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Search Results: 1 - 10 of 118676 matches for " Lakshmi T "
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′Final push of leprosy′ in India: What is being pushed?
Rao P,Lakshmi T
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract:
Pulse therapy and its modifications in pemphigus: A six year study
Rao P,Lakshmi T
Indian Journal of Dermatology, Venereology and Leprology , 2003,
Abstract: Background: Dexamethasone-cyclophosphamide pulse (DCP) therapy for the pemphigus group of disorders is being widely used in India after its introduction in 1986. However, there are certain limitations to its application due to the serious side effects of cyclophosphamide. Methods: Between 1995 and 2001, we treated 41 patients of pemphigus with modified pulse therapy. These modifications included certain changes in the DCP therapy protocol and substitution of cyclophosphamide with either azathioprine or methotrexate in a few patients. Results: We observed a good response to pulse therapy in all 34 patients who took treatment regularly. Conclusions: We found the modifications to the original DCP therapy protocol to be very effective and useful.
Multi focal tuberculosis
Lakshmi T,Rao A
Indian Journal of Dermatology, Venereology and Leprology , 2002,
Abstract: A 19 - year-old salesman presented with multiple fusiform, fluctuant, non-tender swellings involving dorsum of the left hand, left index finger and little finger. He also had multiple sinuses with puckered scars on the right thumb, left little finger and right elbow. He was provisionally diagnosed as tuberculous gumma. X-ray chest showed apical cavity and infiltration suggestive of tuberculosis X-ray both hands showed osteolytic lesions with pathological fracture. AFB was cultured on Lowenstein Jensen medium and the patient was given antituberculosis treatment with clinical improvement.
NOVEL BIOCHEMICAL RISK MARKERS: CRP AND HOMOCYSTEINE IN RENAL RISK
T M Lakshmi
Journal of Global Pharma Technology , 2010, DOI: 10.1234/jgpt.v2i3.153
Abstract: High-sensitive C-reactive protein (CRP) is a sensitive marker of inflammation, has been proposed as a novel predictor of CV outcome: it has been proposed to be a stronger CV risk predictor than low-density lipoprotein cholesterol in many studies. Homocysteine may be a marker of atherosclerosis in patients with or without renal dysfunction; levels in patients maintained on dialysis cannot be fully interpreted without recognition of their nutritional status and concurrent inflammatory processes that may be related to overall mortality. Biochemical risk markers a combination of risk markers will best predict the risk of CV and renal disease progression. Moreover, current risk markers we need them for evaluation of renal risk and CV risk now and in future.
Multifocal tuberculosis
Lakshmi T,Gnaneshwar Rao A
Indian Journal of Dermatology, Venereology and Leprology , 2002,
Abstract: A 19 -year-old salesman presented with multiple fusiform, fluctuant, nontender swellings involving dorsum of left hand, left index finger and little finger. He also had multiple sinuses with puckered scars on right thumb, left little finger, and right elbow. He was provisionally diagnosed as tuberculous gumma and was investigated further. X-ray chest showed apical cavity and infiltration suggestive of tuberculosis. X-ray both hands showed osteolytic lesion with pathological fracture. AFB was cultured on Lowenstien Jensen s medium and the patient was put on ATT with clinical improvement.
Precoder Index Modulation
T. Lakshmi Narasimhan,A. Chockalingam
Mathematics , 2014,
Abstract: Index modulation, where information bits are conveyed through antenna indices (spatial modulation) and subcarrier indices (subcarrier index modulation) in addition to information bits conveyed through conventional modulation symbols, is getting increased research attention. In this paper, we introduce {\em precoder index modulation}, where information bits are conveyed through the choice of a precoder matrix at the transmitter from a set of pre-determined pseudo-random phase precoder (PRPP) matrices. Combining precoder index modulation (PIM) and spatial modulation (SM), we introduce a PIM-SM scheme which conveys information bits through both antenna index as well as precoder index. Spectral efficiency (in bits per channel use) and bit error performance of these index modulation schemes are presented.
M-ary Detection and q-ary Decoding in Large-Scale MIMO: A Non-Binary Belief Propagation Approach
T. Lakshmi Narasimhan,A. Chockalingam
Computer Science , 2013,
Abstract: In this paper, we propose a non-binary belief propagation approach (NB-BP) for detection of $M$-ary modulation symbols and decoding of $q$-ary LDPC codes in large-scale multiuser MIMO systems. We first propose a message passing based symbol detection algorithm which computes vector messages using a scalar Gaussian approximation of interference, which results in a total complexity of just $O(KN\sqrt{M})$, where $K$ is the number of uplink users and $N$ is the number of base station (BS) antennas. The proposed NB-BP detector does not need to do a matrix inversion, which gives a complexity advantage over MMSE detection. We then design optimized $q$-ary LDPC codes by matching the EXIT charts of the proposed detector and the LDPC decoder. Simulation results show that the proposed NB-BP detection-decoding approach using the optimized LDPC codes achieve significantly better performance (by about 1 dB to 7 dB at $10^{-5}$ coded BER for various system loading factors with number of users ranging from 16 to 128 and number of BS antennas fixed at 128) compared to using linear detectors (e.g., MMSE detector) and off-the-shelf $q$-ary irregular LDPC codes. Also, even with estimated channel knowledge (e.g., with MMSE channel estimate), the performance of the proposed NB-BP detector is better than that of the MMSE detector.
Channel Hardening-Exploiting Message Passing (CHEMP) Receiver in Large-Scale MIMO Systems
T. Lakshmi Narasimhan,A. Chockalingam
Computer Science , 2013,
Abstract: In this paper, we propose a MIMO receiver algorithm that exploits {\em channel hardening} that occurs in large MIMO channels. Channel hardening refers to the phenomenon where the off-diagonal terms of the ${\bf H}^H{\bf H}$ matrix become increasingly weaker compared to the diagonal terms as the size of the channel gain matrix ${\bf H}$ increases. Specifically, we propose a message passing detection (MPD) algorithm which works with the real-valued matched filtered received vector (whose signal term becomes ${\bf H}^T{\bf H}{\bf x}$, where ${\bf x}$ is the transmitted vector), and uses a Gaussian approximation on the off-diagonal terms of the ${\bf H}^T{\bf H}$ matrix. We also propose a simple estimation scheme which directly obtains an estimate of ${\bf H}^T{\bf H}$ (instead of an estimate of ${\bf H}$), which is used as an effective channel estimate in the MPD algorithm. We refer to this receiver as the {\em channel hardening-exploiting message passing (CHEMP)} receiver. The proposed CHEMP receiver achieves very good performance in large-scale MIMO systems (e.g., in systems with 16 to 128 uplink users and 128 base station antennas). For the considered large MIMO settings, the complexity of the proposed MPD algorithm is almost the same as or less than that of the minimum mean square error (MMSE) detection. This is because the MPD algorithm does not need a matrix inversion. It also achieves a significantly better performance compared to MMSE and other message passing detection algorithms using MMSE estimate of ${\bf H}$. We also present a convergence analysis of the proposed MPD algorithm. Further, we design optimized irregular low density parity check (LDPC) codes specific to the considered large MIMO channel and the CHEMP receiver through EXIT chart matching. The LDPC codes thus obtained achieve improved coded bit error rate performance compared to off-the-shelf irregular LDPC codes.
Modulation of Antimicrobial Host Defense Peptide Gene Expression by Free Fatty Acids
Lakshmi T. Sunkara, Weiyu Jiang, Guolong Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049558
Abstract: Routine use of antibiotics at subtherapeutic levels in animal feed drives the emergence of antimicrobial resistance. Development of antibiotic-alternative approaches to disease control and prevention for food animals is imperatively needed. Previously, we showed that butyrate, a major species of short-chain fatty acids (SCFAs) fermented from undigested fiber by intestinal microflora, is a potent inducer of endogenous antimicrobial host defense peptide (HDP) genes in the chicken (PLoS One 2011, 6: e27225). In the present study, we further revealed that, in chicken HD11 macrophages and primary monocytes, induction of HDPs is largely in an inverse correlation with the aliphatic hydrocarbon chain length of free fatty acids, with SCFAs being the most potent, medium-chain fatty acids moderate and long-chain fatty acids marginal. Additionally, three SCFAs, namely acetate, propionate, and butyrate, exerted a strong synergy in augmenting HDP gene expression in chicken cells. Consistently, supplementation of chickens with a combination of three SCFAs in water resulted in a further reduction of Salmonella enteritidis in the cecum as compared to feeding of individual SCFAs. More importantly, free fatty acids enhanced HDP gene expression without triggering proinflammatory interleukin-1β production. Taken together, oral supplementation of SCFAs is capable of boosting host immunity and disease resistance, with potential for infectious disease control and prevention in animal agriculture without relying on antibiotics.
SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
LAKSHMI,K.S; RAJESH,T;
Journal of the Chilean Chemical Society , 2010, DOI: 10.4067/S0717-97072010000200023
Abstract: a simple reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of rosiglitazone (rgl) and gliclazide (glc) in puré and pharmaceutical dosage forms. aphenomenex gemini reverse phase c column (150x4.6mm i.d., 5μ) was used with a mobile phase containing a mixture of acetonitrile and water (ph 3 adjusted with ortho phosphoric acid) in the ratio of 70: 30. the flow rate was 0.6ml/min. and effluents were monitored at 250nm and eluted at 2.41min. (rgl) and 5.22min. (glc). calibration curve was plotted with a range from 0.025-2.5μg/ml for rgl and 0.08 to 8μg/ml for glc. the assay was validated for the parameters like accuracy (>97.87% recovery), precision (intra-day and inter-day with %rsd < 2), robustness and system suitability parameters. henee the method was found to suitable for the routine quality control of the drugs in puré and pharmaceutical dosage forms.
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