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Search Results: 1 - 10 of 411126 matches for " Laura M Delbridge "
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TBK1 Protects Vacuolar Integrity during Intracellular Bacterial Infection
Andrea L Radtke,Laura M Delbridge,Siddharth Balachandran,Glen N Barber,Mary X. D O'Riordan
PLOS Pathogens , 2007, DOI: 10.1371/journal.ppat.0030029
Abstract: TANK-binding kinase-1 (TBK1) is an integral component of Type I interferon induction by microbial infection. The importance of TBK1 and Type I interferon in antiviral immunity is well established, but the function of TBK1 in bacterial infection is unclear. Upon infection of murine embryonic fibroblasts with Salmonella enterica serovar Typhimurium (Salmonella), more extensive bacterial proliferation was observed in tbk1?/? than tbk1+/+ cells. TBK1 kinase activity was required for restriction of bacterial infection, but interferon regulatory factor-3 or Type I interferon did not contribute to this TBK1-dependent function. In tbk1?/?cells, Salmonella, enteropathogenic Escherichia coli, and Streptococcus pyogenes escaped from vacuoles into the cytosol where increased replication occurred, which suggests that TBK1 regulates the integrity of pathogen-containing vacuoles. Knockdown of tbk1 in macrophages and epithelial cells also resulted in increased bacterial localization in the cytosol, indicating that the role of TBK1 in maintaining vacuolar integrity is relevant in different cell types. Taken together, these data demonstrate a requirement for TBK1 in control of bacterial infection distinct from its established role in antiviral immunity.
The Macquarie Dictionary, its History and its Editorial Practices Die Macquarie Dictionary, sy geskiedenis en sy redaksionele praktyke
Arthur Delbridge,Susan Butler
Lexikos , 2012, DOI: 10.5788/9-1-920
Abstract: The Macquarie Dictionary, first published in Sydney in 1981, was intended to be the first comprehensive dictionary of Australian English. Now in its third edition it has been widely adopted by institutions and the general community as the national dictionary. This paper traces its development from a difficult birth to its present maturity, from a large set of cards to an electronic database, from a single book to a lexicographic library. The rationale and the methodology are laid out along with an account of the reception given to the dictionary in Australia and internationally. Keywords: dictionary; lexicography; macquarie dictionary; australianness; australianise; australian english; national dictionaries; phonology; international phonetic alphabet; lexical labels; lexicographic style; language style; colloquial; aboriginal words; electronic database; corpus; citation Die Macquarie Dictionary wat vir die eerste keer in 1981 in Sydney gepubliseer is, was bedoel om die eerste omvattende woordeboek van Australiese Engels te wees. Die woordeboek wat tans in sy derde uitgawe is, word reeds algemeen deur instansies en die algemene publiek as nasionale woordeboek aanvaar. Hierdie artikel skets sy ontwikkeling vanaf 'n moeilike geboorte tot sy huidige volwassenheid, vanaf 'n groot versameling kaartjies tot 'n elektroniese databasis, vanaf 'n enkele boek tot 'n leksikografiese biblioteek. Die grondbeginsels en metodologie word gegee saam met 'n verslag van die ontvangs wat dit in Australi en internasionaal gekry het. Sleutelwoorde: woordeboek; leksikografie; macquarie dictionary; australiesheid; australianiseer; australiese engels; nasionale woordeboeke; fonologie; internasionale fonetiese alfabet; leksikale etikette; leksikografiese styl; taalstyl; omgangstaal; aboriginele woorde; elektroniese databasis; korpus; aanhaling
Fructose Modulates Cardiomyocyte Excitation-Contraction Coupling and Ca2+ Handling In Vitro
Kimberley M. Mellor,James R. Bell,Igor R. Wendt,Amy J. Davidoff,Rebecca H. Ritchie,Lea M. D. Delbridge
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0025204
Abstract: High dietary fructose has structural and metabolic cardiac impact, but the potential for fructose to exert direct myocardial action is uncertain. Cardiomyocyte functional responsiveness to fructose, and capacity to transport fructose has not been previously demonstrated.
Branches of 33S(p,γ)34Cl at Oxygen-Neon Nova Temperatures
B. M. Freeman,C. Wrede,B. G. Delbridge,A. Garcia,A. Knecht,A. Parikh,A. L. Sallaska
Physics , 2011, DOI: 10.1103/PhysRevC.83.048801
Abstract: Recent simulations of classical novae on oxygen-neon white-dwarf stars indicate that the isotopic ratio 32S/33S has the potential to be a remarkable indicator of presolar grains of nova origin. The 33S(p,\gamma)34Cl reaction influences this ratio directly by destroying 33S in novae. Additionally, \beta-delayed \gamma-rays from the metastable state of 34Cl (t_{1/2} = 32 min) have been suggested to be potential nova observables. We have measured the branches for known 33S(p,\gamma)34Cl resonances that are activated at temperatures relevant to oxygen-neon novae. We provide the first reliable uncertainties on these branches and the first upper limits for several previously unmeasured branches.
Enhancing the Library and Information Management curriculum through Reusable Learning Objects
Margaret Kendall,Nicola Wakefield,Rachel Delbridge
ITALICS , 2007,
Abstract: Increased communication with practitioners and improved curriculum coverage of specialist sectors have been identified as priorities for Library and Information Management (LIM) educators. This paper discusses a project exploring the potential for reusable learning objects (RLOs) as a response. Ten reusable learning objects on law librarianship, one of which was then repurposed for the health information sector, were created in consultation with practitioners and their use evaluated using an action research strategy. The issues which arose during the creation and deployment of the RLOs are discussed, including granularity, interoperability, levels of learning activity and impact. Positive feedback from both students and practitioners indicates the value of the approach.
A knowledge-to-action approach to food fortification: Guiding principles for the design of fortification programs as a means of effectively addressing micronutrient malnutrition  [PDF]
Laura A. Rowe, David M. Dodson
Health (Health) , 2012, DOI: 10.4236/health.2012.410138
Abstract: The gap that exists between research and the dissemination and implementation of research findings has been well established. Food fortification, one of the most cost-effective means of addressing micronutrient malnutrition, is no exception. With decades of implementation experience, there is need to strengthen mechanisms that effectively broadcast proven strategies to promote the successful implementation of fortification programs in changing, challenging, and dynamic environments. This requires clear channels of communication, well-defined in-country leadership, and a streamlined and focused approach that can be adapted to country-specific contexts. Based on experience designing and implementing fortification programs throughout Africa and a broad understanding of past successes and failures, a model is proposed that articulates often over-looked program elements critical to design and implementation.
Marriage and Psychological Wellbeing: The Role of Social Support  [PDF]
Laura K. Soulsby, Kate M. Bennett
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.611132
Abstract: The married consistently report better levels of psychological health compared to the unmarried. Using a cross-sectional questionnaire design, this research examines to what extent this relationship between marital status and psychological wellbeing can be explained by perceived social support. The data reveal that, after controlling for demographic variables, number of daily hassles and coping strategies, widowed and divorced adults report significantly poorer psychological health compared to those who remain married. Moreover, while there was limited evidence that perceived social support moderates the association between marital status and psychological wellbeing, perceived social support did emerge as a significant mediator of this relationship. Perceived social support explained the influence of being widowed, divorced and never married on psychological wellbeing, such that lower levels of support in these groups resulted in poorer psychological health. Thus, social support may be an important variable for interventions to minimize the negative consequences of a transition out of marriage.
Self-Concept in Kindergarten and First Grade Children: A Longitudinal Study on Structure, Development, and Relation to Achievement  [PDF]
Laura C. Dapp, Claudia M. Roebers
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.97097
Abstract: The self-concept refers to a multidimensional construct that organizes a person’s self-perceptions into a hierarchical structure comprising global and specific facets. Children’s self-concept, however, is believed to be less differentiated and less realistic, as children tend to systematically overestimate their abilities. Since little research has been conducted with children before the beginning of formal schooling, the present longitudinal study aimed to explore the structure of kindergarten children’s self-concept, its development during the transition to school, as well as the links between self-concept and achievement in first grade. Counteracting the positively biased self-ratings in children, self-concept was assessed by an innovative measurement instrument that allows for fine-tuned self-evaluations. Structural Equation Modeling showed that kindergarten children’s self-concept is already organized in a multidimensional structure, and thus, differentiates much earlier than previously believed. Like the self-concept of adults, kindergarten children’s self-concept is composed of domain-specific facets, comprising literacy, mathematical, peer-related and teacher-related self-concept aspects. Moreover, gender stereotype conforming differences—like boys having a higher mathematical and girls having a higher social self-concept—already seem to develop at such a young age. Upon first grade entry, children’s academic self-concept increases and becomes positively related to achievement, indicating at least some realism in children’s self-perceptions. Taken together, the findings provide new insights into the structure, development, and validity of young children’s self-concept, contributing substantially to the generalizability of a multidimensionally organized self-concept.
Cloning and Characterization of a Candidate Auxin Plant Growth Regulator-Activated Cell Surface Hydroquinone (NADH) Oxidase  [PDF]
Laura M. C. Ades, Dorothy M. Morré, D. James Morré
Advances in Biological Chemistry (ABC) , 2014, DOI: 10.4236/abc.2014.47047
Abstract: ENOX (ECTO-NOX) proteins of the external surface of the plasma membrane catalyze oxidation of both NADH and hydroquinones and protein disulfide-thiol interchange. They exhibit both prion-like and time-keeping (clock) properties. The oxidative and interchange activities alternate to generate a regular period of 24 min in length. Here we report the cloning, expression and characterization of a constitutive plant ENOX protein activated by both natural (Indole-3-acetic acid, IAA) and synthetic (2,4-dichlorophenoxyacetic acid, 2,4-D) auxin plant growth regulators with an optimum of about 1 μM, higher concentrations being less effective. The gene encoding the 213 amino acid protein (ABP20) is found in EMBL accession number U81162. Functional motifs characteristic of ENOX1 proteins, previously identified by site-directed mutagenesis, are present in the candidate auxin-activated ENOX (dNOX, ENOX5), including adenine nucleotide and copper binding motifs along with essential cysteines and a motif having homology with a previously identified auxin-binding motif. Periodicity was exhibited by both the oxidative and protein disulfide-thiol inter-change activities as is characteristic for other ENOX proteins. Activity was blocked by the ENOX2-specific quassinoid inhibitor glaucarubolone and other ENOX2 inhibitors but not by the ENOX1-specific quassinoid inhibitor simalikalactone D. Activity required both auxin and bound copper. The inactive auxin 2,3-D was without effects.
Is RNA inheritance possible?
Laura M Hrastar
Genome Biology , 2005, DOI: 10.1186/gb-spotlight-20050324-01
Abstract: "We can imagine two parallel pathways, one of DNA-based inheritance, and in the background you have this other which might be RNA - or an odd form of DNA-based inheritance we don't understand," Pruitt told The Scientist.Pruitt's team was investigating HOTHEAD, a gene responsible for organ fusion and wax cuticle production. Previous research has shown unusual point mutation instability in the gene in Arabidopsis, which results in a high frequency of wildtype plants from mutant parents.In the latest study, Pruitt's team used polymerase chain reaction to determine that 10% of the progeny of mutant plants revert to wildtype, and those plants were heterozygous for the parent's mutant HOTHEAD (hth) allele.Measuring directly in pollen, they also found a strong bias for wildtype changes in the plant's male reproductive system - seen from the creation of dominant allele (HTH/HTH) wildtype progeny when the male parent plant, not the female parent, was a homozygous mutant.The progeny of mutants, Pruitt said, bypass their parents' DNA mutations by some undetermined mechanism, and the allelic reversions restore the original DNA sequence of the grandparent plant."In this study, you have the fascinating proposal that in the rare cases when a DNA mutation occurs, RNA descending from previous generations can lend a hand to assist its superior, more privileged cousin," David Bartel from the Massachusetts Institute of Technology told The Scientist in an E-mail. Bartel was not involved in the current study.Pruitt's group also looked at randomly chosen polymorphisms in F3 generation progeny from crossed mutant plants homozygous for HOTHEAD and found evidence of genetic instability for all sequence polymorphisms across the genome.After tests that found three more independent reversion events within three different mutant hth alleles, a high rate of random mutation was ruled out. Data strongly suggested that the genetic changes were the result of a template-driven process, the authors wri
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