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Search Results: 1 - 10 of 87677 matches for " Latin?i? Stojan "
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Pancreatic tail pseudocyst of type II treated with resection of the tail of the pancreas and splenectomy
?olovi? Radoje,Kaitovi? Marko,LatiniStojan
Srpski Arhiv za Celokupno Lekarstvo , 2011, DOI: 10.2298/sarh1112812c
Abstract: Introduction. Pancreatic pseudocysts of type II are postnecrotic cysts that appear during an acute-on-chronic pancreatitis. In case that surgical treatment is necessary, as a rule it is performed using internal drainage operations. Pancreatic resections are rarely indicated. Case Outline. The authors present a 34 year-old man with a long-lasting history of moderate alcohol consumption in whom an episode of drinking caused an acute-on-chronic pancreatitis so that a 7 cm in diameter cyst was developed inside the tail of the pancreas causing left subcostal pain, mild pleural effusion and pain in the left shoulder. At operation almost entirely inside the tail of the pancreas a cyst of type II unsuitable for internal drainage operation was found so that a spared resection of the tail of the pancreas and splenectomy were carried out. The post-operative recovery was prolonged due to recurrent left pleural effusion requiring punctions, mild suppurative secretion from the splenic fossa and transient postsplenectomy thrombocytosis. Six months after surgery the patient is in good condition and with normal findings. Conclusion. Although rare, pancreatic cysts of type II may be unsuitable for internal drainage operations so that resection of the effected part of the pancreas could be a much better solution than external drainage.
Biliobronchial fistula secondary to percutaneous dilatation of the benign biliary stricture
?olovi? Radoje,Grubor Nikica,Kaitovi? Marko,LatiniStojan
Srpski Arhiv za Celokupno Lekarstvo , 2012, DOI: 10.2298/sarh1212772c
Abstract: Introduction. Biliobronchial fistula is rare. Very rarely it may be congenital, more frequently it is acquired as a complication of the hydatide cyst of the liver, pyogenic abscess, serious trauma and resection of the liver as well as recurrent cholangitis due to benign bile duct stricture or cholangiolithiasis. The main causes of the biliobronchial fistula are billiary obstruction and infectious lesion (abscess) in the liver. Case Outline. We present a 56-year-old man with benign stricture of the hepaticojejunostomy performed after operative common bile duct injury, who developed biliobronchial fistula following repeated percutaneous drainage of the liver abscess and percutaneous dilatation of the strictured anastomosis. Over the years the patient developed atrophy/hypertrophy complex, portal hypertension, grade II esophageal varicosities, ascites and splenomegaly. Although biliobronchial fistula was solved by a successful surgical reconstruction (new wide hepaticojejunostomy), the operation had a limited value as it was performed late after permanent lesions of the liver and intrahepatic bile ducts had already developed. Conclusion. Surgical reconstruction of strictured biliodigestive anastomosis should be considered on time as a possibly better solution than percutaneous dilatation. According to the authors’ knowledge, a similar case of biliobronchial fistula as a complication of percutaneous dilatation of the benign biliary stricture has not been reported before in the literature.
Actinomycosis of the caecum simulating carcinoma in a patient with a long-term intrauterine device
?olovi? Radoje,Grubor Nikica,Micev Marjan,LatiniStojan
Srpski Arhiv za Celokupno Lekarstvo , 2009, DOI: 10.2298/sarh0906285c
Abstract: Introduction. Actinomycosis of the caecum is a rare, but most frequently an abdominally localized disease. It often simulates inflammatory malignancy, rarely a periappendicular abscess or Chron's disease and is only exceptionally the cause of intestinal obstruction or bleeding. Case Outline. The authors present a 35-year-old woman with an intrauterine device which remained inserted for over three years, causing the development of pain, fever, vaginal secretion and bleeding that continued even after the device was removed. Ultrasonography showed a tumorous mass of irregular form located close to the uterus, which after a few months developed into a colliquation filled with pus requiring incision. Bacteriological examination failed to show actinomycosis. Due to the tumorous lesions involving the terminal ileum, appendix, caecum, ascending colon and omentum, a right hemicolectomy was performed. Based on histolopathological findings of the resected sample the diagnosis of actinomycosis was made. Therefore, after surgery the patient began treatment with antibiotics resulting in full recovery. Conclusion. Although rare, actinomycosis of the caecum should be taken into consideration in the differential diagnosis of tumorous lesions of the caecoascending part of the colon, particularly if the tumour is associated with inflammation.
Giant haemorrhagic (pseudo)cyst of the pancreas of unknown aetiology
?olovi? Radoje,Grubor Nikica,Micev Marjan,LatiniStojan
Srpski Arhiv za Celokupno Lekarstvo , 2011, DOI: 10.2298/sarh1106390c
Abstract: Introduction. Cystic lesions of the pancreas are frequent. Most frequently their aetiology can be easily established. It is very rare that the nature and aetiology of these lesions cannot be reliably established. Case Outline. A 40-year-old male without trauma, alcohol abuse, acute or chronic pancreatitis in illness history was successfully operated on for a haemorrhagic (pseudo)cyst of the back wall of the pancreas tail containing 4.5 litres of haemorrhagic content. The cyst did not contain either epithelium or tumour stroma, and the pancreas did not show any changes of acute or chronic pancreatitis. Hystology did not show signs of angiectatic pseudocyst. Conclusion. In spite of all efforts, the authors could not establish the real nature of the (pseudo)cyst of the pancreas or find a similar case described in the literature. Nevertheless, the authors believe that it was probably an angiectatic cyst.
Intraabdominal abscessus of unknown etiology
?olovi? Radoje,Grubor Nikica,LatiniStojan,?olovi? Nata?a
Srpski Arhiv za Celokupno Lekarstvo , 2012, DOI: 10.2298/sarh1202094c
Abstract: Introduction. Intraabdominal abscesses are in 98-99% cases the result of secondary and only in 1-2% of primary peritonitis. They are easy and successfully diagnosed. Abdominal abscesses of unknown cause are extremely rare. Case Outline. The authors present a 68-year-old man, without significant data in past history, who suddenly developed epigastric pain, nausea, vomiting and leukocytosis which was treated with antibiotics resulting in the alleviation of complaints and reduction of white blood cells count. After five days ultrasonography showed incapsulated collection of dense fluid in the epigastrium confirmed by CT scan two days later. Upper endoscopy excluded ulcer and/or perforation of the stomach and duodenum. Under local anesthesia, through the upper part of the left rectal muscle, puncture followed by incision was done, and about 50 ml of dense pus was removed. Finger exploration of the cavity showed no foreign body within the cavity. Using drainage, the recovery was quick and uneventful. By preoperative and postoperative abdominal investigations no cause of the abscess was found. Two and a half years after surgery the patient remained symptom-free with normal clinical, laboratory and ultrasonographic findings. Conclusion. The authors presented an intraabdominal abscess of unknown cause that was successfully treated with antibiotics, percutaneous puncture and drainage under local anaesthesia. In spite of all diagnostic methods the cause of the abscess could not be found. Thus, such a possibility, although being rare, should be taken into account.
Pendular stromal tumour of the stomach with dominant PDGFRA immunoexpression: Case report and short literature review
LatiniStojan,?olovi? Nata?a,Micev Marjan,?olovi? Radoje
Srpski Arhiv za Celokupno Lekarstvo , 2012, DOI: 10.2298/sarh1204216l
Abstract: Introduction. Gastrointestinal stromal tumours are most frequent mesenchimal tumours of the gastrointestinal tract that originate from Cajal’s interstitial cells that are most frequently CD-117 positive. Stromal tumours of the stomach are the most frequent mesenchimal tumours of the gastrointestinal tract. Such tumours are usually sessile, but rarely pendular when they can be easily removed with a limited local excision of the stomach wall around the pedicle. Major stomach resections are rarely necessary. Case Outline. In a 54-year-old woman with abdominal pain and fever of unknown aetiology, a large spherical mobile and almost painless mass was found within the upper right abdomen. US and CT showed a mainly cystic, partly solid tumour, of 15.5×12.5 cm in diameters. Laboratory data including tumour markers were within normal limits. At operation a mobile and free tumour of the stomach attached to the anterior wall with a 2.5 cm pedicle was found and easily excised. Abdominal mucosa was normal. There was no liver metastasis or peritoneal dissemination. Hystology and imunohistochemistry showed a rare sclerosing sincitial subtype of stromal tumour with imunophenotype heterogenicity with a dominant PDGFRA and rare CD-117 immunoexpression. The postoperative recovery was uneventful. The patient was symptom-free with no sign of recurrence after a year and a half. Conclusion. A rare subtype of histological highly malignant stromal tumour of the stomach, macroscopically of pendular type, that was easily excised, was presented which so far showed a favourable evolution with no signs of recurrence.
Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient
Radoje B ?olovi?, Slavko V Mati?, Marjan T Micev, Nikica M Grubor, Henry Dushan Atkinson, Stojan M Latini
World Journal of Gastroenterology , 2009,
Abstract: Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract, first described in the pancreas in 1977 and in the duodenum in 1979. They may be functional and cause somatostatinoma or inhibitory syndrome, but more frequently are non-functioning pancreatic endocrine tumors that produce somatostatin alone. They are usually single, malignant, large lesions, frequently associated with metastases, and generally with poor prognosis. We present the unique case of a 57-year-old woman with two synchronous non-functioning somatostatinomas, one solid duodenal lesion and one cystic lesion within the head of the pancreas, that were successfully resected with a pylorus-preserving Whipple’s procedure. No secondaries were found in the liver, or in any of the removed regional lymph nodes. The patient had an uneventful recovery, and remains well and symptom-free at 18 mo postoperatively. This is an extremely rare case of a patient with two synchronous somatostatinomas of the duodenum and the pancreas. The condition is discussed with reference to the literature.
CYTOKINES AND HEMOKINES IN THE ASTHMA
Milo? Filipovic,Stojan Radi?,Boris ?in?i
Acta Medica Medianae , 2001,
Abstract: The cytokines are regulatory proteins of low molecular weight whose role is ininter-cellular communication. They exhibit the following characteristics: pleitropisni,svnergism, anfagonism, redundancy, as wcll as autocrine, paracrine andendocrine action. The activity of one cylokine can start the release of anothercytokine. Since the asthma is an immunological discases the cytokines have a uniquerole in regulating the inflammatory process induced in the lungs. Various cytokinesac! in acomplex network an that is crucial for determining the nature and the chronicoccurrence of an asthmatic inflammatory process. The Th2 lymphocytes do asynihesisof II-4,II-5,II-9, II-10,II-13 and GM-CSF involved in the process of joiningthe B-ceils immunoglobulin isotype with the SgE production, maintain the Th2 cellpopulation with increased cylokines' production encoded by the so-called II-4 geneticgroup as well as attraction and proiongation of the cell mast, basophils and eosinophils'survival. The hemokines are small proteins classified into four subclasses,namely CC, CXC, C and Cx3C on the basis of the first two cysteine position in theirsequences. The members of the CC subclass lead 1o attraction and activation ofbasophits, eosinophils, monocytes and T-lymphocytcs as well as degranulation ofbasophils and cell mast independently of the IgE mechanism.
On space and time in quantum cosmology
Ne?i? Ljubi?a D.,Obradovi? Stojan
Facta Universitatis Series : Physics, Chemistry and Technology , 2002, DOI: 10.2298/fupct0204173n
Abstract: The paper considers the properties of space and time in quantum cosmology. It presented the basic ideas of the substantial and relational conceptions of space and time, as well the basic ideas of the continuity and discreteness of space and time. The basics of standard quantum cosmology, i.e. quantum cosmology formulated over the field of real numbers R, have also been presented. Quantum cosmology is the application of the quantum theory to the universe as a whole in the early phases of its evolution, when the universe was very small so that all the four interactions were practically unified. In order to obtain the maximum possible information from quantum cosmology it is necessary that it be "complete". The concept "complete" refers here to the formulation of the theory over the field of real numbers and the field of p-adic numbers Qp. Since p-adic numbers are generally not well-known, the idea of their introduction has carefully been considered. Within the p-adic quantum cosmology representing quantum cosmology over the field of p-adic numbers Qp, the main results concerning the de Sitter model have been presented. The consequence of this (complete) formulation of the de Sitter model is the radius discreteness of the universe.
BIOLOGICAL EFFECTS OF MICROWAVE RADIATION ON BRAIN TISSUE IN RATS
Boris ?in?i,Du?an Sokolovi?,Stojan Radi?,Tomislav Pavlovi?
Acta Medica Medianae , 2003,
Abstract: Exposure to microwave radiation induces multiple organ dysfunctions, especially in CNS.The aim of this work was investigation of biological effects of microwave radiation on rats' brain and determination of increased oxidative stress as a possible pathogenetic's mechanism.Wis tar rats 3 months old were divided in experimental (4 female and 4 male animal) and control group (5 female and 4 male). This experimental group was constantly exposed to a magnetic field of 5 mG. We simulated using of mobile phones 30 min every day. The source of NIR emitted MF that was similar to mobile phones at 900 MHz. The rats were killed after 2 months. Biological effects were determined by observation of individual and collective behavior and body mass changes. Lipid per oxidation was determined by measuring quantity of malondialdehyde (MDA) in brain homogenate.The animals in experimental group exposed to EMF showed les weight gain. The most important observations were changing of basic behavior models and expression of aggressive or panic behavior. The content of MDA in brain tissue is singificantly higher (1.42 times) in rats exposed to electromagnetic fields (3,82±0.65 vs. control 2.69±0.42 nmol/mg proteins, p<0.01).Increased oxidative stress and lipid peroxidation after exposition in EM fields induced disorders of function and structure of brain.
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