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Search Results: 1 - 10 of 17261 matches for " Laura Christina Macedo Piosiadlo "
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Rafaela Gessner,Laura Christina Macedo Piosiadlo
Revista Uniandrade , 2012,
Abstract: This study was conducted with the main objective of describing the management of the Residues of Health Services (RHS) yield in different parts of a Hospital on which services are provided with high technological complexity. The RHS are materials produced by all services offered by the health system to animal or human care and its deficient management is responsible for causing harmful effects over the environment and population. The present study has a descriptive nature and the data was collected by semi-structured interviews. It had the participation of 20 professionals responsible for the management of biomedical waste in 20 units of the mentioned Hospital. The data’s analysis was performed on a qualitative perspective. The study has shown that the professionals responsible for the management of RHS are distant from knowing the procedures in its totality, being the sharps residues their major concern (which is responsible for the majority of work injuries when they are inappropriately arranged). It was also noticed the need for larger investments in periodical training about this subject for the professionals.
Análise do discurso: uma reflex?o para pesquisar em saúde
Macedo, Laura Christina;Larocca, Liliana Muller;Chaves, Maria Marta Nolasco;Mazza, Ver?nica de Azevedo;
Interface - Comunica??o, Saúde, Educa??o , 2008, DOI: 10.1590/S1414-32832008000300015
Abstract: in this study, we take speech and writing as means for discourse construction, highlighting the reasons for converting them into objects for analysis, and we present different instruments for doing this. we emphasize the importance of discourse analysis for the development of health studies, since it allows interpretation of the reality from a text or texts and shows the subjects of the production and the interpretation of these subjects, along with the context of their production. historically constructed contradictions, continuities and disruptions that make discourse a social practice are described. we consider discourse analysis to be a way of picking up the implied meaning in speech and writing, and thus a further way to approach the health-illness process. the aim of this reflection was to incorporate discourse analysis into the health field, thereby emphasizing this method as a rich contribution from social sciences.
A Participa o dos Batalh es Estrangeiros na Rebeli o de 1924 em S o Paulo
Laura Christina Mello de Aquino
S?culum : Revista de História , 1996,
Influencia de factores abióticos presentes en el Río de la Plata sobre la genotoxicidad del cromo
Laura Christina López,Juan Moretton
Revista internacional de contaminación ambiental , 1997,
A numerical study of the effects of bell pulsation dynamics and oral arms on the exchange currents generated by the upside-down jellyfish Cassiopea spp
Christina Hamlet,Arvind Santhanakrishnan,Laura A. Miller
Physics , 2010,
Abstract: Mathematical and experimental studies of the flows generated by jellyfish have focused primarily on mechanisms of swimming. More recent work has also considered the fluid dynamics of feeding from currents generated during swimming. Here the benthic lifestyle of the upside down jellyfish (Cassiopea spp.) is capitalized upon to explore the fluids dynamics of feeding uncoupled from swimming. A mathematical model is developed to capture the fundamental characteristics of the motion of the unique concave bell shape. Given the prominence of the oral arms, this structure is included and modeled as a porous layer that perturbs the flow generated by bell contractions. The immersed boundary method is used to solve the fluid-structure interaction problem. Velocity fields obtained from live organisms using digital particle image velocimetry were used to validate the numerical simulations. Parameter sweeps were used to numerically explore the effects of changes in pulse dynamics and the properties of the oral arms independently. Numerical experiments allow the opportunity to examine physical effects and limits within and beyond the biologically relevant range to develop a better understanding of the system. The presence of the prominent oral arm structure in the field of flow increased the flux of new fluid from along the substrate to the bell. The numerical simulations also showed that the presence of pauses between bell expansion and the next contraction alters the flow of the fluid over the bell and through the oral arms.
Histone Deacetylase Inhibitors Restore Cell Surface Expression of the Coxsackie Adenovirus Receptor and Enhance CMV Promoter Activity in Castration-Resistant Prostate Cancer Cells
Laura Kasman,Georgiana Onicescu,Christina Voelkel-Johnson
Prostate Cancer , 2012, DOI: 10.1155/2012/137163
Abstract: Adenoviral gene therapy using the death receptor ligand TRAIL as the therapeutic transgene can be safely administered via intraprostatic injection but has not been evaluated for efficacy in patients. Here we investigated the efficacy of adenoviral TRAIL gene therapy in a model of castration resistant prostate cancer and found that intratumoral injections can significantly delay tumor growth but cannot eliminate established lesions. We hypothesized that an underlying cause is inefficient adenoviral delivery. Using the LNCaP progression model of prostate cancer we show that surface CAR expression decreases with increasing tumorigenicity and that castration resistant C4-2b cells were more difficult to transduce with adenovirus than castration sensitive LNCaP cells. Many genes, including CAR, are epigenetically silenced during transformation but a new class of chemotherapeutic agents, known as histone deacetylase inhibitors (HDACi), can reverse this process. We demonstrate that HDACi restore CAR expression and infectivity in C4-2b cells and enhance caspase activation in response to infection with a TRAIL adenovirus. We also show that in cells with high surface CAR expression, HDACi further enhance transgene expression from the CMV promoter. Thus HDACi have multiple beneficial effects, which may enhance not only viral but also non-viral gene therapy of castration resistant prostate cancer. 1. Introduction Epigenetic alterations, such as aberrant activity of histone deacetylases, are frequently observed in malignancies. Acetylation of histones is associated with less condensed chromatin and a transcriptionally active gene status, while deacetylation is associated with transcriptional silencing. Histone deacetylase inhibitors (HDACiS) were originally found to reverse the malignant phenotype of transformed cells and have subsequently been developed as a new group of chemotherapeutic agents. HDACi can affect numerous signaling pathways to inhibit growth or angiogenesis and induce apoptosis or senescence [1, 2]. Using two HDACi under evaluation for the treatment of prostate cancer, we previously demonstrated that both romidepsin (also known as depsipeptide) and MS-275 enhanced the in vitro efficacy of adenoviral TRAIL gene therapy in castration-sensitive LNCaP prostate cancer cells [3]. This effect was selective for the malignant cells as primary cultures of prostate epithelial cells were not adversely affected [3]. TRAIL gene therapy has been evaluated for safety in prostate cancer patients with locally confined disease scheduled for prostatectomy [4]. Although
Adenoviral infectivity of exfoliated viable cells in urine: Implications for the detection of bladder cancer
Anuradha Murali, Laura Kasman, Christina Voelkel-Johnson
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-168
Abstract: Exfoliated cells from urine were obtained from 36 human subjects (> 40 years old). An adenovirus in which GFP expression is under control of the survivin promoter (Ad.Surv.GFP) was generated. An adenovirus in which GFP is expressed from the CMV promoter served as a control. GFP expression was analyzed by fluorescent microscopy and quantified by flow cytometry.Short-term cultures from exfoliated cells in urine could be established in 16 of 31 samples. These cultures were successfully transduced with Ad.CMV.GFP. Analysis of GFP expression following transduction with Ad.Surv.GFP, indicated that the survivin promoter was preferentially active in UM-UC-3 bladder cancer cells compared to non-malignant UROtsa cells. Interestingly, baseline levels of GFP expression in cultures from exfoliated cells in urine exhibited higher baseline levels than UROtsa following transduction with Ad.Surv.GFP.We demonstrated the feasibility of establishing and analysing short-term cultures isolated from exfoliated cells in voided urine by means of adenoviral transduction, thereby forming the foundation for future studies to determine the specificity and sensitivity of a non-invasive test based on survivin promoter activity.According to the American Cancer Society bladder cancer is the 5th highest in estimated new cases of cancers by site with 14,680 bladder cancer deaths and 70,530 new diagnoses in 2010 [1,2]. Bladder cancer can be categorized into non-muscle-invasive bladder cancer or muscle-invasive bladder cancer where 80% of the newly diagnosed cancers are non-muscle-invasive bladder cancer. Unfortunately, 70% of the patients will have recurrence of the disease and 10-30% will progress to muscle-invasive disease. Bladder cancer is detected as a result of incidental findings or by presenting hematuria. While hematuria is associated with benign conditions such as urinary tract infections and urolithiasis, 10% of the patients with gross hematuria are diagnosed with bladder cancer [3]. Contra
The Use of Hammett Constants to Understand the Non-Covalent Binding of Aromatics
Michael Lewis,Christina Bagwill,Laura K. E. Hardebeck,Selina Wireduaah
Computational and Structural Biotechnology Journal , 2012,
Abstract: Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended to cation-arene and anion-arene binding. This review summarizes how Hammett substituent constants have been employed to understand the non-covalent binding in arene-arene, cation-arene and anion-arene interactions.
Feeding Currents Generated by Upside Down Jellyfish
Terry Rodriguez,Christina Hamlet,Megan Gyoerkoe,Laura Miller
Physics , 2010,
Abstract: We present fluid dynamics videos of the pulsing dynamics and the resulting fluid flow generated by the upside down jellyfish, Cassiopea spp. Medusae of this genus are unusual in that they typically rest upside down on the ocean floor and pulse their bells to generate feeding currents, only swimming when significantly disturbed. The pulsing kinematics and fluid flow around these upside down jellyfish is investigated using a combination of videography, flow visualization, and numerical simulation. Significant mixing occurs around and directly above the oral arms and secondary mouths. Numerical simulations using the immersed boundary method with a porous layer representing the oral arms agree with the experimental results. The simulations also suggest that the presence of porous oral arms induce net horizontal flow towards the bell. Coherent vortex rings are not seen in the wake above the jellyfish, but starting and stopping vortices are observed before breaking up as they pass through the elaborate oral arms (if extended).
Current-driven Flow across a Stationary Jellyfish
Christina Hamlet,Laura Miller,Roger Fan,Makani Dollinger,Steve Harenber
Physics , 2011,
Abstract: We present several dye visualization and numerical simulation fluid dynamics videos of a sessile jellyfish subjected to channel flow. The low resolution video and the high resolution video display the vortex patterns in different channel flows. This description accompanies the video submission V038 to the 2011 APS DFD Gallery of Fluid Motion.
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