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Search Results: 1 - 10 of 64565 matches for " LU Shao-Yong "
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Impact of p27mt gene on transplantation model of human colorectal cancer in nude mice
Jun Chen, Wu-Hua Ding, Guang-Xin Lu, Shao-Yong Xu
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate the inhibitory and anti-metastatic effect of mutant p27 gene (p27mt) on the growth of colorectal cancer xenografts in nude mice and its underlying mechanism.METHODS: Inhibitory effect of p27mt gene on the growth of colorectal cancer xenografts was determined by measurement of tumor size before and after direct intra-tumoral injection of Ad-p27mt in a pre-established transplantation model of human colorectal cancer in nude mice. Cell cycle and apoptosis were detected by flow cytometry performed on single-cell suspension from an isolated tumor. Expression of MMP-9 in tumor tissue was detected by immunohistochemistry.RESULTS: The average sizes of transplantation tumors were 1.94 ± 0.67 cm3, 2.75 ± 0.83 cm3 and 3.01 ± 0.76 cm3 in the Ad-p27mt, Ad-LacZ and control groups, respectively (P < 0.05). The average proliferation rates were 37.34% ± 1.45%, 53.16% ± 3.27% and 54.48% ± 2.43%, in the Ad-p27mt, Ad-LacZ and control groups, respectively (P < 0.05). The average apoptosis rates were 19.79% ± 3.32%, 6.38% ± 4.91% and 7.25% ± 5.20% in the Ad-p27mt, Ad-LacZ and control groups, respectively (P < 0.01). The average MMP-9 expression rates were 20%, 75% and 66.7% in the Ad-p27mt, Ad-LacZ and control groups, respectively (P < 0.01).CONCLUSION: p27mt inhibits the growth of transplanted tumor by blocking the proliferation of cancer xenografts and by promoting apoptosis of transplantated tumor cells, as well as decrease transpl-anted tumor metastasis.
Nitrogen removal mechanism of constructed wetland

LU Shao-Yong,JIN Xiang-Can,YU Gang,

生态学报 , 2006,
Abstract: Eutrophication of lakes and aquatic systems deteriorate the ecosystem and economy. The causes and controls of eutrophication have attracted attentions worldwide, including China. Extensive research has been carried out on problems related to eutrophication in China. Nitrogen is one of the major nutriments contributing to the eutrophication in aquatic environments. The external nitrogen load (including point source and nonpoint source) is an important component of the total water-pollutant load. The traditional wastewater treatment technology, which lacks in integrated collection systems, poses excessive investment costs on the control of nonpoint pollution. The constructed wetland is an important technology to reduce the external nitrogen load, especially from the nonpoint source. It is capable of effectively removing nitrogen and handling a high pollutant load; moreover, it is friendly to eco-system and requires low investment costs. Thus the constructed wetland is especially fit for controlling the eutrophication. Illustrating the nitrogen removal mechanisms in constructed wetland has an important meaning on the eutrophication in aquatic systems. The nitrogen removal mechanism in the constructed wetland with a leak-proof layer consists of volatilization, ammonification, nitrification/denitrification, plant uptake, and matrix adsorption, is reviewed in this paper. In a constructed wetland without a leak-proof layer, the nitrogen exchange with the surrounding environments has significant effects on the nitrogen removal rate. Generally, nitrification/denitrification is the major nitrogen removal mechanism in constructed wetlands. Volatilization is insignificant when the pH of the wastewater is less than 7.5. Volatilization is significant when the pH is higher than 9.3. Nitrification/denitrification is the major nitrogen removal mechanism in constructed wetlands treating domestic wastewater. Under low influent loads, suitable climate conditions, and appropriate plant species, the plant-harvest process maybe the major nitrogen removal pathway. Well-managed artificial wetlands usually show a better nitrogen-removing efficiency than do natural wetlands. Sound system designs (e.g., the medium configuration, the arrangement of helophytes, and the opitimization of water distribution and collection) have a direct impact on the nitrogen removal in constructed wetlands. Reasonable operations and maintenances, such as the effective control of the water level, the correct helophyte cultivation, and the sound helophyte harvest can effectively improve the nitrogen removal in a constructed wetland.
Variation of Nitrogen and Phosphorus Concentration in Water-Sediment System and Influence of Overlying Water on the Algae Growth

LU Shao-yong,JIN Xiang-can,GUO Jian-ning,SHENG Li,

环境科学 , 2007,
Abstract: The effect of biosidal treatment of initial sediment, addition of inhibitor and addition of phosphorus on the transform of nitrogen and phosphorus in the sediment-water simulative system were studied. S. quadricaudain was cultured in overlying waters took from the above experiment sets when the above experiment completed. The result indicated that, biosidal treatment enhanced the concentration of TP while there was no obvious effect on N. The TP, DTP and TN concentrations were closely between inhibitor addition set and the control set in the sediment-water simulative system but the content of NO3(-)-N of the set with inhibitor addition reached 19.2 mg x L(-1), which was much higher than that of the control set. The sediment significantly adsorbed the P added to the system, and the content of TP decreased when the system reached balance. Algae biomass of the biosidal treatment set was higher than that of the control set, and the main cause was sterilizer leaded to higher concentration of TP of the biosidal treatment set. The highest Algae biomass of the group with inhibitor (224.5 x 10(4) unit x L(-1)) was much higher than that of the control set (26 x 10(4) unit x L(-1)), and that was 5-10 times than that of other sets (sterilized set 22.5 x 10(4) unit x L(-1), set with P added 38.5 x 10(4) uni x L(-1)). Inhibitor restrained the microorganism from using some nutrition which was important to alga's growth. At the beginning, the addition of P had no remarkable effect on the alga growth, but along with the experiment, the alga of the P addition set adapted to the environment and algae biomass exceed that of the control set. The increase of biological bioavailable phosphorus of sediment in biosidal treatment set and addition of inhibitor sets were caused by the increase of algae biomass and thus the increase of liable organic phosphorus.
Targeting Poly (ADP-Ribose) Polymerase Partially Contributes to Bufalin-Induced Cell Death in Multiple Myeloma Cells
He Huang, Yang Cao, Wei Wei, Wei Liu, Shao-Yong Lu, Yu-Bao Chen, Yan Wang, Hua Yan, Ying-Li Wu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066130
Abstract: Despite recent pharmaceutical advancements in therapeutic drugs, multiple myeloma (MM) remains an incurable disease. Recently, ploy(ADP-ribose) polymerase 1 (PARP1) has been shown as a potentially promising target for MM therapy. A previous report suggested bufalin, a component of traditional Chinese medicine (“Chan Su”), might target PARP1. However, this hypothesis has not been verified. We here showed that bufalin could inhibit PARP1 activity in vitro and reduce DNA–damage-induced poly(ADP-ribosyl)ation in MM cells. Molecular docking analysis revealed that the active site of bufalin interaction is within the catalytic domain of PAPR1. Thus, PARP1 is a putative target of bufalin. Furthermore, we showed, for the first time that the proliferation of MM cell lines (NCI-H929, U266, RPMI8226 and MM.1S) and primary CD138+ MM cells could be inhibited by bufalin, mainly via apoptosis and G2-M phase cell cycle arrest. MM cell apoptosis was confirmed by apoptotic cell morphology, Annexin-V positive cells, and the caspase3 activation. We further evaluated the role of PARP1 in bufalin-induced apoptosis, discovering that PARP1 overexpression partially suppressed bufalin-induced cell death. Moreover, bufalin can act as chemosensitizer to enhance the cell growth-inhibitory effects of topotecan, camptothecin, etoposide and vorinostat in MM cells. Collectively, our data suggest that bufalin is a novel PARP1 inhibitor and a potentially promising therapeutic agent against MM alone or in combination with other drugs.
Controls on boron isotopic fractionation of tourmaline in magmatic and submarine hydrothermal ore-forming systems
Jiang Shao-Yong,M. R. Palmer
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02891464
Large boron isotopic fractionation during magmatic-hydrothermal processes in the Lavicky leucocratic two-mica granite, Czech Republic
Jiang Shao-Yong,M. Novák
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02891463
Diurnal Variations in Purifying-tanks When Use Pontederia cordata Treating the Malodorous River Water

CHEN Jian-jun,LU Xiao-ming,LU Shao-yong,JIN Xiang-can,HUANG Min-sheng,ZHANG Yong,ZHAO Feng,

环境科学 , 2009,
Abstract: Aquatic plants (Pontederia cordata) were soaked in two purifying-tanks to investigate the effects of illumination intensity and aeration on diurnal variations of Chla,SP,POD of Pontederia cordata and pH,DO,COD,NH_4~+-N,TP of water from purifying-tanks when treating the malodorous river water at seven different times,another blank purifying-tank was set as a control. Comparative studies and correlation analysis of these different indicators were carried out to improve the plants working efficiency and provide scientific basis for optimal operation of plant purifying-tanks. Results showed that all indicators affected by changes of light intensity,TP shows best correlation coefficient (r=0.93,p<0.01) of physicochemical indicators and SP behaves best correlation coefficient (r=0.91,p<0.01) of plant physiology indicators in non-aeration purifying-tank;aeration is necessary as diurnal average of DO shows an increase of 0.13 mg/L by treatment of plant meanwhile 1.8 mg/L by plant with aeration,purifying-tanks with aeration got 7.1%,6.3% higher removing rates of COD,NH_4~+-N and 38% less TP removing rate than non-aeration plant purifying-tanks (p<0.01);with aeration treatment,significant reduction of Chla,SP content (p<0.05) and increase of POD activity (p<0.05) observed in plants;the changes of illumination intensity and aeration can significantly affect physiological characteristics of plants and should be considered carefully and need further study when treating malodorous river water by plant purifying-tanks.
Influence of Stokes component in reflected light on stimulated Brillouin scattering process

Guo Shao-Feng,Lu Qi-Sheng,Cheng Xiang-Ai,Zhou Ping,Deng Shao-Yong,Yin Yan,
,陆启生,程湘爱,周 萍,邓少永,银 燕

物理学报 , 2004,
Abstract: A new stimulated Brillouin scattering (SBS) configuration, SSS(Self Stokes Seeding), is presented to describe the influence of Stokes component in a pump light on SBS process. The fast Fourier transform is used to calculate the Stokes energy ratio which denotes the ratio of the energy of Stokes component to that of total pump laser. The coupled SBS equations is solved numerically and the SSS effects is evaluated. The study shows that when the pump laser is reflected normally by the back surface of the flat sample, the Stokes component plays an important role in SBS process, such as decreasing the initiation duration. The larger the Stokes energy ratio is, the shorter the initiation duration is.
Influence of pump laser parameters on stimulated Brillouin scattering

Deng Shao-Yong,Guo Shao-Feng,Lu Qi-Sheng,Cheng Xiang-Ai,

物理学报 , 2005,
Abstract: Numerical simulation was performed to study the stimulated Brillouin scattering(SBS) amplifier of self Stokes seeding. Chracteristic parameters such as Stokes laser,energy reflectivity,evolvement and distribution of maximum stress,pulse compression and SBS fidelity in fused silica were discussed for different Stokes ratio,wavelength,energy,pulse duration and interaction time.The focused Gaussian pump laser was used.We got conclusions that the damage in near front side of SBS medium was the characteristic of SBS; tuning parameters of pump laser, super sonic stress formed in SBS process would damage the SBS medium not only on the front side, but also the damage near the focus;and the damage near the focus would be made earlier when both parts were damaged.
Numerical study on damage phenomenon induced by transverse stimulated Brillouin scattering

Guo Shao-Feng,Lu Qi-Sheng,Zhou Ping,Zeng Xue-Wen,Deng Shao-Yong,Cheng Xiang-Ai,
,陆启生,周 萍,曾学文,邓少永,程湘爱

物理学报 , 2004,
Abstract: Based on the coupled wave equations of nonlinear optics, a two-dimensional p hysics model is established to describe transverse stimulated Brilluoin satteri ng (TSBS) in large-aperture optics of a high-power laser system. The temporal and spatial profile of the stress induced by TSBS is evaluated numerically, and the damage characteristics of optical components is presented, which agrees well with the experimental phenomenon observed at LLN laboratory. The energy loss induced by TSBS are calculated to be up to 20%, sho wing that TSBS may have strong influence on routine operation of high-power las er systems.
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