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In-Silico Drug Design: A revolutionary approach to change the concept of current Drug Discovery Process
Lakhyajit Boruah, Aparoop Das, Lalit Mohan Nainwal, Neha Agarwal*, Brajesh Shankar
Indian Journal of Pharmaceutical and Biological Research , 2013,
Abstract: Computational methods play a central role in modern drug discovery process. It includes the design andmanagement of small molecule libraries, initial hit identification through virtual screening, optimization ofthe affinity as well as selectivity of hits and improving the physicochemical properties of the leadcompounds. In this review article, computational drug designing approaches have been elucidated anddiscussed. The key considerations and guidelines for virtual chemical library design and whole drugdiscovery process. Traditional approach for discovery of a new drug is a costly and time consuming affairbesides not being so productive. A number of potential reasons witness choosing the In-silico method ofdrug design to be a more wise and productive approach. There is a general perception that applied sciencehas not kept pace with the advances of basic science. Therefore, there is a need for the use of alternativetools to get answers on efficacy and safety faster, with more certainty and at lower cost. In-silico drugdesign can play a significant role in all stages of drug development from the initial lead designing to finalstage clinical development.
ROLE OF PANCHAYATI RAJ INSTITUTIONS IN ASSAM AND PEOPLES PARTICIPATION AFTER 73RD CONSTITUTION AMENDMENT ACT, 1992
Monuj Boruah
International Journal for Basic Sciences and Social Sciences , 2013,
Abstract: People’s participation in PRI devotes to direct involvement of grass root level people in administration. The involvement is not only in policy formation or planning but also in implementation of the policies in the rural and remotes areas. In a predominantly agrarian country like India, any attempt aiming at a radical change in the socio-economic condition of the masses must be directed towards rural masses because they are the backbone of our existence. People’s participation in PRIs is very necessary for the survival of a democracy like India, where the rural peoples forms the base of our existence.This paper tries to examine the question of people’s participation in PRIs specially in Gaon Panchayat and how far the objectives of the Constitution (73rd Amendment) Act; 1992 has executed in Assam with special reference to two Gaon Panchayats, viz., Tamulisiga and Bamunpukhuri Gaon Panchayat under East Jorhat Development Block, Kaliapani in Jorhat District.
Post-Infectional Biochemical Changes in Cymbopogon martinii (Roxb.) Wats and Cymbopogon citratus (DC) Stapf. Due to Leaf Rust Disease  [PDF]
Phatik Tamuli, Mamoni Saikia, Paran Boruah
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.48201
Abstract:

Post-infectional changes in sugars, ascorbic acid, protein, phenols, chlorophyll and carotene of two Cymbopogons viz., Cymbopogon martinii and Cymbopogon citratus due to leaf rust caused by Puccinia nakanishikii (Diet) were investigated. All the biochemical constituents decreased in plants infected by the fungal pathogen.

In-Vitro Efficacy of Certain Essential Oils and Plant Extracts against Three Major Pathogens of Jatropha curcas L.  [PDF]
Purnajyoti Deka Bhuyan, Phatik Tamuli, Paran Boruah
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.62041
Abstract: Antifungal activity of plant extracts and essential oils of six different plant species was tested against three pathogenic fungi, viz., Alternaria alternata, Colletotrichum gloeosporioides and Fusarium moniliforme isolated from Jatropha curcas L. using Poison Food Technique. All the samples tested were found effective in-vitro. More than 60% inhibition of growth of individual fungal species was observed at 100 ppm. Maximum inhibition was observed at concentration of 1000 ppm. However, among the essential oils tested Cinnamomum impressinervium exhibited the strongest activity (80%) in the case of Colletotrichum gloeosporioides and Alternaria alternate and 78.6% in the case of Fusarium oxysporum at concentration of 1000 ppm followed by Cinnamomum tamala, Cymbopogon jwarancusa and Cymbopogon citratus respectively. Among the plant extracts tested, Catharanthus roseus exhibited stronger activity in comparison to Tithonia diversifolia. Inhibition percentage of all the essential oils and plant extracts increased with the increase in concentration.
Utility of Nuclear Morphometry in Predicting Grades of Diffusely Infiltrating Gliomas
Dibyajyoti Boruah,Prabal Deb
ISRN Oncology , 2013, DOI: 10.1155/2013/760653
Abstract: Introduction. The ability to reliably differentiate neoplastic from nonneoplastic specimen and ascertain the tumour grade of diffusely infiltrating gliomas (DIGs) is often challenging. Aims and Objective. To evaluate utility of image morphometry in identifying DIG areas and to predict tumour grade. Materials and Methods. Image morphometry was used to analyze the following nuclear features of 30 DIGs and 10 controls (CG): major axis of nucleus (MAJX), minor axis of nucleus (MINX), nuclear area (NA), nuclear perimeter (NP), nuclear roundness (NR), nuclear density (ND), and percentage of total nuclear area (%TNA). Results. Statistically significant differences in all parameters, except NR, were observed between all groups, with strong positive correlation with tumour grade ( ). The mean values were maximum for HGG and minimum for CG. For NR, the difference between CG/HGG was statistically significant, unlike CG/LGG and LGG/HGG. It was observed that NA distributions for CG were nearly Gaussian type with smaller range, while gliomas displayed erratic pattern with larger range. NA and NP exhibited strong positive correlation with ND. Conclusion. Image morphometry has immense potential in being a powerful tool to distinguish normal from neoplastic tissue and also to differentiate LGG from HGG cases, especially in tiny stereotactic biopsies. 1. Introduction The global annual incidence of primary malignant central nervous system (CNS) tumors is around 37 per million for male and 26?per?million for female [1, 2], with gliomas constituting the majority. In the past several years, it has been well established that quite a few clinical and histopathological parameters are helpful in predicting the clinical outcome of cancer patients. Currently, well-established techniques like morphometry, stereology, static image, and flow cytometry are routinely used in diagnostic quantitative pathology. The potential significance of these techniques includes the objective distinction between benign, borderline, and malignant lesions; the objective grading of invasive tumors; and the prediction of prognosis and therapeutic response. Computer-assisted image analysis is a new powerful tool for high-precision measurement of different facets of tumor cells to achieve similar goals [3–7]. To date only few studies have utilized nuclear morphometric measurements, like mean major axis (MAJX), minor axis (MINX), nuclear area (NA), nuclear perimeter (NP), and roundness of nucleus (NR), to determine the nuclear size and shape profiles in neoplastic tissues in CNS tumors [6–12]. The initial
Simulation of Proton and Iron Induced Extensive Air Showers
C. Thakuria,K. Boruah
Physics , 2011,
Abstract: The reliable simulation of extensive air showers induced by different primary particles (e. g. proton, iron, gamma etc.) is of great importance in high energy cosmic ray research. The CORSIKA is a standard Monte-Carlo simulation package to simulate the four dimensional evolution of Extensive Air Shower (EAS) in the atmosphere initiated by gamma, hadrons and nuclei. CORSIKA has different high energy interaction models like DPMJET, QGSJET, NEXUS, SIBYLL, VENUS and EPOS which are based on different theoretical frameworks. The influence of different hadronic interaction models, viz., QGSJET and DPMJET on the lateral distribution functions (LDF) and muon to electron ratio of cosmic ray EAS induced by 10^17 eV to 10^20 eV proton and iron primaries are explored in this work.
Comparison of EPOS and QGSJET-II in EAS Simulation using CORSIKA
Chabin Ch. Thakuria,K. Boruah
Physics , 2012,
Abstract: In this work we compare the predictions of two representative hadronic interaction models, EPOS 1.99, and QGSJET II-03 with several extensive air showers (EAS) parameters for proton and iron primaries in the energy range $10^{17}$ - $10^{19} eV$ using CORSIKA-6990. The EAS parameters depth of shower maximum, shower size, size of muon shower, muon number distribution, electron number distribution,size of hadron shower, hadron energy sum, electron muon correlations, and, hadron energy spectra are studied in this paper.
Modeling and Simulation of Second-order Phase-locked Loop for Studying the Transient Behavior during Frequency Acquisition and Tracking
N. Haque,P. K. Boruah,T. Bezboruah
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
Susceptibility to and correction of azimuthal aberrations in singular light beams
B R Boruah,M a a Neil
Physics , 2009, DOI: 10.1364/OE.14.010377
Abstract: We show how the effects of azimuthal optical aberrations on singular light beams can result in an intensity modulation in the beam waist or focal point spread function (PSF) that is directly proportional to the amplitude of the applied phase aberration. The resulting distortions are enough to significantly degrade the utility of the singular beams even in well corrected optical systems. However we show that pattern of these intensity modulations is related to the azimuthal order of the applied aberration and we suggest how this can be used to measure those aberrations. We demonstrate a closed loop system using a liquid crystal spatial light modulator as a programmable diffractive optical element to both generate the beam and correct for the sensed aberrations based on feedback from a CCD detected intensity image of the focal point spread function.
Gold Nanoparticles: Promising Nanomaterials for the Diagnosis of Cancer and HIV/AIDS
Anil Kumar,Bhargavi Mazinder Boruah,Xing-Jie Liang
Journal of Nanomaterials , 2011, DOI: 10.1155/2011/202187
Abstract: Gold nanoparticles (AuNPs) are currently playing a significant role for human welfare in the field of clinical diagnosis as well as several biomedical applications. More and more research shows that AuNPs-based technologies are becoming promising approaches in cancer research and AIDS treatment. In this paper, we have focused mainly on the exploitation of unique and characteristic properties of AuNPs such as surface plasmon resonance (SPR), surface enhance Raman scattering (SERS), magnetic properties (MRI), and fluorescence behavior shown upon conjugation with biological and biocompatible ligands. These properties find wide prevalence in biodiagnostics like plasmon-based labeling and imaging, enzyme-linked immunosorbant assay (ELISA), and electrochemical-based methods that can pave the way for developing novel techniques towards diagnosis and therapy of cancer and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). 1. Why Nanoparticles for Biomedical Applications? In contrast to a majority of micro- and macroparticles, nanoparticles (NPs) contain highly significant properties such as molecular fluorophores which make them ideal for biodiagnostic applications. The characteristic properties earmarked for NPs are their (a) small size (1–100?nm) and correspondingly large surface-to-volume ratio, (b) physical and chemical properties that can be tuned depending upon the requirements of size, composition, and shape (e.g., gold nanoparticles), (c) quantitive and qualitative target-binding properties, and (d) high robustness shown by some of the nanostructure materials [1]. The size of NPs plays an indispensable role in the field of nanobiotechnology which makes them suitable for all biological applications. They offer various advantages over a bulk structure; their characteristic properties make them more ideal. The physical and chemical properties of NPs can have significant effect on the overall function such as target-binding event. In the present research scenario, a number of research and publications are focussing on the tunable physicochemical properties of materials to synthesize highly advanced materials and to boost their robustness. Applications of NPs in biological sciences have a long history as NPs have been used in bioconjugation with peptides, proteins, and DNA and also with some other biological molecules as cellular delivery, labeling, and imaging agents [2, 3]. Specifically the size, shape, and absorptive and light-scattering properties of some materials exhibit different phenomenon when a beam of light is incident on
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