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Search Results: 1 - 10 of 301416 matches for " Lars-Petter Jelsness-J?rgensen "
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Worries and Concerns among Inflammatory Bowel Disease Patients Followed Prospectively over One Year
Lars-Petter Jelsness-Jrgensen,Bj?rn Moum,Tomm Bernklev
Gastroenterology Research and Practice , 2011, DOI: 10.1155/2011/492034
Abstract: Disease-related worries are frequently reported in inflammatory bowel disease (IBD), but longitudinal assessments of these worries are scarce. In the present study, patients completed the rating form of IBD patient concerns (RFIPC) at three occasions during one year. One-way analysis of variance (ANO VA), t-tests, bivariate correlation, and linear regression analyses were used to analyse data. The validity and reliability of the Norwegian RFIPC was tested. A total of 140 patients were included (V1), ulcerative colitis (UC) n = 92, Crohn's disease (CD) n = 48, mean age 46.9 and 40.0-year old, respectively. The highest rated worries included having an ostomy bag, loss of bowel control, and reduced energy levels. Symptoms were positively associated with more worries. A pattern of IBD-related worries was consistent over a period of one year. Worries about undergoing surgery or having an ostomy bag seemed to persist even when symptoms improved. The Norwegian RFIPC is valid and reliable. 1. Introduction In inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), the measurement of health-related quality of life (HRQOL) has become important, both as a primary and secondary endpoint [1–4]. In IBD, the decrease in HRQOL scores is well documented in a vast amount of studies [2–4]. Subjective health measurements in patient research may reveal important issues for the patient, but not apparent for the healthcare worker [1]. In accordance with observations made in clinical practice and with intention to help clinicians quantify information about IBD- related worries, Drossman et al. [5] developed the rating form of IBD patient concerns (RFIPC). Various studies have made use of the RFIPC in clinical trials [5–10]. These studies do, however, have a cross-sectional design, which only provide a snapshot at a given point of time. Since worries most often is future directed, they may potentially change in time and space. Our knowledge of IBD-related worries in a longitudinal perspective is limited. Only one study addresses these issues prospectively in CD, but not in UC [11]. Results of a longitudinal assessment of IBD-related worries may facilitate patient-physician communication and consequently be clinically impactful [1]. Different studies have found the RFIPC to be valid and reliable [5–10]. However, the RFIPC needs to be translated and tested psychometrically in the Norwegian language to overcome conceptual, semantic, and linguistic differences across cultures and languages [1, 12]. The primary aim of this study was to assess
Chronic fatigue is associated with increased disease-related worries and concerns in inflammatory bowel disease
Lars-Petter Jelsness-Jrgensen,Tomm Bernklev,Magne Henriksen,Roald Torp
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i5.445
Abstract: AIM: To investigate the impact of chronic fatigue on disease-related worries in inflammatory bowel disease (IBD) and the potential multicolinearity between subjective questionnaires. METHODS: Patients in remission or with mild-to-moderate disease activity completed the fatigue questionnaire (FQ), the rating form of IBD patient concerns (RFIPC), the Short-Form 36 (SF-36), and IBD questionnaire (N-IBDQ). In addition, clinical and epidemiological data were obtained. RESULTS: In total, 140 patients were included; of which 92 were diagnosed with ulcerative colitis and 48 with Crohn’s disease. The mean age of patients with chronic fatigue was 44.2 years (SD = 15.8) and for non-fatigued patients was 44.7 years (SD = 16.0). Chronic fatigued patients had clinically significantly increased levels of disease-related worries, as measured by Cohen’s d effect size. Worries about having an ostomy bag, loss of bowel control, and energy levels were most prominent in both chronic fatigued and non-chronic fatigued IBD patients. Variance inflation factor (VIF) and tolerance indicated that there were no problematic multicolinearity among the FQ, RFIPC, SF-36 and N-IBDQ responses (VIF < 5 and tolerance > 2). CONCLUSION: Chronic fatigue is associated with increased levels of disease-related worries and concerns in IBD. Increased levels of worries were also associated with impaired health-related quality of life.
Sense of Coherence in Patients with Inflammatory Bowel Disease
Randi Opheim,May Solveig Fagermoen,Lars-Petter Jelsness-Jrgensen,Tomm Bernklev,Bj?rn Moum
Gastroenterology Research and Practice , 2014, DOI: 10.1155/2014/989038
Abstract: Background and Aim. Sense of coherence (SOC) is a health-promoting concept reflecting a person’s view of life and response to stressful situations and may be of importance in coping with chronic illness. The aim of this study was to explore associations between SOC and sociodemographic, disease-related, and personal characteristics in a sample of patients with inflammatory bowel disease (IBD). Methods. Measures included sociodemographic and disease-related data, the Sense of Coherence Scale, General Self-Efficacy Scale (GSE), and Fatigue Severity Scale (FSS-5). Results. In total, 428 IBD patients had evaluable questionnaires (response rate 93%). The overall mean SOC total score was 66.25 (SD 11.47) and with no statistically significant difference between patients with ulcerative colitis (UC) and patients with Crohn’s disease (CD). In the multivariate analyses, higher GSE scores were significantly associated with higher SOC scores and higher FSS-5 scores were significantly associated with lower SOC scores in both UC and CD. Conclusion. GSE and FSS-5 contributed more to the variance in SOC than sociodemographic and disease-related variables. Longitudinal studies are warranted to investigate the value of SOC as a predictor of disability, medication adherence, coping behavior, and health-related quality of life. 1. Introduction The inflammatory bowel diseases (IBD), Crohn’s disease (CD), and ulcerative colitis (UC) are chronic inflammatory disorders of the gastrointestinal tract of unknown etiology. The course of disease is characterized by periods of symptom flares and periods with quiescent disease. Common symptoms are diarrhea, bloody stools, fever, fatigue, and abdominal pain [1–3]. As with many chronic diseases, IBD patients’ quality of life and psychosocial function have been shown to be influenced by their disease [4–8]. Further, patients diagnosed with IBD at a young age and with a severe disease course have an increased risk for work disability [9]. Coping with a chronic illness such as IBD involves complex cognitive, physical, emotional, psychological, and behavioral processes [5]. Patients must be able to manage complex medication regimens, find meaning in and adapt to changeable life conditions, and deal with emotions associated with the fact that the disease is not curable. The unpredictable disease course also poses challenges for the patients’ daily life as well their life in general [10]. Given the complexity of living with a chronic illness, personal resources may be of importance for patients’ well-being, quality of life, and ability to
Transcription of reference genes used for quantitative RT-PCR in Atlantic salmon is affected by viral infection
Marie L?voll, Lars Austb?, Jorunn B Jrgensen, Espen Rimstad, Petter Frost
Veterinary Research , 2011, DOI: 10.1186/1297-9716-42-8
Abstract: For transcription profiling of a limited number of genes, relative quantification using RT-qPCR is a widely used method. Levels of target gene transcripts are estimated relative to a reference gene shown to be evenly transcribed in the relevant tissues. Several publications report transcription studies using reference genes without proper validation of their stability. Only a few years ago, ribosomal RNA was widely accepted as an internal control suitable for normalisation of most RT-qPCR data. This assumption has however changed into a general understanding that the transcript levels of reference genes may vary considerably [1].Compared to inbred mammalian species, study of gene transcription in salmonid fish is complicated by high variation between individuals and multiple subtypes and isoforms of genes [2]. Furthermore, transcription studies in fish are often comprehensive and designed to follow a population of healthy fish during experimental challenge. To limit otherwise labour intensive and expensive studies, validation of reference genes are typically done on na?ve fish omitting statistical analyses. The results are often considered to be valid for experimentally treated fish, even though for instance a virus infection has the potential to change the transcription of cellular genes to facilitate virus production. In contrast to the large number of articles describing target gene transcription after infection in fish, only a limited number of articles demonstrate reference gene validation in different tissues and cells isolated from salmon before, during and after viral infection [3-6].In the present study we performed a cohabitant challenge of Atlantic salmon (S. salar) parr/fingerlings with salmon pancreas disease virus (SPDV). Cohabitation represents a natural waterborne route of pathogen exposure [7], and should stimulate natural anti SPDV defence mechanisms, including important innate and acquired immune responses [8]. The transcript levels of four common
Multicenter data acquisition made easy
Jacob Rosenberg, Nadia Henriksen, Lars Jrgensen
Trials , 2010, DOI: 10.1186/1745-6215-11-49
Abstract: In Googledocs the data manager creates a form similar to the paper case record form, which will function as a decentral data entry module. When the forms are submitted, they are presented in a spreadsheet in Googledocs, which can be exported to different standard spreadsheet formats.For a multicenter randomized clinical trial with five different participating hospitals we created a decentral data entry module using the spreadsheet function in Googledocs. The study comprised 332 patients (clinicaltrials.gov identifier: NCT00815698) with five visits per patient. One person at each study site entered data from the original paper based case report forms which were kept at the study sites as originals. We did not experience any technical problems using the system.The system allowed for decentral data entry, and it was easy to use, safe, and free of charge. The spreadsheet function in Googledocs may potentially replace current expensive solutions for data acquisition in multicenter trials.clinicaltrials.gov NCT00815698Data collection in multicenter studies may be troublesome because of considerable amounts of administrative paperwork or the necessity to adopt very expensive commercial solutions. It is normally required to photocopy paper based case record forms (CRFs) and send them to a coordinating centre implying a risk of data loss and considerable delay. Commercial solutions with scanning of CRFs are expensive and still require transportation of the paper based CRFs to the trial administration unit [1,2].There is, however, now a simple, effective and free solution available. The present paper describes an asynchronous collaborative spreadsheet system that allows for decentral data entry using the spreadsheet function in Googledocs [3].In this section we are going to describe the necessary steps required to use Googledocs for data acquisition.Initially, all data collectors must have a Googledocs or Gmail account. This is free of charge and very easy to establish. At th
Effects of 12 Weeks High-Intensity & Reduced-Volume Training in Elite Athletes
Anders Kilen, Tanja Hultengren Larsson, Majke Jrgensen, Lars Johansen, Susanne Jrgensen, Nikolai B. Nordsborg
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095025
Abstract: It was investigated if high-intensity interval training (HIT) at the expense of total training volume improves performance, maximal oxygen uptake and swimming economy. 41 elite swimmers were randomly allocated to a control (CON) or HIT group. For 12 weeks both groups trained ~12 h per week. HIT comprised ~5 h vs. 1 h and total distance was ~17 km vs. 35 km per week for HIT and CON, respectively. HIT was performed as 6-10×10-30 s maximal effort interspersed by 2–4 minutes of rest. Performance of 100 m all-out freestyle and 200 m freestyle was similar before and after the intervention in both HIT (60.4±4.0 vs. 60.3±4.0 s; n = 13 and 133.2±6.4 vs. 132.6±7.7 s; n = 14) and CON (60.2±3.7 vs. 60.6±3.8 s; n = 15 and 133.5±7.0 vs. 133.3±7.6 s; n = 15). Maximal oxygen uptake during swimming was similar before and after the intervention in both the HIT (4.0±0.9 vs. 3.8±1.0 l O2×min?1; n = 14) and CON (3.8±0.7 vs. 3.8±0.7 l O2×min?1; n = 11) group. Oxygen uptake determined at fixed submaximal speed was not significantly affected in either group by the intervention. Body fat % tended to increase (P = 0.09) in the HIT group (15.4±1.6% vs. 16.3±1.6%; P = 0.09; n = 16) and increased (P<0.05) in the CON group (13.9±1.5% vs. 14.9±1.5%; n = 17). A distance reduction of 50% and a more than doubled HIT amount for 12 weeks did neither improve nor compromise performance or physiological capacity in elite swimmers.
Forord
Lars J. Vatten,Petter Kristensen,Lorentz M. Irgens
Norsk Epidemiologi , 2009,
Abstract: -
Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination
Tine Gregersen,Nanna Holt,Henning Gronbaek,Ida Vogel,Lars J. Jrgensen,Klaus Krogh
Case Reports in Gastrointestinal Medicine , 2012, DOI: 10.1155/2012/185730
Abstract: Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix. Neurofibromatosis type 1 is an autosomal dominant disorder caused by a mutation in the NF1 gene. Patients with neurofibromatosis type 1 have an increased incidence of typical neuroendocrine tumors, but it is unknown if this is the case with goblet cell carcinoids. We describe a patient with both neurofibromatosis type 1 and goblet cell carcinoid, that according to literature would occur in 0.00017 per million per year. This may suggest a previously unknown association between neurofibromatosis type 1 and goblet cell carcinoids. 1. Introduction Neuroendocrine tumors (NETs) are rare with an estimated prevalence of 35/100.000 per year [1]. The most frequent location of NETs is the gastrointestinal tract where most originate from enterochromaffin (EC) cells [2, 3]. These cells originate from the neural crest and constitute the diffuse neuroendocrine system. Goblet cell carcinoid (GCC) tumors are a very rare subgroup of mucin producing NETs usually arising in the appendix. The incidence of GCCs is approximately 0.5 per million/year [4]. In contrast to other NETs, GCCs have a mixed phenotype with partial neuroendocrine differentiation and partial intestinal type goblet cell morphology [5]. Neurofibromatosis type 1 (NF1) is an autosomal dominant inherited disorder with an estimated prevalence of 1/3.000 [6]. NF1 is characterised by multiple café au lait spots, axillary and inguinal freckling, cutaneous neurofibromas, and hamartomas of the iris. Learning disabilities are seen in more than half of the affected individuals. Less common, but potentially more harmful manifestations are plexiform neurofibromas, optic tumors, gliomas in the central nervous system, vasculopathy, and an increased risk of malignancies. The disease is caused by heterozygote loss-of-function mutations in the NF1 gene, and more than half of all patients have de novo germ line mutations. For unknown reasons the mutation rate for the NF1 gene is among the highest observed. The function of the protein neurofibromin is not fully known, but it is a multidomain molecule with the capacity to regulate several intracellular processes such as RAS-cyclic AMP and ERK/MAP kinase cascades. Thus, it functions as a tumor suppressor gene. The development of tumors, café au lait spots, and neurofibromas is caused by spontaneous somatic mutations in the one remaining intact NF1 gene leaving these cells unable to express
Review of Survey activities 2009: 3-D geological modelling of the Egebjerg area based on hydrogeophysical data, Denmark,
Jrgensen, Flemming,M?ller, Rasmus, R?nde,Sandersen, Peter ,B.E.,Nebel, Lars
Geological Survey of Denmark and Greenland Bulletin , 2010,
Abstract:
Monitoring the newly qualified nurses in Sweden: the Longitudinal Analysis of Nursing Education (LANE) study
Ann Rudman, Marianne Omne-Pontén, Lars Wallin, Petter J Gustavsson
Human Resources for Health , 2010, DOI: 10.1186/1478-4491-8-10
Abstract: Three Swedish national cohorts of nursing students on university degree programmes were recruited to constitute the cohorts. Of 6138 students who were eligible for participation, a total of 4316 consented to participate and responded at baseline (response rate 70%). The cohorts will be followed prospectively for at least three years of their working life.Sociodemographic data in the cohorts were found to be close to population data, as point estimates only differed by 0-3% from population values. Response rates were found to decline somewhat across time, and this decrease was present in all analysed subgroups. During the first year after graduation, nearly all participants had qualified as nurses and had later also held nursing positions. The most common reason for not working was due to maternity leave. About 10% of the cohorts who graduated in 2002 and 2004 intended to leave the profession one year after graduating, and among those who graduated in 2006 the figure was almost twice as high. Intention to leave the profession was more common among young nurses. In the cohort who graduated in 2002, nearly every fifth registered nurse continued to further higher educational training within the health professions. Moreover, in this cohort, about 2% of the participants had left the nursing profession five years after graduating.Both high response rates and professional retention imply a potential for a thorough analysis of professional practice and occupational health.The main current problem for healthcare organizations worldwide is the shortage of health service providers [1]. This shortage is due to the increasing consumption of healthcare and a growing population that lives longer, in combination with an ageing nursing workforce, migration, reduced working hours, early retirement and the tendency of nurses to leave the profession [2-7]. Other problematic issues involve attrition from undergraduate programmes and retention of recent graduates within the workforce [8].
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