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Antibacterial, antioxidant and acute toxicity tests on flavonoids extracted from some medicinal plants
Akroum Souad,Bendjeddou Dalila,Satta Dalila,Lalaoui Korrichi
International Journal of Green Pharmacy , 2010,
Abstract: Flavonoids are well-known for their many therapeutic and pharmaceutical effects. In this study, we tested the antibacterial activity of 11 flavonoids extracted from some medicinal plants by the agar diffusion method. Then, we measured their antioxidant activity using the DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical assay and we also tested their acute toxicity effect on mice. The results showed that apigenin-7-O-glucoside was more active against the Gram-positive bacteria and quercetin was more active against the Gram-negative ones. Also, quercetin and diosmin showed the best antioxidant activity. Quercetin, apigenin-7-O-glucoside, luteolin-7-O-glucoside and luteolin-3′-O-glucuronide gave the best acute toxicity values. It can be concluded that quercetin was the most interesting compound for all the tested activities. Also, we observed that the presence or the absence of substitutions in flavonoids influenced significantly the results obtained, whereas the substitution type had a low impact.
General characterization of venom from the Moroccan snakes Macrovipera mauritanica and Cerastes cerastes
Oukkache, N;Lalaoui, M;Ghalim, N;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2012, DOI: 10.1590/S1678-91992012000400009
Abstract: ophidian envenomation accidents constitute a serious public health problem in many countries around the globe. over 5 million such accident cases occur each year causing more than 100,000 deaths. in africa, more than 20,000 deaths per year are registered while 400,000 envenomation victims retain severe and permanent functional sequelae. in morocco, snakebites are frequent and of greater severity in children. they occur mostly in rural areas. the incidence of these bites remains poorly understood and vastly underestimated. the epidemiological data are not well known due to the absence of a national registry, whereas a significant proportion of envenomations receive only traditional treatment methods in non-medical intensive care. this prompted us to investigate the enzymatic and biological properties of venom biochemical constituents from two of the most dangerous snake venoms in morocco: cerastes cerastes (cc) and macrovipera mauritanica (mm). also, we studied the immune cross-reactivity of cc and mm venoms in comparison to that of another important dangerous moroccan viper, bitis arietans (ba), to identify the best candidates (venom or a mixture of venoms) for producing the most efficient and protective antivenom. in the present study, we report a preliminary venom characterization of cc and mm and the cross-reactivity that may exist between their venoms and ba. these venoms are known to be highly toxic and contain several proteins that differ by molecular weights. interestingly, both cc and mm venoms are characterized by intense hemorrhagic and phospholipase a2 activities and their ability to degrade the α and γ chains of fibrinogen. they display very low proteolysis through the casein test. after injection into mice, cc and mm induce myonecrosis in skeletal muscles, which most likely reflects direct action of myotoxins and indirect action of hemorrhagic molecules present in these venoms. in mice, this myonecrosis diminishes serum creatine phosphokinase (cpk) leve
Textilome abdominal: à propos d’un cas
I Serghini, A El Fikri, JS Lalaoui, M Zoubir, M Boui, M Boughanem
Pan African Medical Journal , 2011,
Abstract: Le textilome est une complication postopératoire très rare mais bien connue. Il peut s’agir d’un corps étranger composé de compresse(s) ou champ(s) chirurgicaux laissés au niveau d’un foyer opératoire. La découverte du textilome abdominale est généralement tardive. L’anamnèse est donc essentielle pour diagnostic vu que la clinique n’est pas concluante. La clinique associe des troubles chroniques du transit à des syndromes sub-occlusifs, le cliché d’abdomen sans préparation est peu contributif. L’échographie est fiable. La tomodensitométrie permet un diagnostic topographique précis. Certaines équipes proposent des explorations par IRM. Nous rapportons un cas de textilome intra abdominale, chez une patiente opérée 6 mois auparavant d’un fibrome utérin.
Management of undiagnosed pheochromocytoma with acute appendicitis
Mustapha Bensghir, Abderhmane Elwali, Salim Lalaoui, Noureddine kamili, Hassan Alaoui, Jawad Laoutid, Hicham Azendour, Hicham Balkhi, Charqui Haimeur, Mohamed Atmani
World Journal of Emergency Surgery , 2009, DOI: 10.1186/1749-7922-4-35
Abstract: Letter to editor:Pheochromocytoma is a rare catecholamine-secreting tumor. A proportion of patients are diagnosed at the time of incidental surgery, when induction of anaesthesia may precipitate an hypertensive crisis. In this situation, mortality is close to 80% [1]. The authors report a case of an undiagnosed pheochromocytoma patient with an acute appendicitis.A 17 years old man was scheduled for acute appendicitis. The patient's cardiovascular examination was normal, arterial blood pressure was 135/65 mmHg and heart rate was 85 beats/min. A crush-induction (Propofol 3 m/kg, célocurine 1 mg/kg) was used. Anaesthesia was maintained with sevoflurane in a mixture of nitrous oxide and oxygen. Five minutes after resection the appendicitis, just as washing the abdominal cavity, the blood arterial pressure abruptly increased up to 210/110 mmHg and heart rate increased to 200 beats/min. Anaesthesia was deepened. Medication errors were ruled. There was no skeletal muscle rigidity and the body temperature was 37°c. EtCO2 and airway pressure had not changed and kaliemia was 4.5 mmol/L. An arterial catheter was placed to be able to rapidly detect and treat any hypertension crisis. The arterial pressure continued to rise to 220/120. Heart rate varied from 100 to 140 beats/min. The diagnosis of pheochromocytoma was suspected. The anaesthesiologist and surgeon decided to interrupt the surgery. IV incremental dose of nicardipine and esmolol were given and resulted in arterial pressure of 125/50 mmHg and heart rate of 70 beats/min. Once the patient stabilized, closing the fascia and the skin was effected. Infusion of nicardipine was started and adjusted according to the blood pressure. In intensive care unit, aggressive therapy included nicardipine, propanolol and hydration was continued. After extubation the pression was stabilized by nicardipine 6 mg per hour and propanolol 40 mg twice per day. Abdominal injected computerized tomography showed a unilateral suprarenal mass. Measu
TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT
Najoua Lalaoui,Aymeric Morlé,Delphine Mérino,Guillaume Jacquemin,Elisabetta Iessi,Alexandre Morizot,Sarah Shirley,Bruno Robert,Eric Solary,Carmen Garrido,Olivier Micheau
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019679
Abstract: TRAIL/Apo2L is a pro-apoptotic ligand of the TNF family that engages the apoptotic machinery through two pro-apoptotic receptors, TRAIL-R1 and TRAIL-R2. This cell death program is tightly controlled by two antagonistic receptors, TRAIL-R3 and TRAIL-R4, both devoid of a functional death domain, an intracellular region of the receptor, required for the recruitment and the activation of initiator caspases. Upon TRAIL-binding, TRAIL-R4 forms a heteromeric complex with the agonistic receptor TRAIL-R2 leading to reduced caspase-8 activation and apoptosis.
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