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Search Results: 1 - 10 of 302954 matches for " LUCCHI Júlio "
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Testes in vitro e in vivo com o Cora o Artificial Auxiliar (CAA): um novo modelo de cora o artificial totalmente implantável e heterotópico
Revista Brasileira de Cirurgia Cardiovascular , 1999,
Abstract: Um novo modelo de cora o artificial está sendo desenvolvido e testado em nossos laboratórios, o Cora o Artificial Auxiliar (CAA). Este dispositivo foi projetado com dimens es reduzidas para ser implantado em paralelo ao cora o natural do paciente, dentro da cavidade torácica direita de forma heterotópica. Foram realizados testes in vitro, em um circuito simulador do sistema circulatório humano, para verifica o do desempenho hidrodinamico do CAA. Os resultados mostraram que o CAA pode fornecer um fluxo de até 5,8 L/min, com uma pré-carga de 20 mmHg e uma pós-carga de 100 mmHg. A freqüência de batimento do CAA e, consequentemente, o débito cardíaco s o dependentes da pré-carga do ventrículo esquerdo, funcionamento semelhante ao cora o natural (Lei de Frank Starling). Testes in vivo animal est o sendo realizados para avaliar os resultados obtidos com os testes in vitro e para verificar o comportamento do CAA em ambiente e condi es fisiológicas difíceis de serem simuladas. Os testes in vivo est o sendo também importantes para o desenvolvimento de técnicas cirúrgicas e treinamento dos cirurgi es cardiovasculares envolvidos no projeto. Até o momento, dois estudos agudos in vivo foram realizados, com o CAA funcionando por 5h, implantado na cavidade torácica direta de carneiros adultos (50 ± 5 kg). Os resultados destes estudos in vivo demonstraram que o funcionamento do CAA é sincronizado ao cora o natural, sendo possível estudar o comportamento do CAA quando, gradativamente, o cora o natural teve sua contratilidade reduzida até sua parada total.
Testes in vitro e in vivo com o Cora??o Artificial Auxiliar (CAA): um novo modelo de cora??o artificial totalmente implantável e heterotópico
ANDRADE, Aron;OHASHI, Yukio;LUCCHI, Júlio;NICOLOSI, Denys;DINKHUYSEN, Jarbas J.;BISCEGLI, José;ARRUDA, Ant?nio C. F.;CUNHA, Wagner C.;NOSé, Yukihiko;
Revista Brasileira de Cirurgia Cardiovascular , 1999, DOI: 10.1590/S0102-76381999000200010
Abstract: a miniaturized artificial heart is being developed in the authors laboratories, the auxiliary total artificial heart (atah). this device is an electromechanically driven atah using a brushless direct current (dc) motor fixed in a center aluminum piece. this pusher plate type atah is controlled based on frank-starling's law. the beating frequency is regulated through the change of the left preload, assisting the natural heart in obtaining adequate blood flow. with the miniaturization of this pump, the average sized patient can have the surgical procedure of implantation in the right thoracic cavity performed without removal of the natural heart. the left and right stroke volumes are 35 ml and 32 ml, respectively. in vitro tests were made and the performance curves demonstrated that the atah produces 5l/min of cardiac output at 180 bpm (10 mmhg of left inlet mean pressure and 100 mmhg of left outlet mean pressure). preliminary acute in vivo tests were performed in two sheeps with 50 ± 5 kg, during 5 hours. the atah performance is satisfactory for helping the natural heart to obtain the required blood flow and arterial pressure. with the atah and the natural heart working simultaneously the atah control system is simpler, also the risks of a fatal misoperation is minor compared to a total artificial heart, for patients that still present some cardiac function.
Formalizing Mobility in Service Oriented Computing
Claudio Guidi,Roberto Lucchi
Journal of Software , 2007, DOI: 10.4304/jsw.2.1.1-13
Abstract: The usual scenario of service oriented systems is characterized by several services offering the same functionalities, by new services that are continuosly deployed and by other ones that are removed. In this context it can be useful to dynamically discover and compose services at runtime. Orchestration languages provide a mean to deal with service composition, while the problem of fulfilling at runtime the information about the involved services is usually referred to as open-endedness. When designing service-based applications both composition and open endedness play a central role. Such issues are strongly related to mobility mechanisms which make it possible to design applications that acquire, during the execution, the information which are necessary to invoke services. In this paper we discuss the forms of mobility for the service oriented computing paradigm. To this end we model a service by means of the notions of interface, location, internal process and internal state, then we formalize a calculus supporting the mobility of each element listed above. We conclude by tracing a comparison between the proposed calculus and the mobility mechanisms supported by the Web Services technology.
Molecular Diagnosis of Malaria by Photo-Induced Electron Transfer Fluorogenic Primers: PET-PCR
Naomi W. Lucchi, Jothikumar Narayanan, Mara A. Karell, Maniphet Xayavong, Simon Kariuki, Alexandre J. DaSilva, Vincent Hill, Venkatachalam Udhayakumar
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056677
Abstract: There is a critical need for developing new malaria diagnostic tools that are sensitive, cost effective and capable of performing large scale diagnosis. The real-time PCR methods are particularly robust for large scale screening and they can be used in malaria control and elimination programs. We have designed novel self-quenching photo-induced electron transfer (PET) fluorogenic primers for the detection of P. falciparum and the Plasmodium genus by real-time PCR. A total of 119 samples consisting of different malaria species and mixed infections were used to test the utility of the novel PET-PCR primers in the diagnosis of clinical samples. The sensitivity and specificity were calculated using a nested PCR as the gold standard and the novel primer sets demonstrated 100% sensitivity and specificity. The limits of detection for P. falciparum was shown to be 3.2 parasites/μl using both Plasmodium genus and P. falciparum-specific primers and 5.8 parasites/μl for P. ovale, 3.5 parasites/μl for P. malariae and 5 parasites/μl for P. vivax using the genus specific primer set. Moreover, the reaction can be duplexed to detect both Plasmodium spp. and P. falciparum in a single reaction. The PET-PCR assay does not require internal probes or intercalating dyes which makes it convenient to use and less expensive than other real-time PCR diagnostic formats. Further validation of this technique in the field will help to assess its utility for large scale screening in malaria control and elimination programs.
Ruas de Borges e de seus contemporaneos
Pinto, Júlio Pimentel;
História (S?o Paulo) , 2003, DOI: 10.1590/S0101-90742003000200007
Abstract: this article analyses the repetition of the urban representation in latin american vanguards in the xx century beggining, to identify some signs of the city?s celebration in its poetic production. the article focalize four writers: two brazilians, mário and oswald de andrade, and two argentineans, oliverio girondo and jorge luis borges, to recognize similarities and dissimilarities in their urban representation.
Música popular e literatura em diálogo: Mário de Andrade e as poéticas da palavra escrita e cantada
Diniz, Júlio;
Alea : Estudos Neolatinos , 2010, DOI: 10.1590/S1517-106X2010000200008
Abstract: the text analyzes and discusses mário de andrade's critical contribution to the relation between music, culture and literature, particularly poetry. andrade's intellectual production is characterized by a constant search for an understanding of the meaning of art, culture and brazil, through the creation of what might be called a polyphonic view. his studies and essays on music, together with his keen interest in anthropology and ethnography, left deep marks in his fiction, as a reading of a chapter from macunaíma shows clearly.
Applications of flow cytometry to hematopoietic stem cell transplantation
Voltarelli, Júlio C;
Memórias do Instituto Oswaldo Cruz , 2000, DOI: 10.1590/S0074-02762000000300018
Abstract: applications of flow cytometry to clinical and experimental hematopoietic stem cell transplantation (hsct) are discussed in this review covering the following topics: diagnosis and classification of lymphohematologic disorders, quantitation of hematopoietic progenitors in the graft, lymphohematopoietic reconstitution following hsct and animal models of human hsct. at the end, the utilization of flow cytometry in clinical hsct by brazilian transplant centers is briefly reviewed.
A violência escolar e a crise da autoridade docente
Aquino, Júlio Groppa;
Cadernos CEDES , 1998, DOI: 10.1590/S0101-32621998000400002
Abstract: the present article intends to discuss the relationship between the concepts of violence and authority within school context nowadays and, mainly, within teacher-student relationship. for that purpose, it proposes an institutional approach of school violence opposed to the classical approaches of the subject in focus, demonstrating the thesis according to which there is an amount of "productive" violence enclosed in the pedagogical action.
A nova LDB e as necessidades educativas especiais
Ferreira, Júlio Romero;
Cadernos CEDES , 1998, DOI: 10.1590/S0101-32621998000300002
Abstract: this article analyses the provisions for special education in the new lei de diretrizes e bases da educa??o (educations bases and aims act) that aims towards an approach at more closely related to regular education systems and programs. we focus upon some implications and perspectives for this area, in the context of the ongoing educational reforms.
Hematopoietic stem cell transplantation for autoimmune diseases in Brazil: current status and future prospectives
Voltarelli, Júlio C.;
Revista Brasileira de Hematologia e Hemoterapia , 2002, DOI: 10.1590/S1516-84842002000300007
Abstract: in this paper, we discuss the launching of a cooperative protocol of hematopoietic stem cell transplantation for autoimmune diseases in brazil. we present specific conditions of the country's health system which would affect the trial, preliminary results of the first nine patients transplanted under the protocol (4 systemic lupus, 3 multiple sclerosis, one systemic sclerosis and one overlapping lupus + systemic sclerosis) and future prospectives of organizing phase iii randomized trials to answer specific scientific questions pending in the field.
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