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Search Results: 1 - 10 of 66114 matches for " LOPEZ-GARCIA CARLOS "
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The lizard cerebral cortex as a model to study neuronal regeneration
LOPEZ-GARCIA CARLOS,MOLOWNY ASUNCION,NACHER JUAN,PONSODA XAVIER
Anais da Academia Brasileira de Ciências , 2002,
Abstract: The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events.
Are SNOMED CT Browsers Ready for Institutions? Introducing MySNOM
Pablo Lopez-Garcia
Computer Science , 2010,
Abstract: SNOMED Clinical Terms (SNOMED CT) is one of the most widespread ontologies in the life sciences, with more than 300,000 concepts and relationships, but is distributed with no associated software tools. In this paper we present MySNOM, a web-based SNOMED CT browser. MySNOM allows organizations to browse their own distribution of SNOMED CT under a controlled environment, focuses on navigating using the structure of SNOMED CT, and has diagramming capabilities.
The lizard cerebral cortex as a model to study neuronal regeneration
LOPEZ-GARCIA, CARLOS;MOLOWNY, ASUNCION;NACHER, JUAN;PONSODA, XAVIER;SANCHO-BIELSA, FRANCISCO;ALONSO-LLOSA, GREGORI;
Anais da Academia Brasileira de Ciências , 2002, DOI: 10.1590/S0001-37652002000100006
Abstract: the medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. there, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. this happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. this is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events.
DREAM regulates BDNF-dependent spinal sensitization
Ivan Rivera-Arconada, Tomaso Benedet, Carolina Roza, Bego?a Torres, Jorge Barrio, Agnieszka Krzyzanowska, Carlos Avenda?o, Britt Mellstr?m, José A Lopez-Garcia, José R Naranjo
Molecular Pain , 2010, DOI: 10.1186/1744-8069-6-95
Abstract: L1 DREAM transgenic mice showed reduced expression in the spinal cord of several genes related to pain, including prodynorphin and BDNF (brain-derived neurotrophic factor) and a state of basal hyperalgesia without change in A-type currents. Peripheral inflammation produced enhancement of spinal reflexes and increased expression of BDNF in wild type but not in DREAM transgenic mice. The enhancement of the spinal reflexes was reproduced in vitro by persistent electrical stimulation of C-fibers in wild type but not in transgenic mice. Exposure to exogenous BDNF produced a long-term enhancement of dorsal root-ventral root responses in transgenic mice.Our results indicate that endogenous BDNF is involved in spinal sensitization following inflammation and that blockade of BDNF induction in DREAM transgenic mice underlies the failure to develop spinal sensitization.Transcriptional repressor activity of DREAM depends on their high affinity Ca2+- dependent binding as a heterotetramer to DRE (downstream regulatory element) sites in target genes [1-4]. Increased levels of intracellular Ca2+ result in DREAM unbinding from DNA and transcriptional derepression [1]. Binding to DRE sites is controlled also by the interaction with other nucleoproteins [5,6]. DREAM mutants unable to respond to Ca2+, cAMP and/or to establish protein-protein interactions, function as cross-dominant constitutively active mutants (daDREAM) and repress permanently target genes in vivo [7,8]. Several genes have been shown to be regulated by DREAM, including prodynorphin, c-fos [1], AA-NAT, ICER [3], and BDNF [9] NCX-3 [8] and several cytokines in T lymphocytes [7]. DREAM, also known as calsenilin or KChIP-3 (K+ channel interacting protein 3), interacts with presenilins or Kv4 potassium channels, respectively [10,11].Genetic ablation of DREAM in DREAM-/- mice results in increased thresholds for noxious stimuli that have been associated to increased prodynorphin gene expression and to reduction in A-type cur
Resource Usage Analysis of Logic Programs via Abstract Interpretation Using Sized Types
Alejandro Serrano,Pedro Lopez-Garcia,Manuel V. Hermenegildo
Computer Science , 2014, DOI: 10.1017/S147106841400057X
Abstract: We present a novel general resource analysis for logic programs based on sized types. Sized types are representations that incorporate structural (shape) information and allow expressing both lower and upper bounds on the size of a set of terms and their subterms at any position and depth. They also allow relating the sizes of terms and subterms occurring at different argument positions in logic predicates. Using these sized types, the resource analysis can infer both lower and upper bounds on the resources used by all the procedures in a program as functions on input term (and subterm) sizes, overcoming limitations of existing resource analyses and enhancing their precision. Our new resource analysis has been developed within the abstract interpretation framework, as an extension of the sized types abstract domain, and has been integrated into the Ciao preprocessor, CiaoPP. The abstract domain operations are integrated with the setting up and solving of recurrence equations for inferring both size and resource usage functions. We show that the analysis is an improvement over the previous resource analysis present in CiaoPP and compares well in power to state of the art systems.
Deep XMM-Newton observation of the Eta Chamaleontis cluster
J. Lopez-Santiago,J. F. Albacete Colombo,M. A. Lopez-Garcia
Physics , 2010, DOI: 10.1051/0004-6361/201015306
Abstract: The members of the Eta Chamaleontis cluster are in an evolutionary stage in which disks are rapidly evolving. It also presents some peculiarities, such as the large fraction of binaries and accretion disks, probably related with the cluster formation process. Its proximity makes this stellar group an ideal target for studying the relation between X-ray emission and those stellar parameters. The main objective of this work is to determine general X-ray properties of the cluster members in terms of coronal temperature, column density, emission measure, X-ray luminosity and variability. We also aim to establish the relation between the X-ray luminosity of these stars and other stellar parameters, such as binarity and presence of accretion disks. A study of flare energies for each flare event and their relation with some stellar parameters is also performed. We used proprietary data from a deep XMM-Newton observation pointed at the core of the Eta Chamaleontis cluster. Specific software for the reduction of XMM-Newton data was used for the analysis of our observation. For the detection of sources, we used the wavelet-based code PWDetect. General coronal properties were derived from plasma model fitting. We also determined variability of the Eta Chamaleontis members in the EPIC field-of-view. A total of six flare-like events were clearly detected in five different stars. For them, we derived coronal properties during the flare events and pseudo-quiescent state separately. In our observations, stars that underwent a flare event have higher X-ray luminosities in the pseudo-quiescent state than cluster members with similar spectral type with no indications of flaring, independently whether they have an accretion disk or not. Observed flare energies are typical of both pre-main and main-sequence M stars. We detected no difference between flare energies of stars with and without an accretion disk.
ZNF366 is a novel corepressor for estrogen receptor alpha that mediates its effects through interaction with CtBP
S Ali, M Periyasamy, J Lopez-Garcia, RS Thomas, M Christian, MG Parker, L Buluwela
Breast Cancer Research , 2008, DOI: 10.1186/bcr1891
Abstract: We have recently identified a new ER interacting protein, ZNF366, which is recruited to the liganded ER, through interactions involving the zinc finger domains of both proteins. We show that repression of ER-regulated genes by ZNF366 involves recruitment of the well-described corepressor CtBP. This interaction is mediated by two sequence motifs in ZNF366, conforming to the consensus CtBP-binding motif (PXDLS). Mutation of these motifs in ZNF366 reduces, but does not abolish, the corepressor activity of ZNF366. Additionally, ZNF366 interacts with RIP140, raising the possibility that RIP140 and ZNF366 may act synergistically in regulating ER activity [1].Finally, we show that although ZNF366 is expressed in normal breast epithelial cells, its expression is not detected in breast cancer cells. This raises the possibility that regulation of ER activity by ZNF366 may be important in breast cancer development.
Half Mode Microwave Filters Based on Epsilon Near Zero and Mu Near Zero Concepts
Benjamin Lopez-Garcia;Devata Venkata Bhyrava Murthy;Alonso Corona-Chavez
PIER , 2011, DOI: 10.2528/PIER10100707
Abstract: A new design of microwave band pass filter design is presented using metamaterial-inspired Epsilon Near Zero (ENZ) and Mu Near Zero (MNZ) behaviors. These filters are based on waveguide technology. The proposed structure allows us to reduce the number of tunnels normally used for passband filter design by reducing its size. It is also incorporated the half mode concept to the tunnels leading a greater miniaturization. Two Chebyshev filters with two and four-poles were designed, fabricated and measured showing good agreement between simulated and experimental results.
Contrasted crustal sources for peraluminous granites of the segmented Montes de Toledo Batholith (Iberian Variscan Belt)
Billstrom K,Lopez-Garcia J A,Orejana D,Merino E
Journal of Geosciences , 2009, DOI: 10.3190/jgeosci.035
Abstract: The Variscan Montes de Toledo Batholith (MTB) is an E-W linear array of peraluminous granite plutons which is chemically segmented. The study is focused on the western segment of the MTB (W-MTB), mainly composed of granites with slightly lower CaO and higher P2O5 contents than associated eastern plutonic units and nearby S-type granites, giving them a more pronounced peraluminous nature. The chemical contrast is also observed in isotopic composition, especially in radiogenic Nd and Pb ratios. The W-MTB granites have higher initial εNd (-5.0 to -5.9) and lower 206Pb/204Pb and 208Pb/204Pb ratios than peraluminous types from the E-MTB segment. A mixed pelitic-greywackeous derivation from regional Neoproterozoic formations is suggested whereas lower crustal and meta-igneous sources were involved in the origin of the easternmost MTB granites. The presence of igneous muscovite together with coexisting andalusite and sillimanite in some of the studied granites suggests that solidus was reached at 650-700 °C and depth corresponding to the pressure of 2-3 kbar.
Phenomenology Tools on Cloud Infrastructures using OpenStack
I. Campos,E. Fernandez del Castillo,S. Heinemeyer,A. Lopez-Garcia,F. v. d. Pahlen
Computer Science , 2012, DOI: 10.1140/epjc/s10052-013-2375-0
Abstract: We present a new environment for computations in particle physics phenomenology employing recent developments in cloud computing. On this environment users can create and manage "virtual" machines on which the phenomenology codes/tools can be deployed easily in an automated way. We analyze the performance of this environment based on "virtual" machines versus the utilization of "real" physical hardware. In this way we provide a qualitative result for the influence of the host operating system on the performance of a representative set of applications for phenomenology calculations.
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