to Guarantee the Future of Clinical Genomics
Arthur L. Caplan
PLOS Biology , 2013, DOI: 10.1371/journal.pbio.1001663
Chloe’s Law: A Powerful Legislative Movement Challenging a Core Ethical Norm of Genetic Testing
Arthur L. Caplan
PLOS Biology , 2015, DOI: 10.1371/journal.pbio.1002219
Abstract: Since the early 1970s, the ethical norm governing counselors involved in testing and screening for genetic conditions related to reproduction has been strict neutrality. Counseling about reproductive genetics was to be patient centered but nondirective. Many advocates for people with Down syndrome believe that high abortion rates following a diagnosis of this condition show an unfounded bias against those with Down syndrome. These advocates have succeeded in enacting federal and state legislation that requires women who receive a prenatal diagnosis of Down syndrome to receive positive information about the condition, thereby ending the nominal goal of value-neutral counseling and setting the stage for further normative shifts in clinical reproductive genetics as counseling expands because of cell-free testing.
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