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Search Results: 1 - 10 of 118 matches for " Lakis Sotiris "
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Spontaneous perforation of solitary ulcer of transverse colon
Galanis Ioannis,Dragoumis Dimitrios,Kalogirou Thomas,Lakis Sotiris
Indian Journal of Pathology and Microbiology , 2010,
Abstract: Spontaneous ruptures of the colon and rectum are extremely uncommon clinical entities and always require laparotomy. A 44-year-old female was admitted with a 12-hour history of severe abdominal pain periumbilically and at the right hypochondrium. The patient was immediately transferred to the department of surgery for close surgical observation. Computed tomography (CT) of the entire abdomen performed just before the operation demonstrated thickening of the wall of the ascending colon with pericolic fat stranding. Surgery revealed a perforation at the antimesenteric wall of the transverse colon and segmental colectomy of the transverse colon was performed. The histological evaluation demonstrated a perforated solitary ulcer of the transverse colon. There are only few known etiologic factors concerning spontaneous ruptures of the colon and rectum and usually none of these causative factors can easily be recognised. Their clinical appearance is most of the times acute abdomen and, despite the use of all appropriate diagnostic methods, the diagnosis is usually set postoperatively.
AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas
Sotiris Lakis, Theodora Papamitsou, Constantina Panagiotopoulou, Rodoula Kotakidou, Vassiliki Kotoula
World Journal of Gastroenterology , 2010,
Abstract: AIM: To analyze α-methylacyl CoA racemase (AMACR) expression in relation to various dysplasia phenotypes and clinicopathological parameters of sporadic colorectal adenomas.METHODS: Fifty-five cases of sporadic colorectal adenomas were categorized according to the Vienna classification for Gastrointestinal Neoplasia. These corresponded to a total of 98 different intra-lesion microscopic fields that were further independently assigned a histological grade based on the old nomenclature (mild, moderate, severe dyplasia and carcinoma in situ). AMACR expression was evaluated by immunohistochemistry and statistical analysis was performed to investigate possible associations with various clinicopathologic parameters of adenomas i.e. gender, age, localization, grade of dysplasia, size and configuration.RESULTS: Patient age ranged from 41 to 84 years (mean 65 ± 13.2 years); 37 patients were males and 18 were females. Adenomas ranged in size between 0.5 and 30 cm (mean 2 ± 1.3 cm), including 18 tubular, 16 villous, 20 mixed or tubulovillous, and 1 giant sessile villous adenoma. AMACR expression was observed in 3 out of 16 (18.8%) of low-grade vs 23 out of 35 (62.8%) of high-grade lesions (P = 0.002). Most adenomas exhibiting high grade dysplasia with in situ carcinoma-like areas stained positive for AMACR (15/17 or 88.2%) as compared to adenomas with high grade dysplasia which contained severe dysplasia-like foci (6/15 or 40%), (P = 0.005). In AMACR positive adenomas featuring severe dysplasia-like or in situ carcinoma-like areas, AMACR staining was not necessarily observed in the in situ component. Positivity in intra-lesion of mild, moderate or severe dysplasia-like foci was more often encountered in adenomas harboring in situ, intramucosal or infiltrative carcinoma [21/33 (63.6%) vs 9/40 (22.5%), P < 0.001]. Strong AMACR expression was found in 11 out of 17 villous adenomas, but in only 1 out of 18 tubular lesions (P = 0.005). Larger lesions, i.e. > 1 cm stained more frequently for AMACR than smaller ones [27/45 (60%) vs 2/10 (20%), P = 0.02]. Overall, AMACR expression was associated with the grade of dysplasia, as well as with the size and configuration of adenomas, i.e. the consensus risk factors applied to colorectal adenoma patient surveillance.CONCLUSION: It may be worthy to further evaluate the possible use of AMACR as an additional risk factor for the assessment of colorectal adenoma patients.
Supersonic Flutter of a Spherical Shell Partially Filled with Fluid  [PDF]
Mohamed Menaa, Aouni A. Lakis
American Journal of Computational Mathematics (AJCM) , 2014, DOI: 10.4236/ajcm.2014.43014
Abstract:

In the present study, a hybrid ?nite element method is applied to investigate the dynamic behavior of a spherical shell partially filled with fluid and subjected to external supersonic airflow. The structural formulation is a combination of linear spherical shell theory and the classic finite element method. In this hybrid method, the nodal displacements are derived from exact solution of spherical shell theory rather than approximated by polynomial functions. Therefore, the number of elements is a function of the complexity of the structure and it is not necessary to take a large number of elements to get rapid convergence. Linearized first-order potential (piston) theory with the curvature correction term is coupled with the structural model to account for aerodynamic loading. It is assumed that the fluid is incompressible and has no free surface effect. Fluid is considered as a velocity potential at each node of the shell element where its motion is expressed in terms of nodal elastic displacements at the ?uid-structure interface. Numerical simulation is done and vibration frequencies are obtained. The results are validated using numerical and theoretical data available in literature. The investigation is carried out for spherical shells with different boundary conditions, geometries, filling ratios, flow parameters, and radius to thickness ratios. Results show that the spherical shell loses its stability through coupled-mode flutter. This proposed hybrid finite element method can be used efficiently for analyzing the flutter of spherical shells employed in aerospace structures at less computational cost than other commercial FEM software.

Individuals Diagnosed with Schizophrenia Assign Emotional Importance to Neutral Stimuli: An fMRI Study
Nadia Lakis,Adrianna Mendrek
ISRN Psychiatry , 2013, DOI: 10.1155/2013/965428
Abstract: The majority of functional neuroimaging studies investigating neural correlates of emotion processing in schizophrenia report a significant deficit in limbic structures activation in patients relative to control participants. Recently it has been suggested that this apparent “deficit” could be due to an enhanced sensitivity of the neutral material in individuals diagnosed with schizophrenia, rather than due to their inefficiency in emotion processing. The purpose of the present study was to test this supposition and verify if the potential effect is present in both men and women diagnosed with schizophrenia. In order to do that we examined the pattern of cerebral activation associated with processing of neutral stimuli in schizophrenia. Thirty-seven schizophrenia patients and 37 healthy controls viewed neutral and emotional images while in a functional magnetic resonance imaging scanner. Schizophrenia patients rated the neutral images as more emotionally salient than controls. Additionally, patients showed significant activation during processing of neutral images in limbic and prefrontal regions; similar areas were underactivated in patients relative to controls during processing of emotional information. Investigation of sex differences revealed that the enhanced responsiveness to the emotionally neutral material was attributed primarily to men with schizophrenia. 1. Introduction Functional neuroimaging studies, which explored processing of emotional material in schizophrenia, have often reported “deficits” in cerebral activation in patients compared to control participants in various limbic, paralimbic, and prefrontal regions (e.g., [1–4]). A few other studies documented “abnormal overactivation” in patients relative to controls or no difference between the groups [5–10]. These divergent findings have been attributed to the type of emotional task (passive viewing, emotion identification, emotional memory, etc.) and to the characteristics of the recruited patients (first-episode versus chronic, medicated versus unmediated, presence of prominent negative versus prominent positive symptoms, etc.). However, what could have played an equally or even more important role in the obtained results is the kind of functional neuroimaging contrast used in the statistical analysis. It should be pointed out to readers less familiar with the functional neuroimaging literature that the functional magnetic resonance imaging (fMRI) studies in various clinical populations (including schizophrenia and related psychoses) have relied primarily on comparisons between two
REGIONAL INNOVATION SYSTEM FAILURES AND HIGHLIGHTS
Sotiris Zygiaris
Romanian Journal of Regional Science , 2009,
Abstract: The systemic analysis of innovation conceives complex analytical frameworks, with intense socio-technological aspects of knowledge generation and encompasses a detailed analysis of system failures. These frameworks are not suitable for benchmarking a wide range of regions, due to low availability of such elaborate data sources. On the other hand, metric regional innovation micro data offer the opportunity for large-scale cross-regional benchmarking exercise illustrating mainly the market failures of the innovation systems although this type of analysis does not provide any detailed systemic envisioning. Is the combination of these two analytical approaches possible? This study presents the Interaction Intension Indicator (3I) analytical framework, analysing system failures and highlights of various regional innovation deployment patterns along with the analysis of the Romanian innovation system.
Utopia
Sotiris Gakos
Intellectum , 2010,
Abstract: The present article introduces the concept of utopia through the works of thinkers such as Thomas More, Lewis Mumford and Karl Mannheim. It raises the question whether utopia is necessary nowadays and responds positively “since subversion, which is utopia’s main feature, is what is missing from society; a mood subversion, a subversion of crisis and peoples’ unpleasant psychology”.
On holomorphic polydifferentials in positive characteristic
Sotiris Karanikolopoulos
Mathematics , 2009,
Abstract: In this paper we study the space $\Omega(m)$, of holomorphic $m$-(poly)differentials of a function field of a curve defined over an algebraically closed field of characteristic $p>0$ when $G$ is cyclic or elementary abelian group of order $p^n$; we give bases for each case when the base field is rational, introduce the Boseck invariants and give an elementary approach to the $G$ module structure of $\Omega(m)$ in terms of Boseck invariants. The last computation is achieved without any restriction on the base field in the cyclic case, while in the elementary abelian case it is assumed that the base field is rational. An application to the computation of the tangent space of the deformation functor of curves with automorphisms is given.
Cancer, inflammation and the AT1 and AT2 receptors
Gary Smith, Sotiris Missailidis
Journal of Inflammation , 2004, DOI: 10.1186/1476-9255-1-3
Abstract: This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor through systemic oxidative stress and hypoxia mechanisms, thereby triggering chronic inflammatory processes to remodel surrounding tissue and subdue the immune system. Based on current literature and clinical studies on angiotensin receptor inhibitors, the paper concludes that blockade of the AT1 receptor in synergy with cancer vaccines and anti-inflammatory agents should offer a therapy to regress most, if not all, solid tumours.With regard to cancer being a systemic disease, an examination of supporting evidence for a systemic role of AT1 in relationship to inflammation in disease and injury is presented as a logical progression. The evidence suggests that regulation of the mutually antagonistic angiotensin II receptors (AT1 and AT2) is an essential process in the management of inflammation and wound recovery, and that it is an imbalance in the expression of these receptors that leads to disease.In consideration of cancer induced immune suppression, it is further postulated that the inflammation associated with bacterial and viral infections, is also an evolved means of immune suppression by these pathogens and that the damage caused, although incidental, leads to the symptoms of disease and, in some cases, death.It is anticipated that manipulation of the angiotensin system with existing anti-hypertensive drugs could provide a new approach to the treatment of many of the diseases that afflict mankind.Tumour has been linked with inflammation since 1863, when Rudolf Virchow discovered leucocytes in neoplastic tissues and made the first connection between inflammation and cancer [1]. Since then, chronic inflammation has been identified as a risk factor for cancer and even as a means to prognose/diagnose cancer at the onset of the disease. Examples of such association include the Human papiloma virus (HPV) and cancer [2], including cervical [3], cancers of the oesophagus [4] and lar
Acute lymphocytic crisis following herpes simplex type 1 virus hepatitis in a nonimmunocompromised man: a case report
Sotiris Plastiras, Ourania Kampessi
Journal of Medical Case Reports , 2009, DOI: 10.4076/1752-1947-3-7492
Abstract: A 52-year-old man was admitted to our hospital reporting low-grade fever for the previous seven days, and fatigue. During the fifth day of hospitalization, the patient developed a lymphocytic crisis and, after further tests the patient was diagnosed as having herpes simplex virus hepatitis.This case report shows that herpes simplex virus type 1 is a possible cause of an acute lymphocytic crisis similar to other well known infectious agents such as Epstein–Barr virus, cytomegalovirus, human immunodeficiency virus, human herpes virus type 6, adenovirus, toxoplasma and human T-cell lymphotropic virus. Furthermore, this case report expands the clinical spectrum of herpes simplex virus hepatitis, since it is reported in a nonimmunocompromised patient presenting with atypical acute lymphocytic syndrome.An increase in circulating lymphocytes can be seen following infections such as infectious mononucleosis and pertussis [1], or in lymphoproliferative disorders such as acute and chronic lymphocytic leukemia. We report on a patient whose laboratory findings indicated an acute lymphocytic crisis after herpes simplex virus (HSV) hepatitis.A 52-year-old, Caucasian man of Greek origin was admitted to our hospital reporting low-grade fever for the previous 7 days, and fatigue. His past medical history was unremarkable. Clinical examination revealed a low-grade hepatomegaly (1 to 2cm) and two palpable lymph nodes at the left lateral neck with a soft constitution, movable and mildly sensitive when palpated.The results of the laboratory tests carried out on admission are shown in Table 1. Direct and indirect antiglobulin tests were negative; C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were 37.2mg/L and 30mm/hour, respectively. Immunologic tests and urine analysis were normal. Blood and urine cultures and the Mantoux test were negative. Serologic findings including brucella, rickettsia and coxsiella burnetii, borrelia burgdorferi, Epstein–Barr virus (EBV), cytom
Wireless Multimedia Communications Impacts on Tourism Destination Value Chain
Dimitris Kanellopoulos,Sotiris Kotsiantis
Journal of Engineering and Applied Sciences , 2012,
Abstract: Future wireless services for tourism destinations will be implemented using several network technologies focusing on the prospective standardization and specification efforts. Current Destination Management Systems (DMS) span wide areas with heterogeneous tourism destination information resources. Recently, intelligent DMS are aware of different user context environments and satisfy the matchmaking between the mobile user requirements and destination information via various wireless services. This study discusses the evolving wireless technology and the forthcoming applications on long haul tourism destinations. It examines the implications of wireless technology on long haul destinations. Using the Porter`s value chain analysis, light is shed on the future developments and potential alterations with regards to the primary and support activities within the value chain. Finally, future prospects in wireless multimedia communications such as MMS, multimedia browsing, rich call-personal real-time communication and mobile messaging are discussed.
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